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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
bmal1
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "bmal1" in MCE Product Catalog:
11
11 Publications Verification
Synonyms: SR6452
Research Areas:
GSK4112 (SR6452) is a Rev-erbα agonist with an EC50 value of 0.4 μM. GSK4112 can be used as a chemical tool to probe the function of Rev-erbα in transcriptional repression, regulation of circadian biology, and metabolic pathways [1].
3
3 Cited Publications
Target:
Research Areas:
KS15 is an inhibitor of the interactions between cryptochromes (CRYs: CRY1 and CRY2) and the CLOCK:BMAL1 heterodimer. KS15 impairs the feedback actions of CRYs on E-box-dependent transcription (EC50=4.9 μM) by CLOCK:BMAL1 heterodimer, an indispensable transcriptional regulator of the mammalian circadian clock. Anti-proliferative activity [1] .
2
2 Cited Publications
Target:
Research Areas:
STL1267 is a potent and cross-the-blood-brain barrier REV-ERB agonist with a Ki value of 0.16 µM for REV-ERBα. STL1267 shows no cytotoxicity. STL1267 inhibits the gene expression of BMAL1 [1].
1
1 Cited Publications
Target:
Research Areas:
CLK8 is a potent and specific CLOCK inhibitor that can disrupt the interaction between CLOCK and BMAL1 and interfere with nuclear translocation of CLOCK. CLK8 can be used for the research of disorders associated with dampened circadian rhythms [1].
Cat. No.: HY-176851
CAS No.: 2986733-57-5
Target:
Research Areas:
GSK1362 is a selective inverse agonist of REV-ERB. GSK1362disrupts the interaction of REV-ERBα with repressive co-modulators (NCoR1, SMRT2, RIP140). GSK1362 exerts an inverse agonist effect by increasing the transcription of BMAL1 to relieve BMAL1 repression by endogenous REV-ERB ligands. GSK1362 suppresses LPS (HY-D1056)-induced inflammatory cytokine expression, inhibits IL-1β-induced Cxcl5 transcription in cells. GSK1362 can be used for the study of inflammatory diseases [1].
Cat. No.: HY-N10319
CAS No.: 72944-19-5
Cat. No.: HY-RS01529
Target:
Research Areas:
BMAL1 Human Pre-designed siRNA Set A contains three designed siRNAs for BMAL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23574
Target:
Research Areas:
Bmal1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bmal1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17129
Target:
Research Areas:
Bmal1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bmal1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-N10319R
CAS No.: 72944-19-5
Cat. No.: HY-P85059
Synonyms: ARNTL; BHLHE5; bmal1; MOP3; PASD3; Aryl hydrocarbon receptor nuclear translocator-like protein 1; Basic-helix-loop-helix-PAS protein MOP3; Brain and muscle ARNT-like 1; Class E basic helix-loop-helix protein 5; bHLHe5; Member of PAS protein
Cat. No.: HY-P86191
Synonyms: ARNTL; BHLHE5; bmal1; MOP3; PASD3; Aryl hydrocarbon receptor nuclear translocator-like protein 1; Basic-helix-loop-helix-PAS protein MOP3; Brain and muscle ARNT-like 1Class E basic helix-loop-helix protein 5; bHLHe5; Member of PAS protein 3; PAS domain-containing protein 3; bHLH-PAS protein JAP3
Cat. No.: HY-184895
Target:
Cryptochrome REV-ERB Nuclear Hormone Receptor 4A/NR4A FABP PARP Fatty Acid Synthase (FASN) Wnt β-catenin Hormone-Sensitive Lipase (HSL) PGC-1α ROR GLUT
Research Areas:
CM002 is a circadian clock activator. CM002 inhibits the lineage commitment and terminal differentiation of preadipocytes by activating the circadian clock, thereby blocking the adipogenesis process driven by Wnt signaling-mediated transcriptional induction. CM002 attenuates lipid storage in a clock-dependent manner via inhibition of the lipogenic program in mature adipocytes. CM002 enhances circadian clock output across various adipose depots in both lean and obese mice through BMAL1/CLOCK-dependent metabolic reprogramming, inhibits adipocyte development and hypertrophy, and improves insulin sensitivity. CM002 can be used in research on obesity and type 2 diabetes [1].
Cat. No.: HY-P704046
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: bmal1; Basic Helix-Loop-Helix Family Member E5; Prev. ARNTL; PAS Domain-Containing Protein 3; BHLHe5; Member Of PAS Superfamily 3; PASD3; PAS Domain Containing 3; MOP3; Member Of PAS Protein 3; Brain And Muscle ARNT-Like 1; BHLH-PAS Protein JAP3; ARNTL1;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
