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Results for "

fluoride

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (2) Amino Acid Derivatives (1) Androgen Receptor (1) Apoptosis (6) Autophagy (4) Bacterial (1) Bcl-2 Family (3) Biochemical Assay Reagents (22) Btk (3) c-Myc (1) Cathepsin (1) CCR (1) CDK (2) COX (1) Drug Derivative (1) Drug Intermediate (11) E3 Ligase Ligand-Linker Conjugates (5) EGFR (1) Endogenous Metabolite (1) Endothelin Receptor (1) Environmental Pollutants (5) Epigenetic Reader Domain (1) FLT3 (1) Fluorescent Dye (1) Histone Methyltransferase (1) HSP (1) IKZF Family (1) Interleukin Related (1) Isotope-Labeled Compounds (3) Itk (1) Ligands for E3 Ligase (4) Ligands for Target Protein for PROTAC (1) MMP (1) Molecular Glues (1) NF-κB (1) Pregnane X Receptor (PXR) (1) Prostaglandin Receptor (1) PROTACs (8) Radionuclide-Drug Conjugates (RDCs) (1) Reference Standards (2) Ser/Thr Protease (1) TNF Receptor (1)
By Research Areas:	Cancer (23) Cardiovascular Disease (1) Endocrinology (1) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (2)
Click Chemistry:	DBCO (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0496

PMSF 145+ Cited Publications Phenylmethylsulfonyl fluoride; Benzylsulfonyl fluoride	Cathepsin Ser/Thr Protease	Neurological Disease
PMSF (Phenylmethylsulfonyl fluoride) is a nonspecific and irreversible serine proteases inhibitor. PMSF inhibits some thiol proteases, non-protease enzymes, and acetylcholinesterase. PMSF can be used to prepare protein extracts from tissue and cell lysates .

HY-153220

Zelebrudomide NX-2127	PROTACs Btk	Inflammation/Immunology Cancer
Zelebrudomide (NX-2127) (Compound 28) is an orally active PROTAC deggrader, targeting to Bruton’s Tyrosine Kinase (Btk). Zelebrudomide inhibits proliferation of BTK ^C481S mutant TMD8 cells, more effectively than Ibrutinib (HY-10997). Zelebrudomide catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) with of 25 nM and 54 nM, respectively. Zelebrudomide stimulates T cell activation and increases IL-2 production in primary human T Cells . (Pink: BTK ligand 10 (HY-168302); Black: (R)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline (HY-168348); Blue: Thalidomide 5-fluoride (HY-W087383)

HY-153357

NRX-0492	PROTACs Btk	Cancer
NRX-0492 is an orally active PROTAC-class BTK degrader. NRX-0492 catalyzes BTK ubiquitination and proteasome degradation (DC₅₀ ≤ 0.2 nM, DC₉₀ ≤ 0.5 nM). NRX-0492 inhibits B cell receptor (BCR) mediated signaling, transcription programs, and chemokine secretion. NRX-0492 has antitumor effects against chronic lymphocytic leukemia.NRX-0492 consists of a target protein ligand (red part) BTK-IN-40 (HY-170324), an E3 ligase ligand (blue part) Thalidomide 5-fluoride (HY-W087383), and a PROTAC linker (black part) (3R)-3-Pyrrolidinemethanol (HY-60263).

HY-Y0971

*Tetrabutylammonium fluoride* (solution),1M in THF** TBAF	Biochemical Assay Reagents	Others
Tetrabutylammonium fluoride is an organic compound containing both ammonium and fluorine functional groups. It is commonly used as a reagent in various chemical synthesis applications, especially as a source of fluoride ions for nucleophilic reactions. Tetrabutylammonium fluoride has several properties that make it suitable for these applications, including its high solubility in polar solvents and its ability to selectively activate certain chemical bonds. In addition, it can be used as a catalyst for organic reactions and as an electrolyte for batteries.

HY-41547

Thalidomide 4-fluoride Cereblon ligand 4; E3 ligase Ligand 4	Ligands for E3 Ligase Autophagy Apoptosis	Cancer
Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966) .

HY-Y0975

Silver(I) fluoride	Environmental Pollutants Drug Intermediate	Others
Silver(I) fluoride is a drug intermediate for synthesis of various active compounds. Silver(I) fluoride is a silver(I) complex that can form hydrates in aqueous solutions and in the solid state, enabling its localized application to the tooth decay area for oral health research .

