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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
72 Results for "
PPIase
" in MedChemExpress (MCE) Product Catalog:
Products (72)
72 Results for "PPIase" in MCE Product Catalog:
2
2 Cited Publications
KPT-6566 is a selective and covalent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades PIN1. KPT-6566 shows an IC50 value of 640 nM and a Ki value of 625.2 nM for PIN1 PPIase domain. KPT-6566 can be used for the research of cancer .
2
2 Cited Publications
Cat. No.: HY-P70007A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PPIA; Epididymis Secretory Sperm Binding Protein Li 69p; Peptidylprolyl Isomerase A; Peptidylprolyl Isomerase A (Cyclophilin A); CYPA; Peptidyl-Prolyl Cis-Trans Isomerase; Peptidyl-Prolyl Cis-Trans Isomerase A; T Cell Cyclophilin; Cyclosporin A-Binding Protein; HEL-S-69p; Cyclophilin A; PPIase; Rotamase A; CYPH; PPIase A
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor (API-1) with an IC50 of 72.3 nM. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase (PPIase) domain and potently inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development .
1
1 Cited Publications
Cat. No.: HY-P71224
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PPID; PPIase D; Peptidylprolyl Isomerase D; 40 KDa Peptidyl-Prolyl Cis-Trans Isomerase D; CYP-40; Peptidylprolyl Isomerase D (Cyclophilin D); Peptidyl-Prolyl Cis-Trans Isomerase D; Peptidyl-Prolyl Cis-Trans Isomerase; Rotamase D; Testicular Tissue Protein
Species:
Human
Source:
E. coli
Cat. No.: HY-P4581
CAS No.: 128802-78-8
Synonyms: Suc-ALPF-pNA
Cat. No.: HY-157088
Purity: 99.49%
Target:
Research Areas:
C105SR is a cyclophilin D (CypD) inhibitor targeting to peptidyl-prolylcis-trans isomerase (PPIase). C105SR inhibits mitochondrial permeability transition opening (mPTP) with an IC 50 of 5 nM. C105SR inhibits hypoxia and reoxygenation inudced hepatocyte apoptosis and increases the level of calcium retention capacity (CRC). C105SR exhibits hepaprotective effect in ischaemia-reperfusion injury (IRI) mouse model .
PPIase-Parvulin inhibitor (compound B) is a cell-permeable inhibitor targeting PPIase Pin1 and Par14, with IC50s of 1.5 and 1.0 µM, respectively. PPIase-Parvulin inhibitor has anticancer activity and inhibits the growth and proliferation of mouse embryonic fibroblasts (MEFs) .
Cat. No.: HY-W719799
CAS No.: 142997-31-7
Target:
Research Areas:
Cat. No.: HY-W046346
CAS No.: 826998-10-1
D44 is a Plasmodium FKBP35 inhibitor that selectively inhibits the FKBD35 PPIase activity, with PPIase IC50 values of 132 nM and 125 nM for Plasmodium falciparum and Plasmodium vivax, respectively. D44 exhibits antiplasmodium activity and can be used in research related to infectious diseases .
Cat. No.: HY-RS04967
Target:
Research Areas:
FKBP7 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS04962
Target:
Research Areas:
FKBP2 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS04969
Target:
Research Areas:
FKBP9 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS04963
Target:
Research Areas:
FKBP3 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS04961
Target:
Research Areas:
FKBP1B Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP1B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS10954
Target:
Research Areas:
PPIL1 Human Pre-designed siRNA Set A contains three designed siRNAs for PPIL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS04965
Target:
Research Areas:
FKBP5 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS04960
Target:
Research Areas:
FKBP1A Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS04964
Target:
Research Areas:
FKBP4 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS04956
Target:
Research Areas:
FKBP10 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
