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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

alveolar epithelial cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (4) Aryl Hydrocarbon Receptor (2) Bcl-2 Family (1) Caspase (1) CDK (1) CFTR (1) COX (1) DNA Alkylator/Crosslinker (1) Drug Derivative (2) Elastase (1) Environmental Pollutants (1) Exosomes (1) Interleukin Related (2) Liposome (1) NF-κB (2) Phosphodiesterase (PDE) (1) PKA (1) PKC (1) PKG (1) PTEN (1) Reactive Oxygen Species (ROS) (1) Reference Standards (2) SARS-CoV (1) TGF-beta/Smad (2) TNF Receptor (1) Topoisomerase (1) TrxR (1)
By Research Areas:	Cancer (8) Infection (2) Inflammation/Immunology (12) Metabolic Disease (1) Neurological Disease (1)

By Targets:

Akt (1)

Apoptosis (4)

Aryl Hydrocarbon Receptor (2)

Bcl-2 Family (1)

Caspase (1)

CDK (1)

CFTR (1)

COX (1)

DNA Alkylator/Crosslinker (1)

Drug Derivative (2)

Elastase (1)

Environmental Pollutants (1)

Exosomes (1)

Interleukin Related (2)

Liposome (1)

NF-κB (2)

Phosphodiesterase (PDE) (1)

PKA (1)

PKC (1)

PKG (1)

PTEN (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (2)

SARS-CoV (1)

TGF-beta/Smad (2)

TNF Receptor (1)

Topoisomerase (1)

TrxR (1)

By Research Areas:

Cancer (8)

Infection (2)

Inflammation/Immunology (12)

Metabolic Disease (1)

Neurological Disease (1)

Inhibitors & Agonists

Peptides

Natural
Products

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-P5423

GALA	Exosomes Liposome	Cancer
GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. GALA significantly promotes the cytosolic release of cargos carried by exosomes, plasmids and liposomes, effectively enhances gene transfection efficiency, and drives gene knockdown of functional macromolecules (such as siRNA) in alveolar epithelial cells (with no significant cytotoxicity at effective concentrations). GALA serves as a critical tool for studies on lung cancer metastasis (e.g., melanoma lung metastasis) and lung-targeted drug delivery systems .

HY-156562A

5-PT formic 1 Publications Verification 5-Propargyltryptamide formic	Drug Derivative	Inflammation/Immunology
5-PT (5-Propargyltryptamide) formic is an alkyne-functionalized 5-HT (HY-B1473A) derivative and serotonylation substrate, taken up by living cells. 5-PT formic conjugated to a biotin enables identification of serotonylated proteins via copper-click chemistry and mass spectrometry. 5-PT formic labels and isolates serotonylated cells in alveolar epithelial cells for proteomic analysis. 5-PT formic can be used for the research of bronchopulmonary dysplasia .

HY-122308

Militarine	NF-κB Apoptosis Interleukin Related COX Reactive Oxygen Species (ROS)	Inflammation/Immunology
Militarine is a plant growth inhibitor and anti-inflammatory agent. Militarine inhibits the elongation of radicles and hypocotyls in seedlings of lettuce, Italian ryegrass and timothy grass. Militarine alleviates PM_2.5-induced inflammatory injury and inhibits cell migration in human alveolar epithelial A549 cells by inhibiting the NF-κB signaling pathway, reducing oxidative stress and the release of inflammatory factors. Militarine can be used in studies related to PM_2.5-induced pulmonary diseases .

HY-P11178

Corisin	Apoptosis SARS-CoV	Infection Metabolic Disease Inflammation/Immunology
Corisin is a pro-apoptotic small peptide produced by Staphylococcus species. Corisin binds to serum albumin to target organs such as the lungs and kidneys, induces cellular senescence, apoptosis and epithelial-mesenchymal transition, and accelerates the progression of organ fibrosis including pulmonary fibrosis and diabetic renal fibrosis. Corisin levels are closely associated with coronavirus disease 2019 (COVID-19), diabetic chronic kidney disease (CKD), non-diabetic CKD, and idiopathic pulmonary fibrosis (IPF) .

