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Results for "

Zanthoxylum

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) Akt (2) AMPK (3) Apoptosis (5) Bacterial (8) Bcl-2 Family (1) Caspase (1) Cholinesterase (ChE) (1) Environmental Pollutants (1) ERK (2) FAK (2) Fungal (4) HIV (1) Insecticide (1) Interleukin Related (2) Isotope-Labeled Compounds (1) Monoamine Oxidase (1) nAChR (1) NF-κB (2) p38 MAPK (3) Parasite (5) PGE synthase (1) Reactive Oxygen Species (ROS) (1) Reference Standards (3) STAT (2) Succinate Dehydrogenase (1) TNF Receptor (1) Topoisomerase (2) TRP Channel (1) Tyrosinase (3) α-synuclein (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (3) Infection (15) Inflammation/Immunology (6) Metabolic Disease (5) Neurological Disease (5)

By Targets:

Acyltransferase (1)

Akt (2)

AMPK (3)

Apoptosis (5)

Bacterial (8)

Bcl-2 Family (1)

Caspase (1)

Cholinesterase (ChE) (1)

Environmental Pollutants (1)

ERK (2)

FAK (2)

Fungal (4)

HIV (1)

Insecticide (1)

Interleukin Related (2)

Isotope-Labeled Compounds (1)

Monoamine Oxidase (1)

nAChR (1)

NF-κB (2)

p38 MAPK (3)

Parasite (5)

PGE synthase (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (3)

STAT (2)

Succinate Dehydrogenase (1)

TNF Receptor (1)

Topoisomerase (2)

TRP Channel (1)

Tyrosinase (3)

α-synuclein (1)

By Research Areas:

Cancer (7)

Cardiovascular Disease (3)

Infection (15)

Inflammation/Immunology (6)

Metabolic Disease (5)

Neurological Disease (5)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1063

Xanthoxylin Xanthoxyline	Fungal	Infection Metabolic Disease
Xanthoxylin (Xanthoxyline) can be isolated from Zanthoxylum simulans. Xanthoxylin has antifungal and antioxidant effects. The MIC of Xanthoxylin against Toxoplasma neonatorum and Aspergillus fumigatus were 50 µg/mL and 75 µg/mL, respectively. Xanthoxylin can be used in the study of anti-epileptic diseases .

HY-N6824

Hydroxy-β-sanshool 1 Publications Verification	Others	Others
Hydroxy-β-sanshool is an alkylamide exists in Zanthoxylum bungeanum oil and Zanthoxylum schinifolium oil .

HY-N0498

Nitidine chloride 4 Publications Verification	Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB	Inflammation/Immunology Cancer
Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway, also has anti-inflammatory activity. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .

HY-111880

γ-Sanshool	Acyltransferase	Cardiovascular Disease
γ-Sanshool can be isolated from Zanthoxylum piperitum. γ-Sanshool inhibits human ACAT-1 and ACAT-2 activities with IC₅₀s of 12.0 and 82.6 μM .

HY-W017212

Methyl cinnamate 2 Publications Verification Methyl 3-phenylpropenoate	Environmental Pollutants AMPK Bacterial Tyrosinase	Infection Metabolic Disease
Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .

HY-N10879

5,7-Dimethoxyflavanone	Others	Others
5,7-Dimethoxyflavanone is an active compound. 5,7-Dimethoxyflavanone can be Isolated from the roots of Zanthoxylum nitidum .

HY-N3139

Ombuin	Bacterial	Infection
Ombuin, isolated from Zanthoxylum armatum, displays broad spectrum antibacterial effect with MIC ranges from 125 to 500 μg/mL .

HY-N7013

Hydroxy-Epsilon-Sanshool	Others	Neurological Disease
Hydroxy-Epsilon-Sanshool is an alkylamide isolated from Zanthoxylum bungeanum. Hydroxy-Epsilon-Sanshool produces key tingling and numbing chemosensates, and its content is important in determinant the pungency intensity of Zanthoxylum bungeanum .

