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Isoforms Recommended:	TRPV3

Results for "

TRPV3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (2) Bacterial (2) Calcium Channel (1) Cholinesterase (ChE) (2) Drug Isomer (1) Environmental Pollutants (2) IKK (2) Influenza Virus (2) Isotope-Labeled Compounds (1) JNK (2) NF-κB (2) NOD-like Receptor (NLR) (2) Potassium Channel (2) Reference Standards (2) Small Interfering RNA (siRNA) (3) Tau Protein (2) TRP Channel (15)
By Research Areas:	Cancer (5) Infection (2) Inflammation/Immunology (10) Metabolic Disease (3) Neurological Disease (9)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-165559

Trpvicin	TRP Channel	Inflammation/Immunology
Trpvicin is a potent and subtype-selective *TRPV3* inhibitor with IC₅₀s of 0.41 and 0.22 μM for hTRPV3-WT and hTRPV3-G573S mutant, respectively. Trpvicin exhibits minimal effects on other TRP family members (such as TRPV1/2/4/5/6, TRPA1 and TRPM8). Trpvicin inhibits the TRPV3 channel by stabilizing it in a closed state via VSLD-PD binding. Trpvicin accesses additional binding sites inside the central cavity of the G573S mutant to remodel symmetry and block the channel. Trpvicin inhibits itch and hair loss in mouse models. Trpvicin can be used for study of inflammation and immunology .

HY-N0808

Camphor 3 Publications Verification (±)-Camphor	Environmental Pollutants TRP Channel Influenza Virus	Infection Inflammation/Immunology Cancer
Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities . Camphor is a *TRPV3* agonist .

HY-131868

TRPV3 antagonist 74a	TRP Channel	Neurological Disease
TRPV3 antagonist 74a is a potent and selective *TRPV3* antagonist. TRPV3 antagonist 74a displays no significant activity against a panel of other ion channels. TRPV3 antagonist 74a can be used for the research of neuropathic pain .

HY-N8264

Moringin 1 Publications Verification	TRP Channel	Neurological Disease Inflammation/Immunology Cancer
Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC₅₀ of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities .

HY-157131

TRPV2-selective blocker 1 2 Publications Verification	TRP Channel	Neurological Disease
TRPV2-selective blocker 1 is a TRPV2-selective blocker that inhibits calcium influx and ionic currents. TRPV2-selective blocker 1 exhibits an IC₅₀of 6.3 μM against rat *TRPV2, and shows no activity against TRPV1, TRPV3* or *TRPV4* channels. TRPV2-selective blocker 1 attenuates macrophage phagocytosis, LPS-induced macrophage migration, and calcium microdomains generated by peripheral *TRPV2. TRPV2-selective blocker 1 is non-cytotoxic and can be used to investigate the function of TRPV2* during immune processes .

HY-B1239

Drofenine hydrochloride 1 Publications Verification Hexahydroadiphenine hydrochloride	Cholinesterase (ChE) Potassium Channel Amyloid-β TRP Channel Tau Protein NOD-like Receptor (NLR) JNK NF-κB IKK	Neurological Disease Metabolic Disease Inflammation/Immunology
Drofenine (Cycloadiphene; Hexahydroadiphenine) hydrochloride is an brain-penetrant antispasmodic agent. Drofenine hydrochloride is a Kv2.1 channel inhibitor with human IC₅₀ of 9.53 μM. Drofenine hydrochloride is a butyrylcholinesterase (BChE) inhibitor with K_i of 0.003 mM, and is a *TRPV3* activator. Drofenine hydrochloride blocks Kv2.1-dependent potassium efflux, inhibits Kv2.1/JNK/NF-κB and IkBa/NF-kB signaling, suppresses Kv2.1 mRNA/protein expression. Drofenine suppresses oligomeric Aβ-induced microglial *NLRP3* inflammasome activation and neuronal Tau hyperphosphorylation, improves cognitive impairment, promotes neurite outgrowth. Drofenine hydrochloride induces calcium influx in keratinocytes and exert cytotoxicity against keratinocytes. Drofenine hydrochloride ameliorates diabetic peripheral neuropathy -like pathology. Drofenine hydrochloride can be used for the researches of Alzheimer's disease, diabetic peripheral neuropathy and smooth muscle spasm ^[3] .