HY-112465

H-8 dihydrochloride	PKA PKC PKG	Neurological Disease Cancer
H-8 dihydrochloride is a selective Cyclic nucleotide-dependent protein kinase inhibitor. H-8 dihydrochloride potently inhibits cGMP- and cAMP-dependent protein phosphorylation. H-8 dihydrochloride enhances the vasodilatory effect induced by 8-bromo-cAMP (HY-12306A). H-8 dihydrochloride fails to attenuate the vasodilatory effects induced by 8-bromo-cGMP (HY-101379A), atrial natriuretic peptide II, or Sodium nitroprusside (HY-B0564) in rat aorta .

HY-156562

5-PT 5-Propargyltryptamide	Drug Derivative	Inflammation/Immunology
5-PT (5-Propargyltryptamide) is an alkyne-functionalized 5-HT (HY-B1473A) derivative and serotonylation substrate, taken up by living cells. 5-PT conjugated to a biotin enables identification of serotonylated proteins via copper-click chemistry and mass spectrometry. 5-PT labels and isolates serotonylated cells in alveolar epithelial cells for proteomic analysis. 5-PT can be used for the research of bronchopulmonary dysplasia .

HY-N8884

Coelonin	PTEN Akt NF-κB Interleukin Related TNF Receptor	Inflammation/Immunology
Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits NF-κB activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein .

HY-23499

Indeno[1,2,3-cd]pyrene	Environmental Pollutants Aryl Hydrocarbon Receptor	Inflammation/Immunology Cancer
Indeno[1,2,3-cd]pyrene is a polycyclic aromatic hydrocarbon with moderate cytotoxicity in human pulmonary alveolar epithelial cells HPAEpiC. Indeno[1,2,3-cd]pyrene enhances allergic lung infammation via aryl hydrocarbon receptor .

HY-W005379

DGM	TGF-beta/Smad	Inflammation/Immunology
DGM is an inhibitor of the TGF-β1/Smad signaling pathway with significant antifibrotic effects. DGM inhibits the epithelial-mesenchymal transition (EMT) process in alveolar epithelial cells and slows the progression of pulmonary fibrosis in vivo by reducing lung inflammation, improving lung function, and decreasing extracellular matrix (ECM) remodeling. DGM can be used in research on idiopathic pulmonary fibrosis (IPF) and EMT-related diseases .

HY-108534

PMX464 AW 464	TrxR	Inflammation/Immunology Cancer
PMX464 (AW 464), a thiol-reactive quinol, is the inhibitor of thioredoxin-thioredoxin reductase (Trx/TrxR) system. PMX464 can inhibit NF-κB-mediated proinflammatory activation of human type II alveolar epithelial cells .

HY-170813

P162-0948	CDK TGF-beta/Smad	Infection
P162-0948 is a selective CDK8 inhibitor with an IC₅₀ value of 50.4 nM. P162-0948 reduces cell migration and protein expression of EMT-related proteins in A549 human alveolar epithelial cell lines. P162-0948 reduces phosphorylation of Smad, which suggests disruption of the TGF-β/Smad signaling pathway. P162-0948 is promising for research of pulmonary fibrosis .

HY-165407

Neltenexine	Elastase CFTR	Inflammation/Immunology
Neltenexine, a mucolytic agent, is an Elastase inhibitor. Neltenexine diminishes anion secretion in in bronchial epithelial cells by inhibiting the Cl− and HCO3- uptake via Na/K/2Cl++− and Na+/HCO3- cotransporter without blockade of the CFTR channel, and also diminishes anion secretion via stimulation of Cl−/HCO3- exchanger. Neltenexine significantly prevents pulmonary emphysema with a reduction of alveolar deformation in rat models induced by Elastase. Neltenexine can be used for lung diseases such as chronic obstructive pulmonary disease (COPD) research .

