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Results for "

bromodomain

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (234) Cardiovascular Disease (4) Infection (9) Inflammation/Immunology (38) Metabolic Disease (3) Neurological Disease (8)
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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13030

(+)-JQ-1 Maximum Cited Publications 295 Publications Verification JQ1	Epigenetic Reader Domain Autophagy Ligands for Target Protein for PROTAC	Neurological Disease Cancer
(+)-JQ-1 (JQ1), a chemical probe, is a potent, specific, CNS-penetrant and reversible BET bromodomain inhibitor, with IC₅₀s of 77 and 33 nM for the first and second bromodomain (BRD4(1/2)) . (+)-JQ-1 also activates autophagy .

HY-111784

Inobrodib 10+ Cited Publications CCS1477	Epigenetic Reader Domain	Cancer
Inobrodib (CCS1477) is an orally active, potent, and selective inhibitor of the p300/CBP bromodomain. Inobrodib binds to p300 and CBP with K_d values of 1.3 and 1.7 nM, respectively, and with 170/130-fold selectivity compared with BRD4 with a K_d of 222 nM. CCS1477 inhibits cell proliferation in prostate cancer cell lines and decreases androgen receptor (AR)- and C-MYC-regulated gene expression .

HY-78695

JQ-1 carboxylic acid 5+ Cited Publications	Epigenetic Reader Domain PD-1/PD-L1 Ligands for Target Protein for PROTAC	Cancer
JQ-1 carboxylic acid, a (+)-JQ-1 (HY-13030) derivative, is a potent BET bromodomain inhibitor. JQ-1 carboxylic acid can be used to synthesize PROTAC, which can target the degradation of BRD4.

HY-13032

Molibresib 20+ Cited Publications I-BET762; GSK525762; GSK525762A	Epigenetic Reader Domain	Cancer
Molibresib (I-BET762; GSK525762) is a BET bromodomain inhibitor with IC₅₀ of 32.5-42.5 nM.

HY-13235

I-BET151 25+ Cited Publications GSK1210151A	Epigenetic Reader Domain	Cancer
I-BET151 (GSK1210151A) is a BET bromodomain inhibitor which inhibits BRD4, BRD2, and BRD3 with pIC₅₀ of 6.1, 6.3, and 6.6, respectively .

HY-100015

Mivebresib 10+ Cited Publications ABBV-075	Epigenetic Reader Domain Apoptosis	Cancer
Mivebresib (ABBV-075) is a potent and orally active **bromodomain and extraterminal domain (BET) bromodomain inhibitor. Mivebresib binds to BRD4 with a K_i** of 1.5 nM .

HY-18975

I-BRD9 5+ Cited Publications	Epigenetic Reader Domain	Inflammation/Immunology Cancer
I-BRD9 is a selective cellular chemical probe of bromodomain-containing protein 9 (BRD9) with pIC₅₀ value of 7.3 μM. I-BRD9 has high selectivity for bromodomain and extra terminal domain (BET) family and highly homologous bromodomain-containing protein 7 (BRD7). I-BRD9 can be used to identify genes regulated by BRD9 in Kasumi-1 cells involved in oncology and immune response pathways .

HY-136521

AZ13824374	Epigenetic Reader Domain	Cancer
AZ13824374 is a potent and selective ATAD2 bromodomain inhibitor (pIC₅₀ of 6.9 in HCT116 cells). AZ13824374 disrupts chromatin interactions and gene transcription by binding to the acetyl-lysine binding site of the ATAD2 bromodomain. AZ13824374 has anticancer activity against breast cancer .

HY-136938

NEO2734 4 Publications Verification EP31670	Epigenetic Reader Domain Histone Acetyltransferase	Cancer
NEO2734 (EP31670) is an orally active dual p300/CBP and BET bromodomain selective inhibitor, with IC₅₀ values of <30 nM for both p300/CBP and BET bromodomains . NEO2734 is active in SPOP mutant and wild-type prostate cancer .

HY-151594

iBRD4-BD1	Epigenetic Reader Domain	Inflammation/Immunology Cancer
iBRD4-BD1 is selective BRD4 bromodomain inhibitor. iBRD4-BD1 has inhibition activity for BRD4 bromodomain with an IC₅₀ value of 12 nM. iBRD4-BD1 can be used for the research of inflammation and oncology .

