23 Results for "

bacterial growth pathways

" in MedChemExpress (MCE) Product Catalog:
Products (23)

23 Results for "bacterial growth pathways" in MCE Product Catalog:

19
c-di-AMP disodium
c-di-AMP disodium
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19 Publications Verification
Cat. No.: HY-12326A
CAS No.: 2734909-87-4
Synonyms: Cyclic diadenylate disodium; Cyclic-di-AMP disodium
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

STING Bacterial Endogenous Metabolite

c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .
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19
c-di-AMP diammonium
c-di-AMP diammonium
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19 Publications Verification
Cat. No.: HY-12326B
Purity:  99.36%
Synonyms: Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

STING Bacterial Endogenous Metabolite

c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .
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5
Scutellarein tetramethyl ether
Scutellarein tetramethyl ether
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5 Cited Publications
Cat. No.: HY-N4314
CAS No.: 1168-42-9
Synonyms: 4',5,6,7-Tetramethoxyflavone
Category:  

Infection Flavonoids Flavones Plants Compositae Disease Research Fields Genista maderensis (Webb & Berthel.) Lowe Inflammation/Immunology

Target:  

Bacterial COX NO Synthase NF-κB

Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) is a bioactive compound extracted from Eupatorium odoratum. Scutellarein tetramethyl ether exhibits anti-inflammatory, antibacterial, pro-coagulant, and anti-tumor activities. Scutellarein tetramethyl ether exerts its anti-inflammatory effects by modulating the NF-κB pathway and regulates bacterial resistance through the inhibition of efflux pumps. Additionally, Scutellarein tetramethyl ether accelerates coagulation time via the endogenous coagulation pathway. Studies have shown that Scutellarein tetramethyl ether can effectively inhibit the growth of the liver cancer cell line HepG2 (IC50= 20.08 μg/mL) .
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1
Gigantol
Gigantol
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1 Cited Publications
Cat. No.: HY-N10549
CAS No.: 83088-28-2
Category:  

Orchidaceae Other Diseases Phenols Polyphenols Glucosinolates Plants Disease Research Fields Dendrobium nobile Lindl.

Target:  

Ferroptosis c-Myc Glutathione Peroxidase JNK Reactive Oxygen Species (ROS) GSK-3

Gigantol is an orally active bibenzyl compound. Gigantol targets MYC to promote its ubiquitin-proteasomal degradation and inhibit the growth of lung cancer cells. Gigantol exerts anti-lung cancer activity by inducing ferroptosis (Ferroptosis) via the SLC7A11-GPX4 axis. Gigantol restores the sensitivity of mcr-harboring multidrug-resistant bacteria to colistin. Gigantol ameliorates carbon tetrachloride-induced liver injury by inhibiting the activation of the JNK/cPLA2/12-LOX inflammatory pathway. Gigantol promotes cholesterol metabolism and progesterone biosynthesis in Leydig cells. Gigantol can be used in studies related to diseases such as lung cancer, multidrug-resistant Gram-negative bacterial infections, and acute liver injury .
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1
MAC13772
MAC13772
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1 Cited Publications
Cat. No.: HY-116872
CAS No.: 4871-40-3
Purity:  99.33%
Target:  

Bacterial

Research Areas:  

Infection

MAC13772 is a BioA inhibitor with an IC50 of 0.28 μM against E. coli and an IC50 of 0.269 μM against A. baumannii. MAC13772 inhibits bacterial growth by targeting the biotin biosynthesis pathway. MAC13772 can be used in studies related to bacterial infections .
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1
4,5-Di-O-caffeoylquinic acid
4,5-Di-O-caffeoylquinic acid
0 Images
1 Cited Publications
Cat. No.: HY-N11077
CAS No.: 89886-30-6
Synonyms: 4,5-di-O-CQA
Category:  

Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plants Convolvulaceae Ipomoea batatas (Linn.) Lamarck

Target:  

