Search Result

Results for "

SF3b

" in MedChemExpress (MCE) Product Catalog:

By Targets:	SF3B1 (10) ADC Payload (1) Apoptosis (7) Bcl-2 Family (2) Ceramidase (1) Cuproptosis (1) DNA/RNA Synthesis (3) Drug Derivative (1) Drug Isomer (1) Fluorescent Dye (1) LPL Receptor (1) Mitochondrial Metabolism (1) PROTACs (1) Small Interfering RNA (siRNA) (10)
By Research Areas:	Cancer (18) Cardiovascular Disease (1) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (6) siRNAs (10)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: SF3B1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16399

Pladienolide B 5 Publications Verification	Apoptosis SF3B1	Cancer
Pladienolide B is a potent cancer cell growth inhibitor that targets the *SF3B1* subunit of the spliceosome. Pladienolide B exerts antitumor activities mediated through the inhibition of pre-mRNA splicing. Pladienolide B induces apoptosis ^[3].

HY-111517

H3B-8800	Apoptosis SF3B1	Cancer
H3B-8800 is a potent and orally active SF3B splicing modulator. H3B-8800 direct interaction with the SF3b complex and shows anti-cancer activity. H3B-8800 has the potential for the research of acute myeloid leukemia (AML) with SF3B1 mutant .

HY-129589

Thailanstatin A 2 Publications Verification	ADC Payload	Cancer
Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC₅₀=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC₅₀s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC ^[3].

HY-16466

Spliceostatin A	SF3B1	Cancer
Spliceostatin A, the FR901464 (HY-16212) methylated derivative, is a potent anti-tumor agent. Spliceostatin A inhibits splicing and promotes pre-mRNA accumulation by binding *SF3B1. SF3B1* is a subcomplex of U2 small nuclear ribonucleoprotein in the spliceosome. Spliceostatin A induces Apoptosis in chronic lymphocytic leukemia (CLL) cells ^[3].

HY-168534

WX-02-23	SF3B1 Apoptosis	Cancer
WX-02-23 is a small-molecule probe that stereoselectively and site-specifically binds to C258 of FOXA1 and C1111 of *SF3B1. WX-02-23 remodels FOXA1's chromatin binding and pioneer activity in a DNA-dependent manner, disrupts spliceosome assembly, and enhances the thermal stability of SF3B1. WX-02-23 inhibits tumor cell proliferation and induces apoptosis*. WX-02-23 can be used for research on cancers such as prostate cancer ^[3] .

HY-19828

Herboxidiene GEX1A	DNA/RNA Synthesis	Cancer
Herboxidiene (GEX1A) is a potent phytotoxic polyketide from Streptomyces sp. A7847 with a diverse range of activities, including herbicidal, anti-cholesterol, anti-tumor effects. Herboxidiene inhibits the pre-mRNA splicing process by binding to spliceosome-associated protein (SAP) 155, a subunit of SF3b, in the splicesome .

HY-141881

PROTAC-O4I2	PROTACs Apoptosis SF3B1	Cancer
PROTAC-O4I2 is a PROTAC targets splicing factor 3B1 (SF3B1). PROTAC-O4I2 induces FLAG-SF3B1 degradation with an IC₅₀ value of 0.244 μM in K562 cells. PROTAC-O4I2 also induces cellular apoptosis in K562 WT cells .

HY-148384

UHMCP1	Fluorescent Dye	Cancer
UHMCP1 is a chemical probe of U2AF homology motifs (UHM) with a K_d of 79 μM. UHMCP1 prevents the SF3b155/U2AF65 interaction, impacts RNA splicing and cell viability. UHMCP1 has potential anticancer properties .