HY-134463

NHWD-870 1 Publications Verification	Epigenetic Reader Domain Apoptosis	Cancer
NHWD-870 is a potent, orally active and selective BET family bromodomain inhibitor and only binds bromodomains of BRD2, BRD3, BRD4 (IC₅₀=2.7 nM), and BRDT. NHWD-870 has potent tumor suppressive efficacies and suppresses cancer cell-macrophage interaction. NHWD-870 increases tumor apoptosis and inhibits tumor proliferation .

HY-40249

1-Boc-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester	Drug Intermediate	Others
1-Boc-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester is a drug intermediate that can be used for the preparation of SMARCA bromodomain ligands .

HY-145667

Biotinylated-JQ1 1 Publications Verification Biotin-JQ1	Epigenetic Reader Domain	Cancer
Biotinylated-JQ1 (Biotin-JQ1) is a biotinylated derivative of JQ1 with high affinity for the bromodomain of BRD4. Biotinylated-JQ1 inhibits MM1.S multiple myeloma cells proliferation with the EC₅₀ of 0.4 μM .

HY-145550

Amredobresib BI894999	Epigenetic Reader Domain	Cancer
Amredobresib (BI894999) is an orally active BET inhibitor. Amredobresib inhibits the binding of BRD4-BD1 and BRD4-BD2 bromodomains to acetylated histones with IC₅₀ values of 5 nM and 41 nM, respectively. Amredobresib exhibits anticancer activity against acute myeloid leukemia (AML) and NUT cancer .

HY-100220

GSK6853 2 Publications Verification	Epigenetic Reader Domain	Cancer
GSK6853, a chemical probe, is a potent and selective inhibitor of the BRPF1 bromodomain. GSK6853 shows excellent BRPF1 potency (pK_d = 9.5) and greater than 1600-fold selectivity over all other bromodomains .

HY-18665

GSK-5959	Epigenetic Reader Domain	Cancer
GSK-5959 is a potent, selective and cell permeable BRPF1 bromodomain inhibitor with an IC₅₀ of ~ 80 nM .

HY-101088

CeMMEC13 1 Publications Verification	DNA/RNA Synthesis	Cancer
CeMMEC13 is a potent inhibitor of TAF1 (2) bromodomain, with an IC₅₀ of 2.1 μM.

HY-131061

*BET bromodomain* inhibitor 1**	Epigenetic Reader Domain	Cancer
BET bromodomain inhibitor 1 is an orally active, selective **bromodomain and extra-terminal (BET) bromodomain inhibitor with an IC₅₀** of 2.6 nM for BRD4. BET bromodomain inhibitor 1 binds to BRD2(2), BRD3(2), BRD4(1), BRD4(2), and BRDT(2) with high affinities (K_d values of 1.3 nM, 1.0 nM, 3.0 nM, 1.6 nM, 2.1 nM, respectively). bromodomain inhibitor 1 has anti-cancer activity .

HY-103036

*BET bromodomain-IN-5*	Epigenetic Reader Domain Apoptosis	Cancer
BET bromodomain-IN-5 is an orally active BET inhibitor with an IC₅₀ of 14 nM against BRD4 (1). BET bromodomain-IN-5 can inhibit the proliferation of tumor cells and induce cell cycle arrest and apoptosis. BET bromodomain-IN-5 can be used in the research of tumors .

HY-100729

GSK9311 1 Publications Verification	Epigenetic Reader Domain	Cancer
GSK9311, a less active analogue of GSK6853, can be used as a negative control. GSK9311 inhibits BRPF bromodomain with pIC₅₀ values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively .

HY-148116

DN02	Epigenetic Reader Domain	Cancer
DN02 is a potent, selective BRD8 bromodomain probe. DN02 has exhibits high affinity for the BRD8 (1) (K_i=32 nM), which is 30-fold more affinity than BRD8 (2) (K_i>1000 nM) .

HY-19336

BAZ2-ICR 2 Publications Verification	Epigenetic Reader Domain	Cancer
BAZ2-ICR is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC₅₀s of 130 nM and 180 nM, and K_ds of 109 nM and 170 nM, respectively. BAZ2-ICR shows 10-15-fold selectivity for binding BAZ2A/B over CECR2 and >100-fold selectivity over all other bromodomains. BAZ2-ICR is an epigenetic chemical probe .

