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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
32 Results for "
hypoxia-inducible factor-1α
" in MedChemExpress (MCE) Product Catalog:
Products (32)
32 Results for "hypoxia-inducible factor-1α" in MCE Product Catalog:
115
115 Publications Verification
Target:
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
PX-478 is a multifunctional HIF-1α inhibitor with properties including radiosensitization, autophagy activation, and lipid accumulation inhibition. PX-478 also blocks hypoxia-induced VEGF production and regulates β-cell phenotypes under hypoxic conditions. PX-478 induces cell cycle arrest and DNA damage, restores autophagic function, reduces foam cell formation, and maintains glucose homeostasis. PX-478 is widely used in research on related diseases such as human tumors (e.g., prostate cancer), type 2 diabetes, and atherosclerosis .
73
73 Cited Publications
Synonyms: Campathecin; (S)-(+)-Camptothecin; CPT
19
9
9 Cited Publications
Cat. No.: HY-P80704
Synonyms: HIF1A; BHLHE78; MOP1; PASD8; hypoxia-inducible factor 1-alpha; HIF-1-alpha; HIF1-alpha; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; Class E basic helix-loop-helix protein 78; bHLHe78; Member of PAS protein 1; PAS doma
4
4 Cited Publications
Target:
Research Areas:
HIF-1α-IN-2 is an effective HIF-1α inhibitor with anticancer potencies (IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2 suppresses HIF-1α expression by blocking transcription and protein translation .
4
4 Cited Publications
Cat. No.: HY-115903A
Purity: 99.16%
Target:
Research Areas:
HIF-1α-IN-2 hydrochloride is an effective HIF-1α inhibitor with anticancer potencies (IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2 hydrochloride suppresses HIF-1α expression by blocking transcription and protein translation .
4
4 Cited Publications
Cat. No.: HY-P74888
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HIF1A; Basic-Helix-Loop-Helix-PAS Protein MOP1; hypoxia inducible factor 1 Subunit Alpha; HIF-1-Alpha; BHLHe78; hypoxia inducible factor 1 Alpha Subunit; PASD8; hypoxia-inducible factor1alpha; MOP1; Member Of PAS Superfamily 1; Class E Basic Helix-Loop-Helix Protein 78; ARNT Interacting Protein; hypoxia-inducible factor 1-Alpha; ARNT-Interacting Protein; PAS Domain-Containing Protein 8; HIF1-ALPHA; Member Of PAS Protein 1; HIF1-Alpha; HIF-1alpha; BHLHE78; HIF1; HIF-1A; hypoxia inducible factor 1, Alpha Subunit (Basic Helix-Loop-Helix Transcription factor)
Species:
Human
Source:
E. coli
1
Chetomin, an active component of Chaetomium globosum, is a heat shock protein 90/hypoxia-inducible factor 1 alpha (Hsp90/HIF1α) pathway inhibitor. Chetomin is a potent, nontoxic non-small cell lung cancer cancer stem cells (NSCLC CSC)-targeting molecule .
1
1 Cited Publications
Cat. No.: HY-P2324
CAS No.: 11029-61-1
Cat. No.: HY-112253
CAS No.: 15978-08-2
Target:
Target:
Research Areas:
FM19G11 is a hypoxia-inducible factor-1-alpha (HIF-1α) inhibitor, and it inhibits hypoxia-induced luciferase activity with an IC50 of 80 nM in HeLa cells. FM19G11 modulates other signaling pathways, including mTOR and PI3K/Akt/eNOS, when the HIF-1α pathway is inactivated under normoxic conditions .
Cat. No.: HY-168641
Research Areas:
PROTAC HIF-1α degrader-1 is a potent HIF-1α PROTAC degrader. PROTAC HIF-1α degrader-1 induces ubiquitination and degradation of HIF-1α protein under hypoxic conditions. PROTAC HIF-1α degrader-1 induces Apoptosis. PROTAC HIF-1α degrader-1 can be used for the research of breast cancer and hepatocellular carcinoma .
Target:
Cat. No.: HY-15893G
CAS No.: 89464-63-1
Synonyms: Dimethyloxallyl Glycine (GMP)
Cat. No.: HY-16560S
CAS No.: 1329616-37-6
Synonyms: Campathecin-d5; (S)-(+)-Camptothecin-d5; CPT-d5
Cat. No.: HY-179341
CAS No.: 3104302-65-7
Target:
Research Areas:
CHNQD-03301 is an orally active hypoxia-inducible factor-1α (HIF-1α) inhibitor (IC50 = 10.97 nM). CHNQD-03301 promotes the proteasomal degradation of HIF-1α protein, leading to its significant suppression. CHNQD-03301 can reverse HIF accumulation-induced angiogenesis and mitigate the HIF-induced erythrocytosis phenotype in zebrafish models. CHNQD-03301 can be used for the study of colon cancer .
Synonyms: Campathecin (Standard); (S)-(+)-Camptothecin (Standard); CPT (Standard)
Cat. No.: HY-N10330
CAS No.: 959662-26-1
Target:
Cat. No.: HY-B0239S2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