HY-162386

UM4118	Cuproptosis Mitochondrial Metabolism	Cancer
UM4118 is a potent copper-selective non-genotoxic copper ionophore that induces cuproptosis in acute myeloid leukemia cells. UM4118 exhibits stronger activity against SF3B1G12C mutant acute myeloid leukemia cells. UM4118 transports extracellular copper into cells, elevates intracellular and mitochondrial copper levels, and triggers lipoylated DLAT aggregation, proteotoxic stress, iron-sulfur cluster protein depletion, reduced lipoylated protein levels, and maximal mitochondrial respiratory damage. UM4118 cytotoxicity can be enhanced by supplementation with extracellular copper, abolished by copper chelation, and shows synthetic lethal effects in the absence of iron-sulfur cluster biosynthesis/transport genes. UM4118 can be used for the study of acute myeloid leukemia .

HY-133924

18-Deoxyherboxidiene RQN-18690A	SF3B1	Cardiovascular Disease Cancer
18-Deoxyherboxidiene (RQN-18690A) is a potent angiogenesis inhibitor. 18-Deoxyherboxidiene targets SF3b, a spliceosome component that is a subcomplex of the U2 small nuclear ribonucleoprotein (snRNP) in the spliceosome. 18-Deoxyherboxidiene inhibits the migration and tube formation of human umbilical vein endothelial cells (HUVECs) without significant cell toxicity. 18-Deoxyherboxidiene has the potential for cancer research .

HY-158783

SACLAC	Ceramidase Bcl-2 Family LPL Receptor Apoptosis	Neurological Disease
SACLAC, a Ceramide analog, is a potent and covalent acid ceramidase (ASAH1; AC) inhibitor with a K_i of 97.1 nM. SACLAC effectively blocks AC activity and induces a decrease in sphingosine 1-phosphate (S1P) and total ceramide levels. SACLAC reduces the levels of splicing factor SF3B1 and alternative Mcl-1 mRNA splicing, increases pro-apoptotic Mcl-1S levels to induce apoptosis in acute myeloid leukemia (AML) cells. SACLAC reduces the leukemic burden in human AML xenograft mouse models .

HY-114461

FD-895	DNA/RNA Synthesis Apoptosis	Cancer
FD-895 is a spliceosome modulator derived from a polyketide natural product, targeting the SF3b subunit of the spliceosome. FD-895 possesses core biological activities for regulating RNA splicing (intron retention, alternative splicing) and inducing apoptosis of cancer cells. FD-895 can be used for the research of cancer, such as chronic lymphocytic leukemia (CLL) .

HY-RS12760

SF3B1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SF3B1 Human Pre-designed siRNA Set A contains three designed siRNAs for SF3B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SF3B1 Human Pre-designed siRNA Set A SF3B1 Human Pre-designed siRNA Set A

HY-120907

Sudemycin E	SF3B1	Cancer
Sudemycin E is an analog of FR901464 (HY-16212). Sudemycin E can induce reversible changes in alternative splicing and abnormalities in chromatin modifications by binding to SF3B1, a component of the U2 small nuclear ribonucleoprotein (snRNP), thereby leading to the death of cancer cells. Sudemycin E has anti-tumor activity and can be used in tumor research .

HY-RS20489

Sf3b3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sf3b3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sf3b3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sf3b3 Mouse Pre-designed siRNA Set A Sf3b3 Mouse Pre-designed siRNA Set A

HY-RS12764

SF3B5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SF3B5 Human Pre-designed siRNA Set A contains three designed siRNAs for SF3B5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SF3B5 Human Pre-designed siRNA Set A SF3B5 Human Pre-designed siRNA Set A

HY-RS12763

SF3B4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SF3B4 Human Pre-designed siRNA Set A contains three designed siRNAs for SF3B4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SF3B4 Human Pre-designed siRNA Set A SF3B4 Human Pre-designed siRNA Set A

HY-RS26997

Sf3b3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sf3b3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sf3b3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sf3b3 Rat Pre-designed siRNA Set A Sf3b3 Rat Pre-designed siRNA Set A

HY-RS12765

SF3B6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SF3B6 Human Pre-designed siRNA Set A contains three designed siRNAs for SF3B6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SF3B6 Human Pre-designed siRNA Set A SF3B6 Human Pre-designed siRNA Set A

