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U937cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (7) Bacterial (1) Bcl-2 Family (1) Calcium Channel (2) Cathepsin (2) CDK (1) COX (4) Drug Derivative (1) G protein-coupled Bile Acid Receptor 1 (1) Histone Methyltransferase (1) Integrin (2) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (2) Leukotriene Receptor (2) MAPKAPK2 (MK2) (1) Molecular Glues (1) P-selectin (1) Phospholipase (1) Reference Standards (2) RIP kinase (2) Sirtuin (1) TNF Receptor (1)
By Research Areas:	Cancer (13) Infection (1) Inflammation/Immunology (17) Metabolic Disease (1) Neurological Disease (3)

By Targets:

Apoptosis (7)

Bacterial (1)

Bcl-2 Family (1)

Calcium Channel (2)

Cathepsin (2)

CDK (1)

COX (4)

Drug Derivative (1)

G protein-coupled Bile Acid Receptor 1 (1)

Histone Methyltransferase (1)

Integrin (2)

Isocitrate Dehydrogenase (IDH) (1)

Isotope-Labeled Compounds (2)

Leukotriene Receptor (2)

MAPKAPK2 (MK2) (1)

Molecular Glues (1)

P-selectin (1)

Phospholipase (1)

Reference Standards (2)

RIP kinase (2)

Sirtuin (1)

TNF Receptor (1)

By Research Areas:

Cancer (13)

Infection (1)

Inflammation/Immunology (17)

Metabolic Disease (1)

Neurological Disease (3)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17372

Rofecoxib 5 Publications Verification MK 966	COX	Inflammation/Immunology Cancer
Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC₅₀s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC₅₀ > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells).

HY-N6703

ar-Turmerone (+)-ar-Turmerone	Apoptosis	Neurological Disease Inflammation/Immunology Cancer
ar-Turmerone ((+)-ar-Turmerone) is an orally active and major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities. ar-Turmerone induces apoptosis in U937 cells. ar-Turmerone exerts positive modulation on murine DCs. ar-Turmerone induces NSC proliferation in vitro and in vivo, and can be used for various neurologic disorders study .

HY-131249

MK2-IN-3 4 Publications Verification	MAPKAPK2 (MK2)	Inflammation/Immunology
MK2-IN-3 is a potent and selective inhibitor of MAPKAP-K2 (MK-2), with an IC₅₀ of 8.5 nM. MK2-IN-3 shows selectivity for MK-2 over MK-3, MK-5, ERK2, MNK1, p38a (IC₅₀s=0.21, 0.081, 3.44, 5.7, and >100 μM, respectively) and MSK1, MSK2, CDK2, JNK2, IKK2 (IC₅₀s>200 μM). MK2-IN-3 can reduce TNFα production in both U937 cells and in vivo .

HY-103358

KF38789 2 Publications Verification	P-selectin	Inflammation/Immunology
KF38789 is a selective inhibitor of P-selectin-PSGL-1 binding. KF38789 inhibits the binding of U937 cells to immobilized P-selectin immunoglobulin G chimeric protein (P-selectin-Ig) with an IC₅₀ value of 1.97 μM .

HY-103347

M50054	Apoptosis	Inflammation/Immunology
M50054 is a potent inhibitor of apoptosis. M50054 inhibits Etoposide-induced caspase-3 activation of U937 cells with an IC₅₀ of 79 μg/mL. M50054 does not directly inhibit the enzymatic activity of caspase-3. M50054 can be used for the research anti-Fas-antibody-induced hepatitis and chemotherapy-induced alopecia .

HY-P1188

LDV-FITC	Integrin	Cancer
LDV-FITC, a fluorescent peptide, is a FITC-conjugated LDV peptide (HY-P2267). LDV-FITC binds to the α4β1 integrin with high affinity (K_d: 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn ²⁺ respectively). LDV-FITC can be used to detect α4β1 integrin affinity .