HY-N4164

Schinifoline	Fungal Apoptosis	Infection Cancer
Schinifoline is a 4-quinolinone found in Zanthoxylum schinifolium. Schinifoline can inhibit cancer cells proliferation, cause G2/M phase arrest and induce apoptosis. Schinifoline can improve radiosensitizing effect of cancer cells. Schinifoline shows anti-fungal activity. Schinifoline can be used for the researches of cancer and infection, such as lung cancer and C. albicans infection .

HY-N1063R

Xanthoxylin (Standard) Xanthoxyline (Standard)	Reference Standards Fungal	Infection Metabolic Disease
Xanthoxylin (Xanthoxyline) can be isolated from Zanthoxylum simulans. Xanthoxylin has antifungal and antioxidant effects. The MIC of Xanthoxylin against Toxoplasma neonatorum and Aspergillus fumigatus were 50 µg/mL and 75 µg/mL, respectively. Xanthoxylin can be used in the study of anti-epileptic diseases .

HY-N3700

Decarine Rutaceline	Bacterial HIV TNF Receptor Interleukin Related	Infection Inflammation/Immunology
Decarine (Rutaceline) is a benzophenanthridine alkaloid found in Zanthoxylum species. Decarinewith shows anti-inflammatory, antimycobacterial, and anti-HIV activity. Decarine inhibits NO, TNF-α, IL-1β, IL-6, and IL-8 production in inflammatory cell models. Decarine inhibits growth of Mycobacterium tuberculosis strains, reduces intracellular Mycobacterium tuberculosis survival, and shows low cytotoxicity toward human macrophages. Decarine inhibits HIV replication in acutely infected lymphocytes. Decarine can be used for the researches of inflammation, tuberculosis, and HIV infection .

HY-N1053

Zanthobungeanine	Others	Others
Zanthobungeanine is a Alkaloids product that can be isolated from the roots of Zanthoxylum nitidum. .

HY-W017212R

Methyl cinnamate (Standard) Methyl 3-phenylpropenoate (Standard)	Reference Standards Tyrosinase Bacterial AMPK	Infection Metabolic Disease
Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .

HY-N8340

Luvangetin	Others	Others
Luvangetin is a coumarin that can be isolated from Zanthoxylum avicennae .

HY-N3123

Oxychelerythrine Dihydrooxochelerythrine	Others	Cancer
Oxychelerythrine is an alkaloid that can be isolated from Zanthoxylum integrifoliolum. Oxychelerythrine exhibits cytotoxicity against P-388 and HT-29 cell lines with ED₅₀s of 3.25 and 5.48 μg/mL, respectively .

HY-N11979

Dihydronitidine	Others	Others
Dihydronitidine is an alkaloid can be extracted from Zanthoxylum rhoifolium .

HY-N8706

Hydrangetin 7-Hydroxy-8-methoxycoumarin	Others	Cardiovascular Disease
Hydrangetin inhibits platelet aggregation. Hydrangetin can be isolated from Zanthoxylum schinifolium .

HY-N3236

Mullilam diol	Others	Others
Mullilam diol is a Monoterpenoids product that can be isolated from the herbs of Zanthoxylum budrunga Wall. .

HY-N1538

(+)-Piperitol-3,3-dimethylallyl ether	Others	Others
(+)-Piperitol-3,3-dimethylallyl ether can be isolated from the roots and the bark of Zanthoxylum usambarense .

HY-N9926

Pluviatolide (-)-Pluviatolide	Others	Others
Pluviatolide ((-)-Pluviatolide) is a lignan that can be found in the bark of Zanthoxylum pluviatile Hartley. Pluviatolide can be used as (-)-Podophyllotoxin precursor .

HY-N2697

6-Acetonyl-N-methyldihydrodecarine	Monoamine Oxidase	Neurological Disease
6-Acetonyl-N-methyldihydrodecarine is a natural alkaloid that can be isolated from roots of Zanthoxylum rigidum. An inhibitor of monoamine oxidases .

