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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
factor IX
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "factor IX" in MCE Product Catalog:
20
20 Cited Publications
C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B .
1
1 Cited Publications
Art. -Nr.: HY-P70231
Reinheit: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: F9; Autoprothrombin IIA; Coagulation factor IX; Coagulant factor IX; FIX; Christmas Disease; Plasma Thromboplastic Component; Hemophilia B; Plasma Thromboplastin Component; factor IX F9; Christmas factor; factor IX; PTC; factor 9; Truncated Coagulation Fa
Species:
Human
Source:
HEK293
Art. -Nr.: HY-P9940
CAS. Nr.: 1610943-06-0
Synonyms: ACE-910; RG6013
Target:
Forschungsgebiete:
Emicizumab is a bispecific monoclonal antibody that bridges activated factor IX and factor X to replace the function of missing activated factor VIII, thereby restoring hemostasis. Emicizumab can be used for hemophilia A research .
Art. -Nr.: HY-E70541B
CAS. Nr.: 9001-28-9
Target:
Forschungsgebiete:
Canine Factor IX is a functional coagulation factor. Canine Factor IX shortens whole blood clotting time and activated partial thromboplastin time, and restores coagulation function. After intramuscular administration via rAAV vector in hemophilia B dogs, Canine Factor IX maintains a sustained circulating level for at least 1 year, partially corrects the hemophilia B phenotype in a dose-dependent manner, and its plasma expression persists for more than 17 months. Canine Factor IX is applicable to relevant research on hemophilia B .
Synonyms: ATI-5923
Target:
Forschungsgebiete:
Tecarfarin (ATI-5923) is an orally active and non-competitive vitamin K epoxide reductase (VKOR) antagonist, and impairs the activation of the vitamin K-dependent clotting factors II, VII, IX and X . Tecarfarin has the antithrombotic activity .
Art. -Nr.: HY-107966A
CAS. Nr.: 37270-89-6
Synonyms: Nadroparin calcium (MW 3600-5000)
Art. -Nr.: HY-122142A
CAS. Nr.: 127428-47-1
Synonyms: S-2366 (hydrochloride)
Target:
Forschungsgebiete:
Pyr-Pro-Arg-pNA (S-2366) hydrochloride is a chromogenic peptidyl substrate, and a noncompetitive inhibitor that occupies the active sites of FXIa and FXIa-LC to block factor IX activation. Pyr-Pro-Arg-pNA hydrochloride functions as a hydrolyzable substrate for FXIa’s catalytic domain, human APC, murine APC, and purified plasma kallikrein .
Art. -Nr.: HY-P4243A
Target:
Forschungsgebiete:
Art. -Nr.: HY-174232
Target:
Forschungsgebiete:
EGFR/CA-IX-IN-1 (Compound 14) is a dual inhibitor against epidermal growth factor receptor (EGFR) and carbonic anhydrase IX (CA-IX) with IC50 values of 5.92 nM and 63 nM, respectively. EGFR/CA-IX-IN-1 shows strong cytotoxicity against breast cancer cells (MDA-MB-231, MCF-7) with IC50 values of 5.78 μM and 8.05 μM, respectively. EGFR/CA-IX-IN-1 inhibits the catalytic activity of CA-IX, up-regulates BAX/Bcl-2, activates caspases, and arrests the cell cycle at the G1 phase. EGFR/CA-IX-IN-1 is promising for research of breast cancer .
Art. -Nr.: HY-P4243
CAS. Nr.: 69024-84-6
Target:
Forschungsgebiete:
Art. -Nr.: HY-E70541A
CAS. Nr.: 9001-28-9
Target:
Forschungsgebiete:
Bovine Factor IX is prepared from freshly collected bovine plasma. Factor IX activated by the Factor VIIa/tissue factor/phospholipid complex is responsible for the activation of Factor X to Factor Xa .
Art. -Nr.: HY-107966
CAS. Nr.: 37270-89-6
Synonyms: Nadroparin calcium (MW 15000-19000)
Art. -Nr.: HY-122142
CAS. Nr.: 72194-57-1
Synonyms: S-2366
Target:
Forschungsgebiete:
Pyr-Pro-Arg-pNA (S-2366) is a chromogenic peptidyl substrate, and a noncompetitive inhibitor that occupies the active sites of FXIa and FXIa-LC to block factor IX activation. Pyr-Pro-Arg-pNA functions as a hydrolyzable substrate for FXIa’s catalytic domain, human APC, murine APC, and purified plasma kallikrein .
Art. -Nr.: HY-112935
CAS. Nr.: 181054-95-5
Synonyms: BAX326; Coagulation factor IX [Recombinant]; BeneFIX
Target:
Forschungsgebiete:
Category:
Target:
Art. -Nr.: HY-E70393J
Bovine Factor XIa is an enzyme, which is involved in the intrinsic pathway of blood coagulation. Bovine Factor XIa is highly selective and exhibits a minimal extended substrate recognition site of at least five residues long. Bovine Factor XIa is reactive as Bovine Factor IXa (HY-E70393I) does, that it cleaves all the peptides bearing factor IX activation site sequences .
Art. -Nr.: HY-P991213
Synonyms: RIXubis
Target:
Forschungsgebiete:
Art. -Nr.: HY-P9940A
Target:
Forschungsgebiete:
Emicizumab (Anti-F9 & Factor IX) is a bispecific monoclonal antibody that bridges activated factor IX and factor X to replace the function of missing activated factor VIII, thereby restoring hemostasis. Emicizumab (Anti-F9 & Factor IX) can be used for hemophilia A research .
Art. -Nr.: HY-14854A
CAS. Nr.: 1004551-83-0
Synonyms: ATI-5923 sodium
Target:
Forschungsgebiete:
Tecarfarin (ATI-5923) sodium is an orally active VKOR inhibitor with an IC50 of 0.67 μM against VKORC1. Tecarfarin sodium blocks the post-translational modification of vitamin K-dependent coagulation factors II, VII, IX and X, reducing their levels and activities. Tecarfarin sodium prolongs prothrombin time, attenuates venous and arterial thrombosis, increases ear incision bleeding volume, and exerts reversible anticoagulant effects. Tecarfarin sodium is applicable to research related to arterial and venous thrombosis as well as other diseases requiring anticoagulation .
Art. -Nr.: HY-14854R
CAS. Nr.: 867257-26-9
Synonyms: ATI-5923 (Standard)
Target:
Forschungsgebiete:
Tecarfarin (ATI-5923) (Standard) is the analytical standard of Tecarfarin. This product is intended for research and analytical applications. Tecarfarin is an orally active VKOR inhibitor with an IC50 of 0.67 μM against VKORC1. Tecarfarin blocks the post-translational modification of vitamin K-dependent coagulation factors II, VII, IX and X, reducing their levels and activities. Tecarfarin prolongs prothrombin time, attenuates venous and arterial thrombosis, increases ear incision bleeding volume, and exerts reversible anticoagulant effects. Tecarfarin is applicable to research related to arterial and venous thrombosis as well as other diseases requiring anticoagulation .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
