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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
30 Results for "
RANKL-induced osteoclastogenesis
" in MedChemExpress (MCE) Product Catalog:
Products (30)
30 Results for "RANKL-induced osteoclastogenesis" in MCE Product Catalog:
8
8 Publications Verification
6
6 Cited Publications
Cat. No.: HY-N0762
CAS No.: 31524-62-6
4
Category:
Flavonoids Ginkgoaceae Phenols Polyphenols Ginkgo biloba L. Plants Disease Research Fields Inflammation/Immunology Biflavones
Target:
2
2 Cited Publications
Cat. No.: HY-N1419
CAS No.: 53452-16-7
1
1 Cited Publications
Cat. No.: HY-N0755
CAS No.: 17306-46-6
Category:
Rhus succedanea Flavonoids Flavones Plants Disease Research Fields Endocrinology Cancer Anacardiaceae
Target:
1
Category:
Quinones Monophenols Anthraquinones Rubiaceae Metabolic Disease Phenols Plants Disease Research Fields Rubia cordifolia L.
Target:
Synonyms: CID23612552
ML191 (CID23612552) is a GPR55 antagonist. ML191 inhibits ERK phosphorylation and PKC β II translocation downstream of GPR55 signaling. ML191 suppresses LPI-induced activation of ERK1/2 and p38 MAPK signaling, blocks the transcription of RANKL-induced osteoclastogenesis markers, and reduces the bone resorption activity of mature osteoclasts promoted by RANKL. ML191 can be used to investigate diseases associated with bone degradation caused by excessive osteoclast activation, such as osteoporosis and bone damage during the formation stage of bone metastases .
Cat. No.: HY-N10838
CAS No.: 124961-67-7
Category:
Crotalaria sessiliflora L. Euphorbia boetica Labiatae Terpenoids Euphorbiaceae Diterpenoids Plants
Target:
Cat. No.: HY-175703
CAS No.: 3108878-05-0
Research Areas:
RANKL-IN-1 is a selective and orally active Receptor Activator of Nuclear Factor-κ B Ligand (RANKL) inhibitor with a KD value of 7.6 μM. RANKL-IN-1 exhibits inhibitory activity and selectivity against osteoclastogenesis with an IC50 value of 0.07 μM and SI of 82.57. RANKL-IN-1binds directly to RANKL and blocks the RANKL-induced activation of the NF-κB and MAPK pathways. RANKL-IN-1 can be used for the research of metabolic disease, such as osteoporosis .
Cat. No.: HY-169857
CAS No.: 1393999-78-4
Target:
Research Areas:
AS2690168 freebase is an orally active RANKL signal transduction inhibitor which suppresses RANKL-induced osteoclastogenesis of RAW264 cells. AS2690168 can be utilized in research related to pathological osteolysis .
Cat. No.: HY-118482
CAS No.: 128533-02-8
Synonyms: Saurolactam
Category:
Alkaloids Monophenols Aristolochia debilis Sieb. et Zucc. Phenols Plants Aristolochiaceae Indole Alkaloids
Target:
Cat. No.: HY-N0755R
CAS No.: 17306-46-6
Category:
Cat. No.: HY-N9736
CAS No.: 189689-32-5
Target:
Cat. No.: HY-169857A
CAS No.: 1393899-47-2
Target:
Research Areas:
AS2690168 hydrochloride is an orally active RANKL signal transduction inhibitor which suppresses RANKL-induced osteoclastogenesis of RAW264 cells. AS2690168 can be utilized in research related to pathological osteolysis .
Cat. No.: HY-N12740
CAS No.: 111216-63-8
Category:
Target:
Research Areas:
BCPA is a Pin1 regulator without cytotoxicity. BCPA attenuates the reduction of Pin1 protein to inhibit receptor activator of RANKL-induced osteoclastogenesis. BCPA regulates osteoclast activation, used to osteoporosis research .
Cat. No.: HY-N11775
CAS No.: 1934299-51-0
Synonyms: Plebeiolide D
Category:
Target:
Cat. No.: HY-158098
CAS No.: 2157482-40-9
Target:
Research Areas:
FGFR1 inhibitor-11 (compound 5g) binds to FGFR1, inactivation of its downstream ERK1/2 and IκBα/NF-κB signaling inhibited RANKL-induced osteoclastogenesis. FGFR1 inhibitor-11 has oral bioactivity .
Cat. No.: HY-158311
CAS No.: 3036050-96-8
Target:
Research Areas:
Anti-osteoporosis agent-8 (Compound 4aa) is an inhibitor for RANKL, which inhibits RANKL-induced osteoclastogenesis and osteoclast differentiation (IC50 is 2.41 μM) in cells RAW264.7. Anti-osteoporosis agent-8 ameliorates bone loss in an ovariectomized (OVX) mice model .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