HY-138548

4-Ethoxycoumarin	Bacterial	Infection
4-Ethoxycoumarin is an antimicrobial .

HY-129130

Canthin-6-one N-oxide Canthin-6-one 3-oxide	Parasite	Infection
Canthin-6-one N-oxide (Canthin-6-one 3-oxide) is an orally active antiparasitic agent with limited activity .

HY-N9194

5-Methoxycanthin-6-one	Parasite	Infection
5-Methoxycanthin-6-one is an orally active inhibitor of Leishmania strains. 5-Methoxycanthin-6-one shows cytotoxicity with an IC₅₀ of 5.44 μg/mL against Ailanthus altissima cells .

HY-121428

Fagaramide	PGE synthase	Others
Fagaramide is a compound extracted from Zanthoxylum bungeanum with anti-inflammatory activity. It is effective against carrageenan foot swelling in rats and mediates its anti-inflammatory effect partly by inhibiting prostaglandin synthesis. Its activity is about 1/20 of that of indomethacin.

HY-N1065

Xanthoxyletin	Apoptosis	Inflammation/Immunology Cancer
Xanthoxyletin is a coumarin that can be isolated from Genus Zanthoxylum and Clausena. Xanthoxyletin has antioxidant and anti-inflammatory activities. Xanthoxyletin shows cytotoxic effects to cancer cells, and induces apoptosis and necrosis. Xanthoxyletin can be used for the research of cancer and inflammation .

HY-N7505

Norchelerythrine	Bacterial	Infection
Norchelerythrine is an alkaloid isolated from the roots of Zanthoxylum capense with antibacterial activity against gram-positive and gram-negative bacteria. Norchelerythrine exhibits inhibitory activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis and Escherichia coli with MIC values >50 µg/mL .

HY-W017212S

Methyl cinnamate-d7 Methyl 3-phenylpropenoate-d₇	AMPK Tyrosinase Bacterial Isotope-Labeled Compounds	Infection
Methyl cinnamate-d₇ is deuterated labeled Methyl cinnamate (HY-W017212). Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .

HY-N0498R

Nitidine chloride (Standard)	Reference Standards Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB	Inflammation/Immunology Cancer
Nitidine (chloride) (Standard) is the analytical standard of Nitidine (chloride). This product is intended for research and analytical applications. Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .

HY-N18289

8-Hydroxydihydrochelerythrine	Cholinesterase (ChE)	Neurological Disease
8-Hydroxydihydrochelerythrine is a benzophenanthridine alkaloid-derived, selective and competitive AChE inhibitor (IC₅₀=0.61 μM) isolated from the roots of Zanthoxylum nitidum (Roxb.) DC. 8-Hydroxydihydrochelerythrine increases the content of acetylcholine in the synapses of cholinergic neurons and enhances cholinergic neurotransmission. 8-Hydroxydihydrochelerythrine is applicable to the research of neurodegenerative diseases with dementia such as Alzheimer's disease .

HY-N18222

Dihydroavicine	Bacterial Fungal	Infection
Dihydroavicine is a benzophenanthridine alkaloid antibacterial agent isolated from the stem bark of Zanthoxylum rhoifolium. Dihydroavicine inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, and Candida albicans. Dihydroavicine shows no activity against Saccharomyces cerevisiae and Cryptococcus neoformans. Dihydroavicine can be used for the research of bacterial infections and candidal infections .

HY-N18179

8-Acetonyldihydrochelerythrine	Parasite	Infection
8-Acetonylidihydrochelerythrine is a benzophenanthridine alkaloid found in the stem bark of Zanthoxylum gilletii. 8-Acetonylidihydrochelerythrine inhibits growth of Chloroquine (HY-17589A)-resistant and Chloroquine-sensitive Plasmodium falciparum strains. 8-Acetonylidihydrochelerythrine can be used for the research of malaria .