TRP Channel COX Amyloid-β Bacterial

4,5-Di-O-caffeoylquinic acid (4,5-di-O-CQA) is a natural product with multiple activities including anti-inflammatory, antioxidant, and antibacterial properties. 4,5-Di-O-caffeoylquinic acid induces intracellular Ca 2+ influx, and inhibits hypoxia-induced COX-2 expression and cell migration via the TRPV1-mediated pathway. 4,5-Di-O-caffeoylquinic acid scavenges DPPH free radicals, inhibits Cu 2+-mediated LDL oxidation, and reduces the production of TBARS. 4,5-Di-O-caffeoylquinic acid promotes intracellular ATP production, inhibits Aβ42 aggregation and β-sheet conversion, and protects neuroblastoma cells. 4,5-Di-O-caffeoylquinic acid inhibits the growth of Bacillus shigae. 4,5-Di-O-caffeoylquinic acid can be used in studies related to atherosclerosis, Alzheimer's disease, and bacterial infections .
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Phenylpyruvic acid
Phenylpyruvic acid
0 Images
Cat. No.: HY-W012530
CAS No.: 156-06-9
Category:  

Microorganisms Ketones, Aldehydes, Acids Other Diseases Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite PDI

Phenylpyruvic acid is a precursor of the antifungal compound phenyllactic acid. Phenylpyruvic acid can improve the antifungal activity of eight lactic acid bacterial strains through the addition into a dedined growth medium. Phenylpyruvic acid demonstrates improved inhibitory activity against fungal bread contaminants Aspergillus niger and Penicillium roqueforti. Phenylpyruvic acid affects enzyme activity of the pentose phosphate pathway involved in the oxidative phase in rat brain homogenates. Phenylpyruvic acid can reduce glucose-6-phosphate dehydrogenase activity .
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c-di-AMP
c-di-AMP
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Cat. No.: HY-12326
CAS No.: 54447-84-6
Synonyms: Cyclic diadenylate; Cyclic-di-AMP
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

STING Bacterial Endogenous Metabolite

c-di-AMP (Cyclic diadenylate) is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .
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Ribocil
Ribocil
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Cat. No.: HY-19487
CAS No.: 1381289-58-2
Target:  

Bacterial

Research Areas:  

Infection

Ribocil is a selective inhibitor targeting the bacterial FMN riboswitch, regulating the bacterial riboflavin riboswitch. Ribocil competitively binds to the FMN binding site, mimicking the natural ligand FMN to induce conformational changes in the riboswitch, inhibiting ribB gene expression, reducing riboflavin synthesis, and thus inhibiting bacterial growth. Ribocil strongly inhibits GFP expression (EC50=0.3 μM). Ribocil exhibits in vivo antibacterial activity in a mouse model and can be used to study antibacterial drugs related to drug-resistant bacterial infections and bacterial riboflavin metabolic pathways[1][2].
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Hydroquinine
Hydroquinine
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Cat. No.: HY-42034
CAS No.: 522-66-7
Synonyms: Dihydroquinine
Category:  

Alkaloids Rubiaceae Cinchona calisaya Wedd. Quinoline Alkaloids Plants Disease Research Fields Inflammation/Immunology

Target:  

Bacterial Parasite Reactive Oxygen Species (ROS) Protein Arginine Deiminase

Hydroquinine (Dihydroquinine) is an anti-bacterial agent that inhibits both Gram-positive and Gram-negative bacteria. Hydroquinine inhibits the growth of multidrug-resistant pseudomonas aeruginosa via the suppression of the arginine deiminase pathway genes. Hydroquinine inhibits Plasmodium falciparum and Plasmodium berghei. Hydroquinine displays anti-malarial and demelanizing activities. Hydroquinine effectively induces specific RND-type efflux pump systems in Pseudomonas aeruginosa, particularly the MexCD-OprJ and MexXY efflux pumps. Hydroquinine inhibits Pseudomonas aeruginosa adhesion and biofilm formation. Hydroquinine serves as a precursor for derivatives such as C9 epihydroquinine, 9-acetoxy-10,11-dihydroquinine, and 10,11-dihydroquinine monohydrochloride .
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2,6-Dimethoxy-1,4-benzoquinone
2,6-Dimethoxy-1,4-benzoquinone
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Cat. No.: HY-N1677
CAS No.: 530-55-2
Category:  