HY-147868

DC-CPin711	Epigenetic Reader Domain Apoptosis	Cancer
DC-CPin711 is a potent and selective inhibitor of CREB-binding protein (CBP) bromodomain with an IC₅₀ of 0.0626 μM. DC-CPin711 arrests cell cycle at G1 phase and induces apoptosis .

HY-19553

LP99	Epigenetic Reader Domain	Inflammation/Immunology
LP99, an epigenetic probe, is a potent and selective inhibitor of the BRD7 and BRD9 bromodomains with a K_d of 99 nM against BRD9. LP99 disrupts the binding of BRD7 and BRD9 to chromatin in cells .

HY-148739

dBRD 9-A	PROTACs Epigenetic Reader Domain Apoptosis	Cancer
dBRD 9-A is a selective BRD9 PROTAC degrader. dBRD 9-A induces near complete BRD9 degradation dependent on E3 ubiquitin ligase CRBN and BRD9 bromodomain engagement, and drives loss of BRD9 chromatin binding genome-wide. dBRD 9-A downregulates oncogenic SS18-SSX-driven transcriptional programs, super enhancer-associated gene expression, and SS18-SSX1 super enhancer binding, and depletes GBAF complex members GLTSCR1/1L from SS18-SSX complexes. dBRD 9-A induces cell cycle arrest and increases apoptosis in synovial sarcoma cells. dBRD 9-A can be used for the research of synovial sarcoma .

HY-149026

GNE-064	Epigenetic Reader Domain	Others
GNE-064 (compound 5) is a selective, orally active and highly soluble inhibitor of SMARCA4, SMARCA2 and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC₅₀ of 0.035 μM and inhibits SMARCA2 with an EC₅₀ of 0.10 μM. GNE-064 possess K_ds with 0.01, 0.016, 0.018 and 0.049 μM for SMARCA4, SMARCA2, PBRM1 bromodomains 5 and PBRM1 bromodomains 2, repectively. GNE-064 can be used as a chemical probe for the research of agent synthesis .

HY-100517

TP-472 2 Publications Verification	Epigenetic Reader Domain Apoptosis	Cancer
TP-472, a chemical probe, is a selective BRD9/7 inhibitor, with K_ds of 33 nM and 340 nM for BRD9 and BRD7, respectively. TP-472 exhibits >30-fold selectivity for BRD9 over other bromodomain family members except BRD7 . TP-472 induces apoptosis of melanoma cells .

HY-138563

GSK973	Epigenetic Reader Domain	Cancer
GSK973, a chemical probe, is a highly selective, orally bioavailable inhibitor of the BD2s (second bromodomains) of the BET family, with a pIC₅₀ of 7.8 and a pK_d of 8.7 for BRD4 BD2. GSK973 displays a 1600-fold selectivity for BRD4 BD2 over BRD4 BD1. GSK973 shows good potency against BRD2 BD2, BRD3 BD2, and BRDT BD2 (pIC₅₀=7.4~7.8; pK_d=8.3~8.5) .

HY-146208

BRD4 Inhibitor-20 1 Publications Verification	Epigenetic Reader Domain	Cancer
BRD4 Inhibitor-20 is a potent orally active bromodomain protein 4 (BRD4) inhibitor. BRD4 Inhibitor-20 has inhibitory activity for BRD4 (BD1) and BRD4 (BD2) with IC₅₀ values of 19 nM and 28 nM, respectively. BRD4 Inhibitor-20 also has anti-proliferation activities in cancer cell lines. BRD4 Inhibitor-20 can be used for the research of kinds of cancer, such as colon cancer .

HY-43723

PROTAC BET-binding moiety 2	Ligands for Target Protein for PROTAC	Cancer
PROTAC BET-binding moiety 2 is an inhibitor of BET bromodomain .

HY-110374

NVS-CECR2-1 1 Publications Verification	Epigenetic Reader Domain Apoptosis	Cancer
NVS-CECR2-1, a non-BET family Bromodomain (BRD) inhibitor, is a potent and selective cat eye syndrome chromosome region, candidate 2 (CECR2) inhibitor. NVS-CECR2-1 binds to CECR2 BRD with high affinity (IC₅₀=47 nM; K_D=80 nM). NVS-CECR2-1 exhibits cytotoxic activity and induces apoptosis against various cancer cells by targeting CECR2 as well as via CECR2-independent mechanism . NVS-CECR2-1 is a chemical probe.