HY-N2678

5-Hydroxymethyl-7-methoxybenzofuran	Others	Others
5-Hydroxymethyl-7-methoxybenzofuran is a Phenols product that can be isolated from the fruits of Zanthoxylum bungeanum .

HY-N1906

4-Methoxy-1-methylquinolin-2-one	Others	Others
4-Methoxy-1-methylquinolin-2-one is a Alkaloids product that can be isolated from the herbs of Zanthoxylum nitidum .

HY-N17458

N-Acetyldehydroanonaine	Akt p38 MAPK	Cancer
N-Acetyldehydroanonaine is an alkaloid that acts as a ligand for AKT1 and MAPK1. N-Acetyldehydroanonaine can be isolated from plants of the Zanthoxylum genus. N-Acetyldehydroanonaine is applicable to the research of diseases such as gastric cancer .

HY-N18367

Lemairamin Wgx-50	nAChR Interleukin Related Akt	Neurological Disease Inflammation/Immunology
Lemairamin (Wgx-50) is a hydroxylamine compound. Lemairamin can be isolated from the pericarps of the Zanthoxylum plants. Lemairamin activates α7nAChR, stimulates the expression of IL-10 and POMC. Lemairamin shows a decrease in Akt. Lemairamin attenuates DSS-induced intestinal inflammation. Lemairamin alleviates pain hypersensitivity .

HY-N12639

β-Sanshool	TRP Channel	Others
β-Sanshool is found in Zanthoxylum bungeanum and has a unique pungent taste. β-Sanshool is a TRPV1 activator that activates TRPV1 to increase intracellular calcium concentration. β-Sanshool has antioxidant effects and enhances free radical scavenging activity. β-Sanshool increases the thermal denaturation temperature and stabilizes protein structures. β-Sanshool induces sensory experiences of numbness and bitterness .

HY-N17816

Tambulin	Apoptosis Reactive Oxygen Species (ROS) α-synuclein Succinate Dehydrogenase Bcl-2 Family Caspase	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Tambulin is an orally active flavonol compound found in Zanthoxylum armatum. Tambulin can inhibit cell proliferation, induce apoptosis and inhibit ROS production. Tambulin upregulates cleaved caspase-3, cleaved caspase-9, and Bax, downregulates Bcl-2 levels. Tambulin can stimulate glucose-dependent insulin secretion and induce endothelium-independent vasorelaxation. Tambulin binds to succinate dehydrogenase (SDH) (Ki = 11.02 μM) and shows significant ferric reducing power. Tambulin can enhances oxidative stress resistance, reduces, lipofuscin deposits, lipid levels, α-synuclein levels, improves locomotary behavior, and dopamine levels in in age-synchronized L1 hermaphrodite Caenorhabditis elegans models of ageing and Parkinson's disease. Tambulin can be used for the researches of Parkinson's disease, lung squamous cell carcinoma, and diabetes .

HY-W269352

2-Dodecanone	Insecticide	Infection
2-Dodecanone is an insecticide with repellent activity against specific insect species. 2-Dodecanone exhibits contact toxicity against adult Tribolium castaneum, Lasioderma serricorne and Liposcelis bostrychophila. 2-Dodecanone shows repellent effects against adult Lasioderma serricorne .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1063

Xanthoxylin Xanthoxyline	Zanthoxylum bungeanum Maxim. Infection Monophenols Classification of Application Fields Rutaceae Phenols Plants Zanthoxylum simulans Hance Disease Research Fields	Fungal
Xanthoxylin (Xanthoxyline) can be isolated from Zanthoxylum simulans. Xanthoxylin has antifungal and antioxidant effects. The MIC of Xanthoxylin against Toxoplasma neonatorum and Aspergillus fumigatus were 50 µg/mL and 75 µg/mL, respectively. Xanthoxylin can be used in the study of anti-epileptic diseases .