Infection Quinones other families Metabolic Disease Benzene Quinones Plants Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Akt mTOR Bacterial Fungal AMPK

2,6-Dimethoxy-1,4-benzoquinone is a 1,4-benzoquinone derivative. 2,6-Dimethoxy-1,4-benzoquinone promotes phosphorylation of AKT, S6K, mTOR, 4E-BP1, and AMPK, and attenuates mTORC1 activity as part of the AKT/mTOR pathway. 2,6-Dimethoxy-1,4-benzoquinone stimulates myoblast differentiation, increases myotube size, elevates MHC protein expression, enhances mitochondrial biogenesis, respiration, and DNA content, and increases skeletal muscle weights, fiber size, grip strength, and treadmill performance. 2,6-Dimethoxy-1,4-benzoquinone exerts anti-cancer, anti-inflammatory, anti-adipogenic, antibacterial, and antimutagenic effects, inhibits adipogenic transcription factors, nitric oxide production, skin tumor development, Magnaporthe oryzae growth, spore germination, appressorium formation, and growth of select bacterial species, induces H2O2 generation and rice defense gene expression, and reduces rice blast lesion formation. 2,6-Dimethoxy-1,4-benzoquinone can be used for the research of obesity, skin tumorigenesis, rice blast disease, and food-borne illness .
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Isopimaric acid
Isopimaric acid
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Cat. No.: HY-N3463
CAS No.: 5835-26-7
Category:  

Other Terpenoids Pinus nigra Arn. Pinaceae Terpenoids Plants

Target:  

Akt mTOR Apoptosis Autophagy Reactive Oxygen Species (ROS) Potassium Channel Sodium Channel Calcium Channel PINK1/Parkin Oxidative Phosphorylation Wnt Bacterial

Isopimaric acid is a coniferous tree defense compound. Isopimaric acid binds to AKT and inhibits mTOR phosphorylation, thereby regulating the AKT/mTOR pathway. Isopimaric acid inhibits oxidative stress, inflammation, microglial migration, apoptosis, autophagic flux, ornithine decarboxylase activity, breast cancer proliferation and metastasis, and fungal spore germination. Isopimaric acid also induces M2 microglial polarization, mitochondrial damage, ROS accumulation, starvation-induced colon cancer cell apoptosis, and breast cancer cell cycle arrest. Isopimaric acid activates potassium channels, regulates sodium channels and calcium channels, reduces myocardial excitability, and improves arrhythmia. Isopimaric acid acts as an oxidative substrate for CYP6BW1/3, down-regulates PINK1/Parkin, and regulates calcium homeostasis, oxidative phosphorylation, EMT, and the Wnt pathway. Isopimaric acid exhibits activity against drug-resistant Staphylococcus aureus, repels feeding, and promotes the growth of rice seedlings. Isopimaric acid is suitable for research related to epilepsy, tumors, drug-resistant bacterial infections, atrial fibrillation, hypertension, hyperlipidemia, pulmonary tuberculosis, etc .
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Phenylpyruvic acid (Standard)
Phenylpyruvic acid (Standard)
0 Images
Cat. No.: HY-W012530R
CAS No.: 156-06-9
Category:  

Microorganisms Ketones, Aldehydes, Acids Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite

Target:  

Reference Standards Endogenous Metabolite PDI

Phenylpyruvic acid (Standard) is the analytical standard of Phenylpyruvic acid. This product is intended for research and analytical applications. Phenylpyruvic acid is a precursor of the antifungal compound phenyllactic acid. Phenylpyruvic acid can improve the antifungal activity of eight lactic acid bacterial strains through the addition into a dedined growth medium. Phenylpyruvic acid demonstrates improved inhibitory activity against fungal bread contaminants Aspergillus niger and Penicillium roqueforti. Phenylpyruvic acid affects enzyme activity of the pentose phosphate pathway involved in the oxidative phase in rat brain homogenates. Phenylpyruvic acid can reduce glucose-6-phosphate dehydrogenase activity .
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Phenylpyruvic acid sodium
Phenylpyruvic acid sodium
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Cat. No.: HY-W016203
CAS No.: 114-76-1
Synonyms: Sodium phenylpyruvate
Target:  