HY-W087383

Thalidomide 5-fluoride	Ligands for E3 Ligase Autophagy Apoptosis	Cancer
Thalidomide 5-fluoride is a thalidomide-based Cereblon ligand used to recruit Cereblon protein. Thalidomide 5-fluoride can be linked to target protein ligands (e.g. IRAK4) through a linker to form PROTAC molecules (e.g. PROTAC IRAK4 degrader-1). PROTAC IRAK4 degrader-1 caused <20%, >20-50%, and >50% IRAK4 protein degradation in OCI-LY-10 cells at concentrations of 0.01, 0.1, and 1 μM, respectively .

HY-21190

Perfluorobutylsulfonyl fluoride	Drug Intermediate	Others
Perfluorobutylsulfonyl fluoride is a four-carbon polyfluorinated sulfonyl fluoride. Perfluorobutylsulfonyl fluoride serves as an intermediate that can be used for the synthesis of other compounds .

HY-128383

1-Methylpyrrolidine	Environmental Pollutants Drug Intermediate	Others
1-Methylpyrrolidine is a methylated pyrrolidine, and cation with thermal-origin negative nonlinear optical (self-defocusing) properties .

HY-P11111

QP5	Drug Derivative	Others
QP5 is an Amelogenin (HY-P71627)-derived peptide. QP5 binds to hydroxyapatite and demineralized enamel surfaces, temporarily stabilizes amorphous calcium phosphate (ACP), and regulates the crystallization of hydroxyapatite. QP5 promotes remineralization of artificial enamel caries in vitro, and acts synergistically with fluoride to enhance enamel caries remineralization. QP5 can be used in studies related to enamel caries and early enamel caries .

HY-W587839

4,8-Dioxa-3H-perfluorononanoic acid	Pregnane X Receptor (PXR)	Endocrinology
4,8-Dioxa-3H-perfluorononanoic acid is an ether-substituted polyfluoroalkyl compound and also a ligand of human pregnane X receptor (hPXR), which binds to the ligand-binding domain of hPXR. 4,8-Dioxa-3H-perfluorononanoic acid targets Arg-410, Lys-210, Lys-226, Met-323 and His-327 residues. Its binding process relies on long-range electrostatic interactions, and no significant hydrogen bonds form with hPXR residues. 4,8-Dioxa-3H-perfluorononanoic acid is used as a substitute for PFOA in Germany. 4,8-Dioxa-3H-perfluorononanoic acid is detectable in environmental matrices such as river water near fluoride production plants, accumulates in organisms including grass, deer liver and locusts, and is present in plasma samples of populations in southern Germany .

HY-W019922

Magnesium fluoride	Biochemical Assay Reagents	Others
Magnesium fluoride is a kind of biological materials or organic compounds that are widely used in life science research .

HY-W145436

*Thalidomide-Piperazine 5-fluoride* hydrochloride**	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-Piperazine 5-fluoride hydrochloride is a derivative of cereblon (CRBN) inhibitor Thalidomide (HY-14658), which can be used as ligands for E3 ubiquitin ligase (Ligands for E3 Ligase) for PROTACs Synthesis .

HY-W075766

Nickel(II) fluoride Nickel difluoride	Biochemical Assay Reagents	Others
Nickel(II) fluoride (Nickel difluoride) is a fluorinating agent and catalyst suitable for surface treatment of aluminum profiles and the production of inks, fluorescent lamps, and organic synthesis. Nickel(II) fluoride is a kind of biological materials or organic compounds that are widely used in life science research .

HY-134983

Thalidomide-Piperazine 5-fluoride	E3 Ligase Ligand-Linker Conjugates Apoptosis Autophagy	Cancer
Thalidomide-piperazine hydrochloride is a synthetic E3 ligase ligand-linker conjugate, containing a cereblon ligand based on Thalidomide (HY-14658) and one linker. Thalidomide-piperazine hydrochloride can be used in studies related to PROTAC synthesis .

HY-153220A

(R)-Zelebrudomide (R)-NX-2127	PROTACs Btk	Inflammation/Immunology Cancer
(R)-Zelebrudomide ((R)-NX-2127) ((R)-Compound 28) is an isomer of the BTK PROTAC degrader Zelebrudomide (HY-153220) . (Pink: BTK ligand 10 (HY-168302); Black: (S)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline (HY-168303); Blue: Thalidomide 5-fluoride (HY-W087383).

