514-51-2
Chemical Structure
β-Patchoulene
- CAS No.: 514-51-2
- Formula:C15H24
- Molecular Weight:204.35
InChIKey: CSKINCSXMLCMAR-RWSFTLGLSA-N
SMILES: C[C@]1(CC2)C(CC[C@@H]3C)=C3C[C@]2([H])C(C)1C
Biological Activity: β-Patchoulene is an orally active anti-inflammatory, antioxidant, and anti-apoptotic agent. β-Patchoulene inhibits the NF-κB, TLR4, and cAMP/PKA/CREB signaling pathways; activates the Sirt1/Nrf2 and AMPK signaling pathways; and targets Fas/FasL, Caspase-3, ERK1/2, ROCK1/MLC2 for inhibition. β-Patchoulene regulates cytokine secretion, inflammatory cell infiltration, lipid peroxidation, cell polarization, gut microbiota, and lipid metabolism, restores barrier function, mitochondrial function, and cell viability, and exhibits repellent activity against Spodoptera exigua larvae. β-Patchoulene can be used in research related to various inflammatory, ischemic, fibrosis-associated diseases, as well as hepatocellular carcinoma[1][2][3][4][5][6][7][8][9][10][11][12].
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β-Patchoulene | β-Patchoulene is an orally active anti-inflammatory, antioxidant, and anti-apoptotic agent. β-Patchoulene inhibits the NF-κB, TLR4, and cAMP/PKA/CREB signaling pathways; activates the Sirt1/Nrf2 and AMPK signaling pathways; and targets Fas/FasL, Caspase-3, ERK1/2, ROCK1/MLC2 for inhibition. β-Patchoulene regulates cytokine secretion, inflammatory cell infiltration, lipid peroxidation, cell polarization, gut microbiota, and lipid metabolism, restores barrier function, mitochondrial function, and cell viability, and exhibits repellent activity against Spodoptera exigua larvae. β-Patchoulene can be used in research related to various inflammatory, ischemic, fibrosis-associated diseases, as well as hepatocellular carcinoma. | |||||||||||||||||||||
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- [1]. Chen XY, et al. β-Patchoulene from patchouli oil protects against LPS-induced acute lung injury via suppressing NF-κB and activating Nrf2 pathways. Int Immunopharmacol. 2017;50:270-278. [Content Brief]
- [2]. Liu Y, et al. Transformation of patchouli alcohol to β-patchoulene by gastric juice: β-patchoulene is more effective in preventing ethanol-induced gastric injury. Sci Rep. 2017;7(1):5591. [Content Brief]
- [3]. Tian Y, et al. β-patchoulene alleviates cognitive dysfunction in a mouse model of sepsis associated encephalopathy by inhibition of microglia activation through Sirt1/Nrf2 signaling pathway. PLoS One. 2023;18(1):e0279964. [Content Brief]
- [4]. Zhang Z, et al. Anti-inflammatory activity of β-patchoulene isolated from patchouli oil in mice. Eur J Pharmacol. 2016;781:229-238. [Content Brief]
- [5]. Tao T, et al. β-Patchoulene Preconditioning Protects Mice Against Hepatic Ischemia-Reperfusion Injury by Regulating Nrf2/HO-1 Signaling Pathway. J Surg Res. 2022;275:161-171. [Content Brief]
- [6]. Zhang FB, et al. Effect of β-patchoulene on cerebral ischemia-reperfusion injury and the TLR4/NF-κB signaling pathway. Exp Ther Med. 2019;17(5):3335-3342. [Content Brief]
- [7]. Liu Y, et al. β-patchoulene simultaneously ameliorated dextran sulfate sodium-induced colitis and secondary liver injury in mice via suppressing colonic leakage and flora imbalance. Biochem Pharmacol. 2020
- [8]. Wu J, et al. β-Patchoulene Ameliorates Water Transport and the Mucus Barrier in 5-Fluorouracil-Induced Intestinal Mucositis Rats via the cAMP/PKA/CREB Signaling Pathway. Front Pharmacol. 2021;12:689491. [Content Brief]
- [9]. Xu N, et al. β-patchoulene improves lipid metabolism to alleviate non-alcoholic fatty liver disease via activating AMPK signaling pathway. Biomed Pharmacother. 2021;134:111104. [Content Brief]
- [10]. Tu H, et al. β-Patchoulene represses hypoxia-induced proliferation and epithelial-mesenchymal transition of liver cancer cells. Bioengineered. 2022;13(5):11907-11922. [Content Brief]
- [11]. Pu Q, et al. A Wheat β-Patchoulene Synthase Confers Resistance Against Herbivory in Transgenic Arabidopsis. Genes (Basel). 2019;10(6):441. [Content Brief]
- [12]. Li D, et al. DoAP2/ERF89 activated the terpene synthase gene DoPAES in Dendrobium officinale and participated in the synthesis of β-patchoulene. PeerJ. 2024 Jan 18;12:e16760.
Keywords
