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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
52 Results for "
basis
" in MedChemExpress (MCE) Product Catalog:
Products (52)
52 Results for "basis" in MCE Product Catalog:
9
9 Publications Verification
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CL-82198 is a selective inhibitor of MMP-13. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs . CL-82198 is a pharmacologic treatment for preventing osteoarthritis (OA) progression .
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Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). Trifluridine/tipiracil hydrochloride mixture (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA .
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PFB-FDGlu is a selective lysosomal Glucocerebrosidase (GCase) substrate, which is metabolised by GCase to yield fluorescein. PFB-FDGlu is cell permeable and can be used with a flow cytometer to measure GCase activity in living cells on a single-cell basis .
Cat. No.: HY-W011517
CAS No.: 146-78-1
Synonyms: 2FA
Cat. No.: HY-W003969
CAS No.: 695-34-1
Synonyms: Ascensil; 2-Amino-4-methylpyridine
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Aminopicoline (Ascensil) is a potent and non-selective inhibitor of nitric oxide synthase (NOS) isoenzymes (iNOS, nNOS, eNOS). Aminopicoline competes with arginine at the substrate-binding site of nitric oxide synthase, reduces cellular nitric oxide production, inhibits the elevation of plasma nitrate, increases mean arterial pressure at high doses, and also serves as a basis for radiolabeled ligands to localize nitric oxide synthase binding sites. Aminopicoline can be used in the research of diseases associated with septic shock, joint inflammation, intestinal inflammation, and CNS inflammation .
Synonyms: Potassium chloride, suitable for the extraction and solubilization of proteins
Cat. No.: HY-W073196
CAS No.: 27988-77-8
Synonyms: Tetrachloroauric(III)) acid hydrate (48% Au basis)
Cat. No.: HY-W073196A
CAS No.: 27988-77-8
Synonyms: Tetrachloroauric(Ⅲ) acid hydrate (50% Au basis)
NMT-IN-1 is a Trypanosoma brucei N-myristoyltransferase (TbNMT) inhibitor, with an IC50 of 31 μM against TbNMT and an IC50 of 66 μM against hNMT. As a thiazolidinone hit compound identified via virtual screening, NMT-IN-1 exerts enzymatic inhibitory effects by binding to the active site of TbNMT. NMT-IN-1 adopts a binding mode distinct from that of pyrazole sulfonamide inhibitors and can inhibit the myristoyl transfer reaction catalyzed by TbNMT. NMT-IN-1 is mainly used in the research of anti-parasitic lead compounds for human African trypanosomiasis (African sleeping sickness). It provides a structural basis for the subsequent optimization of TbNMT inhibitors with high activity, high selectivity and blood-brain barrier permeability .
Cat. No.: HY-22009A
CAS No.: 10476-85-4
Cat. No.: HY-W540600
CAS No.: 53850-34-3
Category:
Marantaceae Thaumatococcus daniellii (Benn.) Benth. Natural Products Other Diseases Plants Disease Research Fields Sweeteners Food Research
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Cat. No.: HY-W116336B
CAS No.: 1314-13-2
Cat. No.: HY-W129975
CAS No.: 1303-86-2
Synonyms: Boron trioxide,99.98% trace metals basis
Cat. No.: HY-N17260
CAS No.: 21391-98-0
Category:
Natural Products Ketones, Aldehydes, Acids Eucalyptus camaldulensis Dehnh. Myrtaceae Plants
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
