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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
TAO
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "TAO" in MCE Product Catalog:
6
TAO Kinase inhibitor 1 (compound 43) is a selective, ATP-competitive thousand-and-one amino acid kinases (TAOK) inhibitor with IC50s of 11 to 15 nM for TAOK1 and 2, respectively. TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death .
Cat. No.: HY-139439
Purity: 98.83%
Target:
Research Areas:
SBI-581 is an orally active and potent selective serine-threonine kinase TAO3 inhibitor, with an IC50 of 42 nM. SBI-581 promotes TKS5α accumulation at RAB11-positive vesicles. SBI-581 inhibits invadopodia formation. SBI-581 shows reasonable pharmacokinetics in mice using IP injection. SBI-581 shows antitumor activity . SBI-581 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-135562
CAS No.: 38462-04-3
Target:
Ascofuranone is an orally active inhibitor of Trypanosoma brucei brucei (TAO) with a Ki value of 2.38 nM. Ascofuranone inhibits IGF-1-induced cancer cell migration, invasion, motility and actin cytoskeleton formation, and exerts anti-tumor effects. Ascofuranone can be used in research related to tumor metastasis, African trypanosomiasis, bacterial infections, lung cancer and hepatocellular carcinoma .
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TAO Kinase inhibitor 2 (Example 49) is a TAO Kinase inhibitor (IC50=between 50 and 500 nM). TAO Kinase inhibitor 2 also inhibits KIAA1361 and JIK with IC50s of 50-500 nM .
Cat. No.: HY-176253
CAS No.: 2601665-22-7
Antitrypanosomal agent 26 (Compound 1) is an allosteric trypanosome alternative oxidase (TAO) inhibitor. Antitrypanosomal agent 26 exhibits potent activity against African animal trypanosomes (e.g., Trypanosoma brucei, etc.) with an IC50 value of 1.3 nM for recombinant TAO. Antitrypanosomal agent 26 blocks the mitochondrial electron transport chain of trypanosomes and inhibits glucose-dependent respiration. Antitrypanosomal agent 26 is promising for research of African animal trypanosomiasis, such as bovine trypanosomiasis .
Cat. No.: HY-188020
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TAO-E Phosphoramidite is a phosphoramidite monomer with dual quenching properties for oligonucleotide synthesis. It contains a TAO anthraquinone quenching group, an ODMT protecting group, and a standard phosphoramidite structure. TAO-E Phosphoramidite can be used in RNA/DNA modification and fluorescent probe-related research.
Cat. No.: HY-178064
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Antiparasitic agent-29 (Compound 5) is a Trypanosome alternative oxidase (TAO) inhibitor with an IC50 of 1.3 nM in Trypanosoma brucei. Antiparasitic agent-29 has a broad-spectrum antiparasitic activity against Trypanosoma and Leishmania spp. Antiparasitic agent-29 accumulates in parasite mitochondria, selectively disrupting its energy metabolism and has potent membrane-perturbing activity with no cross-resistance. Antiparasitic agent-29 shows low ecotoxicity in zebrafish and Daphnia magna models. Antiparasitic agent-29 can be used for parasitic diseases like surra and dourine research .
Cat. No.: HY-W1061750
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TAO-C Phosphoramidite is a phosphoramidite monomer that can be used for the preparation of oligonucleotides.
Cat. No.: HY-W1061733
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TAO-F Phosphoramidite is a type of phosphoramidite monomer that can be used for solid-phase synthesis of oligonucleotides. TAO-F Phosphoramidite is used to prepare fluorescent-labeled probes and primers, and is widely applied in real-time quantitative PCR (qPCR), fluorescence in situ hybridization (FISH), and microarray molecular diagnostic techniques.
Cat. No.: HY-181619
CAS No.: 3114565-22-6
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TAO Kinase-IN-3 is a potent pan-TAOK (Thousand-And-One Kinase) inhibitor that specifically binds to and inhibits the kinase activities of TAOK1, TAOK2 and TAOK3 with Kd values of <0.17 nM, 0.34 nM, and 0.17 nM, respectively. TAO Kinase-IN-3 can be used to study Alzheimer's disease, primary tauopathies and related syndromes. In addition, TAO Kinase-IN-3 is also widely used in research on the mechanisms of cancer cachexia and the muscle atrophy it induces .
Cat. No.: HY-W1061590
CAS No.: 676225-09-5
Research Areas:
5'-TAO-A Phosphoramidite is a phosphoramidite derivative that can be used for oligonucleotide synthesis.
Cat. No.: HY-W1061589
CAS No.: 676225-11-9
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5'-TAO-B Phosphoramidite is a phosphoramidite monomer that can be used in the preparation of oligonucleotides.
Cat. No.: HY-P701641
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TAOK2; Prostate-Derived Sterile 20-Like Kinase 1; TAO Kinase 2; Kinase From Chicken Homolog C; Serine/Threonine-Protein Kinase TAO2; PSK1-BETA; MAP3K17; KIAA0881; HKFC-C; TAO2beta; PSK-1; TAO1; PSK1; TAO2; PSK; Prostate-Derived STE20-Like Kinase 1; Thousa
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702749
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: TAOK1; Serine/Threonine-Protein Kinase TAO1; TAO Kinase 1; Prostate-Derived STE20-Like Kinase 2; MAP3K16; Kinase From Chicken Homolog B; HTAOK1; FLJ14314; HKFC-B; PSK-2; MARKK; Microtubule Affinity Regulating Kinase Kinase; PSK2; Serine/Threonine Protein
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P77222
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TAOK3; CTCL-Associated Antigen HD-CL-09; TAO Kinase 3; Kinase From Chicken Homolog A; MAP3K18; Jun Kinase-Inhibitory Kinase; JIK; JNK/SAPK-Inhibitory Kinase; DPK; HKFC-A; Thousand And One Amino Acid Protein 3; Non-Specific Serine/Threonine Protein Kinase
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P703907
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TAOK3; CTCL-Associated Antigen HD-CL-09; TAO Kinase 3; Kinase From Chicken Homolog A; MAP3K18; Jun Kinase-Inhibitory Kinase; JIK; JNK/SAPK-Inhibitory Kinase; DPK; HKFC-A; Thousand And One Amino Acid Protein 3; Non-Specific Serine/Threonine Protein Kinase
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