HY-N6824

Hydroxy-β-sanshool 1 Publications Verification	Zanthoxylum bungeanum Maxim. Alkaloids Classification of Application Fields Other Diseases Rutaceae Plants Disease Research Fields Source Classification	Others
Hydroxy-β-sanshool is an alkylamide exists in Zanthoxylum bungeanum oil and Zanthoxylum schinifolium oil .

HY-N0498

Nitidine chloride 4 Publications Verification	Alkaloids Classification of Application Fields Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Source Classification	Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB
Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway, also has anti-inflammatory activity. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .

HY-111880

γ-Sanshool	Zanthoxylum bungeanum Maxim. Structural Classification Alkaloids Other Alkaloids Rutaceae Plants Source Classification	Acyltransferase
γ-Sanshool can be isolated from Zanthoxylum piperitum. γ-Sanshool inhibits human ACAT-1 and ACAT-2 activities with IC₅₀s of 12.0 and 82.6 μM .

HY-W017212

Methyl cinnamate 2 Publications Verification Methyl 3-phenylpropenoate	Structural Classification Classification of Application Fields Simple Phenylpropanols Rutaceae Metabolic Disease Phenylpropanoids Plants Disease Research Fields Zanthoxylum armatum DC. Source Classification	Environmental Pollutants AMPK Bacterial Tyrosinase
Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .

HY-N10879

5,7-Dimethoxyflavanone	Flavonoids Flavonones Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants Source Classification	Others
5,7-Dimethoxyflavanone is an active compound. 5,7-Dimethoxyflavanone can be Isolated from the roots of Zanthoxylum nitidum .

HY-N3139

Ombuin	Infection Flavonols Flavonoids Classification of Application Fields Rutaceae Phenols Polyphenols Plants Disease Research Fields Zanthoxylum armatum DC. Source Classification	Bacterial
Ombuin, isolated from Zanthoxylum armatum, displays broad spectrum antibacterial effect with MIC ranges from 125 to 500 μg/mL .

HY-N7013

Hydroxy-Epsilon-Sanshool	Zanthoxylum bungeanum Maxim. Natural Products Rutaceae Plants Source Classification	Others
Hydroxy-Epsilon-Sanshool is an alkylamide isolated from Zanthoxylum bungeanum. Hydroxy-Epsilon-Sanshool produces key tingling and numbing chemosensates, and its content is important in determinant the pungency intensity of Zanthoxylum bungeanum .

HY-N4164

Schinifoline	Zanthoxylum bungeanum Maxim. Alkaloids Classification of Application Fields Rutaceae Quinoline Alkaloids Plants Disease Research Fields Source Classification Cancer	Fungal Apoptosis
Schinifoline is a 4-quinolinone found in Zanthoxylum schinifolium. Schinifoline can inhibit cancer cells proliferation, cause G2/M phase arrest and induce apoptosis. Schinifoline can improve radiosensitizing effect of cancer cells. Schinifoline shows anti-fungal activity. Schinifoline can be used for the researches of cancer and infection, such as lung cancer and C. albicans infection .

HY-N1063R

Xanthoxylin (Standard) Xanthoxyline (Standard)	Zanthoxylum bungeanum Maxim. Structural Classification Monophenols Rutaceae Phenols Plants Zanthoxylum simulans Hance	Reference Standards Fungal
Xanthoxylin (Xanthoxyline) can be isolated from Zanthoxylum simulans. Xanthoxylin has antifungal and antioxidant effects. The MIC of Xanthoxylin against Toxoplasma neonatorum and Aspergillus fumigatus were 50 µg/mL and 75 µg/mL, respectively. Xanthoxylin can be used in the study of anti-epileptic diseases .

