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Results for "

SIRT1-IN-2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (2) Apoptosis (8) Autophagy (4) Caspase (2) Dihydroorotate Dehydrogenase (2) Epigenetic Reader Domain (2) ERK (4) FASTK (2) GABA Receptor (1) Isotope-Labeled Compounds (1) JNK (2) Keap1-Nrf2 (6) MDM-2/p53 (4) Microtubule/Tubulin (1) NF-κB (6) NOD-like Receptor (NLR) (1) p38 MAPK (2) PKA (2) PPAR (1) Pyroptosis (1) Reactive Oxygen Species (ROS) (3) Reference Standards (2) ROCK (2) Sirtuin (20) SOD (2) Syk (1) TGF-beta/Smad (1) Toll-like Receptor (TLR) (3) TSH Receptor (2)
By Research Areas:	Cancer (17) Cardiovascular Disease (4) Inflammation/Immunology (9) Metabolic Disease (6) Neurological Disease (7)

By Targets:

AMPK (2)

Apoptosis (8)

Autophagy (4)

Caspase (2)

Dihydroorotate Dehydrogenase (2)

Epigenetic Reader Domain (2)

ERK (4)

FASTK (2)

GABA Receptor (1)

Isotope-Labeled Compounds (1)

JNK (2)

Keap1-Nrf2 (6)

MDM-2/p53 (4)

Microtubule/Tubulin (1)

NF-κB (6)

NOD-like Receptor (NLR) (1)

p38 MAPK (2)

PKA (2)

PPAR (1)

Pyroptosis (1)

Reactive Oxygen Species (ROS) (3)

Reference Standards (2)

ROCK (2)

Sirtuin (20)

SOD (2)

Syk (1)

TGF-beta/Smad (1)

Toll-like Receptor (TLR) (3)

TSH Receptor (2)

By Research Areas:

Cancer (17)

Cardiovascular Disease (4)

Inflammation/Immunology (9)

Metabolic Disease (6)

Neurological Disease (7)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15452

Selisistat Maximum Cited Publications 292 Publications Verification EX-527	Sirtuin	Inflammation/Immunology Cancer
Selisistat (EX-527) is a potent and selective *SirT1* (Sir2 in Drosophila melanogaster) inhibitor with an IC₅₀ of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease .

HY-116152

Cipepofol Ciprofol; HSK3486	GABA Receptor Sirtuin Keap1-Nrf2 Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cipepofol (Ciprofol), a novel 2,6-disubstituted phenol derivative, is a positive allosteric modulator and direct agonist of the GABA_A receptor. Cipepofol can cause the central nerve inhibition and promote sleep based on the structural modification of Propofol (HY-B0649). Cipepofol can activate the sirtuin1 (Sirt1)/Nrf2 pathway. Cipepofol protects the heart against Isoproterenol (ISO; HY-B0468)-induced myocardial infarction by reducing cardiac oxidative stress, inflammatory response and cardiomyocyte apoptosis .

HY-N0526

2"-O-Galloylhyperin 2 Publications Verification	Sirtuin Keap1-Nrf2 NF-κB ERK p38 MAPK JNK TSH Receptor Reactive Oxygen Species (ROS) SOD	Neurological Disease Inflammation/Immunology
2''-O-Galloylhyperin is an active natural compound with anti‑inflammatory, antioxidant, anti‑adipogenic, antifibrotic, and cytostatic activities. 2''-O-Galloylhyperin upregulates *SIRT1/Nrf2* signaling, inhibits NF-κB and *MAPK (ERK1/2, p38, JNK)* phosphorylation, suppresses TSHR activation, reduces ROS accumulation, and enhances SOD and GSH-Px activities. 2''-O-Galloylhyperin protects against LPS-induced tissue injury, enhances survival, and inhibits adipogenesis and fibrosis. 2"-O-Galloylhyperin can be used for the research of sepsis, acute lung injury, and thyroid eye disease .

HY-15510

Tenovin-6 5 Publications Verification	MDM-2/p53 Dihydroorotate Dehydrogenase Sirtuin Autophagy	Cancer
Tenovin-6, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC₅₀s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 also inhibits dihydroorotate dehydrogenase (DHODH) .