HY-RS12761

SF3B2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SF3B2 Human Pre-designed siRNA Set A contains three designed siRNAs for SF3B2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SF3B2 Human Pre-designed siRNA Set A SF3B2 Human Pre-designed siRNA Set A

HY-RS12762

SF3B3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SF3B3 Human Pre-designed siRNA Set A contains three designed siRNAs for SF3B3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SF3B3 Human Pre-designed siRNA Set A SF3B3 Human Pre-designed siRNA Set A

HY-122637

Sudemycin K	SF3B1	Cancer
Sudemycin K is a selective splicing inhibitor targeting *SF3B1. Sudemycin K blocks U2 snRNP recognition of branch point sequences in pre-mRNA, inducing tumor-specific splicing deregulation and apoptosis. Sudemycin K is promising for research of SF3B1-mutated* malignancies such as chronic lymphocytic leukemia (CLL) and myelodysplastic syndromes (MDS) .

HY-148384A

UHMCP1 dihydrochloride	DNA/RNA Synthesis	Cancer
UHMCP1 dihydrochloride is a potent UHM domain splicing inhibitor with a K_d value of 79 μM. UHMCP1 dihydrochloride prevents the SF3b155/U2AF ⁶⁵ interaction. UHMCP1 dihydrochloride impacts cell viability and RNA splicing .

HY-RS23526

Sf3b1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sf3b1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sf3b1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sf3b1 Rat Pre-designed siRNA Set A Sf3b1 Rat Pre-designed siRNA Set A

HY-RS17082

Sf3b1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sf3b1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sf3b1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sf3b1 Mouse Pre-designed siRNA Set A Sf3b1 Mouse Pre-designed siRNA Set A

HY-148384B

trans-UHMCP1	Drug Isomer	Cancer
Trans-UHMCP1 is the trans-isomer of UHMCP1 (HY-148384). UHMCP1 is a chemical probe of the U2AF homologous motif (UHM), with a K_d value of 79 μM. UHMCP1 inhibits the interaction between SF3b155/U2AF ⁶⁵, affecting RNA splicing and cell viability. UHMCP1 has potential anti-cancer properties .

HY-181421

WX-02-43	SF3B1	Cancer
WX-02-43 is a weak covalent inhibitor of *SF3B1, and is the (1S,3R) enantiomer of WX-02-23 (HY-168534). WX-02-43 cannot effectively covalently modify the C258* site in the DNA-binding domain of FOXA1, and its inhibitory activity against SF3B1 is also weaker than that of WX-02-23. WX-02-43 serves as a negative control probe that fails to remodel the chromatin binding pattern and transcriptional activity of FOXA1. WX-02-43 can be used in studies on cancers such as prostate cancer to verify the specific effects of WX-02-23 on FOXA1 and SF3B1 targets ^[3].

HY-15867

Meayamycin B (+)-Meayamycin B	SF3B1 Bcl-2 Family Apoptosis	Cancer
Meayamycin B ((+)-Meayamycin B) is a potent *SF3B1* inhibitor. Meayamycin B upregulates the proapoptotic Mcl-1_S and downregulates Mcl-1_L at the pre-mRNA splicing level. Meayamycin B does not regulate the alternative splicing of Bcl-x. Meayamycin B and ABT-737 (HY-50907) synergistically causes Apoptosis. Meayamycin B exhibits anticancer activity against non-small cell lung cancer .

HY-114461A

(16R,17S)-FD-895	Drug Derivative	Cancer
(16R,17S)-FD-895, a similar compound to FD-895 (HY-114461), is a potent in vivo splice regulatory agent. (16R,17S)-FD-895 retains the similar anti-proliferative activity as FD-895. (16R,17S)-FD-895 can be used for research on colon cancer .

