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SCaBER

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By Targets:	Antibiotic (2) Antibody-Drug Conjugates (ADCs) (1) ATP Synthase (1) Autophagy (1) Bacterial (4) Cytochrome P450 (2) Environmental Pollutants (2) Fungal (11) Mitochondrial Metabolism (2) Myosin (1) NF-κB (2) Parasite (2) Reactive Oxygen Species (ROS) (1) Reference Standards (3) RSV (1) Succinate Dehydrogenase (1)
By Research Areas:	Cancer (6) Infection (14) Inflammation/Immunology (1)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7432

DIMBOA	Antibiotic Bacterial Fungal	Infection
DIMBOA, an antibiotic, has antibacterial properties and inhibits bacteria such as Staphylococcus aureus and the mycotoxin-producing fungus Fusarium graminearum (which causes scab). DIMBOA exhibits strong free radical scavenging activity and weak iron(III) ion reducing activity, and has antioxidant activity. DIMBOA inhibits the biosynthesis and accumulation of toxic trichothecenes by affecting the expression of Tri6 and Tri5. DIMBOA reduces plant susceptibility to scab. DIMBOA also exhibits cytotoxicity to plant cells, causing plasmolysis, cell collapse, and cell rupture .

HY-N2491

Deoxyelephantopin 1 Publications Verification	NF-κB	Cancer
Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling .

HY-134338

Ipflufenoquin	Environmental Pollutants Parasite	Others
Ipflufenoquin is an insecticide with the potential to control primary infection with apple scab. Ipflufenoquin should be applied between half an inch of green and fruit set .

HY-P11211A

D2A21 TFA	Bacterial	Infection Cancer
D2A21 TFA is an antimicrobial peptide with significant antimicrobial activity against Pseudomonas and bactericidal effect on burn scabs. D2A21 TFA has antitumor activity and can be used in prostate cancer research .

HY-P99719

Lupartumab Amadotin BAY 1129980; Anti-C4.4a antibody-drug conjugates	Antibody-Drug Conjugates (ADCs)	Cancer
Lupartumab Amadotin (BAY 1129980) is an antibody–drug conjugate (ADC) consisting of a fully human C4.4A (LYPD3)-targeting mAb (BAY 1135626) (HY-147281) conjugated to a novel, highly potent derivative of the microtubule-disrupting cytotoxic drug auristatin via a noncleavable alkyl hydrazide linker. Lupartumab Amadotin can be used for the research of non-small cell lung cancer .

HY-W020777

Triflumizole	Environmental Pollutants Fungal	Infection
Triflumizole is one of imidazole fungicides that works by inhibiting ergosterol biosynthesis, and is widely used for the control of powdery mildew and scabs on various fruits and crops .

HY-N8448

3,4-Di-O-caffeoyl quinic acid methyl ester Macroantoin F	RSV	Infection
3,4-Di-O-caffeoyl quinic acid methyl ester (Macroantoin F) is a dicaffeoyl derivative isolated from the rhizome of Elephantopus scaber Linn. 3,4-Di-O-caffeoyl quinic acid methyl ester exhibited in vitro antiviral activity against respiratory syncytial virus (RSV) with an IC₅₀* value of 0.78 μg/mL .*

HY-N2585

Isodeoxyelephantopin 1 Publications Verification	Reactive Oxygen Species (ROS) NF-κB Autophagy	Cancer
Isodeoxyelephantopin is a sesquiterpene lactone isolated from Elephantopus scaber. Isodeoxyelephantopin induces ROS generation, suppresses NF-κB activation. Isodeoxyelephantopin also modulates LncRNA expression and exhibit activities against breast cancer .