HY-124596

CD161	Epigenetic Reader Domain	Cancer
CD161 is a potent, selective and orally bioavailable **bromodomain and extra-terminal (BET) bromodomain inhibitor with an IC₅₀**s of 28.2 nM and 7.2 nM for BRD4 BD1 and BRD4 BD2, respectively. CD161 has good anticancer activity .

HY-145125

SJ995973	PROTACs	Others
SJ995973 (PROTAC) is a uniquely potent degrader of bromodomain and extra-terminal (BET) proteins.

HY-W017851

4-Phenyl-2-pyrrolidinone	Drug Intermediate	Neurological Disease
4-Phenyl-2-pyrrolidinone is a precursor and synthetic intermediate. 4-Phenyl-2-pyrrolidinone can be used as a precursor in the synthesis of compounds with anticonvulsant and nootropic activities and is an intermediate in the synthesis of bromodomain-containing protein 4 (BRD4) bromodomain 1 inhibitors .

HY-111420

CBP/p300-IN-1	Epigenetic Reader Domain	Cancer
CBP/p300-IN-1 is a CBP/EP300 bromodomain inhibitor.

HY-139148

UMB298	Epigenetic Reader Domain	Cancer
UMB298 is a potent and selective CBP/P300 bromodomain inhibitor .

HY-170817

SMI-1074	Ligands for Target Protein for PROTAC SWI/SNF Complex	Cancer
SMI-1074, a SMARCA bromodomain inhibitor, is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). SMI-1074 can be used for synthesis SMD-3236 (HY-170824) and SMD-1087 (HY-170828). SMI-1074 can be used for the research of smarca4-deficient cancers .

HY-143332

TRIM24/BRPF1-IN-2	Epigenetic Reader Domain	Cancer
TRIM24/BRPF1-IN-2 (compound 20l) is a potent TRIM24/BRPF1 dual inhibitor, with IC₅₀ values of 0.98 and 1.16 μM, respectively. TRIM24/BRPF1-IN-2 shows TRIM24/BRPF1 bromodomain binding affinity. TRIM24/BRPF1-IN-2 can be used for prostate cancer research .

HY-112149A

(E/Z)-ZL0420	Epigenetic Reader Domain	Inflammation/Immunology Cancer
(E/Z)-ZL0420 is a racemic compound of (Z)-ZL0420 and (E)-ZL0420 isomers. (E)-ZL0420 is a potent and selective bromodomain-containing protein 4 (BRD4) inhibitor with IC₅₀ values of 27 nM against BRD4 BD1 and 32 nM against BRD4 BD2 .

HY-151364

HDAC6/8/BRPF1-IN-1	HDAC	Cancer
HDAC6/8/BRPF1-IN-1 is a dual inhibitor of both *HDAC6/8 and the bromodomain* and PHD finger containing protein 1 (BRPF1). HDAC6/8/BRPF1-IN-1 has inhibitory activity for HDAC1, HDAC6 and HDAC8 with IC₅₀ values of 797 nM, 344 nM and 908 nM, respectively. HDAC6/8/BRPF1-IN-1 has inhibitory activity for BRPF1 with an K_d** value of 175.2 nM. HDAC6/8/BRPF1-IN-1 can be used for the research of cancer .

HY-177124

Repibresib VYN201	Epigenetic Reader Domain	Cancer
Repibresib (VYN201) is a bromodomain and extra-terminal motif (BET) inhibitor. Repibresib shows antineoplastic activity .

HY-145431

(S)-GSK1379725A	Epigenetic Reader Domain Parasite	Infection
(S)-GSK1379725A (compound AU1) is a selective **bromodomain and PHD finger containing transcription factor (BPTF) bromodomain inhibitor with a K_d** of 2.8 μM. (S)-GSK1379725A shows to be selective for BPTF over BRD4 bromodomain. (S)-GSK1379725A shows antimalarial activity .