HY-P3600

FIZZ-1 (32-51) (mouse)	Apoptosis	Inflammation/Immunology
FIZZ-1 (32-51) (mouse) is a cysteine-rich secretory protein that is highly expressed by macrophages, bronchial epithelial and type II alveolar epithelial cells (AEC) in allergic airway inflammation. FIZZ1 (32-51) (mouse) also shows an antiapoptotic effect on lung fibroblasts. FIZZ-1 (32-51) (mouse) can be used in the study of allergic pneumonia .

HY-143582

ATX inhibitor 9	Phosphodiesterase (PDE)	Cancer
ATX inhibitor 9 is a potent inhibitor of ATX. ATX inhibitor 9 is a thickened heteroaryl derivatives compound. Autotaxin (ATX), also known as ENPP2, is a secreted enzyme that is highly expressed mainly in cancer cells, bronchial epithelial cells and alveolar macrophages in the lung. ATX inhibitor 9 has the potential for the research of cancer or fibrous degenerative disease (extracted from patent WO2021078227A1, compound 3) .

HY-23499R

Indeno[1,2,3-cd]pyrene (Standard)	Reference Standards Aryl Hydrocarbon Receptor	Inflammation/Immunology Cancer
Indeno[1,2,3-cd]pyrene (Standard) is the analytical standard of Indeno[1,2,3-cd]pyrene. This product is intended for research and analytical applications. Indeno[1,2,3-cd]pyrene is a polycyclic aromatic hydrocarbon with moderate cytotoxicity in human pulmonary alveolar epithelial cells HPAEpiC. Indeno[1,2,3-cd]pyrene enhances allergic lung infammation via aryl hydrocarbon receptor .

HY-122308R

Militarine (Standard)	Reference Standards Others	Inflammation/Immunology
Militarine (Standard) is the analytical standard of Militarine (HY-122308). This product is intended for research and analytical applications. Militarine is a plant growth inhibitor and anti-inflammatory agent. Militarine inhibits the elongation of radicles and hypocotyls in seedlings of lettuce, Italian ryegrass and timothy grass. Militarine alleviates PM_2.5-induced inflammatory injury and inhibits cell migration in human alveolar epithelial A549 cells by inhibiting the NF-κB signaling pathway, reducing oxidative stress and the release of inflammatory factors. Militarine can be used in studies related to PM_2.5-induced pulmonary diseases .

HY-182759

MN33-47	DNA Alkylator/Crosslinker Topoisomerase Caspase Bcl-2 Family Apoptosis	Cancer
MN33-47 is a multi-target anti-tumor compound with broad-spectrum anti-proliferative activity. MN33-47 relieves the inhibition of the mitochondrial apoptosis pathway by downregulating the anti-apoptotic protein Bcl-2, while activating caspase-3 and inhibiting Topoisomerase I activity, thereby promoting its degradation through the ubiquitin-proteasome and autophagy-lysosome pathways. MN33-47 can also induce DNA cross-linking and G2/M cell cycle arrest, inhibit cancer cell migration and activate the mitochondrial apoptosis pathway, thus exerting potent anti-tumor effects. MN33-47 can improve the water solubility of SN-38 (HY-13704), and exhibits dose-dependent tumor growth inhibition effects in CT26 tumor-bearing mouse models without obvious toxic and side effects. MN33-47 can be used in related studies on colorectal adenocarcinoma, cervical adenocarcinoma, hepatocellular carcinoma, alveolar basal epithelial adenocarcinoma, gastric cancer and colon cancer .

HY-N17074

Ethyl (10E,12E)-9-oxooctadeca-10,12-dienoate	Others	Cancer
Ethyl (10E,12E)-9-oxooctadeca-10,12-dienoate is a conjugated ketonic fatty acid that can be found in the leaves of Vernicia fordii. Ethyl (10E,12E)-9-oxooctadeca-10,12-dienoate shows no significant cytotoxic activity against cancer cells .