HY-149917

ITK degrader 1	PROTACs Itk	Cancer
ITK degrader 1 is a highly selective degrader of interleukin-2-inducible T-cell kinase (ITK; DC₅₀=3.6 nM in vivo in mice), with good plasma exposure levels. ITK degrader 1 induces rapid, and prolonged ITK degradation and suppresses IL-2 secretion (EC₅₀=35.2 nM, Jurkat cells) stimulated by anti-CD3 antibodyin vivo. ITK degrader 1 consists of target protein ligand (red part) ITK ligand 1 (HY-168387), PROTAC linker (black part) Piperidine-C2-piperazine-Boc (HY-168388) and E3 ubiquitinase ligand (blue part) Thalidomide 5-fluoride (HY-W087383). E3 ubiquitinase and PROTAC linker can form Thalidomide-piperidine-C2-piperazine-Boc (HY-168389) .

HY-21195

Perfluorohexylsulfonyl fluoride Perfluorohexanesulphonyl fluoride	Biochemical Assay Reagents	Others
Perfluorohexylsulfonyl fluoride (Perfluorohexanesulphonyl fluoride) is a perfluoroalkyl and polyfluoroalkyl substances, that is defined as persistant organic pollutant by 2022 Stockholm Convention. Perfluorohexylsulfonyl fluoride can be used for drug modification .

HY-W019962

Calcium fluoride 1 Publications Verification	Biochemical Assay Reagents	Others
Calcium fluoride is a kind of biological materials or organic compounds that are widely used in life science research .

HY-W460193

N-Me-Thalidomide 4-fluoride	Ligands for E3 Ligase	Cancer
N-Me-Thalidomide 4-fluoride is a ligand for E3 ligase, used for the synthesis of Anti-inflammatory agent 70 (HY-157570) .

HY-W093286

*Aluminum fluoride* trihydrate**	Biochemical Assay Reagents	Others
Aluminum fluoride trihydrate is a kind of biological materials or organic compounds that are widely used in life science research .

HY-W014895

Ethyl 4-methylbenzenesulfonate Ethyl p-toluenesulfonate; Ethyl tosylate	Drug Intermediate	Others
Ethyl 4-methylbenzenesulfonate (Ethyl p-toluenesulfonate) is a drug intermediate that can be used for the synthesis of alkyl and substituted alkyl fluorides .

HY-P2496

*Endothelin 1 (swine, human), Alexa Fluor* 488-labeled**	Endothelin Receptor Fluorescent Dye NF-κB COX Prostaglandin Receptor Apoptosis TNF Receptor Interleukin Related MMP	Cardiovascular Disease Inflammation/Immunology Cancer
Endothelin 1 (swine, human), Alexa Fluor 488-labeled is an Endothelin-1 conjugated with Alexa Fluor 488 (HY-D1304). Endothelin-1 is an endogenous vasoconstrictor and agonist of ETA/ETB receptor. Endothelin 1 (swine, human) exerts effects including promoting mitosis, angiogenesis, tumor invasion and metastasis, and inhibiting apoptosis. Endothelin 1 (swine, human) induces inflammation and oxidative stress by activating the NF-κB pathway. Endothelin 1 (swine, human), Alexa Fluor 488-labeled is specifically designed for fluorescence imaging, flow cytometry or receptor localization studies, and can be used in research related to sepsis, atherosclerosis, systemic inflammatory response syndrome, cancer and congestive heart failure .

HY-164576

NCS-MP-NODA NODA-Bz-SCN	Radionuclide-Drug Conjugates (RDCs)	Cancer
NCS-MP-NODA (NODA-Bz-SCN) is a bifunctional chelator that can be used to bind to the labeled peptide DK222 with high specificity for PD-L1. The corresponding fluorinated radioactive is synthesized by the aluminum fluoride method, and NCS-MP-NODA targets DK222 to obtain the radioactive analog [18/19F]DK222. [18F]DK222 can quantify PD-L1 in vivo via PET tracking in xenograft models of multiple cancer types.

HY-W763812

(S)-Thalidomide 4-fluoride	Ligands for E3 Ligase	Others
(S)-Thalidomide 4-fluoride is a CRBN E3 ligase ligand that can be used for synthesis of DeDPP4 (HY-182336).

HY-W095635

*Tetramethylammonium fluoride* tetrahydrate**	Biochemical Assay Reagents	Others
Tetramethylammonium fluoride tetrahydrate (TMAF) is a quaternary ammonium salt. TMAF is commonly used as a weak base and a source of fluoride ions in various organic reactions, including nucleophilic substitution, functional group deprotection, and ring-opening polymerization. Unlike other fluoride sources, TMAF is compatible with many functional groups, making it a versatile tool in synthetic chemistry. Functional reagents, In addition, TMAF has been used as a fluorinating agent in medicinal chemistry, for the preparation of radiotracers and protein modification in biochemistry, and the tetrahydrate form of TMAF is more stable and easier to handle than the anhydrous form.