HY-123626

BiBET	Epigenetic Reader Domain	Cancer
BiBET is a chemical probe of BET/BRD4 and is able to bind to two bromodomains simultaneously in a bivalent and cis-binding mode .

HY-151528

PBRM1-BD2-IN-1	Epigenetic Reader Domain	Cancer
PBRM1-BD2-IN-1 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-1 has binding affinity and inhibitory activity for PBRM1-BD2 with K_d and IC₅₀ values of 0.7 μM and 0.2 μM, respectively. PBRM1-BD2-IN-1 can be used for the research of cancer .

HY-146445

*P300 bromodomain-IN-1*	Epigenetic Reader Domain Histone Acetyltransferase	Cancer
P300 bromodomain-IN-1 (Compoun 1u) is a potent p300 (EP300) bromodomain inhibitor with an IC₅₀ of 49 nM. P300 bromodomain-IN-1 suppresses the expression of c-Myc and induces G1/G0 phase arrest and apoptosis in OPM-2 cells .

HY-116349

Bromodomain IN-1	Epigenetic Reader Domain	Cancer
Bromodomain IN-1 is a *Bromodomain* inhibitor extracted from patent WO2016069578A1, compound 4 .

HY-135236

OXFBD04	Epigenetic Reader Domain	Cancer
OXFBD04 is a potent and selective BRD4 inhibitor with an IC₅₀ of 166 nM. OXFBD04 is a potent BET bromodomain ligand with additional modest affinity for the CREBBP bromodomain. OXFBD04 has anti-cancer activity .

HY-19549

RX-37	Epigenetic Reader Domain	Cancer
RX-37 is a selective BET inhibitor. RX-37 binds to BET bromodomain proteins (BRD2, BRD3, and BRD4) with K_i values of 3.2-24.7 nM. RX-37 can be used for research of cancers .

HY-150516S

BET-IN-12	Epigenetic Reader Domain	Cancer
BET-IN-12 is an orally avtive inhibitor of bromodomain and extra-terminal (BET) with an IC₅₀ of 0.9 nM for BRD4 .

HY-78197

3,5-Dimethylisoxazole-4-boronic acid pinacol ester	Drug Intermediate	Others
3,5-Dimethylisoxazole-4-boronic acid pinacol ester is a drug intermediate that can be used for the synthesis of bromodomain inhibitors .

Cat. No.	Product Name	Type

HY-112803

GNE-371	Fluorescent Dyes
GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like, with an IC₅₀ of 10 nM for TAF1(2).

HY-D3393

JQ1-FITC TFA	Fluorescent Dyes
JQ1-FITC TFA is a BRD4-binding fluorescent tracer. JQ1-FITC TFA binds to BRD4 BD1, BD2, recombinant bromodomains, and endogenous BRD4 in cell lysates. JQ1-FITC TFA can be used for the research of breast cancer and cancer (Ex/Em = 495/525 nm) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3213

Naringenin triacetate	Flavonoids Classification of Application Fields Flavonones Rutaceae Plants Disease Research Fields Citrus Cancer Source Classification	Epigenetic Reader Domain
Naringenin triacetate is a flavonoid isolated from plant, exhibits a good binding affinity with multiple crystal structures of first bromodomain BRD4 (BRD4 BD1) .

Species:	Virus (1) Human (10)
Tag:	SUMO (1) His (6) Tag Free (4) Flag (1)
Source:	E. coli (10)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702058

	BRPF3 Protein, Human BRPF3; bromodomain and PHD finger-containing protein 3	Human	E. coli
	The BRPF3 protein is a scaffold in various HAT complexes such as MOZ/MORF and HBO1 and is critical for histone H3 acetylation, especially in directing the specificity of KAT7/HBO1 for H3K14ac. In the HBO1 complex, BRPF3 promotes DNA replication initiation and activates replication origins. BRPF3 Protein, Human is the recombinant human-derived BRPF3 protein, expressed by E. coli , with tag free.

