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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
33 Results for "
SNAPTag
" in MedChemExpress (MCE) Product Catalog:
Products (33)
33 Results for "SNAPTag" in MCE Product Catalog:
Cat. No.: HY-W017776
CAS No.: 674799-96-3
Synonyms: SNAP-NH2
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BG-NH2 (SNAP-NH2) is an O6-alkylguanine cofactor and an amine-terminated building block. BG-NH2 serves as a key intermediate for the synthesis of various functionalized SNAP-tag fluorescent/functional substrates .
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Alkyne-SNAP (compound 3) is an Alkyne-conjugated benzylguanine. The benzylguanine moiety reacts with the SNAP-tag, allowing irreversible and covalent labeling of SNAP fusion proteins with an additional alkyne functionality for further click chemistry conjugation .
Cat. No.: HY-131028
Purity: ≥95.0%
Synonyms: JF646 TFA
Cat. No.: HY-151646
Purity: 99.59%
Synonyms: Alkyne-PEG5-BG
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Alkyne-PEG5-SNAP is a click chemistry reagent containing an alkyne group. Alkyne-PEG5-SNAP can alkyne conjugated benzylguanine (BG), the BG moiety reacts specifically and rapidly with SNAP-tag, a polypeptide protein tag, allowing irreversible and covalent labeling of SNAP fusion proteins with an additional alkyne functionality suitable for further conjugation . Alkyne-PEG5-SNAP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-130736
CAS No.: 1811539-32-8
Synonyms: JF549, SE; JF549, NHS
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BGN3 is a good substrate for the SNAP-tag ? and H 5 enzymes. The activities of SNAP-tag ? and H 5 enzymes on BGN3 are reasonable (IC50= 15.6 and 23.5 μM, respectively) . BGN3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cat. No.: HY-148958
CAS No.: 471918-16-8
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SNAP-Biotin is a cell-permeable SNAP-tag-targeted labeling reagent. SNAP-Biotin undergoes an irreversible covalent reaction with SNAP-tag to transfer biotin to the tag. SNAP-Biotin enables the detection of SNAP-tag fusion proteins via a streptavidin-HRP immunoblotting system and achieves biotinylation of SNAP-tag fusion proteins. SNAP-Biotin is applicable to triple-negative breast cancer-related research .
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BGSN3 is a good substrate for the SNAP-tag ? and H 5 enzymes. The activities of SNAP-tag ? and H 5 enzymes on BGSN3 are reasonable (IC50=17.8 and 10 μM, respectively) . BGSN3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cat. No.: HY-175417
VHL-SNAP2-5C is a PROTAC degrader targeting SNAP-tag fusion proteins, with an IC50 of 0.33 μM for binding to VHL. VHL-SNAP2-5C covalently binds to the SNAP-tag target at one end and recruits the VHL ubiquitin E3 ligase at the other end to form a ternary complex, thereby inducing proteasome-dependent ubiquitination and degradation of SNAP fusion proteins through its heterobifunctional structure. VHL-SNAP2-5C can be used in studies of protein homeostasis and degradation mechanisms .
Cat. No.: HY-136937
CAS No.: 2067339-51-7
Cat. No.: HY-D2994
CAS No.: 2434651-49-5
Synonyms: SNAP-MaP555
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SPY555-BG (SNAP-MaP555) is a cell-permeable fluorescent dye for SNAP-tag labeling of HIV-1 Gag, which enables visualization of HIV-1 intercellular transmission via SNAPf. SPY555-BG relies on irreversible covalent binding to the active-site cysteine of the SNAPf tag fused to HIV-1 Gag .
Cat. No.: HY-D2966
CAS No.: 1928762-04-2
Cat. No.: HY-D2949
CAS No.: 2836233-28-2
Cat. No.: HY-D2933
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SNAP-505 is a cell-permeable green fluorescent dye (Ex/Em ≈504/532 nm). It binds specifically and covalently to SNAP-tag fusion proteins, and is used for pulse-chase labeling and localization tracking of proteins in living cells. SNAP-505 can be applied to studies related to insulin granule formation, ER-Golgi protein trafficking, and other relevant processes .
Cat. No.: HY-D2926
Synonyms: BG-Tz; SNAP-Tetrazine
Cat. No.: HY-D2980
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DSPE-PEG45-BG is a SNAP-tag reactive phospholipid-anchored molecule that enables targeted localization and spatiotemporal controlled immobilization of proteins on phospholipid membranes. DSPE-PEG45-BG can be applied to any SNAP-tag fusion protein .
Cat. No.: HY-W1124386
CAS No.: 1820756-74-8
Synonyms: SNAP-DBCO
Cat. No.: HY-D2948
CAS No.: 928760-60-5
Cat. No.: HY-D2984
CAS No.: 1308789-62-9
Synonyms: SNAP-PEG-NH2
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BG-PEG-NH2 (SNAP-PEG-NH2) is an amino-terminal fluorescent probe building block and a precursor for site-specific labeling of SNAP-tag fusion proteins. BG-PEG-NH2 undergoes one-step coupling with activated carboxyl esters to form customized SNAP-tag substrates, which covalently bind to SNAP tags via a thioether bond formed at the Cys145 site. After coupling with a caged carboxyfluorescein, BG-PEG-NH2 forms a probe with Ex/Em = 500/524 nm following ultraviolet uncaging. Coupling of BG-PEG-NH2 with SeTau-647-NHS enables visualization of GPCR signal transduction. BG-PEG-NH2 is suitable for coupling reactions in aqueous phases or buffers, conjugation of labels, and labeling of intracellular or cell-surface proteins .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
