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Results for "

PDX-1

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

1

Inhibitory Antibodies

3

Natural
Products

1

Isotope-Labeled Compounds

3

Antibodies

6

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-133668
    Monoethyl phthalate

    		Drug Metabolite Cytochrome P450 PPAR Endocrinology Cancer
    Monoethyl phthalate is an orally active PDX-1 activator and the major hydrolytic metabolite of Diethyl phthalate (HY-Y0284) in vivo, with reproductive toxicity. Monoethyl phthalate targets aromatase (aromatase/CYP19A1) and PPAR to induce cell proliferation. The plasma protein binding rate of Monoethyl phthalate in rats and humans is lower than that of Diethyl phthalate. It exhibits significant enterohepatic circulation in rats and mainly accumulates in liver tissues. Monoethyl phthalate shows no estrogenic activity in estrogen-dependent human breast cancer cells. Monoethyl phthalate can be used in studies of reproductive toxicity and related environmental endocrine disruption mechanisms [1] .
    Monoethyl phthalate
  • HY-N0777
    Isorhamnetin-3-O-glucoside
    3 Publications Verification

    		 Others PERK ERK Akt PI3K Lipase Metabolic Disease
    Isorhamnetin-3-O-glucoside is an orally active natural compound. Isorhamnetin 3-O-glucoside increases P-ERK, ERK, P-Akt (Ser473), P-PI3K, and PDX-1. Isorhamnetin 3-O-glucoside downregulates C/EBPα and inhibits lipase. Isorhamnetin 3-O-glucoside reduces lipids and inhibits obesity [1] .
    Isorhamnetin-3-O-glucoside
  • HY-19694
    BRD7552

    		Insulin Receptor Endocrinology
    BRD7552, a potent PDX1 transcription factor inducer, upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. BRD7552 increases insulin expression. PDX1 is a key transcription factor involved in pancreas development and β cell function [1].
    BRD7552
  • HY-RS10295
    PDX1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    PDX1 Human Pre-designed siRNA Set A contains three designed siRNAs for PDX1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PDX1 Human Pre-designed siRNA Set A
    PDX1 Human Pre-designed siRNA Set A
  • HY-174547
    Human PDX1 mRNA

    		mRNA Metabolic Disease
    Human PDX1 mRNA encodes the human pancreatic and duodenal homeobox 1 (PDX1) protein, a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. PDX1 may be involved in the early development of the pancreas. It also plays a major role in glucose-dependent regulation of insulin gene expression.
    Human PDX1 mRNA
  • HY-RS27306
    Pdx1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Pdx1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pdx1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Pdx1 Rat Pre-designed siRNA Set A
    Pdx1 Rat Pre-designed siRNA Set A
  • HY-RS20792
    Pdx1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Pdx1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pdx1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Pdx1 Mouse Pre-designed siRNA Set A
    Pdx1 Mouse Pre-designed siRNA Set A
  • HY-133668S
    Monoethyl phthalate-d4

    		Isotope-Labeled Compounds Drug Metabolite Cytochrome P450 PPAR Cancer
    Monoethyl phthalate-d4 is the deuterium labeled Monoethyl phthalate. Monoethyl phthalate is an orally active PDX-1 activator and the major hydrolytic metabolite of Diethyl phthalate (HY-Y0284) in vivo, with reproductive toxicity. Monoethyl phthalate targets aromatase (aromatase/CYP19A1) and PPAR to induce cell proliferation. The plasma protein binding rate of Monoethyl phthalate in rats and humans is lower than that of Diethyl phthalate. It exhibits significant enterohepatic circulation in rats and mainly accumulates in liver tissues. Monoethyl phthalate shows no estrogenic activity in estrogen-dependent human breast cancer cells. Monoethyl phthalate can be used in studies of reproductive toxicity and related environmental endocrine disruption mechanisms [1] .
    Monoethyl phthalate-d4
  • HY-RS10264
    PDHX Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    PDHX Human Pre-designed siRNA Set A contains three designed siRNAs for PDHX gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PDHX Human Pre-designed siRNA Set A
    PDHX Human Pre-designed siRNA Set A
  • HY-P991294
    MGTA-117 Antibody

    		ADC Antibody Cancer
    MGTA-117 is a humanized monoclonal antibody targeting CD117. MGTA-117 can be used for synthesis of antibody-drug conjugate (ADC), utilizing an amanitin payload. MGTA-117 has potent anti-tumor activity and increases survival in three acute myeloid leukemia (AML) xenograft hNSG mice models (Kasumi-1, AML PDX 1 and AML PDX 2). MGTA-117 enables hematopoietic stem cell transplantation (HSCT) preprocessing in AML, myelodysplasia with excess blasts (MDS-EB) and gene therapy [1] .
    MGTA-117 Antibody
  • HY-N19830
    Guavenoic acid

    		Reactive Oxygen Species (ROS) Apoptosis Cancer
    Guavenoic acid is a triterpenoid compound that can be isolated from fresh leaves of Psidium guajava. Guavenoic acid protects cells in cellular oxidative damage models, inhibits intracellular ROS production, and suppresses cell apoptosis. Guavenoic acid significantly enhances cellular proliferation, promotes insulin synthesis and secretion, and upregulates the messenger RNA expression of insulin gene, PDX-1 and MafA. Guavenoic acid can be used in the research of diseases such as pancreatic islet β-cell tumors [1].
    Guavenoic acid
  • HY-RS21404
    Pdhx Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Pdhx Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pdhx gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Pdhx Mouse Pre-designed siRNA Set A
    Pdhx Mouse Pre-designed siRNA Set A

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