1 Result for "

Santamarin

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Santamarin" in MCE Product Catalog:

Santamarine
Santamarine
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Cat. No.: HY-N1326
CAS No.: 4290-13-5
Synonyms: Santamarin; Balchanin
Category:  

Terpenoids Magnoliaceae Sesquiterpenes Plants Disease Research Fields Inflammation/Immunology Magnolia grandiflora L.

Target:  

JNK p38 MAPK MMP NF-κB COX TNF Receptor Interleukin Related Reactive Oxygen Species (ROS) Apoptosis Mitochondrial Metabolism DNA/RNA Synthesis Keap1-Nrf2 Bcl-2 Family Caspase PARP TGF-beta/Smad

Santamarine (Santamarin; Balchanin) is a sesquiterpene lactone found in Artemisia scoparia. Santamarine shows anti-inflammatory, antioxidant, anticancer and anti-photoaging activities. Santamarine suppresses UVA-induced phosphorylation of JNK and p38 MAPK, nuclear translocation of phosphorylated c-Fos and c-Jun, and AP-1-mediated MMP-1 transcription and secretion. Santamarine suppresses NF-κB signaling, iNOS, COX-2, TNF-α, and IL-1β production. Santamarine inhibits thioredoxin reductase activity, induces ROS production, mitochondrial apoptosis, G2/M cell cycle arrest, and DNA damage, and reduces cancer cell growth. Santamarine can be used for the photoaging, inflammatory diseases and cancer .
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