Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
58 Results for "
fluoride
" in MedChemExpress (MCE) Product Catalog:
Products (58)
58 Results for "fluoride" in MCE Product Catalog:
161
161 Cited Publications
Synonyms: Phenylmethylsulfonyl fluoride; Benzylsulfonyl fluoride
Target:
Research Areas:
PMSF (Phenylmethylsulfonyl fluoride) is a nonspecific and irreversible serine proteases inhibitor. PMSF inhibits some thiol proteases, non-protease enzymes, and acetylcholinesterase. PMSF can be used to prepare protein extracts from tissue and cell lysates .
1
1 Cited Publications
Cat. No.: HY-W019962
CAS No.: 7789-75-5
Cat. No.: HY-41547
CAS No.: 835616-60-9
Synonyms: Cereblon ligand 4; E3 ligase Ligand 4
Target:
Research Areas:
Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966) .
Research Areas:
Silver(I) fluoride is a drug intermediate for synthesis of various active compounds. Silver(I) fluoride is a silver(I) complex that can form hydrates in aqueous solutions and in the solid state, enabling its localized application to the tooth decay area for oral health research .
Cat. No.: HY-W087383
CAS No.: 835616-61-0
Target:
Research Areas:
Thalidomide 5-fluoride is a thalidomide-based Cereblon ligand used to recruit Cereblon protein. Thalidomide 5-fluoride can be linked to target protein ligands (e.g. IRAK4) through a linker to form PROTAC molecules (e.g. PROTAC IRAK4 degrader-1). PROTAC IRAK4 degrader-1 caused <20%, >20-50%, and >50% IRAK4 protein degradation in OCI-LY-10 cells at concentrations of 0.01, 0.1, and 1 μM, respectively .
Target:
Research Areas:
Perfluorobutylsulfonyl fluoride is a four-carbon polyfluorinated sulfonyl fluoride. Perfluorobutylsulfonyl fluoride serves as an intermediate that can be used for the synthesis of other compounds .
Research Areas:
1-Methylpyrrolidine is a methylated pyrrolidine, and cation with thermal-origin negative nonlinear optical (self-defocusing) properties .
Cat. No.: HY-P11111
CAS No.: 1501983-51-2
Target:
Research Areas:
Cat. No.: HY-W019922
CAS No.: 7783-40-6
Cat. No.: HY-W587839
CAS No.: 919005-14-4
Target:
Research Areas:
4,8-Dioxa-3H-perfluorononanoic acid is an ether-substituted polyfluoroalkyl compound and also a ligand of human pregnane X receptor (hPXR), which binds to the ligand-binding domain of hPXR. 4,8-Dioxa-3H-perfluorononanoic acid targets Arg-410, Lys-210, Lys-226, Met-323 and His-327 residues. Its binding process relies on long-range electrostatic interactions, and no significant hydrogen bonds form with hPXR residues. 4,8-Dioxa-3H-perfluorononanoic acid is used as a substitute for PFOA in Germany. 4,8-Dioxa-3H-perfluorononanoic acid is detectable in environmental matrices such as river water near fluoride production plants, accumulates in organisms including grass, deer liver and locusts, and is present in plasma samples of populations in southern Germany .
Cat. No.: HY-W145436
CAS No.: 2222114-23-8
Research Areas:
Thalidomide-Piperazine 5-fluoride hydrochloride is a derivative of cereblon (CRBN) inhibitor Thalidomide (HY-14658), which can be used as ligands for E3 ubiquitin ligase (Ligands for E3 Ligase) for PROTACs Synthesis .
Cat. No.: HY-W075766
CAS No.: 10028-18-9
Synonyms: Nickel difluoride
Research Areas:
Thalidomide-piperazine hydrochloride is a synthetic E3 ligase ligand-linker conjugate, containing a cereblon ligand based on Thalidomide (HY-14658) and one linker. Thalidomide-piperazine hydrochloride can be used in studies related to PROTAC synthesis .
Target:
Research Areas:
Perfluorohexylsulfonyl fluoride (Perfluorohexanesulphonyl fluoride) is a perfluoroalkyl and polyfluoroalkyl substances, that is defined as persistant organic pollutant by 2022 Stockholm Convention. Perfluorohexylsulfonyl fluoride can be used for drug modification .
Cat. No.: HY-W460193
CAS No.: 2244520-92-9
Target:
Research Areas:
N-Me-Thalidomide 4-fluoride is a ligand for E3 ligase, used for the synthesis of Anti-inflammatory agent 70 (HY-157570) .
Cat. No.: HY-W093286
CAS No.: 15098-87-0
Cat. No.: HY-W014895
CAS No.: 80-40-0
Synonyms: Ethyl p-toluenesulfonate; Ethyl tosylate
Cat. No.: HY-164576
CAS No.: 1374994-81-6
Synonyms: NODA-Bz-SCN
Research Areas:
NCS-MP-NODA (NODA-Bz-SCN) is a NODA-derived bifunctional chelator. NCS-MP-NODA can conjugate with biomolecules including the RGD tripeptide, and is used for aluminum-[ 18F] fluoride-based positron emission tomography (PET) radiolabeling. NCS-MP-NODA can conjugate with the free lysine amino group of the PD-L1-specific peptide DK221 to generate DK222, which can be radiolabeled with 18F to form [ 18F]DK222. NCS-MP-NODA can be used in studies related to triple-negative breast cancer, melanoma and colon cancer .
Cat. No.: HY-W763812
CAS No.: 911109-85-8
Target:
Research Areas:
(S)-Thalidomide 4-fluoride is a CRBN E3 ligase ligand that can be used for synthesis of DeDPP4 (HY-182336).
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