Cat. No.	상품명	Target	Research Area

HY-P5423

GALA	Exosomes Liposome	Cancer
GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. GALA significantly promotes the cytosolic release of cargos carried by exosomes, plasmids and liposomes, effectively enhances gene transfection efficiency, and drives gene knockdown of functional macromolecules (such as siRNA) in alveolar epithelial cells (with no significant cytotoxicity at effective concentrations). GALA serves as a critical tool for studies on lung cancer metastasis (e.g., melanoma lung metastasis) and lung-targeted drug delivery systems .

HY-P11178

Corisin	Apoptosis SARS-CoV	Infection Metabolic Disease Inflammation/Immunology
Corisin is a pro-apoptotic small peptide produced by Staphylococcus species. Corisin binds to serum albumin to target organs such as the lungs and kidneys, induces cellular senescence, apoptosis and epithelial-mesenchymal transition, and accelerates the progression of organ fibrosis including pulmonary fibrosis and diabetic renal fibrosis. Corisin levels are closely associated with coronavirus disease 2019 (COVID-19), diabetic chronic kidney disease (CKD), non-diabetic CKD, and idiopathic pulmonary fibrosis (IPF) .

HY-P3600

FIZZ-1 (32-51) (mouse)	Apoptosis	Inflammation/Immunology
FIZZ-1 (32-51) (mouse) is a cysteine-rich secretory protein that is highly expressed by macrophages, bronchial epithelial and type II alveolar epithelial cells (AEC) in allergic airway inflammation. FIZZ1 (32-51) (mouse) also shows an antiapoptotic effect on lung fibroblasts. FIZZ-1 (32-51) (mouse) can be used in the study of allergic pneumonia .

Militarine	Bletilla striata (Thunb. ex Murray) Rchb. f. Structural Classification Classification of Application Fields Orchidaceae Phenols Metabolic Disease Plants Disease Research Fields Source Classification	NF-κB Apoptosis Interleukin Related COX Reactive Oxygen Species (ROS)
Militarine is a plant growth inhibitor and anti-inflammatory agent. Militarine inhibits the elongation of radicles and hypocotyls in seedlings of lettuce, Italian ryegrass and timothy grass. Militarine alleviates PM_2.5-induced inflammatory injury and inhibits cell migration in human alveolar epithelial A549 cells by inhibiting the NF-κB signaling pathway, reducing oxidative stress and the release of inflammatory factors. Militarine can be used in studies related to PM_2.5-induced pulmonary diseases .

Coelonin	Appendicula reflexa Blume Orchidaceae Phenols Polyphenols Plants Source Classification	PTEN Akt NF-κB Interleukin Related TNF Receptor
Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits NF-κB activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein .

Militarine (Standard)	Bletilla striata (Thunb. ex Murray) Rchb. f. Structural Classification Orchidaceae Phenols Plants Source Classification	Reference Standards Others
Militarine (Standard) is the analytical standard of Militarine (HY-122308). This product is intended for research and analytical applications. Militarine is a plant growth inhibitor and anti-inflammatory agent. Militarine inhibits the elongation of radicles and hypocotyls in seedlings of lettuce, Italian ryegrass and timothy grass. Militarine alleviates PM_2.5-induced inflammatory injury and inhibits cell migration in human alveolar epithelial A549 cells by inhibiting the NF-κB signaling pathway, reducing oxidative stress and the release of inflammatory factors. Militarine can be used in studies related to PM_2.5-induced pulmonary diseases .

Ethyl (10E,12E)-9-oxooctadeca-10,12-dienoate	Structural Classification Natural Products Vernicia fordii (Hemsl.) Airy Shaw Euphorbiaceae Plants Source Classification	Others
Ethyl (10E,12E)-9-oxooctadeca-10,12-dienoate is a conjugated ketonic fatty acid that can be found in the leaves of Vernicia fordii. Ethyl (10E,12E)-9-oxooctadeca-10,12-dienoate shows no significant cytotoxic activity against cancer cells .

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