HY-W127635

*Tetraethylammonium fluoride* trihydrofluoride**	Biochemical Assay Reagents	Others
Tetraethylammonium fluoride trihydrofluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W612372

4-(Bromomethyl)benzenesulfonyl fluoride Fluorosulfonylbenzyl bromide	Biochemical Assay Reagents Endogenous Metabolite
4-(Bromomethyl)benzenesulfonyl fluoride (Fluorosulfonylbenzyl bromide) is an important chemical reagent with good biological activity. 4-(Bromomethyl)benzenesulfonyl fluoride can be used to prepare various bioactive molecules, especially in the process of compound discovery and synthesis, showing excellent reactivity. 4-(Bromomethyl)benzenesulfonyl fluoride is often used in the development of new biological agents, promoting the research progress of organic chemistry and biochemistry.

HY-W145623

2,3,4,6-Tetra-O-benzyl-β-D-glucopyranosyl fluoride 2,3,4,6-Tetra-O-benzyl-beta-D-glucopyranosyl fluoride	Biochemical Assay Reagents	Others
2,3,4,6-Tetra-O-benzyl-β-D-glucopyranosyl Fluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-135859

NH2-MPAA-NODA	ADC Linker	Cancer
NH2-MPAA-NODA is a nitroveratryl-based photocleavable linker, it has a NODA motif and a methyl phenyl acetic acid (MPAA) backbone . NH2-MPAA-NODA can be used as a radiolabel by labeling with ¹⁸F-fluoride.

HY-135859A

NH2-MPAA-NODA TFA	ADC Linker	Cancer
NH2-MPAA-NODA TFA is a nitroveratryl-based photocleavable linker, it has a NODA motif and a methyl phenyl acetic acid (MPAA) backbone . NH2-MPAA-NODA can be used as a radiolabel by labeling with ¹⁸F-fluoride.

HY-141464

Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH Fmoc-Asn(Ac3AcNH-beta-Glc)-OH	Amino Acid Derivatives	Cancer
Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH (Fmoc-Asn(Ac3AcNH-beta-Glc)-OH) can be used in the synthesis of silicon-fluoride acceptor (SiFA) derivatized octreotate derivatives. SiFA-octreotate analogues, as tumor imaging agents, are useful tool for the research of positron emission tomography (PET) .

HY-W998239

*Thalidomide 5-fluoride* 6-piperidine-C-OH**	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide 5-fluoride 6-piperidine-C-OH is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

HY-165291

Olaflur hydrofluoride	Bacterial	Metabolic Disease
Olaflur hydrofluoride is an amine fluoride with anticaries activity. Olaflur hydrofluoride can be used as an ingredient of toothpastes . Olaflur hydrofluoride also exhibits antibacterial activity .

HY-W145636

2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl fluoride 2,3,4,6-Tetra-O-benzyl-alpha-D-glucopyranosyl fluoride	Biochemical Assay Reagents	Others
2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl Fluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W106762

Perylene-3,4,9,10-tetracarboxylic acid 3,4,9,10-Perylenetetracarboxylic acid	Drug Intermediate Biochemical Assay Reagents	Others
Perylene-3,4,9,10-tetracarboxylic acid (3,4,9,10-Perylenetetracarboxylic acid) is a chemical intermediate. Derivatives formed from Perylene-3,4,9,10-tetracarboxylic acid can serve as colorimetric and fluorescent chemosensors with selectivity for fluoride ions, and also act as charge generation materials in electrophotographic photoreceptors, organic electrophotographic photoreceptors, optoelectronic and photonic devices .

HY-176808

Thalidomide-amine-C11-acid	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-amine-C11-acid is an E3 ligase ligand-linker conjugate which consists of Thalidomide 5-fluoride (HY-W087383) and a linker (HY-W105740). Thalidomide-amine-C11-acid can be used to synthesize JQAD1 (HY-145765) .