HY-N3700

Decarine Rutaceline	Structural Classification Alkaloids Rutaceae Plants Isoquinoline Alkaloids Zanthoxylum simulans Hance Source Classification	Bacterial HIV TNF Receptor Interleukin Related
Decarine (Rutaceline) is a benzophenanthridine alkaloid found in Zanthoxylum species. Decarinewith shows anti-inflammatory, antimycobacterial, and anti-HIV activity. Decarine inhibits NO, TNF-α, IL-1β, IL-6, and IL-8 production in inflammatory cell models. Decarine inhibits growth of Mycobacterium tuberculosis strains, reduces intracellular Mycobacterium tuberculosis survival, and shows low cytotoxicity toward human macrophages. Decarine inhibits HIV replication in acutely infected lymphocytes. Decarine can be used for the researches of inflammation, tuberculosis, and HIV infection .

HY-N1053

Zanthobungeanine	Alkaloids Other Alkaloids Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants Source Classification	Others
Zanthobungeanine is a Alkaloids product that can be isolated from the roots of Zanthoxylum nitidum. .

HY-W017212R

Methyl cinnamate (Standard) Methyl 3-phenylpropenoate (Standard)	Structural Classification Simple Phenylpropanols Rutaceae Phenylpropanoids Plants Zanthoxylum armatum DC. Source Classification	Reference Standards Tyrosinase Bacterial AMPK
Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .

HY-N8340

Luvangetin	Structural Classification Zanthoxylum avicennae (Lam.) DC. Rutaceae Coumarins Phenylpropanoids Plants Source Classification	Others
Luvangetin is a coumarin that can be isolated from Zanthoxylum avicennae .

HY-N3123

Oxychelerythrine Dihydrooxochelerythrine	Zanthoxylum integrifoliolum (Merr.) Merr. Rutaceae Plants Source Classification	Others
Oxychelerythrine is an alkaloid that can be isolated from Zanthoxylum integrifoliolum. Oxychelerythrine exhibits cytotoxicity against P-388 and HT-29 cell lines with ED₅₀s of 3.25 and 5.48 μg/mL, respectively .

HY-N11979

Dihydronitidine	Alkaloids Other Alkaloids Rutaceae Zanthoxylum rhoifolium Lam. Plants Source Classification	Others
Dihydronitidine is an alkaloid can be extracted from Zanthoxylum rhoifolium .

HY-N8706

Hydrangetin 7-Hydroxy-8-methoxycoumarin	Zanthoxylum schinifolium Sieb. et Zucc. Rutaceae Coumarins Phenylpropanoids Plants Source Classification	Others
Hydrangetin inhibits platelet aggregation. Hydrangetin can be isolated from Zanthoxylum schinifolium .

HY-N3236

Mullilam diol	Zanthoxylum bungeanum Maxim. Other Monoterpenes Terpenoids Rutaceae Plants Source Classification	Others
Mullilam diol is a Monoterpenoids product that can be isolated from the herbs of Zanthoxylum budrunga Wall. .

HY-N1538

(+)-Piperitol-3,3-dimethylallyl ether	Structural Classification Lignans Rutaceae Phenylpropanoids Plants Zanthoxylum usambarense (Engl.) Kokwaro Source Classification	Others
(+)-Piperitol-3,3-dimethylallyl ether can be isolated from the roots and the bark of Zanthoxylum usambarense .

HY-N9926

Pluviatolide (-)-Pluviatolide	Zanthoxylum bungeanum Maxim. Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Rutaceae Phenols Plants Disease Research Fields Source Classification	Others
Pluviatolide ((-)-Pluviatolide) is a lignan that can be found in the bark of Zanthoxylum pluviatile Hartley. Pluviatolide can be used as (-)-Podophyllotoxin precursor .

HY-N2697

6-Acetonyl-N-methyldihydrodecarine	Alkaloids Zanthoxylum rigidum Humb. & Bonpl. ex Willd. Rutaceae Plants Isoquinoline Alkaloids Source Classification	Monoamine Oxidase
6-Acetonyl-N-methyldihydrodecarine is a natural alkaloid that can be isolated from roots of Zanthoxylum rigidum. An inhibitor of monoamine oxidases .