Endogenous Metabolite PDI

Research Areas:  

Infection Metabolic Disease

Phenylpyruvic acid sodium is a endogenous metabolite that participates in the synthesis of 3-phenyllactic acid (PLA) by lactate dehydrogenase. Phenylpyruvic acid is a precursor of the antifungal compound phenyllactic acid. Phenylpyruvic acid can improve the antifungal activity of eight lactic acid bacterial strains through the addition into a dedined growth medium. Phenylpyruvic acid demonstrates improved inhibitory activity against fungal bread contaminants Aspergillus niger and Penicillium roqueforti. Phenylpyruvic acid affects enzyme activity of the pentose phosphate pathway involved in the oxidative phase in rat brain homogenates. Phenylpyruvic acid can reduce glucose-6-phosphate dehydrogenase activity .
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Azaleatin
Azaleatin
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Cat. No.: HY-N7653
CAS No.: 529-51-1
Category:  

Flavonols Flavonoids Carthamus tinctorius L. Metabolic Disease Phenols Polyphenols Plants Compositae Disease Research Fields

Target:  

Dipeptidyl Peptidase NF-κB MyD88 JAK Toll-like Receptor (TLR) STAT Interleukin Related COX Reactive Oxygen Species (ROS) Glutathione S-transferase SOD Bcl-2 Family Caspase Apoptosis Dengue Virus

Azaleatin is an orally active inhibitor of hQC, NS2B-NS3 protease and E. coli β-glucuronidase, with IC50 values of 1.1 μM, 38.00 μg/mL and 0.57 μM, respectively. Azaleatin inhibits the activities of NF-κB, MyD88, JAK1, TLR4, STAT3, IL-1β, IL-6, COX-2, TNF-α and β-glucuronidase, blocks pro-inflammatory signaling pathways, reduces the levels of ROS, MDA and uric acid, elevates the levels of GPx, GSR, GST, SOD, CAT, HO-1 and GSH, scavenges free radicals and exerts reducing capacity. Azaleatin inhibits the expression of pro-apoptotic proteins Bax, Caspase-9 and Caspase-3, and upregulates the expression of anti-apoptotic protein Bcl-2. Azaleatin reduces the levels of cardiac injury markers, restores cardiac histological structure, inhibits Aβ aggregation, dengue protease activity, hepatic stellate cell proliferation and cancer cell growth, and also exhibits antibacterial activity. Azaleatin can be used in studies related to subchronic cardiotoxicity, Alzheimer's disease, dengue fever, hyperuricemia, liver fibrosis, gastric cancer and bacterial infections .
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Triplin
Triplin
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Cat. No.: HY-120743
CAS No.: 1421584-86-2
Target:  

Biochemical Assay Reagents

Research Areas:  

Metabolic Disease

Triplin is a copper chelator, Triplin perturbs copper ion transport involved in the interaction of RAN1 and ATX1. Triplin suppresses the toxic effects of excess copper ions on plant root growth. Triplin increases the RNA expression of ERF1. Triplin acts through the ethylene signal transduction pathway. Triplin also is a bacterial pore-former .
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AGS1286 sodium
AGS1286 sodium
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Cat. No.: HY-W158160
CAS No.: 144254-93-3
Target:  

Bacterial

Research Areas:  

Infection

AGS1286 (sodium 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate) is an organosulfur compound that serves as a model for investigating the impact of sulfur-containing compounds on enzymatic activities and metabolic pathways. Additionally, it has been employed to explore the regulatory effects of these compounds on bacterial growth and gene expression.
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Scutellarein tetramethyl ether (Standard)
Scutellarein tetramethyl ether (Standard)
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Cat. No.: HY-N4314R
CAS No.: 1168-42-9
Synonyms: 4',5,6,7-Tetramethoxyflavone (Standard)
Category:  