HY-N1990

Gypenoside XLIX 2 Publications Verification	PPAR Sirtuin Keap1-Nrf2 Toll-like Receptor (TLR) NF-κB Reactive Oxygen Species (ROS) NOD-like Receptor (NLR) Apoptosis Pyroptosis Autophagy	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Gypenoside XLIX is a multifunctional bioactive compound that can be isolated from Gynostemma pentaphyllum, with a K_a value of 1.58 μM for its binding to *SIRT1. Gypenoside XLIX acts as a PPAR-α* agonist. It inhibits the activation of TLR4-mediated NF-κB signaling pathway by activating the *Sirt1/Nrf2* signaling pathway, reduces ROS accumulation, and alleviates hepatic inflammatory injury in mice with sepsis-induced liver disease. Gypenoside XLIX targets *SIRT1* to block YAP-NLRP3 activation and improve sepsis-induced cardiomyopathy. Gypenoside XLIX inhibits apoptosis (Apoptosis), pyroptosis (Pyroptosis), autophagy (Autophagy), lipid peroxidation, pro-inflammatory cytokines and anti-inflammatory cytokines. Gypenoside XLIX alleviates sepsis-induced splenic injury by inhibiting inflammation and oxidative stress, and mitigates sepsis-associated encephalopathy by targeting PPAR-α. Gypenoside XLIX prevents acute kidney injury by inhibiting IGFBP7/IGF1R-mediated programmed cell death and inflammation. Gypenoside XLIX inhibits the expression and activity of vascular cell adhesion molecule-1 in cytokine-induced human endothelial cells. Gypenoside XLIX is applicable to research related to acute liver injury, lung injury, cardiomyopathy, acute splenic injury, sepsis-associated encephalopathy, acute kidney injury, atherosclerosis and chronic inflammation .

HY-N7675

Flavanomarein	NF-κB TGF-beta/Smad Syk	Cardiovascular Disease Neurological Disease Metabolic Disease
Flavanomarein is a substance with cytoprotective, anti-inflammatory and antioxidant activities, with a K_a of 3.064e-5 M against human Syk. Flavanomarein enhances the phosphorylation level of AKT, regulates the expression of PKC-δ, P85α, PKC-β1, Sirt1, Bcl-2 and ICAD, and inhibits the nuclear translocation of NF-κB p65. Flavanomarein regulates EMT marker proteins, promotes the proliferation of HK-2 cells, and protects neuronal cells from 6-OHDA-induced neurotoxic damage. Flavanomarein can be used in studies related to Parkinson's disease and diabetic nephropathy.

HY-15869

Inauhzin 3 Publications Verification INZ	Sirtuin MDM-2/p53	Cancer
Inauhzin is a dual *SirT1/IMPDH2* inhibitor, and acts as an activator p53, used in the research of cancer.

HY-148712

SIRT6 activator 12q	Apoptosis Sirtuin	Cancer
SIRT6 activator 12q is potent, selective and orally active *SIRT6* activator with IC₅₀ values of 171.20, >200, >200, >200, 0.58 μM for SIRT1, SIRT2, SIRT3, SIRT5, SIRT6, respectively. SIRT6 activator 12q inhibits cell growth and migration. SIRT6 activator 12q induces Apoptosis and cell cycle arrest at G2 phase. SIRT6 activator 12q shows anticancer activity .

HY-146689

*SIRT1-IN-2*	Sirtuin	Cancer
SIRT1-IN-2 (compound 3h) is a potent and selective *SIRT1* (silent information regulator 1) inhibitor, with an IC₅₀ of 1.6 μM .

HY-15510B

Tenovin-6 Hydrochloride 5 Publications Verification	MDM-2/p53 Dihydroorotate Dehydrogenase Sirtuin Autophagy	Cancer
Tenovin-6 Hydrochloride, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 Hydrochloride inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC₅₀s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 Hydrochloride also inhibits dihydroorotate dehydrogenase (DHODH) .

HY-N12378

β-Patchoulene	NF-κB Toll-like Receptor (TLR) PKA Epigenetic Reader Domain Keap1-Nrf2 Sirtuin AMPK Caspase FASTK ERK ROCK Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
β-Patchoulene is an orally active anti-inflammatory, antioxidant, and anti-apoptotic agent. β-Patchoulene inhibits the NF-κB, TLR4, and cAMP/PKA/CREB signaling pathways; activates the *Sirt1/Nrf2* and AMPK signaling pathways; and targets Fas/FasL, Caspase-3, *ERK1/2, ROCK1/MLC2* for inhibition. β-Patchoulene regulates cytokine secretion, inflammatory cell infiltration, lipid peroxidation, cell polarization, gut microbiota, and lipid metabolism, restores barrier function, mitochondrial function, and cell viability, and exhibits repellent activity against Spodoptera exigua larvae. β-Patchoulene can be used in research related to various inflammatory, ischemic, fibrosis-associated diseases, as well as hepatocellular carcinoma ^[12].

HY-156023

*SIRT1 activator 2*	Sirtuin	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
SIRT1 activator 2 is a *SIRT1* activator with an ED₅₀ value <5 μM. SIRT1 activator 2 modulates SIRT1 deacetylase activity. SIRT1 activator 2 can be used for aging research .

HY-15452R

Selisistat (Standard) EX-527 (Standard)	Sirtuin Reference Standards	Inflammation/Immunology Cancer
Selisistat (Standard) is the analytical standard of Selisistat. This product is intended for research and analytical applications. Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC50 of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease .

HY-155727

Sirt1/2-IN-2	Sirtuin Apoptosis	Cancer
Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor of SIRT1/2 with IC₅₀s of 1.8 μM (SIRT1) and 2.4 μM (SIRT2), respsectivley. Sirt1/2-IN-2 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-2 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines .

HY-146013

Sirt1/2-IN-1	Sirtuin Microtubule/Tubulin	Cancer
Sirt1/2-IN-1 (Compound 7) is a *SIRT1* and *SIRT2* inhibitor with IC₅₀ values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and *SIRT3, respectively. Sirt1/2-IN-1* displays activity in hyperacetylation of α-tubulin protein with an IC₅₀ of 32.05 µg/mL. Sirt1/2-IN-1 shows prominent anticancer activity .

HY-172204

SIRT-IN-7	Sirtuin Apoptosis Autophagy MDM-2/p53	Cancer
SIRT-IN-7 (Compound 7ba) is a *SIRT* inhibitor. SIRT-IN-7 can inhibit the expression of *SIRT1, SIRT2*, and *SIRT3, and increase the acetylation and activation of p53. SIRT-IN-7 can inhibit the proliferation, and induce apoptosis* and autophagy of breast cancer cells. SIRT-IN-7 has anti-tumor activity .

HY-N0526R

2"-O-Galloylhyperin (Standard)	Reference Standards Sirtuin Keap1-Nrf2 NF-κB ERK p38 MAPK JNK TSH Receptor Reactive Oxygen Species (ROS) SOD	Neurological Disease Inflammation/Immunology
2"-O-Galloylhyperin (Standard) is the analytical standard of 2"-O-Galloylhyperin (HY-N0526). This product is intended for research and analytical applications. 2''-O-Galloylhyperin is an active natural compound with anti‑inflammatory, antioxidant, anti‑adipogenic, antifibrotic, and cytostatic activities. 2''-O-Galloylhyperin upregulates *SIRT1/Nrf2* signaling, inhibits NF-κB and *MAPK (ERK1/2, p38, JNK)* phosphorylation, suppresses TSHR activation, reduces ROS accumulation, and enhances SOD and GSH-Px activities. 2''-O-Galloylhyperin protects against LPS-induced tissue injury, enhances survival, and inhibits adipogenesis and fibrosis. 2"-O-Galloylhyperin can be used for the research of sepsis, acute lung injury, and thyroid eye disease .

HY-114906

SIRT1/2/3-IN-2	Sirtuin	Cancer
SIRT1/2/3-IN-2 (compound 9) is a potent SIRT inhibitor, with inhibition rates of 27%, 72%, and 71% targeting SIRT1, SIRT2, and SIRT3, respectively, at 200 μM. SIRT3 is a potential tumor suppressor or promoter, and its increased transcription may be associated with lymph node-positive breast cancer and oral squamous cell carcinoma .

HY-155728

Sirt1/2-IN-3	Sirtuin Apoptosis	Cancer
Sirt1/2-IN-3 (compound PS9) is a dual inhibitor of SIRT1/2 with IC₅₀s of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respsectivley. Sirt1/2-IN-3 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-3 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines .

HY-136713

Sirt1/2-IN-5	Sirtuin	Neurological Disease Cancer
Sirt1/2-IN-5 is a *SIRT1/SIRT2* inhibitor with human SIRT1 IC₅₀ 0.3 μM and human SIRT2 IC₅₀ values 1.2 μM and pIC₅₀ 5.82. Sirt1/2-IN-5 inhibits NAD ⁺-dependent deacetylase activity of SIRT1 and SIRT2. Sirt1/2-IN-5 can be used for the research of cancer, neurodegenerative disease .

HY-N12378A

α-Patchoulene	AMPK FASTK Sirtuin ROCK Keap1-Nrf2 Toll-like Receptor (TLR) Apoptosis PKA ERK NF-κB Epigenetic Reader Domain Caspase	Metabolic Disease Inflammation/Immunology Cancer
α-Patchoulene is an orally active anti-inflammatory, antioxidant, and anti-apoptotic agent. α-Patchoulene inhibits the NF-κB, TLR4, and cAMP/PKA/CREB signaling pathways; activates the *Sirt1/Nrf2* and AMPK signaling pathways; and targets Fas/FasL, Caspase-3, *ERK1/2, ROCK1/MLC2* for inhibition. α-Patchoulene regulates cytokine secretion, inflammatory cell infiltration, lipid peroxidation, cell polarization, gut microbiota, and lipid metabolism, restores barrier function, mitochondrial function, and cell viability, and exhibits repellent activity against Spodoptera exigua larvae. α-Patchoulene can be used in research related to various inflammatory, ischemic, fibrosis-associated diseases, as well as hepatocellular carcinoma ^[12].

HY-15510S

Tenovin-6-d6	Isotope-Labeled Compounds	Others
Tenovin-6-d₆ is the deuterium labeled Tenovin-6 (HY-15510). Tenovin-6, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC₅₀s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 also inhibits dihydroorotate dehydrogenase (DHODH).

Cat. No.	Product Name	Category	Target	Chemical Structure