HY-B1173

(+)-Camphor 1 Publications Verification D-(+)-Camphor; (1R)-(+)-Camphor	Environmental Pollutants Bacterial	Neurological Disease Inflammation/Immunology Cancer
(+)-Camphor (D-(+)-Camphor; (1R)-(+)-Camphor) is an isomer of Camphor. Camphor is an agonist of monoterpenoid transient receptor potential (TRP) channels (such as *TRPV1, TRPV3, TRPM8) and an inhibitor of TRPA1* channels. Camphor's derivatives have multiple biological activities, including antibacterial, antiviral, antioxidant, analgesic and anticancer. Camphor can selectively activate cold-sensitive TRP channels and inhibit TRPA1-mediated nociceptive signals. Camphor stimulates the cold-sensing nerve endings in the skin and regulates the activity of ion channels to exert analgesic, anti-inflammatory and anti-itching effects. It also has anti-proliferative and anti-mutagenic activities on tumor cells, which may be related to inhibiting ribosome function or inducing cell apoptosis. Camphor can be absorbed through the skin and (+)-Camphor can be used in the study of muscle and joint pain and inflammation .

HY-N0808R

Camphor (Standard) (±)-Camphor (Standard)	Reference Standards TRP Channel Influenza Virus	Infection Inflammation/Immunology Cancer
Camphor (Standard) is the analytical standard of Camphor. This product is intended for research and analytical applications. Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities . Camphor is a *TRPV3* agonist .

HY-160900

RN-1665 1 Publications Verification	TRP Channel	Others
RN-1665 is an orally active *TRPV4* antagonist that exhibits excellent selectivity for related TRP receptors such as TRPV1, TRPV3 and TRPM8. RN-1665 is a TRPV4 probe for focus screens, with IC50s of 0.26 μM and 0.39 μM for hTRPV4 and rTRPV4 from human and rat, respectively .

HY-125527A

17(R)-Resolvin D1 1 Publications Verification 17(R)-RvD1; AT-RvD1	TRP Channel	Inflammation/Immunology
17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells . 17R-Resolvin D1 specificially inhibits *TRPV3* with an IC₅₀ of 398 nM and exhibits peripheral anti-nociceptive efficacy .

HY-RS15123

TRPV3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TRPV3 Human Pre-designed siRNA Set A contains three designed siRNAs for TRPV3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TRPV3 Human Pre-designed siRNA Set A TRPV3 Human Pre-designed siRNA Set A

HY-183281

TRPV3 antagonist-1	TRP Channel	Others
TRPV3 antagonist-1 is a selective *TRPV3* channel antagonist with an IC₅₀ of 11.97 μM. TRPV3 antagonist-1 shows selectivity over hTRPV1, hTRPV4, hTRPA1, and hTRPM8. TRPV3 antagonist-1 shows low cytotoxicity .

HY-186008

TRPV3 modulator-1	TRP Channel	Neurological Disease
TRPV3 modulator-1 is a *TRPV3* modulator.

HY-RS16860

Trpv3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Trpv3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Trpv3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Trpv3 Mouse Pre-designed siRNA Set A Trpv3 Mouse Pre-designed siRNA Set A

HY-RS23301

Trpv3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Trpv3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Trpv3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Trpv3 Rat Pre-designed siRNA Set A Trpv3 Rat Pre-designed siRNA Set A

