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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
graft rejection
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "graft rejection" in MCE Product Catalog:
6
6 Publications Verification
Synonyms: Immunomycin; FR-900520; FK520
Category:
Microorganisms Neurological Disease Macrolide Antibiotics Antifungal Anti-inflammation/Immunoregulatory Antibiotics Disease Research Disease Research Fields Inflammation/Immunology
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1 Cited Publications
Cat. No.: HY-160214
CAS No.: 1567836-70-7
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Perforin-IN-2 (Compound 1) is the inhibitor for perforin that inhibits perforin-mediated cell lysis, thereby reducing graft rejection during allogeneic bone marrow/stem cell transplantation .
Cat. No.: HY-P990083
CAS No.: 2628092-47-5
Synonyms: AT-1501
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Cat. No.: HY-P99152
CAS No.: 140608-64-6
Synonyms: Muromanab-CD3
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Cat. No.: HY-P1973
CAS No.: 63775-95-1
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Cat. No.: HY-32340
CAS No.: 131875-08-6
Synonyms: KH1060
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Lexacalcitol (KH1060), a vitamin D analog, is a potent regulator of cell growth and immune responses. Lexacalcitol can be used for the research of graft rejection, psoriasis, cancer and auto-immune diseases .
Cat. No.: HY-13557R
CAS No.: 104987-12-4
Synonyms: Immunomycin (Standard); FR-900520 (Standard); FK520 (Standard)
Category:
Microorganisms Macrolide Antibiotics Antifungal Anti-inflammation/Immunoregulatory Antibiotics Disease Research
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Cat. No.: HY-P991543
CAS No.: 339181-10-1
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BTI-322 is a human IgG1κ antibody directed against the CD2 antigen on T cells and NK cells. BTI-322 can block primary and memory alloantigen proliferative responses in vitro. BTI-322 recognizes over 90% of E-rosette-forming peripheral blood lymphocytes and T-cell leukemias. BTI-322 has immunosuppressive activity. BTI-322 effectively inhibits T cell responses in vitro to allogeneic cells. BTI-322 can be used as a T-cell deplting agent. BTI-322 can be studied in research for renal allograft rejection and steroid-refractory acute graft-versus-host disease .
Cat. No.: HY-119681
CAS No.: 79889-39-7
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YM 11124 is an orally active selective immunosuppressive agent. YM 11124 can inhibit cell-mediated immune responses (type IV allergic reactions, such as delayed-type hypersensitivity and allogenic skin graft rejection) and type III allergic reactions (such as passive Arthus reaction). YM 11124 has no effect on type I, type II allergic reactions or acute inflammation. YM 11124 can be used in research related to organ transplantation and immune hypersensitivity .
Cat. No.: HY-117638
CAS No.: 128312-71-0
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CB 966 a Vitamin D3 (HY-15398) analogue, is an immunosuppressant. CB 966 delays rejection of allogeneic skin grafts in mice. CB 966 moderately increases serum calcium levels. CB 966 can be used for the research of allogeneic skin graft rejection .
Cat. No.: HY-184788
CAS No.: 42571-07-3
Synonyms: SANA
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2-Hydroxy-5-(2-nitrovinyl) benzoic acid (SANA) is an orally active pleiotropic anti-inflammatory metabolic modulator. 2-Hydroxy-5-(2-nitrovinyl) benzoic acid inhibits NF-κB, activates Nrf2/Keap1 and AMPK, suppresses inflammasome activity, induces thermogenesis, reverses insulin resistance and alleviates skin graft rejection. 2-Hydroxy-5-(2-nitrovinyl) benzoic acid can be used in research related to obesity, glucose intolerance, skin graft rejection and insulin resistance .
Cat. No.: HY-P990083A
CAS No.: 2628092-47-5
Synonyms: AT-1501 (powder)
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Cat. No.: HY-165526
CAS No.: 362508-67-6
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S101 is an inhibitor of SLP-76 and AhR. By inhibiting SLP-76 phosphorylation, S101 blocks the TCR signaling pathway and prevents AhR nuclear translocation, thereby selectively suppressing the proliferation of activated T cells, inducing their apoptosis, and reducing TNF-α levels. S101 can be used in studies of graft rejection, psoriasis, and superantigen-induced toxic shock .
Cat. No.: HY-W989139
CAS No.: 178970-88-2
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Perforin-IN-3 is a specific perforin inhibitor that blocks perforin-mediated lytic pore formation and subsequent cell lysis. Perforin-IN-3 potently inhibits the killing effect of NK cells on target cells such as leukemia cells, without interfering with FasL- or TRAIL-mediated cell death pathways. Perforin-IN-3 has no effect on pneumolysin and can be used to study autoimmune diseases, allograft rejection, graft-versus-host disease, and familial hemophagocytic lymphohistiocytosis .
Cat. No.: HY-183074
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RO8323 is an orally active, selective CDK8/CDK19 inhibitor, with an IC50 of 2 nM against CDK8 and 3 nM against CDK19. RO8323 promotes regulatory T cell differentiation, inhibits effector T cell generation, reverses the Teff/Treg ratio, upregulates IL-10 production in myeloid cells, and suppresses the production of TNF-α, IL-6 and IL-12. RO8323 enhances immune reconstitution and prolongs cardiac allograft survival in a dose-dependent manner. RO8323 can be used in the research of chronic graft-versus-host disease, cardiac allograft rejection, acute graft-versus-host disease and experimental autoimmune encephalomyelitis .
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(2-Fluorophenyl) diphenylmethanol is a IKCa1 channel blocker with a Kd value of 700 nM. (2-Fluorophenyl) diphenylmethanol is used in the research of graft-versus-host disease and inflammatory diseases .
Cat. No.: HY-P992014
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Anti-Human/Mouse/Monkey CXCR3 Antibody (9C5) is an antibody targeting CXCR3, which specifically binds to an epitope within amino acid residues 23 to 44 of human CXCR3 .
Cat. No.: HY-P12125
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Cat. No.: HY-P992063
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Anti-Mouse CD8α Antibody (YTS 105.18) is a non-depleting rat IgG2a monoclonal antibody that binds to CD8α on mouse CD8 + T cells. When used in combination with a non-depleting anti-CD4 antibody, Anti-Mouse CD8α Antibody (YTS 105.18) does not deplete CD8 + T cells, but instead promotes the induction of peripheral tolerance in this cell subset. Anti-Mouse CD8α Antibody (YTS 105.18) can be used for research on graft rejection. The recommended isotype control is Mouse IgG2a kappa, Isotype Control (HY-P99978) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
