2 Results for "

ex vivo human lung tissue

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "ex vivo human lung tissue" in MCE Product Catalog:

Polzastobart
Polzastobart
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Cat. No.: HY-P990061
CAS No.: 2640981-19-5
Synonyms: JTX 8064

Target:  

Transmembrane Glycoprotein LILRB

Research Areas:  

Inflammation/Immunology Cancer

Polzastobart (JTX-8064) is a humanized IgG4 monoclonal antibody and LILRB2 (ILT4) antagonist. Polzastobart specifically binds to and antagonizes LILRB2, relieves ILT4-mediated myeloid immunosuppression, and promotes the polarization of macrophages from an M2-like phenotype to an M1-like phenotype. Polzastobart induces macrophage polarization, IFNγ signaling, and T cell inflammation-related pharmacodynamic responses in ex vivo human renal cancer, lung cancer, and head and neck cancer tissues. Polzastobart can be used in studies related to tumor-associated macrophages and tumor immunity. For the isotype control of Polzastobart, refer to: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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oLOX
oLOX
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Cat. No.: HY-D3208
CAS No.: 2241794-11-4
oLOX is a fluorescent activity reporter. oLOX can be activated by lysyl oxidase family (LOXF) enzymes, which in turn releases a luciferin fluorescent product that reports LOXF enzyme activity. After oLOX is activated in in vitro fibrotic lung tissues, the fluorescence intensity increases, enabling real-time detection of fibrotic activity. oLOX can be used in studies related to pulmonary fibrosis .
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