HY-138548

4-Ethoxycoumarin	Structural Classification Rutaceae Zanthoxylum zanthoxyloides (Lam.) Zepern. & Timler Coumarins Phenylpropanoids Plants Source Classification	Bacterial
4-Ethoxycoumarin is an antimicrobial .

HY-129130

Canthin-6-one N-oxide Canthin-6-one 3-oxide	Alkaloids Simaroubaceae Other Alkaloids Eurycoma harmandiana Pierre Plants Source Classification	Parasite
Canthin-6-one N-oxide (Canthin-6-one 3-oxide) is an orally active antiparasitic agent with limited activity .

HY-N9194

5-Methoxycanthin-6-one	Infection Alkaloids Classification of Application Fields Rutaceae Pyridine Alkaloids Zanthoxylum chiloperone var. angustifolium Plants Disease Research Fields Indole Alkaloids Source Classification	Parasite
5-Methoxycanthin-6-one is an orally active inhibitor of Leishmania strains. 5-Methoxycanthin-6-one shows cytotoxicity with an IC₅₀ of 5.44 μg/mL against Ailanthus altissima cells .

HY-N1065

Xanthoxyletin	Rutaceae Coumarins Phenylpropanoids Plants Clausena harmandiana (Pierre) Guillaumin Source Classification	Apoptosis
Xanthoxyletin is a coumarin that can be isolated from Genus Zanthoxylum and Clausena. Xanthoxyletin has antioxidant and anti-inflammatory activities. Xanthoxyletin shows cytotoxic effects to cancer cells, and induces apoptosis and necrosis. Xanthoxyletin can be used for the research of cancer and inflammation .

HY-N7505

Norchelerythrine	Infection Alkaloids Classification of Application Fields Macleaya cordata (Willd.) R. Br. Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Source Classification	Bacterial
Norchelerythrine is an alkaloid isolated from the roots of Zanthoxylum capense with antibacterial activity against gram-positive and gram-negative bacteria. Norchelerythrine exhibits inhibitory activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis and Escherichia coli with MIC values >50 µg/mL .

HY-N0498R

Nitidine chloride (Standard)	Alkaloids Structural Classification Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants Isoquinoline Alkaloids Source Classification	Reference Standards Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB
Nitidine (chloride) (Standard) is the analytical standard of Nitidine (chloride). This product is intended for research and analytical applications. Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .

HY-N18289

8-Hydroxydihydrochelerythrine	Structural Classification Alkaloids Other Alkaloids Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants Source Classification	Cholinesterase (ChE)
8-Hydroxydihydrochelerythrine is a benzophenanthridine alkaloid-derived, selective and competitive AChE inhibitor (IC₅₀=0.61 μM) isolated from the roots of Zanthoxylum nitidum (Roxb.) DC. 8-Hydroxydihydrochelerythrine increases the content of acetylcholine in the synapses of cholinergic neurons and enhances cholinergic neurotransmission. 8-Hydroxydihydrochelerythrine is applicable to the research of neurodegenerative diseases with dementia such as Alzheimer's disease .

HY-N18222

Dihydroavicine	Zanthoxylum bungeanum Maxim. Structural Classification Alkaloids Rutaceae Plants Isoquinoline Alkaloids Source Classification	Bacterial Fungal
Dihydroavicine is a benzophenanthridine alkaloid antibacterial agent isolated from the stem bark of Zanthoxylum rhoifolium. Dihydroavicine inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, and Candida albicans. Dihydroavicine shows no activity against Saccharomyces cerevisiae and Cryptococcus neoformans. Dihydroavicine can be used for the research of bacterial infections and candidal infections .

HY-N18179

8-Acetonyldihydrochelerythrine	Structural Classification Alkaloids Rutaceae Quinoline Alkaloids Plants Zanthoxylum gilletii (De Wild.) P.G.Waterman Source Classification	Parasite
8-Acetonylidihydrochelerythrine is a benzophenanthridine alkaloid found in the stem bark of Zanthoxylum gilletii. 8-Acetonylidihydrochelerythrine inhibits growth of Chloroquine (HY-17589A)-resistant and Chloroquine-sensitive Plasmodium falciparum strains. 8-Acetonylidihydrochelerythrine can be used for the research of malaria .

