Ipflufenoquin
Based on 1 publication(s) in Google Scholar
Ipflufenoquin is a quinoline fungicide with broad-spectrum antifungal activity, exhibiting an IC50 of 0.77 µM against Aspergillus fumigatus. Ipflufenoquin possesses DHODH inhibitory activity and blocks pyrimidine nucleotide biosynthesis. Ipflufenoquin binds to the class 2 DHODH ubiquinone-binding tunnel, disrupting coenzyme Q10 electron acceptor function and the conversion of dihydroorotate to orotate. Ipflufenoquin controls gray mold, can select A. fumigatus DHODH variants, and shifts fungal communities toward less sensitive pathogens. Ipflufenoquin can be used for plant infection-related research.
For research use only. We do not sell to patients.
- Purity : 99.78%
- CAS No.: 1314008-27-9
- Formula: C19H16F3NO2
- Molecular Weight:347.33
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Ipflufenoquin (100 mg/L; 3 days) shows control efficacy of 63.2% and 76.2% against cucumber gray mold caused by B. cinerea Mie 16176 and MAFF306812, respectively[1].
Ipflufenoquin (100 mg a.i./L; 2 days) provides 62.9% control efficacy against Chinese cabbage Sclerotinia rot caused by S. sclerotiorum Nakayagi 3-2[1].
Ipflufenoquin (100 mg a.i./L) achieves 99.5% control efficacy against cucumber anthracnose caused by a mixed strain of C. orbiculare CL‑2 and CL‑10, but shows lower control efficacy against cucumber target leaf spot caused by C. cassiicola AI06 and Kara 2‑1‑1, and has no control effect on grape white rot caused by C. vitis Nagano 1[1].
Ipflufenoquin (0.01-100 mg/L; 3 days) inhibits the mycelial growth of 88 strawberry Botrytis cinerea isolates with a mean EC50 of 0.46 mg/L, and also inhibits spore elongation of 16 Botrytis cinerea isolates with a mean EC50 of 0.07 mg/L[2].
Ipflufenoquin (0.001-100 mg/L; up to 9 days) exhibits species-dependent in vitro activity against strawberry-associated fungi, with EC50 <0.003 mg/L against Chaetomium globosum and Aspergillus flavus, and EC50 >100 mg/L against Cladosporium tenuissimum, Rhizopus oryzae, and Rhizoctonia solani[2].
Ipflufenoquin (25-100 mg/L) has a control effect on gray mold caused by Botrytis cinerea CMML23‑BC95 on greenhouse strawberry plants; it is also effective against the SDHI-resistant Botrytis cinerea CMML23‑BC79[2].
Aspergillus fumigatus MFIG001 and all 30 tested natural isolates; exogenous pyrimidines reverse its antifungal activity, and the MIC of MFIG001 increases to > 50 mg/L in RPMI‑1640 medium supplemented with uridine‑uracil; Aspergillus fumigatus DHODH mutants G119C, G119S, and G119A are resistant to it, all with MICs > 50 mg/L[3].
Ipflufenoquin (0.17-50 mg/L; 48 h) is resisted by the reconstructed H116R, L164P, and V200E mutants, with MIC > 50 mg/L for all mutants and reduced sub-MIC susceptibility[3].
Ipflufenoquin (3.125-25 mg/L) causes V200E to predominate in mixed Aspergillus fumigatus populations, and G119C and H116R also exhibit a fitness advantage[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1314008-27-9
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Appearance Solid
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Molecular Weight 347.33
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Formula C19H16F3NO2
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Color Off-white to light yellow
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SMILES
OC(C)(C)C1=C(F)C=CC=C1OC2=CC3=CC=C(F)C(F)=C3N=C2C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (287.91 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 5 mg/mL (14.40 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (298 KB)
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SDS (398 KB)
- English - EN (398 KB)
- Français - FR (398 KB)
- Deutsch - DE (398 KB)
- Norwegian - NO (398 KB)
- Español - ES (398 KB)
- Swedish - SV (398 KB)
- Italian - IT (398 KB)
- Korean - KR (398 KB)
- Portuguese - PT (398 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8791 mL | 14.3955 mL | 28.7911 mL | 71.9777 mL |
| 5 mM | 0.5758 mL | 2.8791 mL | 5.7582 mL | 14.3955 mL | |
| 10 mM | 0.2879 mL | 1.4396 mL | 2.8791 mL | 7.1978 mL | |
| 15 mM | 0.1919 mL | 0.9597 mL | 1.9194 mL | 4.7985 mL | |
| 20 mM | 0.1440 mL | 0.7198 mL | 1.4396 mL | 3.5989 mL | |
| 25 mM | 0.1152 mL | 0.5758 mL | 1.1516 mL | 2.8791 mL | |
| 30 mM | 0.0960 mL | 0.4799 mL | 0.9597 mL | 2.3993 mL | |
| 40 mM | 0.0720 mL | 0.3599 mL | 0.7198 mL | 1.7994 mL | |
| 50 mM | 0.0576 mL | 0.2879 mL | 0.5758 mL | 1.4396 mL | |
| 60 mM | 0.0480 mL | 0.2399 mL | 0.4799 mL | 1.1996 mL | |
| 80 mM | 0.0360 mL | 0.1799 mL | 0.3599 mL | 0.8997 mL | |
| 100 mM | 0.0288 mL | 0.1440 mL | 0.2879 mL | 0.7198 mL |
Ipflufenoquin Related Classifications
HY-134338 Related Classifications
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