HY-B1173R

(+)-Camphor (Standard) D-(+)-Camphor (Standard); (1R)-(+)-Camphor (Standard)	Reference Standards Bacterial	Neurological Disease Inflammation/Immunology Cancer
(+)-Camphor (Standard) is the analytical standard of (+)-Camphor. This product is intended for research and analytical applications. (+)-Camphor (D-(+)-Camphor; (1R)-(+)-Camphor) is an isomer of Camphor. Camphor is an agonist of monoterpenoid transient receptor potential (TRP) channels (such as *TRPV1, TRPV3, TRPM8) and an inhibitor of TRPA1* channels. Camphor's derivatives have multiple biological activities, including antibacterial, antiviral, antioxidant, analgesic and anticancer. Camphor can selectively activate cold-sensitive TRP channels and inhibit TRPA1-mediated nociceptive signals. Camphor stimulates the cold-sensing nerve endings in the skin and regulates the activity of ion channels to exert analgesic, anti-inflammatory and anti-itching effects. It also has anti-proliferative and anti-mutagenic activities on tumor cells, which may be related to inhibiting ribosome function or inducing cell apoptosis. Camphor can be absorbed through the skin and (+)-Camphor can be used in the study of muscle and joint pain and inflammation .

HY-118535

N-Oleoyl valine	TRP Channel	Neurological Disease
N-Oleoyl valine is a N-acyl valine compound that acts as a TRPV3 receptor antagonist .

HY-B1239A

Drofenine Cycloadiphene; Hexahydroadiphenine	Potassium Channel Cholinesterase (ChE) TRP Channel NOD-like Receptor (NLR) Amyloid-β Tau Protein JNK NF-κB IKK	Neurological Disease Metabolic Disease Inflammation/Immunology
Drofenine (Cycloadiphene; Hexahydroadiphenine) is an brain-penetrant antispasmodic agent. Drofenine is a Kv2.1 channel inhibitor with human IC₅₀ of 9.53 μM. Drofenine is a butyrylcholinesterase (BChE) inhibitor with K_i of 0.003 mM, and is a *TRPV3* activator. Drofenine blocks Kv2.1-dependent potassium efflux, inhibits Kv2.1/JNK/NF-κB and IkBa/NF-kB signaling, suppresses Kv2.1 mRNA/protein expression. Drofenine suppresses oligomeric Aβ-induced microglial *NLRP3* inflammasome activation and neuronal Tau hyperphosphorylation, improves cognitive impairment, promotes neurite outgrowth. Drofenine induces calcium influx in keratinocytes and exert cytotoxicity against keratinocytes. Drofenine ameliorates diabetic peripheral neuropathy -like pathology. Drofenine can be used for the researches of Alzheimer's disease, diabetic peripheral neuropathy and smooth muscle spasm ^[3] .

HY-125527AS

17(R)-Resolvin D1-d5 17(R)-RvD1-d₅; AT-RvD1-d₅	Isotope-Labeled Compounds TRP Channel	Inflammation/Immunology
17(R)-Resolvin D1-d₅ (17(R)-RvD1-d₅) is deuterium labeled 17(R)-Resolvin D1. 17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells . 17R-Resolvin D1 specificially inhibits *TRPV3* with an IC₅₀ of 398 nM and exhibits peripheral anti-nociceptive efficacy .

HY-186172

KS0365	TRP Channel Calcium Channel	Metabolic Disease
KS0365 is a selective *TRPV3* agonist with an EC₅₀ of 5.08 μM. KS0365 does not activate TRPV2 or TRPV4 channels. KS0365 triggers an increase in [Ca ²⁺]_i and accelerates keratinocyte migration. KS0365 can be used in studies related to impaired skin wound healing .

HY-153275A

KM-001-E2 (S)-KM-001	Drug Isomer	Others
(S)-KM-001 ((S)-KM-001) is the enantiomer of KM-001 (HY-153275). KM-001 is a TRPV3 channel antagonist and can be used for studying skin itching and keratinosis diseases .

N-Oleoyl valine	TRP Channel	Neurological Disease
N-Oleoyl valine is a N-acyl valine compound that acts as a TRPV3 receptor antagonist .

Cat. No.	Product Name	Category	Target	Chemical Structure