Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
hypocretin
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "hypocretin" in MCE Product Catalog:
12
12 Publications Verification
Synonyms: hypocretin-1 (human, rat, mouse)
Target:
Research Areas:
12
12 Publications Verification
Cat. No.: HY-106224B
Purity: 99.93%
Synonyms: hypocretin-1 (human, rat, mouse) acetate
Target:
Research Areas:
12
12 Publications Verification
Cat. No.: HY-106224A
Purity: 97.13%
Synonyms: hypocretin-1 (human, rat, mouse) TFA
Target:
Research Areas:
9
Research Areas:
Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca 2+ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis .
9
9 Cited Publications
Synonyms: ACT 078573 hydrochloride
Research Areas:
Almorexant (ACT 078573) hydrochloride is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant hydrochloride reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant hydrochloride totally blocked the intracellular Ca 2+ signal pathway. Almorexant hydrochloride stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis .
3
3 Cited Publications
Target:
Research Areas:
SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd=5.03 nM), exhibits 100-fold selectivity for OX1 over OX2 receptors with IC50 values of 3.76 nM and 531 nM, respectively .
1
1 Cited Publications
Target:
Research Areas:
TCS 1102 is a potent, dual orexin receptor antagonist, with Ki values of 0.2 nM and 3 nM for OX2 and OX1 receptors, respectively. TCS 1102 demonstrates excellent blood-brain barrier penetrability and moderate bioavailability in rats .
Category:
Human Gut Microbiota Metabolites Natural Products Neurological Disease Endogenous metabolite Disease Research Fields
Target:
Cat. No.: HY-106224AS1
Synonyms: hypocretin-1-13C18,15N3 (human, rat, mouse) TFA
Research Areas:
Cat. No.: HY-P3867
CAS No.: 1129545-33-0
Research Areas:
Cat. No.: HY-128850R
CAS No.: 3615-17-6
Synonyms: N-Acetylmannosamine (Standard); ManNAc (Standard)
Cat. No.: HY-10805R
CAS No.: 871224-64-5
Synonyms: ACT 078573 (Standard)
Research Areas:
Almorexant (Standard) is the analytical standard of Almorexant. This product is intended for research and analytical applications. Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca2+ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis .
Cat. No.: HY-106224AS
Synonyms: hypocretin-1-13C6,15N (human, rat, mouse) TFA
Research Areas:
Cat. No.: HY-P703944
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HCRTR1; Orexin/hypocretin receptor type 1; hypocretin receptor type 1; Orexin receptor type 1; Ox-1-R; Ox1-R; Ox1R
Cat. No.: HY-10900R
CAS No.: 916141-36-1
Research Areas:
TCS 1102 (Standard) is the analytical standard of TCS 1102 (HY-10900). This product is intended for research and analytical applications. TCS 1102 is a potent, dual orexin receptor antagonist, with Ki values of 0.2 nM and 3 nM for OX2 and OX1 receptors, respectively. TCS 1102 demonstrates excellent blood-brain barrier penetrability and moderate bioavailability in rats .
Cat. No.: HY-10805AR
CAS No.: 913358-93-7
Synonyms: ACT 078573 hydrochloride (Standard)
Research Areas:
Almorexant hydrochloride (Standard) is the analytical standard of Almorexant (hydrochloride) (HY-10805A). This product is intended for research and analytical applications. Almorexant (ACT 078573) hydrochloride is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant hydrochloride reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant hydrochloride totally blocked the intracellular Ca2+ signal pathway. Almorexant hydrochloride stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis .
Cat. No.: HY-10898R
CAS No.: 483313-22-0
Research Areas:
SB-674042 (Standard) is the analytical standard of SB-674042 (HY-10898). This product is intended for research and analytical applications. SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd=5.03 nM), exhibits 100-fold selectivity for OX1 over OX2 receptors with IC50 values of 3.76 nM and 531 nM, respectively .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