Herboxidiene GEX1A	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Biological Pesticide Research Cancer Agricultural Research Source Classification	DNA/RNA Synthesis
Herboxidiene (GEX1A) is a potent phytotoxic polyketide from Streptomyces sp. A7847 with a diverse range of activities, including herbicidal, anti-cholesterol, anti-tumor effects. Herboxidiene inhibits the pre-mRNA splicing process by binding to spliceosome-associated protein (SAP) 155, a subunit of SF3b, in the splicesome .

Species:	Human (2)
Tag:	His (1) Strep (1) Tag Free (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701566

	SF3B3 Protein, Human (sf9) SF3b3; Splicing factor 3b subunit 3; Pre-mRNA-splicing factor SF3b 130 kDa subunit; SF3b130; STAF130; Spliceosome-associated protein 130; SAP 130	Human	Sf9 insect cells
	SF3B3 protein is a key splicing factor in the SF3B complex and plays a central role in pre-mRNA splicing. It is essential for "A" complex assembly and stabilizes U2 snRNP binding to branch point sequences. SF3B3 Protein, Human (sf9) is the recombinant human-derived SF3B3 protein, expressed by sf9 insect cells , with tag free.

HY-P701567

	SF3B3 Protein, Human (sf9, His, StrepII) SF3b3; Splicing factor 3b subunit 3; Pre-mRNA-splicing factor SF3b 130 kDa subunit; SF3b130; STAF130; Spliceosome-associated protein 130; SAP 130	Human	Sf9 insect cells
	SF3B3 protein is a key splicing factor in the SF3B complex and plays a central role in pre-mRNA splicing. It is essential for "A" complex assembly and stabilizes U2 snRNP binding to branch point sequences. SF3B3 Protein, Human (sf9, His, Strep) is the recombinant human-derived SF3B3 protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Mouse (2) Rabbit (4)
Reactivity:	Human (5) Rat (3) Mouse (3)
Application:	IHC-P (6) ICC/IF (1) IF-Tissue (1) IHC-F (1) WB (2) FC (1)
Isotype:	IgG (4) IgG2b (2)
Conjugation:	Non-conjugated (6)
Clonality:	Monoclonal (3) Recombinant (3)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82511

	SF3B1 Antibody (YA2256) SF3b1; SAP155; Splicing factor 3b subunit 1; Pre-mRNA-splicing factor SF3b 155 kDa subunit; SF3b155; Spliceosome-associated protein 155; SAP 155	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	SF3B1 Antibody (YA2256) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SF3B1.

HY-P81426

	SF3B3 Antibody (YA1171) SF3b3; KIAA0017; SAP130; Splicing factor 3b subunit 3; Pre-mRNA-splicing factor SF3b 130 kDa subunit; SF3b130; STAF130; Spliceosome-associated protein 130; SAP 130	IHC-P	Human
	SF3B3 Antibody (YA1171) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SF3B3.

HY-P81426A

	SF3B3 Antibody (YA1171)(PBS only) SF3b3; KIAA0017; SAP130; Splicing factor 3b subunit 3; Pre-mRNA-splicing factor SF3b 130 kDa subunit; SF3b130; STAF130; Spliceosome-associated protein 130; SAP 130	IHC-P	Human
	SF3B3 Antibody (YA1171) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SF3B3.

HY-P88589

	SF3B14 Antibody (YA8273) CGI-110; HSPC175; Ht006; P14; SAP14; SAP14a; SF3b14; SF3b14a	IHC-P	Human, Mouse, Rat
	SF3B14 Antibody (YA8273) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to SF3B14.

HY-P87960

	SF3B3 Antibody (YA7645)	WB, IHC-P, IHC-F, IF-Tissue
	SF3B3 Antibody (YA7645) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SF3B3.

HY-P88589A

	SF3B14 Antibody (YA8273)(PBS only) CGI-110; HSPC175; Ht006; P14; SAP14; SAP14a; SF3b14; SF3b14a	IHC-P	Human, Mouse, Rat
	SF3B14 Antibody (YA8273) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to SF3B14.