HY-N2678

5-Hydroxymethyl-7-methoxybenzofuran	Zanthoxylum bungeanum Maxim. Monophenols Rutaceae Phenols Plants Source Classification	Others
5-Hydroxymethyl-7-methoxybenzofuran is a Phenols product that can be isolated from the fruits of Zanthoxylum bungeanum .

HY-N1906

4-Methoxy-1-methylquinolin-2-one	Alkaloids Rutaceae Zanthoxylum nitidum (Roxb.) DC. Quinoline Alkaloids Plants Source Classification	Others
4-Methoxy-1-methylquinolin-2-one is a Alkaloids product that can be isolated from the herbs of Zanthoxylum nitidum .

HY-N17458

N-Acetyldehydroanonaine	Structural Classification Alkaloids Other Alkaloids Rutaceae Plants Zanthoxylum simulans Hance Source Classification	Akt p38 MAPK
N-Acetyldehydroanonaine is an alkaloid that acts as a ligand for AKT1 and MAPK1. N-Acetyldehydroanonaine can be isolated from plants of the Zanthoxylum genus. N-Acetyldehydroanonaine is applicable to the research of diseases such as gastric cancer .

HY-N18367

Lemairamin Wgx-50	Zanthoxylum bungeanum Maxim. Structural Classification Simple Phenylpropanols Rutaceae Phenylpropanoids Plants Source Classification	nAChR Interleukin Related Akt
Lemairamin (Wgx-50) is a hydroxylamine compound. Lemairamin can be isolated from the pericarps of the Zanthoxylum plants. Lemairamin activates α7nAChR, stimulates the expression of IL-10 and POMC. Lemairamin shows a decrease in Akt. Lemairamin attenuates DSS-induced intestinal inflammation. Lemairamin alleviates pain hypersensitivity .

HY-N12639

β-Sanshool	Zanthoxylum bungeanum Maxim. Structural Classification Natural Products Rutaceae Plants Source Classification	TRP Channel
β-Sanshool is found in Zanthoxylum bungeanum and has a unique pungent taste. β-Sanshool is a TRPV1 activator that activates TRPV1 to increase intracellular calcium concentration. β-Sanshool has antioxidant effects and enhances free radical scavenging activity. β-Sanshool increases the thermal denaturation temperature and stabilizes protein structures. β-Sanshool induces sensory experiences of numbness and bitterness .

HY-N17816

Tambulin	Structural Classification Flavonoids Flavones Rutaceae Plants Zanthoxylum armatum DC. Source Classification	Apoptosis Reactive Oxygen Species (ROS) α-synuclein Succinate Dehydrogenase Bcl-2 Family Caspase
Tambulin is an orally active flavonol compound found in Zanthoxylum armatum. Tambulin can inhibit cell proliferation, induce apoptosis and inhibit ROS production. Tambulin upregulates cleaved caspase-3, cleaved caspase-9, and Bax, downregulates Bcl-2 levels. Tambulin can stimulate glucose-dependent insulin secretion and induce endothelium-independent vasorelaxation. Tambulin binds to succinate dehydrogenase (SDH) (Ki = 11.02 μM) and shows significant ferric reducing power. Tambulin can enhances oxidative stress resistance, reduces, lipofuscin deposits, lipid levels, α-synuclein levels, improves locomotary behavior, and dopamine levels in in age-synchronized L1 hermaphrodite Caenorhabditis elegans models of ageing and Parkinson's disease. Tambulin can be used for the researches of Parkinson's disease, lung squamous cell carcinoma, and diabetes .

Cat. No.	Product Name	Chemical Structure

HY-W017212S

Methyl cinnamate-d7

Methyl cinnamate-d₇ is deuterated labeled Methyl cinnamate (HY-W017212). Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .

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