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PDIA3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) MicroRNA (2) PDI (4) Reference Standards (2) Small Interfering RNA (siRNA) (3) STAT (3)
By Research Areas:	Cancer (3) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0177

Diosgenin 5+ Cited Publications	STAT MicroRNA	Metabolic Disease
Diosgenin, a steroidal saponin, can inhibit *STAT3* signaling pathway . Diosgenin is an exogenous activator of *Pdia3/ERp57* . Diosgenin inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression .

HY-100432

LOC14 4 Publications Verification	PDI	Neurological Disease Inflammation/Immunology
LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC₅₀ and K_d values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding . LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells ^[3].

HY-122895

E64FC26 2 Publications Verification	Apoptosis PDI	Cancer
E64FC26 is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC₅₀s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6, respectively. E64FC26 shows anti-myeloma activity .

HY-RS10266

PDIA3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PDIA3 Human Pre-designed siRNA Set A contains three designed siRNAs for PDIA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PDIA3 Human Pre-designed siRNA Set A PDIA3 Human Pre-designed siRNA Set A

HY-122895A

(E/Z)-E64FC26	Apoptosis PDI	Cancer
(E/Z)-E64FC26 is a mixture complex of E-E64FC26 and Z-E64FC26. E64FC26 (E-E64FC26) is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC₅₀s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6. E64FC26 shows anti-myeloma activity .

HY-RS10267

Pdia3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pdia3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pdia3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pdia3 Mouse Pre-designed siRNA Set A Pdia3 Mouse Pre-designed siRNA Set A

HY-RS10268

Pdia3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pdia3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pdia3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pdia3 Rat Pre-designed siRNA Set A Pdia3 Rat Pre-designed siRNA Set A

HY-N0177R

Diosgenin (Standard)	Reference Standards STAT MicroRNA	Metabolic Disease
Diosgenin (Standard) is the analytical standard of Diosgenin. This product is intended for research and analytical applications. Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway . Diosgenin is an exogenous activator of Pdia3/ERp57 . Diosgenin inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression .

HY-151286

Antitumor agent-73	STAT	Cancer
Antitumor agent-73 is a Diosgenin (HY-N0177) derivative, which inhibits *STAT3* signaling and activates *Pdia3/ERp57* exogenously. Antitumor agent-73 shows potent anti-tumor activity against various cancer cell lines, 7.9-341.7-fold stronger than Diosgenin .

HY-100432R

LOC14 (Standard)	PDI Reference Standards	Neurological Disease Inflammation/Immunology
LOC14 (Standard) is the analytical standard of LOC14 (HY-100432). This product is intended for research and analytical applications. LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC50 and Kd values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding . LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells ^[3].

Diosgenin 5+ Cited Publications	Human Gut Microbiota Metabolites other families Classification of Application Fields Metabolic Disease Plants Endogenous metabolite Disease Research Fields Steroids Source Classification	STAT MicroRNA
Diosgenin, a steroidal saponin, can inhibit *STAT3* signaling pathway . Diosgenin is an exogenous activator of *Pdia3/ERp57* . Diosgenin inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression .

Diosgenin (Standard)	Structural Classification Human Gut Microbiota Metabolites other families Plants Endogenous metabolite Steroids Source Classification	Reference Standards STAT MicroRNA
Diosgenin (Standard) is the analytical standard of Diosgenin. This product is intended for research and analytical applications. Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway . Diosgenin is an exogenous activator of Pdia3/ERp57 . Diosgenin inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71148

	PDIA3 Protein, Human (HEK293, His) PDIA3 protein; Protein disulfide-isomerase A3; 58 kDa glucose-regulated protein; Disulfide isomerase ER-60; ER protein 57	Human	HEK293
	The PDIA3 protein is a disulfide isomerase that catalyzes disulfide bonding processes and serves as a key protein folding partner. It is the core of the MHC I peptide loading complex and is essential for TAPBP folding. PDIA3 Protein, Human (HEK293, His) is the recombinant human-derived PDIA3, expressed by HEK293, with C-6*His labeled tag.

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HY-P83555

	ERp57 Antibody (YA3300) ERp57; ERp60; ERp61; Glucose Regulated Protein 58 Kd; HsT17083; p58; PDIA3; Phospholipase C alpha; PI PLC	WB, IHC-P, IP	Human
	ERp57 Antibody (YA3300) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ERp57.

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PDIA3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PDIA3 Human Pre-designed siRNA Set A contains three designed siRNAs for PDIA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pdia3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Pdia3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pdia3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pdia3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Pdia3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pdia3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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