HY-P702059

	BRPF3 Protein, Human (His) BRPF3; bromodomain and PHD finger-containing protein 3	Human	E. coli
	The BRPF3 protein is a scaffold in various HAT complexes such as MOZ/MORF and HBO1 and is critical for histone H3 acetylation, especially in directing the specificity of KAT7/HBO1 for H3K14ac. In the HBO1 complex, BRPF3 promotes DNA replication initiation and activates replication origins. BRPF3 Protein, Human (His) is the recombinant human-derived BRPF3 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P702876

	BRD3 Protein, Human (BD2, His) KIAA0043; RING3L; bromodomain-containing protein 3	Human	E. coli
	BRD3 Protein, Human (BD2, His) is the recombinant human-derived BRD3, expressed by E. coli, with N-6*His labeled tag.

HY-P702191

	BRPF1 Protein, Human BRPF1; Peregrin; bromodomain and PHD finger-containing protein 1; Protein Br140	Human	E. coli
	The BRPF1 protein is a key scaffold in HAT complexes such as MOZ/MORF and HBO1, and has histone H3 acetyltransferase activity. In the HBO1 complex, BRPF1 directs the specificity of KAT7/HBO1 for H3K14ac. BRPF1 Protein, Human is the recombinant human-derived BRPF1 protein, expressed by E. coli , with tag free.

HY-P702192

	BRPF1 Protein, Human (His) BRPF1; Peregrin; bromodomain and PHD finger-containing protein 1; Protein Br140	Human	E. coli
	The BRPF1 protein is a key scaffold in HAT complexes such as MOZ/MORF and HBO1, and has histone H3 acetyltransferase activity. In the HBO1 complex, BRPF1 directs the specificity of KAT7/HBO1 for H3K14ac. BRPF1 Protein, Human (His) is the recombinant human-derived BRPF1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701713

	BRDT Protein, Human BRDT; bromodomain testis-specific protein; Cancer/testis antigen 9; CT9; RING3-like protein	Human	E. coli
	The BRDT protein is a testis-specific chromatin factor that is essential for acetylated histones and specifically recognizes H4K5ac and H4K8ac. It plays a key role in spermatogenesis by promoting gene activation at specific developmental stages in late pachytene spermatocytes. BRDT Protein, Human is the recombinant human-derived BRDT protein, expressed by E. coli , with tag free.

HY-P701714

	BRDT Protein, Human (His, SUMO) BRDT; bromodomain testis-specific protein; Cancer/testis antigen 9; CT9; RING3-like protein	Human	E. coli
	The BRDT protein is a testis-specific chromatin factor that is essential for acetylated histones and specifically recognizes H4K5ac and H4K8ac. It plays a key role in spermatogenesis by promoting gene activation at specific developmental stages in late pachytene spermatocytes. BRDT Protein, Human (His, SUMO) is the recombinant human-derived BRDT protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P7846

	BRD4 Protein, Human (His-Flag) 3 Publications Verification rHubromodomain-containing protein 4/BRD4, His-Flag; HUNK1; HUNK1bromodomain-containing protein 4; HUNKI; MCAP	Human	E. coli
	The BRD4 protein is a chromatin reader that recognizes and binds acetylated histones, transmits epigenetic memory and regulates transcription during cell division. It associates with acetylated chromatin throughout the cell cycle, maintaining chromatin structure and contributing to epigenetic memory. BRD4 Protein, Human (His-Flag) is the recombinant human-derived BRD4 protein, expressed by E. coli , with N-10*His, N-Flag labeled tag.

HY-P701611

	BPTF Protein, Human BPTF; Nucleosome-remodeling factor subunit BPTF; bromodomain and PHD finger-containing transcription factor; Fetal Alz-50 clone 1 protein; Fetal Alzheimer antigen	Human	E. coli
	BPTF proteins are regulatory subunits in the NURF-1 and NURF-5 ISWI chromatin remodeling complexes that assemble ordered nucleosome arrays to access DNA during replication, transcription, and repair. The NURF-1 complex is critical for brain development and actively regulates the expression of En1 and En2. BPTF Protein, Human is the recombinant human-derived BPTF protein, expressed by E. coli , with tag free.

HY-P701612

	BPTF Protein, Human (His) BPTF; Nucleosome-remodeling factor subunit BPTF; bromodomain and PHD finger-containing transcription factor; Fetal Alz-50 clone 1 protein; Fetal Alzheimer antigen	Human	E. coli
	BPTF proteins are regulatory subunits in the NURF-1 and NURF-5 ISWI chromatin remodeling complexes that assemble ordered nucleosome arrays to access DNA during replication, transcription, and repair. The NURF-1 complex is critical for brain development and actively regulates the expression of En1 and En2. BPTF Protein, Human (His) is the recombinant human-derived BPTF protein, expressed by E. coli , with N-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-150516S

BET-IN-12
BET-IN-12 is an orally avtive inhibitor of bromodomain and extra-terminal (BET) with an IC₅₀ of 0.9 nM for BRD4 .

