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Results for "

TPR

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

3

Peptides

1

Recombinant Proteins

2

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W1128879
    XMU-MP-8

    SKPer1

    		 Molecular Glues E1/E2/E3 Enzyme Cancer
    XMU-MP-8 (SKPer1) is a potent molecular glue degrader that targets the oncoprotein SKP2. XMU-MP-8 simultaneously binds to the F-box domain of SKP2 (Kd ≈ 36 μM) and the N-terminal TPR domain of the E3 ligase STUB1 (Kd ≈ 2.5 μM), forming a stable SKP2-SKPer1-STUB1 ternary complex (Kd ≈ 8.9 nM) that induces SKP2 ubiquitination and proteasomal degradation. XMU-MP-8 selectively eliminates SKP2-expressing cancer cells. XMU-MP-8 exhibits substantial tumour suppression with good safety profiles in vivo. XMU-MP-8 can be used for cancer research, such as non-small cell lung adenocarcinoma (NSCLC) and prostatic adenocarcinoma .
    XMU-MP-8
  • HY-175552
    CHIPOpt

    		Tau Protein Neurological Disease
    CHIPOpt, a peptide, is an orthosteric CHIP TPR domain inhibitor with a Kd of ∼16 nM. CHIPOpt has anti-aggregation activity and decreases p.tau ubiquitination with little effect on unmodified tau. CHIPOpt can be used for Alzheimer’s disease research .
    CHIPOpt
  • HY-103241
    Ro 90-7501
    3 Publications Verification

    		 Amyloid-β ATM/ATR Phosphatase Apoptosis Neurological Disease Cancer
    Ro 90-7501 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC50 of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response . Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner . Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells .
    Ro 90-7501
  • HY-125759
    3-Phenyltoxoflavin

    		HSP Cancer
    3-Phenyltoxoflavin, a derivative of Toxoflavin, is an Hsp90 inhibitor, with a Kd of 585 nM for the interaction of Hsp90-TPR2A. 3-Phenyltoxoflavin has anti-cancer activity .
    3-Phenyltoxoflavin
  • HY-RS14946
    TPR Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    TPR Human Pre-designed siRNA Set A contains three designed siRNAs for TPR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TPR Human Pre-designed siRNA Set A
    TPR Human Pre-designed siRNA Set A
  • HY-RS18457
    Tpr Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Tpr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tpr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Tpr Mouse Pre-designed siRNA Set A
    Tpr Mouse Pre-designed siRNA Set A
  • HY-P1896
    Hsp70-derived octapeptide

    		HSP Infection Neurological Disease Cancer
    Hsp70-derived octapeptide is a conserved octapeptide of the C-terminal end of Hsp70, which physically interacts with tetratricopeptide repeat (TPR) motifs .
    Hsp70-derived octapeptide
  • HY-P11185
    Hsp90β decapeptide

    		HSP Cancer
    Hsp90β decapeptide is a C-terminal peptide of Hsp90β, which contains conserved TPR-domain MEEVD. Hsp90β decapeptide is able to bind tightly the Tah1 protein with a Kd of 1.0 μM .
    Hsp90β decapeptide
  • HY-RS24938
    Tpr Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Tpr Rat Pre-designed siRNA Set A contains three designed siRNAs for Tpr gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Tpr Rat Pre-designed siRNA Set A
    Tpr Rat Pre-designed siRNA Set A
  • HY-179343
    Hsp90-IN-43

    		HSP Cancer
    Hsp90-IN-43 (Compound 12) is a Hsp90-TPR2A interaction inhibitor with an IC50 of 360 nM and a Kd of 928 nM. Hsp90-IN-43 effectively inhibits the proliferation of BT474 cells. Hsp90-IN-43 can be used for the study of breast cancer .
    Hsp90-IN-43
  • HY-103241R
    Ro 90-7501 (Standard)

    		Reference Standards Amyloid-β ATM/ATR Phosphatase Apoptosis Neurological Disease Cancer
    Ro 90-7501 (Standard) is the analytical standard of Ro 90-7501 (HY-103241). This product is intended for research and analytical applications. Ro 90-7501 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC50 of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response . Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner . Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells .
    Ro 90-7501 (Standard)

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