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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
dicer
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "dicer" in MCE Product Catalog:
1
1 Cited Publications
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Anticancer agent 73 (compound CIB-3b) is a anticancer agent, potently targeting TAR RNA-binding protein 2 (TRBP) and disrupts its interaction with Dicer. Anticancer agent 73 can rebalance the expression profile of oncogenic or tumor-suppressive miRNAs. Anticancer agent 73 suppresses the proliferation and metastasis of HCC in vitro and in vivo .
Cat. No.: HY-170791
CAS No.: 1082942-70-8
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CIB-L43 is an orally active TRBP inhibitor (KD = 4.78 nM) and enhances disruption of TRBP-Dicer interactions (IC50 = 2.34 μM). CIB-L43 suppresses oncogenic miR-21 biosynthesis, increasing PTEN and Smad7 expression and inhibiting AKT and TGF-β signaling, thereby reducing HCC cell proliferation and migration .
Cat. No.: HY-130487
CAS No.: 304880-74-8
miR-21-IN-2 is a high-affinity miR-21 inhibitor. miR-21-IN-2 binds to the apical loop region of the pre-miR-21 hairpin, inhibits Dicer-mediated processing, and thereby blocks the biosynthesis of mature miR-21. miR-21-IN-2 can be used for the research of microRNA-related diseases .
IR415 is a potent anti-HBV agent and inhibits HBV replication by blocking the HBx activity. IR415 selectively interacts with HBx (Kd=2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease . HBx: hepatitis B virus X protein.
Cat. No.: HY-112573A
CAS No.: 3863-80-7
Synonyms: Phacolysine sodium
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Azapentacene (Phacolysine) sodium is an anti-cataract compound. Azapentacene sodium prevents cataract formation in guinea pigs with vitamin C deficiency and delays the progression of congenital cataract in Nakano mice. Azapentacene sodium undergoes reversible one-electron oxidation to form a stable radical cation, undergoes irreversible secondary oxidation to form a hydrolyzable unstable dication, and can also be oxidized by thallium (III) trifluoroacetate in trifluoroacetic acid to generate a detectable radical cation. Azapentacene sodium is used in research related to cataracts, vitamin C deficiency-induced cataracts, and congenital cataracts .
Cat. No.: HY-RS03766
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DICER1 Human Pre-designed siRNA Set A contains three designed siRNAs for DICER1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-115551
CAS No.: 1994258-88-6
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BzDANP is a modulator of pre-miR-29a maturation by dicer. BzDANP shows much affinity to the bulged RNAs .
Cat. No.: HY-160110
CAS No.: 874338-20-2
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pre-miR-372-IN-1 is a pre-miR-372 inhibitor that binds to the internal loop region of pre-miR-372 and inhibits Dicer-mediated processing, with an IC50 of 1.06 μM and a Kd of 0.15 μM. pre-miR-372-IN-1 exhibits selectivity over tRNA and DNA competitors. pre-miR-372-IN-1 can be used for research on gastric adenocarcinoma .
Cat. No.: HY-160475
CAS No.: 1804942-56-0
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AD-9308 is an orally active, highly selective aldehyde dehydrogenase 2 (ALDH2) activator. AD-9308 alleviates oxidative stress, improves mitochondrial function, restores cell viability, reduces renal tubular injury, fibrosis and inflammatory responses, reverses ventricular remodeling, restores the activities of Dicer and superoxide dismutase, inhibits the IL-6 signaling pathway, reduces the accumulation of 4-HNE-protein adducts, and improves glucose homeostasis. AD-9308 can be used in studies related to acrolein-induced kidney injury, diabetes, cardiomyopathy, heart failure, diet-induced obesity, fatty liver, insulin resistance and glucose intolerance .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