HY-105358

CP-288886	Leukotriene Receptor Calcium Channel	Inflammation/Immunology
CP-288886 is a cysLT₁ receptor antagonist with a K_i value of 0.004 μM. CP-288886 exhibits comparable activity to Zafirlukast (HY-17492) and Pranlukast (HY-B0290). CP-288886 inhibits calcium mobilization with an IC₅₀ of 0.0005 μM in human U937 cells. CP-288886 has high oral bioavailability. CP-288886 possesses anti-asthmatic activity in a guinea pig asthma model and can be used for the research of diseases such as asthma .

HY-147086

CAY10789	Leukotriene Receptor G protein-coupled Bile Acid Receptor 1 TNF Receptor	Metabolic Disease Inflammation/Immunology
CAY10789 is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist (IC₅₀=2.80 μM) and GPBAR1 (G-protein-coupled bile acid receptor 1) agonist (EC₅₀=3 μM). CAY10789 significantly reduces the adhesion of U937 cells to HAEC, reduces the expression of TNF-α. CAY10789 shows very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used for the research of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases .

HY-146758

RIPK1-IN-14	RIP kinase	Neurological Disease Inflammation/Immunology
RIPK1-IN-14 (Compound 41) is a potent inhibitor of RIPK1 with an IC₅₀ value of 92 nM. RIPK1-IN-14 shows a significant anti-necroptotic effect in a necroptosis model in U937 cells .

HY-146581

Cathepsin C-IN-4	Cathepsin	Inflammation/Immunology
Cathepsin C-IN-4 (compound SF27) is a potent Cathepsin C (Cat C) inhibitor, with an IC₅₀ of 65.6 nM. Cathepsin C-IN-4 also inhibits THP-1 and U937 cell, with IC₅₀ values of 203.4 and 177.6 nM, respectively .

HY-146580

Cathepsin C-IN-3	Cathepsin	Inflammation/Immunology
Cathepsin C-IN-3 (compound SF11) is a potent Cathepsin C (Cat C) inhibitor, with an IC₅₀ of 61.79 nM. Cathepsin C-IN-3 also inhibits THP-1 and U937 cell, with IC₅₀ values of 101.5 and 86.5 nM, respectively .

HY-120621

BMS-229724	Phospholipase	Inflammation/Immunology
BMS-229724 is an orally active and tight-binding cytosolic phospholipase A₂ (cPLA₂) inhibitor with an IC₅₀ of 2.8 μM. BMS-229724 can inhibit the production of arachidonic acid and eicosanoids in U937 cells, neutrophils, platelets, and other cells. BMS-229724 has anti-inflammatory activity and can be used in the research of diseases such as skin inflammation .

HY-17372S

Rofecoxib-d5	Isotope-Labeled Compounds COX	Inflammation/Immunology Cancer
Rofecoxib-d₅ is the deuterium labeled Rofecoxib. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC₅₀s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC₅₀ > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells) .

HY-173526

H052	Bacterial Calcium Channel	Infection
H052 is a selective Staphylococcus aureus α-hemolysin (Hla) inhibitor. H052 binds to Hla monomers, disrupts the interaction with host cell membranes to block pore formation, inhibiting calcium ion influx, cytotoxicity, and inflammatory responses. H052 exhibits potency (EC₅₀=30 nM in U937 cells) against Hla-induced calcium influx. H052 is promising for research of lung infections caused by S. aureus .

HY-120765

BRD2879	Isocitrate Dehydrogenase (IDH)	Cancer
BRD2879 is a potent IDH1-R132H inhibitor with IC₅₀ values of 0.05, 2.5, >20, >20 µM for IDH1-R132H, IDH1-R132C, IDH1-WT, IDH2-R140Q, respectively. BRD2879 reduces (R)-2-hydroxyglutarate (R-2HG) levels .

HY-W025074

BML-278	Sirtuin Histone Methyltransferase	Cancer
BML-278 is a SIRT1 activator (EC₁₅₀: 1 μM). BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in both the paternal and maternal pronucleus. BML-278 improves early embryonic development. BML-278 arrests the cell cycle at the G1/S phase, and reduces senescence in primary human mesenchymal cells. BML-278 reduces tubulin acetylation in U937 cells. BML-278 also increases mitochondrial density in murine C2C12 myoblasts .