HY-168148S

CZL-046
CZL-046 (compund 29) is an oral p300 bromodomain inhibitor .

Host:	Mouse (1) Rabbit (4)
Reactivity:	Human (5) Rat (4) Mouse (4) Monkey (1)
Application:	IHC-P (3) ICC/IF (4) IP (4) WB (5)
Isotype:	IgG (5)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (4) Recombinant (3)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80976

	BRD4 Antibody (YA3486) 1 Publications Verification Brd4; CAP; HUNK1; MCAP; bromodomain containing 4; chromosome associated protein	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	BRD4 Antibody (YA3486) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BRD4.

HY-P80976A

	BRD4 Antibody (YA3486)(PBS only) Brd4; CAP; HUNK1; MCAP; bromodomain containing 4; chromosome associated protein	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	BRD4 Antibody (YA3486) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BRD4.

HY-P810292

	BRD9 Antibody (YA9635) bromodomain containing 9 antibody; bromodomain containing protein 9 antibody; DKFZp434D0711 antibody; DKFZp686L0539 antibody; FLJ13441 antibody; LAVS3040 antibody; PRO9856 antibody; Rhabdomyosarcoma antigen MU RMS 40.8 antibody; Sarcoma antigen NY SAR 29 antibody; UNQ3040 antibody	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat, Monkey
	BRD9 Antibody (YA9635) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BRD9.

HY-P85065

	BPTF Antibody (YA4757) BPTF; FAC1; FALZ; Nucleosome-remodeling factor subunit BPTF; bromodomain and PHD finger-containing transcription factor; Fetal Alz-50 clone 1 protein; Fetal Alzheimer antigen	WB, IP	Human
	BPTF Antibody (YA4757) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to BPTF.

HY-P810421

	WSTF Antibody (YA9735) baz1b, BAZ1B_HUMAN, bromodomain adjacent to zinc finger domain protein 1B, hWALP 2, hWALP-2, hWALP2, transcription factor WSTF, Tyrosine-protein kinase BAZ1B, WALP-2, WALP2	WB, ICC/IF	Human, Mouse, Rat
	WSTF Antibody (YA9735) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to WSTF.

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Cat. No.	Product Name		Classification

HY-112789

(+)-JQ1 PA 1 Publications Verification		Alkynes
(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1, with an IC₅₀ of 10.4 nM. (+)-JQ1 PA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-136857

BRD4 degrader-3		PROTAC Synthesis
BRD4 degrader-3 is a potent bromodomain BRD4 degrader extracted from patent WO2020055976A1, example 1a, has IC₅₀s of 15.5 and 12.3 nM for BRD4-BD1 and BRD4-BD2, respectively . PROTAC BRD4 Degrader-7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-101460

Tz-Thalidomide		Tetrazine
Tz-Thalidomide is a tetrazine-tagged Thalidomide (HY-14658), an E3 ligase ligand. Tz-Thalidomide self-assembles with TCO-labeled target protein inhibitors, forming a CLIP-TAC (targeted protein degradation chimera) via click chemistry. This chimera recruits the E3 ubiquitin ligase CRBN to the target protein, thereby inducing ubiquitination and subsequent degradation of the target protein. When used in combination with JQ1-TCO (HY-148864), Tz-Thalidomide induces concentration-dependent degradation of BRD4 in cells. When combined with ERK-targeting protein inhibitors, Tz-Thalidomide induces degradation of ERK1/2 in cells. Tz-Thalidomide can be used in cancer-related research .

HY-182371

BRD4 ligand 15		Alkynes
BRD4 ligand 15 (compound 5) is a BRD4 ligand and alkyne-modified chalcone derivative, which serves as a building block for the synthesis of BRD4-targeting PROTAC TKP-5 (HY-182370) .

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bromodomain

Inhibitors & Agonists

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Recombinant Proteins

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