HY-N11546

Sapindoside B	Cytochrome P450 Bacterial Fungal	Infection Cancer
Sapindoside B is a substance with hepatoprotective activity, and also acts as a cytochrome P-450 (cytochrome P-450) inhibitor, antibacterial agent and membrane-disrupting agent. Sapindoside B reversibly inhibits the content of cytochrome P-450 in liver microsomes, suppresses the phenobarbital-induced increase in enzyme content, reduces the production of active metabolites mediated by cytochrome P-450, and alleviates hepatotoxic injury. Sapindoside B binds to Cutibacterium acnes lipase, reduces lipase activity, inhibits biofilm formation, and decreases bacterial adhesion. Sapindoside B exhibits cytotoxicity against human cancer, liver cancer, leukemia and glioblastoma cells. Sapindoside B inhibits mycelial growth of phytopathogenic fungal strains, possesses antibacterial activity against dermatophytes, and also has hemolytic/membrane-lytic activity. Sapindoside B can be used in research related to liver injury, Cutibacterium acnes biofilm-associated infections, gastric cancer, carcinoma, promyelocytic leukemia, glioblastoma, apple scab and grape gray mold .

HY-179120

ZJS178	Myosin	Infection
ZJS178 is a novel inhibitor of myosin I. ZJS178 is a fungicide that has inhibitory activity against Fusarium graminearum and can reduce DON toxin synthesis. ZJS178 can be used for research on plant diseases such as wheat scab .

HY-N2596

Isoscabertopin	Others	Inflammation/Immunology Cancer
Isoscabertopin is a sesquiterpene lactone isolated from Elephantopus scaber* L* and shows anti-tumor activities .

HY-174390

SDH-IN-29	Fungal Succinate Dehydrogenase	Infection
SDH-IN-29 (Compound A33) is a SDH inhibitor with an IC₅₀ of 0.0709 μM. SDH-IN-29 has a broad spectrum of antifungal activities (EC₅₀s of 0.356, 0.798 and 0.146 μg/mL for Fusarium graminearum, Sclerotinia sclerotiorum, and Rhizoctonia solani, respectively). SDH-IN-29 has moderate to significant protective effects against rice blast, wheat scab and cucumber powdery mildew .

HY-W020777R

Triflumizole (Standard)	Reference Standards Fungal	Infection
Triflumizole (Standard) is the analytical standard of Triflumizole. This product is intended for research and analytical applications. Triflumizole is one of imidazole fungicides that works by inhibiting ergosterol biosynthesis, and is widely used for the control of powdery mildew and scabs on various fruits and crops .

HY-N7432R

DIMBOA (Standard)	Antibiotic Bacterial Fungal Reference Standards	Infection
DIMBOA (Standard) is the analytical standard of DIMBOA. This product is intended for research and analytical applications. DIMBOA, an antibiotic, has antibacterial properties and inhibits bacteria such as Staphylococcus aureus and the mycotoxin-producing fungus Fusarium graminearum (which causes scab). DIMBOA exhibits strong free radical scavenging activity and weak iron(III) ion reducing activity, and has antioxidant activity. DIMBOA inhibits the biosynthesis and accumulation of toxic trichothecenes by affecting the expression of Tri6 and Tri5. DIMBOA reduces plant susceptibility to scab. DIMBOA also exhibits cytotoxicity to plant cells, causing plasmolysis, cell collapse, and cell rupture[1][2][3][4][5].

HY-W320538

Benz[g]isoquinoline-5,10-dione	Fungal	Infection
Benz[g]isoquinoline-5,10-dione, an active component isolated from the ethanolic extract of the aerial parts of Mitracarpus scaber, demonstrates notable in vitro inhibitory activity against AIDS-related pathogens, along with significant antibacterial and antifungal properties, as evidenced by the agar well-diffusion assay.

HY-134338R

Ipflufenoquin (Standard)	Reference Standards Parasite	Others
(R)-Omeprazole (sodium) (Standard) is the analytical standard of (R)-Omeprazole (sodium). This product is intended for research and analytical applications. (R)-Omeprazole sodium is a gastric acid resistant compound with activity to inhibit gastric acid secretion. (R)-Omeprazole sodium is metabolized in vivo, and its metabolism is primarily affected by cytochrome P450 enzymes. The interaction between (R)-Omeprazole sodium and mannitol may affect its bioavailability in formulations. (R)-Omeprazole sodium exhibits reversible direct and metabolism-dependent inhibition of CYP2C19 .