HY-177766

GSPT1 degrader-17	Molecular Glues Apoptosis	Cancer
GSPT1 degrader-17 (Compound 9q) is a potent and selective cereblon-based molecular glue degrader that targets G1 to S phase transition 1 (GSPT1). GSPT1 degrader-17 degrades GSPT1 in U937 cells with a DC₅₀ of 35 nM and Dmax of 81.65%. GSPT1 degrader-17 has a strong inhibitory effect on U937, MOLT-4 and MV4-11 cells with IC₅₀ values of 0.019, 0.006 and 0.027 μM. GSPT1 degrader-17 can induce cells apoptosis and G0/G1 phase arrest. GSPT1 degrader-17 can be used for the research of cancer, such as acute myeloid leukemia .

HY-W747533

C8 Ceramine, D-erythro C8 Ceramine; Ceramine (d18:1/8:0)	Drug Derivative	Others
C8 Ceramine is an analog of ceramide in which the carbonyl group of the ceramide is replaced by a methylene group. At a concentration of 10 μM, C8 ceramine induces maximal DNA fragmentation in U937 cells after 6 hours of incubation, compared to 12 hours for C8 ceramide.

HY-143727

RIPK1-IN-9	RIP kinase	Inflammation/Immunology
RIPK1-IN-9 (example 45), a dihydronaphthyridone compound, is a potent and selective RIPK1 inhibitor. RIPK1-IN-9 inhibits U937 cell (IC₅₀=2 nM) and L929 cell (IC₅₀=1.3 nM) .

HY-P1188A

LDV-FITC TFA	Integrin	Cancer
LDV-FITC TFA, a fluorescent peptide, is a FITC-conjugated LDV peptide (HY-P2267). LDV-FITC TFA binds to the α4β1 integrin with high affinity (K_d: 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn ²⁺ respectively). LDV-FITC TFA can be used to detect α4β1 integrin affinity .

HY-N6703S

ar-Turmerone-d3 (+)-ar-Turmerone-d₃	Isotope-Labeled Compounds Apoptosis	Neurological Disease Inflammation/Immunology Cancer
ar-Turmerone-d₃ is the deuterium labeled ar-Turmerone. ar-Turmerone ((+)-ar-Turmerone) is an orally active and major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities. ar-Turmerone induces apoptosis in U937 cells. ar-Turmerone exerts positive modulation on murine DCs. ar-Turmerone induces NSC proliferation in vitro and in vivo, and can be used for various neurologic disorders study .

HY-103347R

M50054 (Standard)	Reference Standards Apoptosis	Inflammation/Immunology
M50054 (Standard) is the analytical standard of M50054. This product is intended for research and analytical applications. M50054 is a potent inhibitor of apoptosis. M50054 inhibits Etoposide-induced caspase-3 activation of U937 cells with an IC50 of 79 μg/mL. M50054 does not directly inhibit the enzymatic activity of caspase-3. M50054 can be used for the research anti-Fas-antibody-induced hepatitis and chemotherapy-induced alopecia .

HY-17372R

Rofecoxib (Standard) MK 966 (Standard)	Reference Standards COX	Inflammation/Immunology Cancer
Rofecoxib (Standard) is the analytical standard of Rofecoxib. This product is intended for research and analytical applications. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC₅₀s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC₅₀ > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells).

HY-159513

Bcl-2/Mcl-1-IN-4	Bcl-2 Family Apoptosis	Cancer
Bcl-2/Mcl-1-IN-4 (compound 20) is a dual inhibitor targeting Bcl-2 (K_i=0.49 μM) and Mcl-1 (K_i=0.51 μM). Bcl-2/Mcl-1-IN-4 significantly inhibits cancer cell proliferation and effectively induces apoptosis in U937 cells. Bcl-2/Mcl-1-IN-4 can be used in cancer research .

HY-169795

C8 D-threo Ceramide (d18:1/8:0)	Apoptosis	Cancer
C8 D-threo Ceramide (d18:1/8:0) is a sphingolipid analog that can effectively induce apoptosis in U937 cells and cause fragmentation of nucleosomal DNA .

