48 Results for "

heme oxygenase 1

" in MedChemExpress (MCE) Product Catalog:
Products (48)

48 Results for "heme oxygenase 1" in MCE Product Catalog:

71
71 Publications Verification
Cat. No.: HY-101193
CAS No.: 15442-64-5
Purity:  99.87%
Synonyms: Zn(II)-protoporphyrin IX; ZnPP; Zinc Protoporphyrin-9
Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor. Zinc Protoporphyrin regulates expression of HO-1 at the transcriptional level. The effect of Zinc Protoporphyrin on HO-1 expression is controversial.  It was shown to induce HO-1 expression in some cells, but suppress it in others. Zinc Protoporphyrin is used as a screening marker of iron deficiency in vivo. Zinc Protoporphyrin has anti-cancer activity .
loading...
    loading...
24
24 Cited Publications
Cat. No.: HY-101194
CAS No.: 14325-05-4
Purity:  96.2%
Synonyms: Tin-protoporphyrin IX; Sn-Protoporphyrin; SnPPIX
Research Areas:  

Cancer

Tin protoporphyrin IX dichloride (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin protoporphyrin IX dichloride sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model .
loading...
    loading...
17
17 Cited Publications
Cat. No.: HY-N0643
CAS No.: 5957-80-2
Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC50 of ~5.5 μM . Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) .
loading...
    loading...
12
12 Cited Publications
Cat. No.: HY-111798A
CAS No.: 1092851-70-1
Purity:  99.03%
Research Areas:  

Cancer

Heme Oxygenase-1-IN-1 (Compound 2) hydrochloride is a heme oxygenase 1 (HO-1) inhibitor with an IC50 of 0.25 μM .
loading...
    loading...
12
12 Cited Publications
Cat. No.: HY-111798
CAS No.: 1093058-52-6
Purity:  99.11%
Research Areas:  

Cancer

Heme Oxygenase-1-IN-1 (compound 2) is a potent heme oxygenase 1 (HO-1) inhibitor, with an IC50 of 0.25 μM. Heme Oxygenase-1-IN-1 can be used for cancer research .
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-N0061
CAS No.: 4046-02-0
Ethyl ferulate, a naturally lipophilic derivative of ferulic acid originally derived from Rhizoma Chuanxiong, induces heme oxygenase-1 (HO-1) and protects rat neurons against oxidative stress . Ethyl ferulate also protects neurons against amyloid β peptide (1-42)-induced oxidative stress and neurotoxicity .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-P70276
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HMOX1; heme oxygenase; heme oxygenase 1; HMOX1D; HO-1; HSP32; BK286B10; HO1; heme oxygenase (Decycling) 1; HO; Heat Shock Protein, 32-KD
Species:  
Human
Source:  
E. coli
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-B2184
CAS No.: 64506-49-6
Target:  

Autophagy Bacterial

Research Areas:  

Infection Inflammation/Immunology

Sofalcone, a gastric antiulcer agent, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-N2535
CAS No.: 458-36-6
Synonyms: 4-Hydroxy-3-methoxycinnamaldehyde
Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P80499
Synonyms: HO, HO1, HMOX1, heme oxygenase 1, HO-1

Host:  

Rabbit

Application:  

WB, IHC-P, IP, FC, IF-Tissue

Reactivity:  

Human

loading...
    loading...
Cat. No.: HY-134608
CAS No.: 14325-03-2
Synonyms: Co-PPIX
Research Areas:  

