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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
231 Results for "
Vascular endothelial growth factor
" in MedChemExpress (MCE) Product Catalog:
Products (231)
231 Results for "Vascular endothelial growth factor" in MCE Product Catalog:
115
115 Publications Verification
Target:
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
PX-478 is a multifunctional HIF-1α inhibitor with properties including radiosensitization, autophagy activation, and lipid accumulation inhibition. PX-478 also blocks hypoxia-induced VEGF production and regulates β-cell phenotypes under hypoxic conditions. PX-478 induces cell cycle arrest and DNA damage, restores autophagic function, reduces foam cell formation, and maintains glucose homeostasis. PX-478 is widely used in research on related diseases such as human tumors (e.g., prostate cancer), type 2 diabetes, and atherosclerosis .
19
19 Cited Publications
Cat. No.: HY-P7110A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: VEGFA; Vascular endothelial growth factor A; VEGF; VPF; Vascular Permeability factor; Vascular endothelial growth factor A, Long Form; VEGF-A; L-VEGF; Vascular endothelial growth factor A121; Vascular endothelial growth factor A165; Vascular endothelial G
Species:
Human
Source:
HEK293
19
12
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Alvelestat (AZD9668) is an orally active, selective inhibitor of neutrophil elastase. Alvelestat reduces elastase activity, myeloperoxidase release, neutrophil recruitment and activation, and calcium phosphate precipitation; promotes smooth muscle cell colonization and collagen deposition; and inhibits the formation of neutrophil extracellular traps (NETs) as well as NET-derived neutrophil elastase activity. Alvelestat restores endothelial dysfunction, regulates antioxidant factors, improves the expression of endothelial tight junctions, reduces vascular leakage, and accelerates wound healing. Alvelestat prevents pulmonary hemorrhage, matrix protein degradation, airspace enlargement, and small airway wall remodeling; and alleviates cigarette-induced inflammatory responses. Alvelestat inhibits the growth of abdominal aortic aneurysms exacerbated by Porphyromonas gingivalis. Alvelestat can be used in research related to chronic obstructive pulmonary disease, abdominal aortic aneurysm, radiation-induced skin injury, and bronchiectasis .
10
10 Cited Publications
Synonyms: AV-951; KRN951
Tivozanib (AV-951; KRN951) is a selective, orally active inhibitor for vascular endothelial growth factor receptor (VEGFR)-1, 2 3, with IC50s of 30, 6.5 and 15 nM, respectively. Tivozanib exhibits antitumor efficacy .
10
10 Cited Publications
Synonyms: AV-951 hydrochloride hydrate; KRN951 hydrochloride hydrate
Tivozanib hydrochloride hydrate is the hydrate hydrochloride form of Tivozanib (HY-10977). Tivozanib hydrochloride hydrate is a selective, orally active inhibitor for vascular endothelial growth factor receptor (VEGFR)-1, 2 3, with IC50s of 30, 6.5 and 15 nM, respectively. Tivozanib hydrochloride hydrate exhibits antitumor efficacy .
10
10 Cited Publications
Synonyms: AV-951 hydrate; KRN951 hydrate
Tivozanib hydrate (AV-951 hydrate; KRN951 hydrate) is the hydrate form of Tivozanib (HY-10977). Tivozanib hydrate is a selective, orally active inhibitor for vascular endothelial growth factor receptor (VEGFR)-1, 2 3, with IC50s of 30, 6.5 and 15 nM, respectively. Tivozanib hydrate exhibits antitumor efficacy .
9
9 Cited Publications
Cat. No.: HY-P7312
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: VEGFA; Vascular endothelial growth factor A; VEGF; VPF; Vascular Permeability factor; Vascular endothelial growth factor A, Long Form; VEGF-A; L-VEGF; Vascular endothelial growth factor A121; Vascular endothelial growth factor A165; Vascular endothelial G
Species:
Mouse
Source:
E. coli
7
7 Cited Publications
Cat. No.: HY-P74474
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: VEGFC; Vascular endothelial growth factor C; Vascular endothelial growth factor-Related Protein; VRP; VEGF-C; Flt4 Ligand; Flt4-L; FLT4 Ligand DHM; LMPH1D; LMPHM4
Species:
Mouse
Rat
Source:
HEK293
6
4
4 Cited Publications
Research Areas:
Ki20227 is an orally active and highly selective c-Fms tyrosine kinase (CSF1R) inhibitor with IC50s of 2 nM, 12 nM, 451 and 217 nM for CSF1R, VEGFR2 (vascular endothelial growth factor receptor-2), c-Kit (stem cell factor receptor) and PDGFRβ (platelet-derived growth factor receptor β). Ki20227 suppresses osteoclast differentiation and osteolytic bone destruction .
3
3 Cited Publications
Cat. No.: HY-P7311
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: VEGFA; Vascular endothelial growth factor A; VEGF; VPF; Vascular Permeability factor; Vascular endothelial growth factor A, Long Form; VEGF-A; L-VEGF; Vascular endothelial growth factor A121; Vascular endothelial growth factor A165; Vascular endothelial G
Species:
Rat
Source:
CHO
3
3 Cited Publications
Cat. No.: HY-P7313
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: VEGFC; Vascular endothelial growth factor C; Vascular endothelial growth factor-Related Protein; VRP; VEGF-C; Flt4 Ligand; Flt4-L; FLT4 Ligand DHM; LMPH1D; LMPHM4
Species:
Human
Source:
HEK293
3
3
3 Cited Publications
Cat. No.: HY-P70147
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NRP1; Transmembrane Receptor; Neuropilin 1; CD304 Antigen; VEGF165R; DKFZp686M1967; NRP; Neuropilin; Neuropilin-1; BDCA4; CD304; NP1; Vascular endothelial Cell growth factor 165 Receptor
Species:
Human
Source:
HEK293
2
2 Cited Publications
Cat. No.: HY-P7420
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: VEGFA; Vascular endothelial growth factor A; VEGF; VPF; Vascular Permeability factor; Vascular endothelial growth factor A, Long Form; VEGF-A; L-VEGF; Vascular endothelial growth factor A121; Vascular endothelial growth factor A165; Vascular endothelial G
Species:
Human
Source:
E. coli
2
2 Cited Publications
Cat. No.: HY-P70458A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: VEGFA; Vascular endothelial growth factor A; VEGF; VPF; Vascular Permeability factor; Vascular endothelial growth factor A, Long Form; VEGF-A; L-VEGF; Vascular endothelial growth factor A121; Vascular endothelial growth factor A165; Vascular endothelial growth factor; VEGFA Protein; MVCD1
Species:
Human
Source:
HEK293
2
2 Cited Publications
Cat. No.: HY-P81643
Synonyms: KDR; FLK1; VEGFR2; Vascular endothelial growth factor receptor 2; VEGFR-2; Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; KDR; Protein-tyrosine kinase receptor flk-1; CD antigen CD309
2
2 Cited Publications
Cat. No.: HY-N0249
CAS No.: 20736-08-7
Target:
1
1 Cited Publications
Cat. No.: HY-P7110
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: VEGFA; Vascular endothelial growth factor A; VEGF; VPF; Vascular Permeability factor; Vascular endothelial growth factor A, Long Form; VEGF-A; L-VEGF; Vascular endothelial growth factor A121; Vascular endothelial growth factor A165; Vascular endothelial G
Species:
Human
Source:
P. pastoris
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