HY-138101

Desmethyl etoricoxib	COX	Inflammation/Immunology
Desmethyl etoricoxib (example 21) is a selective COX-2 inhibitor with an IC₅₀ of 1 μM in whole blood. Desmethyl etoricoxib inhibits COX-1 with an IC₅₀ of 16 μM in U937 cells. Desmethyl etoricoxib has anti-inflammatory effects .

HY-10380

(R)-DRF053	CDK	Others
(R)-DRF053 is a CDK inhibitor. (R)-DRF053 inhibits Cdk5 and promotes the formation of ductal precursor β cells. (R)-DRF053 inhibits Dil-ox-LDL uptake and CD36 gene expression induced by advanced glycation end products (AGEs) in U937 cells .

HY-N9284

5,19-Epoxy-19R,25-dimethoxycucurbita-6,23-dien-3-ol	Others	Cancer
5,19-Epoxy-19R,25-dimethoxycucurbita-6,23-dien-3-ol is a triterpenoid compound derived from Momordica charantia with antitumor activity, exhibiting an IC₅₀ of 32.52 μM against U937 cells. 5,19-Epoxy-19R,25-dimethoxycucurbita-6,23-dien-3-ol shows promise for research in the field of cancer .

Cat. No.	Product Name	Target	Research Area

HY-P1188

LDV-FITC	Integrin	Cancer
LDV-FITC, a fluorescent peptide, is a FITC-conjugated LDV peptide (HY-P2267). LDV-FITC binds to the α4β1 integrin with high affinity (K_d: 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn ²⁺ respectively). LDV-FITC can be used to detect α4β1 integrin affinity .

HY-P1188A

LDV-FITC TFA	Integrin	Cancer
LDV-FITC TFA, a fluorescent peptide, is a FITC-conjugated LDV peptide (HY-P2267). LDV-FITC TFA binds to the α4β1 integrin with high affinity (K_d: 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn ²⁺ respectively). LDV-FITC TFA can be used to detect α4β1 integrin affinity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6703

ar-Turmerone (+)-ar-Turmerone	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Plants Curcuma longa Inflammation/Immunology Disease Research Fields Source Classification Zingiberaceae	Apoptosis
ar-Turmerone ((+)-ar-Turmerone) is an orally active and major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities. ar-Turmerone induces apoptosis in U937 cells. ar-Turmerone exerts positive modulation on murine DCs. ar-Turmerone induces NSC proliferation in vitro and in vivo, and can be used for various neurologic disorders study .

HY-N9284

5,19-Epoxy-19R,25-dimethoxycucurbita-6,23-dien-3-ol	Triterpenes Terpenoids Cucurbitaceae Plants Momordica charantia Linn. Source Classification	Others
5,19-Epoxy-19R,25-dimethoxycucurbita-6,23-dien-3-ol is a triterpenoid compound derived from Momordica charantia with antitumor activity, exhibiting an IC₅₀ of 32.52 μM against U937 cells. 5,19-Epoxy-19R,25-dimethoxycucurbita-6,23-dien-3-ol shows promise for research in the field of cancer .

Cat. No.	Product Name	Chemical Structure

HY-17372S

Rofecoxib-d5
Rofecoxib-d₅ is the deuterium labeled Rofecoxib. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC₅₀s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC₅₀ > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells) .

HY-N6703S

ar-Turmerone-d3
ar-Turmerone-d₃ is the deuterium labeled ar-Turmerone. ar-Turmerone ((+)-ar-Turmerone) is an orally active and major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities. ar-Turmerone induces apoptosis in U937 cells. ar-Turmerone exerts positive modulation on murine DCs. ar-Turmerone induces NSC proliferation in vitro and in vivo, and can be used for various neurologic disorders study .

ar-Turmerone-d3

ar-Turmerone-d₃ is the deuterium labeled ar-Turmerone. ar-Turmerone ((+)-ar-Turmerone) is an orally active and major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities. ar-Turmerone induces apoptosis in U937 cells. ar-Turmerone exerts positive modulation on murine DCs. ar-Turmerone induces NSC proliferation in vitro and in vivo, and can be used for various neurologic disorders study .

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