HY-W725177

Inpyrfluxam	Fungal Mitochondrial Metabolism	Infection
Inpyrfluxam is a succinate dehydrogenase (SDH) inhibitor. Inpyrfluxam targets the ubiquinone binding pocket of mitochondrial SDH complex subunits ViSDHB, ViSDHC, ViSDHD, interfering with cellular respiration. Inpyrfluxam inhibits conidial germination and mycelial growth of Venturia inaequalis in vitro. Inpyrfluxam can be used for the research of apple scab .

HY-N2767

Naphtho[1,2-b]furan, 2-propenoic acid deriv.	Others	Others
Naphtho[1,2-b]furan, 2-propenoic acid deriv. is a Sesquiterpenoids product that can be isolated from the herbs of Elephantopus scaber .

HY-165191

LY214352	Fungal	Infection
LY214352 is an antifungal agent that targets dihydroorotate dehydrogenase (DHO-DH). LY214352 exhibits antifungal activity against Aspergillus nidulans and agriculturally important ascomycete fungi. LY214352 can be used in studies related to grape gray mold, apple scab, and fungal infections caused by ascomycetes .

HY-122480

Fenaminstrobin SYP-1620	Fungal ATP Synthase Cytochrome P450	Infection
Fenaminstrobin (SYP-1620) is a strobilurin Fungicide. Fenaminstrobin binds to cytochrome bc1 in the mitochondrial respiratory chain, thereby inhibiting ATP production. Fenaminstrobin exhibits acute toxicity to Daphnia magna. Fenaminstrobin effectively controls diseases such as Fusarium ear rot, downy mildew, rice blast and pear scab .

HY-138439

Mandestrobin	Fungal Mitochondrial Metabolism	Infection
Mandestrobin is a fungicide that exerts fungal killing activity by inhibiting mitochondrial respiratory chain complex III. Mandestrobin exhibits differential fungicidal activity between its enantiomers, and the R-enantiomer possesses stronger activity than the S-enantiomer. Mandestrobin is used in studies related to fungal infections and the agricultural field .

Cat. No.	Product Name	Target	Research Area

HY-P11211A

D2A21 TFA	Bacterial	Infection Cancer
D2A21 TFA is an antimicrobial peptide with significant antimicrobial activity against Pseudomonas and bactericidal effect on burn scabs. D2A21 TFA has antitumor activity and can be used in prostate cancer research .

DIMBOA	Infection Zea mays L. Classification of Application Fields Antibiotics Gramineae Antibacterial Disease Research Plants Disease Research Fields Other Antibiotics Source Classification	Antibiotic Bacterial Fungal
DIMBOA, an antibiotic, has antibacterial properties and inhibits bacteria such as Staphylococcus aureus and the mycotoxin-producing fungus Fusarium graminearum (which causes scab). DIMBOA exhibits strong free radical scavenging activity and weak iron(III) ion reducing activity, and has antioxidant activity. DIMBOA inhibits the biosynthesis and accumulation of toxic trichothecenes by affecting the expression of Tri6 and Tri5. DIMBOA reduces plant susceptibility to scab. DIMBOA also exhibits cytotoxicity to plant cells, causing plasmolysis, cell collapse, and cell rupture .

Deoxyelephantopin 1 Publications Verification	Classification of Application Fields Terpenoids Sesquiterpenes Amorpha fruticosaL. Plants Compositae Disease Research Fields Source Classification Cancer	NF-κB
Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling .

3,4-Di-O-caffeoyl quinic acid methyl ester Macroantoin F	Phenols Polyphenols Amorpha fruticosaL. Plants Compositae Source Classification	RSV
3,4-Di-O-caffeoyl quinic acid methyl ester (Macroantoin F) is a dicaffeoyl derivative isolated from the rhizome of Elephantopus scaber Linn. 3,4-Di-O-caffeoyl quinic acid methyl ester exhibited in vitro antiviral activity against respiratory syncytial virus (RSV) with an IC₅₀* value of 0.78 μg/mL .*

Isodeoxyelephantopin 1 Publications Verification	Classification of Application Fields Terpenoids Sesquiterpenes Amorpha fruticosaL. Plants Compositae Disease Research Fields Source Classification Cancer	Reactive Oxygen Species (ROS) NF-κB Autophagy
Isodeoxyelephantopin is a sesquiterpene lactone isolated from Elephantopus scaber. Isodeoxyelephantopin induces ROS generation, suppresses NF-κB activation. Isodeoxyelephantopin also modulates LncRNA expression and exhibit activities against breast cancer .

Sapindoside B	Structural Classification Eleutherococcus sieboldianus Makino Terpenoids Diterpenoids Plants Araliaceae Source Classification	Cytochrome P450 Bacterial Fungal
Sapindoside B is a substance with hepatoprotective activity, and also acts as a cytochrome P-450 (cytochrome P-450) inhibitor, antibacterial agent and membrane-disrupting agent. Sapindoside B reversibly inhibits the content of cytochrome P-450 in liver microsomes, suppresses the phenobarbital-induced increase in enzyme content, reduces the production of active metabolites mediated by cytochrome P-450, and alleviates hepatotoxic injury. Sapindoside B binds to Cutibacterium acnes lipase, reduces lipase activity, inhibits biofilm formation, and decreases bacterial adhesion. Sapindoside B exhibits cytotoxicity against human cancer, liver cancer, leukemia and glioblastoma cells. Sapindoside B inhibits mycelial growth of phytopathogenic fungal strains, possesses antibacterial activity against dermatophytes, and also has hemolytic/membrane-lytic activity. Sapindoside B can be used in research related to liver injury, Cutibacterium acnes biofilm-associated infections, gastric cancer, carcinoma, promyelocytic leukemia, glioblastoma, apple scab and grape gray mold .

Isoscabertopin	Classification of Application Fields Terpenoids Sesquiterpenes Amorpha fruticosaL. Plants Compositae Disease Research Fields Inflammation/Immunology Source Classification	Others
Isoscabertopin is a sesquiterpene lactone isolated from Elephantopus scaber* L* and shows anti-tumor activities .

DIMBOA (Standard)	Structural Classification Zea mays L. Antibiotics Gramineae Antibacterial Disease Research Plants Other Antibiotics Source Classification	Antibiotic Bacterial Fungal Reference Standards
DIMBOA (Standard) is the analytical standard of DIMBOA. This product is intended for research and analytical applications. DIMBOA, an antibiotic, has antibacterial properties and inhibits bacteria such as Staphylococcus aureus and the mycotoxin-producing fungus Fusarium graminearum (which causes scab). DIMBOA exhibits strong free radical scavenging activity and weak iron(III) ion reducing activity, and has antioxidant activity. DIMBOA inhibits the biosynthesis and accumulation of toxic trichothecenes by affecting the expression of Tri6 and Tri5. DIMBOA reduces plant susceptibility to scab. DIMBOA also exhibits cytotoxicity to plant cells, causing plasmolysis, cell collapse, and cell rupture[1][2][3][4][5].

Naphtho[1,2-b]furan, 2-propenoic acid deriv.	Terpenoids Sesquiterpenes Amorpha fruticosaL. Plants Compositae Source Classification	Others
Naphtho[1,2-b]furan, 2-propenoic acid deriv. is a Sesquiterpenoids product that can be isolated from the herbs of Elephantopus scaber .

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SCaBER

Inhibitors & Agonists

Peptides

NaturalProducts

Natural
Products