77 Results for "

Pyrrolizidine alkaloids

" in MedChemExpress (MCE) Product Catalog:
Products (77)

77 Results for "Pyrrolizidine alkaloids" in MCE Product Catalog:

48
48 Publications Verification
Cat. No.: HY-N0750
CAS No.: 315-22-0
Synonyms: Crotaline
Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid. Monocrotaline inhibits OCT-1 and OCT-2 with IC50s of 36.8 µM and 1.8 mM, respectively. Monocrotaline has antitumor activity and is cytotoxic to hepatocellular carcinoma cells. Monocrotaline is used to induce a model of pulmonary hypertension in rodents. [2][6][8].
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2
2 Cited Publications
Cat. No.: HY-N6638
CAS No.: 480-54-6
Retrorsine is a naturally occurring toxic pyrrolizidine alkaloid. Retrorsine can bind with DNA and inhibits the proliferative capacity of hepatocytes. Retrorsine can be used for the research of hepatocellular injury .
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1
1 Cited Publications
Cat. No.: HY-113845
CAS No.: 10285-06-0
Purity:  ≥99.0%
(+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs) .
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Cat. No.: HY-N2560
CAS No.: 130-01-8
Synonyms: Senecionan-11,16-dione, 12-hydroxy-; Aureine; Senecionin
Senecionine (Senecionan-11,16-dione, 12-hydroxy-) is a pyrrolizidine alkaloid could be isolated from Senecio vulgaris. Senecionine decreases the activities of glutathione S-transferase, aminopyrine demethylase and arylhydrocarbon hydroxylase (AHH) .
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Cat. No.: HY-W017167
CAS No.: 71985-79-0
Pyrrolidin-2-yl-acetic acid hydrochloride is the precursor for the biosynthesis of Tussilagine (HY-N1388) and Isotussilagine. Pyrrolidin-2-yl-acetic acid hydrochloride can be used in neurological research .
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Cat. No.: HY-N1282
CAS No.: 480-81-9
Seneciphylline is an orally effective hepatotoxic inducer. Seneciphylline is metabolized by CYP450 enzymes into active intermediates, which covalently bind to intracellular biomacromolecules such as proteins and DNA to form adducts, which in turn trigger a series of toxic reactions, such as inducing cell apoptosis and damaging mitochondrial function. Seneciphylline can be used in hepatotoxicity research[1][2].
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Cat. No.: HY-122509
CAS No.: 2318-18-5
Purity:  98.79%
Synonyms: Senkirkine; Renardin
Senkirkin is a pyrrolizidine alkaloid derived from Tussilago farfara. Senkirkin induces chromosomal damage in lymphocytes and is metabolized by CYP3A4 .
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Cat. No.: HY-133591
CAS No.: 72755-25-0
Purity:  95.39%
Target:  

Bacterial

Research Areas:  

Infection

Senecivernine, a pyrrolizidine alkaloid isolated from Senecio species, exhibits a weakly mutagenic activity .
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Cat. No.: HY-N6637S
Senecionine N-oxide-d3 is the deuterium labeled Senecionine N-oxide. Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity .
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Cat. No.: HY-60252
CAS No.: 56879-46-0
Synonyms: 2-Pyrrolidineacetic acid
(±)-Homoproline (2-Pyrrolidineacetic acid) is the precursor for the biosynthesis of Tussilagine (HY-N1388) and Isotussilagine. (±)-Homoproline can be used in neurological research .
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Cat. No.: HY-124058
CAS No.: 6870-67-3
Jacobine?is a pyrrolizidine alkaloid (PA) from Senecio jacobaea . Jacobine is active against second instar larvae of thrips .
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Cat. No.: HY-N6931
CAS No.: 15503-87-4
Usaramine is a pyrrolizidine alkaloid that can be isolated from seeds of Crolatalaria pallida. Usaramine selective Usaramine demonstrates antibiofilm activity against Staphylococcus epidermidis. Usaramine can be used for the research of bacterial infections .
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Cat. No.: HY-N8623
CAS No.: 14140-18-2
Trachelanthamine is a pyrrolizidine alkaloid isolated from the plant .
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Cat. No.: HY-126128
CAS No.: 303-33-3
Research Areas:  

Cancer

Heliotrine is a monoester pyrrolizidine alkaloid and is used for obtaining models of hepatitis and cirrhosis of the liver .
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Cat. No.: HY-105529
CAS No.: 41708-76-3
Synonyms: (+)-Indicine N-oxide; NSC 132319
Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, is an antitumor agent for pediatric cancer and solid tumors research .
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Cat. No.: HY-N16470
CAS No.: 633-16-9
Echiumine, a pyrrolizidine alkaloid, is a major dehydropyrrolizidine metabolite of Echium plantagineum. Echiumine has significant hepatotoxic activity and can persist intact from honey through to the resulting mead .
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Cat. No.: HY-133590
CAS No.: 6209-65-0
Research Areas:  

Cancer

Heliotrine N-oxide is the corresponding PA (pyrrolizidine alkaloid) N-oxide of Heliotrine (HY-126128). Heliotrine N-oxide leads to the formation of pyrrolic DNA adducts and potential initiation of PA-induced liver tumors in vivo .
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Cat. No.: HY-N1282R
CAS No.: 480-81-9
Seneciphylline (Standard) is the analytical standard of Seneciphylline. This product is intended for research and analytical applications. Seneciphylline is a toxic pyrrolizidine alkaloid in Gynura japonica . Seneciphylline significantly increases the activities of epoxide hydrase and glutathione-S-transferase but causes reduction of cytochrome P-450 and related monooxygenase activities .
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Cat. No.: HY-N8419
CAS No.: 480-85-3
Synonyms: (+)-Retronecine
Retronecine ((+)-Retronecine) is a pyrrolizidine alkaloid found in a variety of plants. Retronecine is the most common central core for other pyrrolizidine alkaloids .
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Cat. No.: HY-122488
CAS No.: 6029-84-1
Synonyms: Heliotridine trachelanthate
Rinderine (Heliotridine trachelanthate) is a pyrrolizidine alkaloid .
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