Anti-Human/Mouse/Monkey CXCR3 Antibody (9C5)
Based on 1 Customer Validation
Anti-Human/Mouse/Monkey CXCR3 Antibody (9C5) is an antibody targeting CXCR3, which specifically binds to an epitope within amino acid residues 23 to 44 of human CXCR3.
For research use only. We do not sell to patients.
- Purity : 99.33%
- Molecular Weight:146.54 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Mouse IgG2a kappa
Recommend Isotype Controls
Species Reactivity
Human/Mouse/Monkey
In Vitro
Anti-Human/Mouse/Monkey CXCR3 Antibody (9C5) specifically binds to mouse, human, and marmoset CXCR3 expressed on transfected cells and primary immune cells[1].
Anti-Human/Mouse/Monkey CXCR3 Antibody (9C5) binds to an epitope within amino acid residues 23 to 44 of human CXCR3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
Anti-Human/Mouse/Monkey CXCR3 Antibody (9C5) (0.5-10 mg/kg; i.v.; single dose) dose-dependently depletes CXCR3-expressing CD4+, CD8+, and B cells in mice, with complete depletion at doses ≥ 2 mg/kg lasting for more than 3 weeks[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (streptozotocin-induced diabetic, pancreatic islet allograft recipients)[1]
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Dosage:5 mg/kg (single pre-transplant dose); 2 mg/kg (weekly post-transplant doses); 2 mg/kg (weekly post-transplant + daily rapamycin for 7 days)
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Administration:i.v.; single dose (4-5 hours pre-transplant); i.v.; weekly (days 0,7,14,21 post-transplant); i.v.; weekly (days 0,7,14,21 post-transplant) + p.o.; daily (rapamycin, 7 days post-transplant)
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Result:Increased mean survival time (MST) of islet grafts from 17 to 33 days.
Increased MST of islet grafts to 35 days, with 2 out of 7 mice showing graft survival >100 days.
Resulted in 50% graft survival at 60 days.
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Animal Model:C57BL/6[1]
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Dosage:0.5-10 mg/kg
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Administration:i.v.; single dose
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Result:Almost completely depleted CD4+/CXCR3+, CD8+/CXCR3+, and B220+/CXCR3+ cells within 4 days at doses of 2 mg/kg and higher; 0.5 mg/kg had no depletion effect.
Maintained depletion of CXCR3+ cells for more than 3 weeks after a single 5 mg/kg dose.
Reduced effector CD4+ T-cells (CD44high/CD62Llow) and memory CD4+ T-cells (CD44high/CD62Lhigh) from 27.1% to 13.5% relative to isotype control-treated mice after a single 5 mg/kg dose.
Gene ID
Accession
P49682-1
Target
CXCR3/GPR9/CD183
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized CXCR3 Protein, Human (HY-P700539A) can bind Anti-Human/Mouse/Monkey CXCR3 Antibody (9C5), The ED50 for this effect is 24.5 ng/mL.
Chemical Information
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Appearance Liquid
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Molecular Weight 146.54 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Human/Mouse/Monkey CXCR3 Antibody (9C5)]
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Human/Mouse/Monkey CXCR3 Antibody (9C5) Related Classifications
HY-P992014 Related Classifications
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