Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
enzyme-substrate complex
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "enzyme-substrate complex" in MCE Product Catalog:
Cat. No.: HY-W015616
CAS No.: 2550-26-7
Synonyms: 4-Penylbutan-2-one
Category:
Ketones, Aldehydes, Acids Metabolic Disease Plants Thymelaeaceae Extract Disease Research Fields Aquilaria sinensis (Lour.) Spreng.
Target:
Cat. No.: HY-126877
CAS No.: 78582-17-9
3-Deaza-2 '-deoxyadenosine is a nucleoside analog synthesized from 2' -deoxyadenosine. 3-Deaza-2 '-deoxyadenosine inhibits RNA synthesis by binding to ribose fragments of ribonucleotides, thereby preventing the formation of enzyme-substrate complexes, thereby preventing chain elongation, It can also inhibit DNA synthesis by binding deoxyribose fragments of DNA and preventing DNA polymerase from adding nucleotides to the growth chain. 3-Deaza-2 '-deoxyadenosine has antiviral activity .
Cat. No.: HY-181744
Target:
Research Areas:
AChE-IN-108 is a potent mixed-type acetylcholinesterase (AChE) inhibitor with an in vitro IC50 of 0.17 nM. AChE-IN-108 acts on both free AChE and the enzyme-substrate complex to exert mixed-type inhibition. AChE-IN-108 can be used for the study of acetylcholinesterase inhibition in Alzheimer’s disease (AD) .
Cat. No.: HY-W714186
CAS No.: 60207-93-4
Synonyms: Etaconazole
Etaconazol (Etaconazole) is an azole fungicide. Etaconazol possesses endocrine-disrupting potential and inhibits placental steroidogenesis by suppressing 3β-hydroxysteroid dehydrogenase (3β-HSD1). Etaconazol binds to the NAD +/steroid-binding site of the target enzyme and acts on both the free enzyme and enzyme-substrate complex to inhibit their activity .
Cat. No.: HY-181161
Target:
Research Areas:
AChE-IN-107 is a selective acetylcholinesterase (AChE) inhibitor with an IC50 of 0.22 μM and a Ki of 0.207 μM. AChE-IN-107 shows no inhibitory effect on equine serum BChE at 10 μM. AChE-IN-107 exhibits mixed-type inhibition of electric eel acetylcholinesterase, binding to both free enzyme and enzyme-substrate complex. AChE-IN-107 acts as a cytotoxin, reduces cell viability in hepatocellular carcinoma HepG2 cells.AChE-IN-107 can be used for the research of alzheimer's disease .
Cat. No.: HY-184382
Target:
Research Areas:
α-Amylase-IN-15 is a dual inhibitor of α-amylase and α-glucosidase, with IC50 values of 6.7 μM and 18.55 μM, respectively, and a Ki value of 50.9 μM against α-amylase. α-Amylase-IN-15 binds to both free α-amylase and the enzyme-substrate complex. By inhibiting α-glucosidase, α-Amylase-IN-15 achieves dual inhibition of carbohydrate metabolic enzymes. α-Amylase-IN-15 can be used in the research of type 2 diabetes .
Cat. No.: HY-187382
HDAC8-IN-17 is a histone deacetylase 8 inhibitor with human IC50 values of 0.08 μM, 0.44 μM, and 1.9 μM, and high selectivity over HDAC1, HDAC2, HDAC3, and HDAC6. HDAC8-IN-17 exhibits slow-binding, reversible uncompetitive inhibition via allosteric binding to the enzyme-substrate complex. HDAC8-IN-17 induces selective hyperacetylation of SMC3. HDAC8-IN-17 can be used for the research of cancer .
Cat. No.: HY-W015616R
CAS No.: 2550-26-7
Synonyms: 4-Penylbutan-2-one (Standard)
Target:
Cat. No.: HY-189055
CAS No.: 3132205-57-0
Target:
Research Areas:
β-Glucuronidase-IN-6 is an Escherichia coli β-glucuronidase (EcGUS) inhibitor with an IC50 of 0.39 μM, Ki of 0.60 μM, selectivity over bovine liver β-glucuronidase, and oral effectiveness. β-Glucuronidase-IN-6 preferentially binds the enzyme-substrate complex, interacts with residues Asp163, Glu413, and Trp549 to stabilize the binding complex. β-Glucuronidase-IN-6 does not inhibit Escherichia coli growth and exhibits low cytotoxicity toward human epithelial cells. β-Glucuronidase-IN-6 attenuates irinotecan-induced weight loss, diarrhea, and colonic injury in mice. β-Glucuronidase-IN-6 can be used for the research of irinotecan-induced gastrointestinal toxicity .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
