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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
32 Results for "
Rela
" in MedChemExpress (MCE) Product Catalog:
Products (32)
32 Results for "Rela" in MCE Product Catalog:
29
29 Publications Verification
Synonyms: BBI608; BB608
Napabucasin (BBI608; BB608) is an orally active STAT3 inhibitor. Napabucasin inhibits STAT3/RelA signaling and induces cancer cell apoptosis, cell cycle arrest, and ROS/DNA damage, inhibiting cancer cell proliferation, migration, and invasion. Napabucasin, upon activation by NQO1/POR, enhances Docetaxel (HY-B0011) sensitivity and inhibits BCR-ABL1-positive leukemia self-renewal. Napabucasin recruits cytotoxic T/B lymphocytes, enhances immune checkpoint blockade, prevents liver metastasis, and radiosensitizes diffuse midline glioma. Napabucasin can be used in research on cancers such as glioblastoma, pancreatic ductal adenocarcinoma, and prostate cancer .
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4 Cited Publications
Cat. No.: HY-P73681
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Rela; NF-Kappa-B Transcription Factor P65; Prev. NFKB3; P65 Iso5 Isoform Delta 10; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 3; Alternative Protein Rela; P65; NF-Kappa-B P65delta3; V-Rel Avian Reticuloendotheliosis Viral Oncogene
Species:
Human
Source:
E. coli
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2
2 Cited Publications
Cat. No.: HY-121309
CAS No.: 24385-10-2
Synonyms: Adriamycin aglycone; Adriamycinone
2
2 Cited Publications
Cat. No.: HY-N7043
CAS No.: 142796-21-2
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1
1 Cited Publications
Cat. No.: HY-N2441
CAS No.: 74805-90-6
Category:
Liliaceae Extract Other Flavonoids Asparagaceae Extract Plant Flavonoids Phenols Polyphenols Ophiopogon japonicus (L. f.) Ker Gawl. Extract Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-170316
Ibetazol is a Importin β1 (KPNB1) inhibitor and nucleocytoplasmic transport disruptor. Ibetazol binds covalently to Cys585 of Importin β1, blocks both Importin β1-mediated direct transport and Importin α-dependent nuclear import processes, without affecting transport mediated by other nucleocytoplasmic transport proteins. Ibetazol induces cytoplasmic accumulation of Importin α1, and inhibits nuclear import of substrates carrying nuclear localization signals (NLS), including the NLS-cMyc reporter gene, RelA/p65 and SREBP1. Ibetazol triggers spindle malformation and chromosome misalignment by disrupting the mitotic function of Importin β1. Ibetazol inhibits the proliferation of cells expressing wild-type Importin β1. Ibetazol has a high activity-cytotoxicity window, lacks intrinsic fluorescence, and acts rapidly on nucleocytoplasmic transport processes. Ibetazol serves as a tool compound for investigating nuclear import processes specifically mediated by Importin β1 .
Cat. No.: HY-174864
CAS No.: 3100147-70-1
JP-163-16 is a NF-κB RelA/p65 PROTAC degrader that recruits CRBN. JP-163-16 selectively induces RelA/p65 degradation via the ubiquitin-proteasome pathway, exerts cytotoxicity and induces apoptosis in cancer cells, while showing low toxicity to non-malignant lymphocytes. JP-163-16 can be used for the research of chronic lymphocytic leukemia, triple-negative breast cancer and multiple myeloma .
Cat. No.: HY-RS11827
Target:
연구분야:
Rela Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rela gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-174865
CAS No.: 3100147-71-2
연구분야:
MMH-165-26 is a ligand for RelA/p65. MMH-165-26 reduces the expression of RelA/p65 and has significant cytotoxicity in MEC-1 (LC50 = 0.37 μM) cells. MMH-165-26 can be used for synthesizing PROTACs such as JP-163-16 (HY-174864) .
Cat. No.: HY-121309R
CAS No.: 24385-10-2
Synonyms: Adriamycin aglycone (Standard); Adriamycinone (Standard)
Category:
Cat. No.: HY-RS11826
Target:
연구분야:
RELA Human Pre-designed siRNA Set A contains three designed siRNAs for RELA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS11828
Target:
연구분야:
Rela Rat Pre-designed siRNA Set A contains three designed siRNAs for Rela gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-101512D
CAS No.: 2747996-65-0
Target:
연구분야:
rel-A-395 hydrochloride is the relative configuration of A-395 (HY-101512) hydrochloride. A-395 is an antagonist of polycomb repressive complex 2 (PRC2) protein-protein interactions that potently inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12) with an IC50 of 18 nM .
Cat. No.: HY-N7043R
CAS No.: 142796-21-2
Cat. No.: HY-N2441R
CAS No.: 74805-90-6
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