HY-161650

PROTAC BRD4 Degrader-26	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-26 (PROTAC-2) is a photo-regulated PROTAC, which degrades 80% BRD4 at 1 μM by using photocleavable linker. PROTAC BRD4 Degrader-26 will be deactivated by UV light. (Pink: ligand for target protein BRD4 ligand 6 (HY-161651); Black: linker (HY-161653); Blue: E3 ligase ligand Thalidomide 4-fluoride (HY-41547))

HY-161708

PROTAC FLT3/CDKs degrader-1	PROTACs CDK FLT3	Cancer
PROTAC FLT3/CDKs degrader-1 (Compound C3) is a degrader for cyclin-dependent kinases (DC₅₀ is 18.73 nM for CDK2) and the FMS-like tyrosine kinase 3 (FLT3). PROTAC FLT3/CDKs degrader-1 induces differentation of HL-60 (72.77% differentation at 6.25 nM), inhibits proliferation of AML cells, with IC₅₀s of 2.9-37 nM. PROTAC FLT3/CDKs degrader-1 is potential for ameliorating acute myeloid leukemia. (Pink: ligand for target protein FLT3/CDKs ligand-1 (HY-161709); Black: linker (HY-W012935); Black: ligand for E3 ligase Thalidomide 5-fluoride (HY-W087383))

HY-170820

XYD049	Molecular Glues Bcl-2 Family CDK EGFR HSP Androgen Receptor c-Myc	Cancer
XYD049 is a CRBN-based molecular glue degrader targeting GSPT1, with a DC₅₀ of 19 nM. XYD049 mediates the formation of a ternary complex between CRBN and GSPT1, thereby triggering CRBN- and proteasome-dependent degradation of GSPT1. By degrading GSPT1, XYD049 downregulates castration-resistant prostate cancer (CRPC)-related oncogenes, including BCL2, CDK2, E2F3, EGFR, HSP90B1, TMPRSS2, AR, AR-V7, PSA and c-Myc. XYD049 inhibits cancer cell growth and suppresses tumor growth in mice. XYD049 can be used for research on castration-resistant prostate cancer. XYD049 consists of a linker (black part) NH2-C5-NH-Boc (HY-W004710), a CRBN-based E3 ligase ligand (blue part) Thalidomide 4-fluoride (HY-41547), and a target protein ligand (red part) GSPT1 ligand-1 (HY-170821), among which the E3 ligase ligand plus linker forms the conjugate E3 Ligase Ligand-linker Conjugate 158 (HY-170822) .

HY-172368

PROTAC CARM1/IKZF3 degrader-1	PROTACs Histone Methyltransferase IKZF Family Apoptosis	Inflammation/Immunology Cancer
PROTAC CARM1/IKZF3 degrader-1 (Compound 074) inhibits CARM1, reduces the methylation level of its substrate BAF155. PROTAC CARM1/IKZF3 degrader-1 is the PROTAC degrader for IKZF 1/3 through a CRBN-dependent pathway. PROTAC CARM1/IKZF3 degrader-1 inhibits the expression of MYC protein, thereby inhibiting the proliferation of a variety of multiple myeloma cells. PROTAC CARM1/IKZF3 degrader-1 induces apoptosis in cell H929. PROTAC CARM1/IKZF3 degrader-1 overcomes immunomodulatory drugs (IMiD, such as pomalidomide) resistance. PROTAC CARM1/IKZF3 degrader-1 can be used in cancer and immunology research . (Pink: ligand for target protein CARM1/IKZF3 ligand 1 (HY-172369); Active form of target protein ligand: EZM 2302 (HY-111109); Black: linker (HY-21999); Blue: ligand for E3 ligase Cereblon Thalidomide 4-fluoride (HY-41547))

HY-Y0415

Tetraethylammonium fluoride N,N,N-triethylethanaminium fluoride	Biochemical Assay Reagents	Others
Tetraethylammonium fluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W127636

*Tetraethylammonium fluoride* tetrahydrofluoride**	Biochemical Assay Reagents	Others
Tetraethylammonium Fluoride Tetrahydrofluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-169381

hMcl-1-IN-1	Bcl-2 Family	Others
hMcl-1-IN-1 (Compound 9) is an hMcl-1 inhibitor based on His224 aryl sulfonate fluoride, with an IC₅₀ value of 5.8 nM .

HY-164084

DBCO-NHCO-C5-O-phenylethenesulfonyl fluoride	Biochemical Assay Reagents	Others
DBCO-NHCO-C5-O-phenylethenesulfonyl fluoride is a DBCO containing linker, which can be used in bioconjugate, drug delivery and other biochemical research .

HY-W145533

2,3,4,6-Tetrakis-O-(phenylmethyl)-D-glucopyranosyl fluoride	Biochemical Assay Reagents	Others
2,3,4,6-Tetra-O-benzyl-D-glucopyranosyl Fluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P10386

155H1	Bcl-2 Family	Cancer
155H1 (Compound 11) is a stapled peptide, that covalently binds hMcl1 (172-323) with IC₅₀ of 18 nM .