Infection

Cobalt protoporphyrin IX (Co-PPIX) is a potent and specific heme oxygenase-1 (HO-1) inducer. Cobalt protoporphyrin IX exhibits broad-spectrum antiviral activities against Influenza A virus (IAV) .
loading...
    loading...
Cat. No.: HY-W013812
CAS No.: 544-35-4
Synonyms: Linoleic Acid ethyl ester; Mandenol
Ethyl linoleate (Linoleic Acid ethyl ester) is an orally active unsaturated fatty acid. Ethyl linoleate inhibits the Akt/GSK3β/β-catenin signaling pathway and the activation of NF-κB. Ethyl linoleate induces heme oxygenase-1 and inhibits tyrosinase. Ethyl linoleate has whitening and anti-inflammatory effects. Ethyl linoleate promotes compound absorption. Ethyl linoleate has a significant influence on atherosclerosis. Ethyl linoleate is used in the research of inflammatory diseases. Ethyl linoleate can be used in cosmetics
loading...
    loading...
Cat. No.: HY-B1817A
CAS No.: 557-34-6
Synonyms: Zinc(II) acetate, 99.99% trace metals basis
Zinc (Zinc (II)) acetate, 99.99% trace metals basis is a heme oxygenase 1 (HO-1) activator and apoptosis inducer with cytotoxic and anticancer activities. Zinc acetate, 99.99% trace metals basis enhances HO-1 expression, alters the microRNA profile, and increases the level of caspase-cleaved cytokeratin 18. Zinc acetate, 99.99% trace metals basis also regulates the expression of Cdk2/cyclin E and interferes with cell cycle progression. Zinc acetate, 99.99% trace metals basis effectively inhibits cancer cell proliferation and induces their rapid death, with no significant cytotoxicity to non-tumor tissues. Zinc acetate, 99.99% trace metals basis has been widely used in studies related to hepatocellular carcinoma, prostate cancer, and other conditions .
loading...
    loading...
Cat. No.: HY-162857
CAS No.: 1043712-39-5
Target:  

Heme Oxygenase (HO)

Research Areas:  

Neurological Disease Cancer

Heme Oxygenase-1-IN-3 (compound 4) is a highly selective heme oxygenase-1 (HO-1) inhibitor (Kd=141 nM) that can be used in the research of cancer and neurodegenerative diseases .
loading...
    loading...
Cat. No.: HY-34748
CAS No.: 625-33-2
Synonyms: Ethylideneacetone; (3Z)-pent-3-en-2-one
3-Penten-2-one (Ethylideneacetone) inhibits nitric oxide production and inducible nitric oxide synthase expression via heme oxygenase-1 induction in RAW264.7 macrophages activated with Lipopolysaccharides (HY-D1056) (LPS) .
loading...
    loading...
Cat. No.: HY-124815
CAS No.: 895470-67-4
Purity:  99.69%
Research Areas:  

Others

CP-312 is a potent Heme Oxygenase-1 (HO-1) inducer. CP-312 protects hiPSC-CM viability by targeting the antioxidant response network through induction of HMOX1 expression. CP-312 protects human iPSC-derived cardiomyocytes from oxidative stress .
loading...
    loading...
Cat. No.: HY-147517
CAS No.: 2769963-24-6
Purity:  98.52%
Target:  

Keap1-Nrf2

Keap1-Nrf2-IN-9 (Compound 11) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) inhibitor with an IC50 of 0.575 μM. Keap1-Nrf2-IN-9 increases the expression of Nrf2 target genes including heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and glutamate-cysteine ligase catalytic (Gclc) and modulatory (Gclm) subunits. Keap1-Nrf2-IN-9 shows no cytotoxic activity in ARPE19 cells .
loading...
    loading...
Cat. No.: HY-115713
CAS No.: 2839158-50-6
Research Areas:  

Cancer

Heme Oxygenase-1-IN-2 is a novel heme oxygenase-1 inhibitor (IC50 = 0.95 μM) with potent in vitro antiproliferative activity.
loading...
    loading...
Cat. No.: HY-106359A
CAS No.: 501019-16-5
Purity:  98.55%
Synonyms: RDP-58 acetate
Research Areas:  

Cancer

Delmitide (RDP58) acetate is an orally active d-isomer decapeptide with potent anti-inflammatory activity. Delmitide acetate inhibits production of TNF-α, IFN-γ, and interleukin (IL)-12, and up-regulates heme oxygenase 1 activity. Delmitide acetate can be used for the research of ulcerative colitis .
loading...
    loading...
Cat. No.: HY-101193R
CAS No.: 15442-64-5
Synonyms: Zn(II)-protoporphyrin IX (Standard); ZnPP (Standard); Zinc Protoporphyrin-9 (Standard)
Zinc Protoporphyrin (Standard) is the analytical standard of Zinc Protoporphyrin. This product is intended for research and analytical applications. Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2 . Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration . Zinc Protoporphyrin has anti-cancer activity .
loading...
    loading...