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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
chronic viral hepatitis
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "chronic viral hepatitis" in MCE Product Catalog:
8
8 Publications Verification
Synonyms: Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine
8
8 Publications Verification
Cat. No.: HY-N6666
CAS No.: 24356-66-9
Research Areas:
Vidarabine monohydrate is a Purine nucleoside derivative and Antiviral agent. The triphosphate derivative of Vidarabine monohydrate competitively inhibits DNA polymerase, incorporates into the terminus of elongating DNA molecules, and interferes with the early steps of viral DNA synthesis. Vidarabine monohydrate inhibits the replication of herpes simplex virus, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus and vaccinia virus, reduces viral shedding, and accelerates skin healing. Vidarabine monohydrate is metabolized to arabinosyl hypoxanthine, causes minimal impairment of corneal wound healing in rabbit models, and is associated with recurrence of herpes simplex encephalitis. Vidarabine monohydrate can be used in the research of herpetic keratoconjunctivitis, herpes simplex encephalitis, herpetic uveitis, and chronic active hepatitis associated with hepatitis B virus .
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Research Areas:
Rencofilstat (CRV431) is an orally active pan-cyclophilin inhibitor with IC50 values of 2.5 nM, 3.1 nM, 2.8 nM, 7.3 nM for Cyp A, CypB, Cyp D and Cyp G, respectively. Rencofilstat reduces fibrosis and tumor growth in models of chronic liver disease. Rencofilstat can be used for the study of nonalcoholic steatohepatitis (NASH), hepatocellular carcinoma and viral hepatitis-induced liver disease .
Cat. No.: HY-E70529
Target:
Research Areas:
Ribonucleoside vanadyl complexes are a class of potent RNase and Taq polymerase inhibitors. Ribonucleoside vanadyl complexes protect RNA during RNA isolation by inhibiting ribonucleases, and also reduce the viability of bacteria and eukaryotic cells by interfering with ribosomal subunit assembly. Ribonucleoside vanadyl complexes block PCR and reverse transcription reactions templated by viral nucleic acids and enhance the effects of antibiotics against Staphylococcus aureus, but do not directly inhibit protein synthesis. Ribonucleoside vanadyl complexes can be effectively removed by phenol-chloroform extraction, thus enabling subsequent PCR analysis. Ribonucleoside vanadyl complexes can be applied in research related to chronic hepatitis C (HCV) and Staphylococcus aureus infection .
Cat. No.: HY-147266
Purity: 95.83%
Synonyms: VIR-2218 sodium
Target:
Research Areas:
Elebsiran (VIR-2218) sodium is a siRNA that targets and degrades hepatitis B virus (HBV) and hepatitis D virus (HDV) RNA transcripts. Elebsiran sodium leads to a significant decrease in HBV surface antigen (HBsAg) and a reduction in viral load. Elebsiran sodium binds to the sialic acid-depleted glycoprotein receptor (ASGPR) on the surface of liver cells through the GalNAc ligand, achieving liver-targeted delivery and demonstrating improved liver safety. Elebsiran sodium can be used for the study of chronic HBV/HDV infections .
Cat. No.: HY-W352344
CAS No.: 14365-45-8
2'-Deoxy-L-adenosine is an orally active synthon for modified oligodeoxyribonucleotides. 2'-Deoxy-L-adenosine is a potent, specific and selective inhibitor of the replication of hepatitis B virus (HBV) as well as the closely related duck and woodchuck hepatitis viruses (WHV) .
Cat. No.: HY-147266A
CAS No.: 2648009-64-5
Synonyms: VIR-2218
Target:
Research Areas:
Elebsiran (VIR-2218) is a siRNA that targets and degrades hepatitis B virus (HBV) and hepatitis D virus (HDV) RNA transcripts. Elebsiran leads to a significant decrease in HBV surface antigen (HBsAg) and a reduction in viral load. Elebsiran binds to the sialic acid-depleted glycoprotein receptor (ASGPR) on the surface of liver cells through the GalNAc ligand, achieving liver-targeted delivery and demonstrating improved liver safety. Elebsiran can be used for the study of chronic HBV/HDV infections .
Target:
Research Areas:
Monoethylglycinexylidide (MEGX; Norlidocaine) is the major metabolite of Lidocaine (HY-B0185), produced via oxidative metabolism by cytochrome P-450 enzymes in the liver. Monoethylglycinexylidide can be used for research on liver cirrhosis .
Cat. No.: HY-W099331
CAS No.: 7729-94-4
Synonyms: MEGX hydrochloride; Norlidocaine hydrochloride
Target:
Research Areas:
Monoethylglycinexylidide hydrochloride (MEGX hydrochloride; Norlidocaine hydrochloride) is the major metabolite of Lidocaine (HY-B0185), produced via oxidative metabolism by cytochrome P-450 enzymes in the liver. Monoethylglycinexylidide hydrochloride can be used for research on liver cirrhosis .