HY-W145569

2,3,4,6-Tetra-O-acetyl-D-mannopyranosyl fluoride (3,4,5-Triacetyloxy-6-fluorooxan-2-yl)methyl acetate	Biochemical Assay Reagents	Others
2,3,4,6-Tetra-O-acetyl-D-mannopyranosyl Fluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-168190

PROTAC TBL1X degrader-1	PROTACs	Cancer
PROTAC TBL1X degrader-1 (Compound TD11) is a PROTAC degrader for Transducin β-like protein 1 X-linked (TBL1X), and exhibits cytotoxicity in lymphoma cell Riva, Pfeiffer and Granta-519 with IC₅₀ of 0.795, 0.397 and 0.522 μM, respectively. (Pink: ligand for target protein: TBL1X ligand 1 (HY-168191); Black: linker (HY-168193); Blue: ligand for E3 ligase: Thalidomide 4-fluoride (HY-41547))

HY-W014895R

Ethyl 4-methylbenzenesulfonate (Standard) Ethyl p-toluenesulfonate (Standard); Ethyl tosylate (Standard)	Reference Standards Drug Intermediate	Others
Ethyl 4-methylbenzenesulfonate (Ethyl p-toluenesulfonate; Ethyl tosylate) (Standard) is the analytical standard of Ethyl 4-methylbenzenesulfonate. This product is intended for research and analytical applications. Ethyl 4-methylbenzenesulfonate is a drug intermediate that can be used for the synthesis of alkyl and substituted alkyl fluorides.

Cat. No.	Product Name

HY-L945

Sulfonyl Fluoride Fragment Library

1162 compounds

Sulfonyl fluoride (-SO₂F) overcomes the bottleneck of target selectivity in traditional covalent warheads through its unique chemical and biological properties, which rely heavily on cysteine (Cys) residues. Featuring high stability and tunable electrophilicity under physiological conditions, it can target a wide range of nucleophilic residues including lysine (Lys), tyrosine (Tyr), serine (Ser), and histidine (His). It offers the advantages of a broader druggable space, lower off-target risks, and long-lasting efficacy, with numerous reported cases in the research of covalent inhibitors, Molecular glue, PROTACs, and chemical biology probe development.

MCE constructs a highly diverse sulfonyl fluoride fragment library based on the reactivity, stability and physiological compatibility of sulfonyl fluoride. The library contains 1000 efficiently synthesized and stable sulfonyl fluoride fragments, which ensure precise reactivity of the warhead and retain sufficient derivatization space for subsequent optimization. Combined with the modular strategy of SuFEx click chemistry, it enables versatile modification of compounds and functionalization of complex molecules, improves the efficiency of structural optimization and rapidly expands druggability, making it suitable for high-throughput probe and custom covalent library construction. It provides an efficient research tool for the development of broad-spectrum covalent inhibitors targeting Lys/Tyr/Ser/His, covalent PROTACs for E3 ligases and chemical biology probe development, meeting the requirements of modern drug research for high throughput, high success rate and high derivatization potential.

This library contains 1,162 sulfonyl fluoride fragments with high structural diversity, favorable drug-like properties and tunable electrophilicity. It is well suited for precise targeting of non-Cys residues and meets the criteria of simple structure and high derivatization potential. It effectively improves

HY-L036

Covalent Screening Library

1,546 compounds

Small molecule covalent inhibitors, or irreversible inhibitors, are a type of inhibitors that exert their biological functions by irreversibly binding to target through covalent bonds. Compared with non-covalent inhibitors, covalent inhibitors have obvious advantages in bioactivity, such that covalent warheads can target rare residues of a particular target protein, thus leading to the development of highly selective inhibitors and achieving a more complete and continued target occupancy in living systems. In recent years, the distinct strengths of covalent inhibitors in overcoming drug resistance had been recognized. However, toxicity can be a real challenge related to this class of therapeutics due to their potential for off-target reactivity and has led to these drugs being disfavored as a drug class. The drug design and optimization of covalent inhibitors has become a hot spot in drug discovery.

MCE covalent inhibitor library contains 1,546 small molecules including identified covalent inhibitors and other bioactive molecules having common covalent reactive groups as warheads, such as acrylamides, activated terminal acetylenes, Sulfonyl fluorides/esters, cloracetamides, alkyl halides, epoxides, aziridines, disulfides, etc.

