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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
32 Results for "
depsipeptide
" in MedChemExpress (MCE) Product Catalog:
Products (32)
32 Results for "depsipeptide" in MCE Product Catalog:
75
75 Publications Verification
Synonyms: FK 228; FR 901228; NSC 630176
Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC50s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively . Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis .
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4 Cited Publications
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1 Cited Publications
Category:
Natural Products Animals Marine natural products Other marine organisms Disease Research Fields Cancer
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Cat. No.: HY-P3990
CAS No.: 1029227-48-2
Cat. No.: HY-N7491A
CAS No.: 2056011-05-1
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ent-(+)-verticilide is a potent and selective inhibitor of cardiac ryanodine receptor (RyR2) calcium release channels with antiarrhythmic activity. ent-(+)-verticilide inhibits RyR2-mediated diastolic Ca2+ leak and exhibits higher potency and a distinct mechanism of action compared with theDantrolene and Tetracaine. ent-(+)-verticilide is a useful tool to investigate the therapeutic potential of targeting RyR2 hyperactivity in heart and brain pathologies .
Cat. No.: HY-P3116
CAS No.: 173046-02-1
Cat. No.: HY-P4669
CAS No.: 1122484-55-2
Synonyms: BPR277
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Lobaric acid is a depsipeptide metabolite isolated from Stereocaulon lichen with antioxidant, antiproliferative, antiviral and enzyme inhibitory activities. Lobaric acid scavenges superoxide free radicals (IC50=97.9 μM) and inhibits cancer cell proliferation (EC50 of 15.2-63.9 μg/mL against leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic and lung cancer cell lines). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50=0.87 μM for human recombinant enzyme) and 12(S)-HETE produced by 12(S)-lipoxygenase (IC50=28.5 μM). Lobaric acid (250 μM) also reduced pathological changes in tobacco leaves infected with tobacco mosaic virus (TMV).
Cat. No.: HY-P1699
CAS No.: 162478-50-4
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Cat. No.: HY-19829
CAS No.: 100940-65-6
Category:
Infection Microorganisms Antibiotics Disease Research Antibacterial Anticancer Disease Research Fields Other Antibiotics
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Cat. No.: HY-P1126
CAS No.: 123884-00-4
Synonyms: DLS 15
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Cat. No.: HY-P11337
CAS No.: 403479-63-0
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Cat. No.: HY-N12618
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Cat. No.: HY-P11342
CAS No.: 1619244-34-6
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Cat. No.: HY-W010835
CAS No.: 87494-13-1
Synonyms: Boc-S-trityl-D-cysteine
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Cat. No.: HY-P4519
CAS No.: 65882-12-4
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Cat. No.: HY-P2783
CAS No.: 79386-00-8
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Cat. No.: HY-P2087
CAS No.: 64763-82-2
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Cat. No.: HY-13760
CAS No.: 623174-20-9
Synonyms: ILX651
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Tasidotin hydrochloride is a peptide analog of the antimitotic depsipeptide dolastatin 15, as an inhibitor of microtubule assembly and microtubule dynamics.
Cat. No.: HY-N14856
CAS No.: 74758-64-8
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