Cat. No.: HY-148768
CAS No.: 2245020-50-0
Target:
Research Areas:
AB-506 is an orally active inhibitor of HBV replication targeting the viral core protein. AB-506 can bind to HBV core protein, accelerate capsid assembly and inhibit HBV pgRNA encapsidation. AB-506 can be used in chronic hepatitis B (CHB) research .
Cat. No.: HY-14404
CAS No.: 924270-31-5
Target:
Research Areas:
MK-1220 is a covalently reversible inhibitor of the hepatitis C virus (HCV) NS3/4A protease (NS3/4A protease) with a Ki of 0.02 nM. MK-1220 in cell models simulating viral replication exhibits EC50s of 4 (with 10% fetal bovine serum) and 11 nM (50% normal human serum). MK-1220 can be used for the study of chronic hepatitis C virus infection .
Synonyms: Ara-A (Standard); Adenine Arabinoside (Standard); 9-β-D-Arabinofuranosyladenine (Standard)
Cat. No.: HY-177300
CAS No.: 1402802-45-2
Research Areas:
TLR7/8 agonist 13 is an orally active dual agonist of TLR7 (lowest effective concentrations (LEC) [hTLR7] = 1.6 μM) and TLR8 (LEC [hTLR8] = 1.6 μM). TLR7/8 agonist 13 exhibits agonistic activity against human peripheral blood mononuclear cells (hPBMCs) (LEC [hPBMC] = 0.5 μM). TLR7/8 agonist 13 induces endogenous IFNα, activating myeloid dendritic cells and monocytes toward a TH1 phenotype in mice and cynomolgus monkeys. TLR7/8 agonist 13 reduces viral load and HBV surface antigen expression in a mouse model of chronic AAV-HBV infection. TLR7/8 agonist 13 has the potential to indirectly induce IFNγ, which may promote HBV antigen-specific CD8 T cell-mediated responses. TLR7/8 agonist 13 can be used to study hepatitis B virus .
Cat. No.: HY-N6666R
CAS No.: 24356-66-9
Research Areas:
Vidarabine monohydrate (Standard) is the analytical standard of Vidarabine monohydrate (HY-N6666). This product is intended for research and analytical applications. Vidarabine monohydrate is a Purine nucleoside derivative and Antiviral agent. The triphosphate derivative of Vidarabine monohydrate competitively inhibits DNA polymerase, incorporates into the terminus of elongating DNA molecules, and interferes with the early steps of viral DNA synthesis. Vidarabine monohydrate inhibits the replication of herpes simplex virus, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus and vaccinia virus, reduces viral shedding, and accelerates skin healing. Vidarabine monohydrate is metabolized to arabinosyl hypoxanthine, causes minimal impairment of corneal wound healing in rabbit models, and is associated with recurrence of herpes simplex encephalitis. Vidarabine monohydrate can be used in the research of herpetic keratoconjunctivitis, herpes simplex encephalitis, herpetic uveitis, and chronic active hepatitis associated with hepatitis B virus .
Cat. No.: HY-118167R
CAS No.: 7728-40-7
Synonyms: MEGX (Standard); Norlidocaine (Standard)
Target:
Research Areas:
Monoethylglycinexylidide (Standard) is the analytical standard of Monoethylglycinexylidide (HY-118167). This product is intended for research and analytical applications. Monoethylglycinexylidide (MEGX; Norlidocaine) is the major metabolite of Lidocaine (HY-B0185), produced via oxidative metabolism by cytochrome P-450 enzymes in the liver. Monoethylglycinexylidide can be used for research on liver cirrhosis .
Cat. No.: HY-118167S
CAS No.: 1216698-89-3
Synonyms: MEGX-d6; Norlidocaine-d6
Cat. No.: HY-118167S1
CAS No.: 2748541-96-8
Synonyms: MEGX-d6 hydrochloride; Norlidocaine-d6 hydrochloride
Cat. No.: HY-W099331R
CAS No.: 7729-94-4
Synonyms: MEGX hydrochloride (Standard); Norlidocaine hydrochloride (Standard)
Target:
Research Areas:
Monoethylglycinexylidide hydrochloride (Standard) is the analytical standard of Monoethylglycinexylidide hydrochloride (HY-W099331). This product is intended for research and analytical applications. Monoethylglycinexylidide hydrochloride (MEGX hydrochloride; Norlidocaine hydrochloride) is the major metabolite of Lidocaine (HY-B0185), produced via oxidative metabolism by cytochrome P-450 enzymes in the liver. Monoethylglycinexylidide hydrochloride can be used for research on liver cirrhosis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