HY-L036P

Covalent Screening Library Plus

5,994 compounds

MCE covalent inhibitor library contains 5,994 small molecules including identified covalent inhibitors and other molecules having common covalent reactive groups as warheads, such as acrylamides, activated terminal acetylenes, sulfonyl fluorides/esters, cloracetamides, alkyl halides, epoxides, aziridines, disulfides, etc.

MCE Covalent inhibitor Library plus, with more powerful screening capability, further complement Covalent inhibitor Library (HY-L036) by adding some fragment compounds with covalent warheads.

Cat. No.	Product Name	Type

HY-Y0971

Tetrabutylammonium fluoride (solution),1M in THF

TBAF

Biochemical Assay Reagents

Tetrabutylammonium fluoride is an organic compound containing both ammonium and fluorine functional groups. It is commonly used as a reagent in various chemical synthesis applications, especially as a source of fluoride ions for nucleophilic reactions. Tetrabutylammonium fluoride has several properties that make it suitable for these applications, including its high solubility in polar solvents and its ability to selectively activate certain chemical bonds. In addition, it can be used as a catalyst for organic reactions and as an electrolyte for batteries.

HY-W019922

Magnesium fluoride	Biochemical Assay Reagents
Magnesium fluoride is a kind of biological materials or organic compounds that are widely used in life science research .

HY-W075766

Nickel(II) fluoride Nickel difluoride	Biochemical Assay Reagents
Nickel(II) fluoride (Nickel difluoride) is a fluorinating agent and catalyst suitable for surface treatment of aluminum profiles and the production of inks, fluorescent lamps, and organic synthesis. Nickel(II) fluoride is a kind of biological materials or organic compounds that are widely used in life science research .

HY-W019962

Calcium fluoride 1 Publications Verification	Biochemical Assay Reagents
Calcium fluoride is a kind of biological materials or organic compounds that are widely used in life science research .

HY-W093286

*Aluminum fluoride* trihydrate**	Biochemical Assay Reagents
Aluminum fluoride trihydrate is a kind of biological materials or organic compounds that are widely used in life science research .

HY-W014895

Ethyl 4-methylbenzenesulfonate Ethyl p-toluenesulfonate; Ethyl tosylate	Biochemical Assay Reagents
Ethyl 4-methylbenzenesulfonate (Ethyl p-toluenesulfonate) is a drug intermediate that can be used for the synthesis of alkyl and substituted alkyl fluorides .

HY-W095635

Tetramethylammonium fluoride tetrahydrate

Biochemical Assay Reagents

Tetramethylammonium fluoride tetrahydrate (TMAF) is a quaternary ammonium salt. TMAF is commonly used as a weak base and a source of fluoride ions in various organic reactions, including nucleophilic substitution, functional group deprotection, and ring-opening polymerization. Unlike other fluoride sources, TMAF is compatible with many functional groups, making it a versatile tool in synthetic chemistry. Functional reagents, In addition, TMAF has been used as a fluorinating agent in medicinal chemistry, for the preparation of radiotracers and protein modification in biochemistry, and the tetrahydrate form of TMAF is more stable and easier to handle than the anhydrous form.

HY-W127635

*Tetraethylammonium fluoride* trihydrofluoride**	Biochemical Assay Reagents
Tetraethylammonium fluoride trihydrofluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145623

2,3,4,6-Tetra-O-benzyl-β-D-glucopyranosyl fluoride 2,3,4,6-Tetra-O-benzyl-beta-D-glucopyranosyl fluoride	Biochemical Assay Reagents
2,3,4,6-Tetra-O-benzyl-β-D-glucopyranosyl Fluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145636

2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl fluoride 2,3,4,6-Tetra-O-benzyl-alpha-D-glucopyranosyl fluoride	Biochemical Assay Reagents
2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl Fluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-Y0415

Tetraethylammonium fluoride N,N,N-triethylethanaminium fluoride	Biochemical Assay Reagents
Tetraethylammonium fluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W127636

*Tetraethylammonium fluoride* tetrahydrofluoride**	Biochemical Assay Reagents
Tetraethylammonium Fluoride Tetrahydrofluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145533

2,3,4,6-Tetrakis-O-(phenylmethyl)-D-glucopyranosyl fluoride	Biochemical Assay Reagents
2,3,4,6-Tetra-O-benzyl-D-glucopyranosyl Fluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145569

2,3,4,6-Tetra-O-acetyl-D-mannopyranosyl fluoride (3,4,5-Triacetyloxy-6-fluorooxan-2-yl)methyl acetate	Biochemical Assay Reagents
2,3,4,6-Tetra-O-acetyl-D-mannopyranosyl Fluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W014895R

Ethyl 4-methylbenzenesulfonate (Standard) Ethyl p-toluenesulfonate (Standard); Ethyl tosylate (Standard)	Biochemical Assay Reagents
Ethyl 4-methylbenzenesulfonate (Ethyl p-toluenesulfonate; Ethyl tosylate) (Standard) is the analytical standard of Ethyl 4-methylbenzenesulfonate. This product is intended for research and analytical applications. Ethyl 4-methylbenzenesulfonate is a drug intermediate that can be used for the synthesis of alkyl and substituted alkyl fluorides.