Flavonoids Flavones Plants Compositae Genista maderensis (Webb & Berthel.) Lowe

Target:  

Reference Standards Bacterial COX NO Synthase NF-κB

Scutellarein tetramethyl ether (Standard) is the analytical standard of Scutellarein tetramethyl ether. This product is intended for research and analytical applications. Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) is a bioactive compound extracted from Eupatorium odoratum. Scutellarein tetramethyl ether exhibits anti-inflammatory, antibacterial, pro-coagulant, and anti-tumor activities. Scutellarein tetramethyl ether exerts its anti-inflammatory effects by modulating the NF-κB pathway and regulates bacterial resistance through the inhibition of efflux pumps. Additionally, Scutellarein tetramethyl ether accelerates coagulation time via the endogenous coagulation pathway. Studies have shown that Scutellarein tetramethyl ether can effectively inhibit the growth of the liver cancer cell line HepG2 (IC50= 20.08 μg/mL) .
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Hydroquinine (Standard)
Hydroquinine (Standard)
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Cat. No.: HY-42034R
CAS No.: 522-66-7
Synonyms: Dihydroquinine (Standard)
Category:  

Alkaloids Rubiaceae Cinchona calisaya Wedd. Quinoline Alkaloids Plants

Target:  

Reference Standards Bacterial Parasite Reactive Oxygen Species (ROS) Protein Arginine Deiminase

Hydroquinine (Standard) is the analytical standard of Hydroquinine. Hydroquinine (Dihydroquinine) is an anti-bacterial agent that inhibits both Gram-positive and Gram-negative bacteria. Hydroquinine inhibits the growth of multidrug-resistant pseudomonas aeruginosa via the suppression of the arginine deiminase pathway genes. Hydroquinine inhibits Plasmodium falciparum and Plasmodium berghei. Hydroquinine displays anti-malarial and demelanizing activities. Hydroquinine effectively induces specific RND-type efflux pump systems in Pseudomonas aeruginosa, particularly the MexCD-OprJ and MexXY efflux pumps. Hydroquinine inhibits Pseudomonas aeruginosa adhesion and biofilm formation. Hydroquinine serves as a precursor for derivatives such as C9 epihydroquinine, 9-acetoxy-10,11-dihydroquinine, and 10,11-dihydroquinine monohydrochloride .
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2,6-Dimethoxy-1,4-benzoquinone (Standard)
2,6-Dimethoxy-1,4-benzoquinone (Standard)
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Cat. No.: HY-N1677R
CAS No.: 530-55-2
Category:  

Quinones other families Benzene Quinones Plants Endogenous metabolite

Target:  

Reference Standards Akt mTOR Bacterial Fungal AMPK

2,6-Dimethoxy-1,4-benzoquinone (Standard) is the analytical standard of 2,6-Dimethoxy-1,4-benzoquinone (HY-N1677). This product is intended for research and analytical applications. 2,6-Dimethoxy-1,4-benzoquinone is a 1,4-benzoquinone derivative. 2,6-Dimethoxy-1,4-benzoquinone promotes phosphorylation of AKT, S6K, mTOR, 4E-BP1, and AMPK, and attenuates mTORC1 activity as part of the AKT/mTOR pathway. 2,6-Dimethoxy-1,4-benzoquinone stimulates myoblast differentiation, increases myotube size, elevates MHC protein expression, enhances mitochondrial biogenesis, respiration, and DNA content, and increases skeletal muscle weights, fiber size, grip strength, and treadmill performance. 2,6-Dimethoxy-1,4-benzoquinone exerts anti-cancer, anti-inflammatory, anti-adipogenic, antibacterial, and antimutagenic effects, inhibits adipogenic transcription factors, nitric oxide production, skin tumor development, Magnaporthe oryzae growth, spore germination, appressorium formation, and growth of select bacterial species, induces H2O2 generation and rice defense gene expression, and reduces rice blast lesion formation. 2,6-Dimethoxy-1,4-benzoquinone can be used for the research of obesity, skin tumorigenesis, rice blast disease, and food-borne illness.
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