HY-W036734

Tetrabutylammonium hydrogen difluoride

Biochemical Assay Reagents

Tetrabutylammonium (hydrogen difluoride) is a quaternary ammonium salt containing fluoride ions. It is a highly active and effective reagent, often used in organic synthesis reactions, especially for the modification of organic molecules with fluorine atoms. Tetrabutylammonium (hydrogen difluoride) is also used as a catalyst for various chemical reactions such as esterification and transesterification. Additionally, it is used in the production of specialty chemicals such as surfactants and detergents.

HY-107991

Acorea sodium Fluorophosphate sodium	Biochemical Assay Reagents
Acorea (Fluorophosphate) sodium is an inorganic compound and an important fluoride salt .

Cat. No.	Product Name	Target	Research Area

HY-P11111

QP5	Drug Derivative	Others
QP5 is an Amelogenin (HY-P71627)-derived peptide. QP5 binds to hydroxyapatite and demineralized enamel surfaces, temporarily stabilizes amorphous calcium phosphate (ACP), and regulates the crystallization of hydroxyapatite. QP5 promotes remineralization of artificial enamel caries in vitro, and acts synergistically with fluoride to enhance enamel caries remineralization. QP5 can be used in studies related to enamel caries and early enamel caries .

HY-P2496

*Endothelin 1 (swine, human), Alexa Fluor* 488-labeled**	Endothelin Receptor Fluorescent Dye NF-κB COX Prostaglandin Receptor Apoptosis TNF Receptor Interleukin Related MMP	Cardiovascular Disease Inflammation/Immunology Cancer
Endothelin 1 (swine, human), Alexa Fluor 488-labeled is an Endothelin-1 conjugated with Alexa Fluor 488 (HY-D1304). Endothelin-1 is an endogenous vasoconstrictor and agonist of ETA/ETB receptor. Endothelin 1 (swine, human) exerts effects including promoting mitosis, angiogenesis, tumor invasion and metastasis, and inhibiting apoptosis. Endothelin 1 (swine, human) induces inflammation and oxidative stress by activating the NF-κB pathway. Endothelin 1 (swine, human), Alexa Fluor 488-labeled is specifically designed for fluorescence imaging, flow cytometry or receptor localization studies, and can be used in research related to sepsis, atherosclerosis, systemic inflammatory response syndrome, cancer and congestive heart failure .

HY-P10386

155H1	Bcl-2 Family	Cancer
155H1 (Compound 11) is a stapled peptide, that covalently binds hMcl1 (172-323) with IC₅₀ of 18 nM .

Cat. No.	Product Name	Chemical Structure

HY-W014895S

Ethyl 4-methylbenzenesulfonate-d5
Ethyl 4-methylbenzenesulfonate-d₅ (Ethyl p-toluenesulfonate-d₅; Ethyl tosylate-d₅) is deuterium labeled Ethyl 4-methylbenzenesulfonate (HY-W014895). Ethyl 4-methylbenzenesulfonate is a drug intermediate that can be used for the synthesis of alkyl and substituted alkyl fluorides.

HY-128383S1

1-Methylpyrrolidine-d3
1-Methylpyrrolidine-d₃ is the deuterium labeled 1-Methylpyrrolidine (HY-128383). 1-Methylpyrrolidine is a methylated pyrrolidine, and cation with thermal-origin negative nonlinear optical (self-defocusing) properties .

HY-128383S

1-Methylpyrrolidine-d8
1-Methylpyrrolidine-d₈ is the deuterium labeled 1-Methylpyrrolidine (HY-128383). 1-Methylpyrrolidine is a methylated pyrrolidine, and cation with thermal-origin negative nonlinear optical (self-defocusing) properties .

Cat. No.	Product Name		Classification

HY-164084

DBCO-NHCO-C5-O-phenylethenesulfonyl fluoride		DBCO
DBCO-NHCO-C5-O-phenylethenesulfonyl fluoride is a DBCO containing linker, which can be used in bioconjugate, drug delivery and other biochemical research .

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