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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
insertion into membranes
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "insertion into membranes" in MCE Product Catalog:
1
Cat. No.: HY-P4116
CAS No.: 2293160-09-3
Synonyms: pHLIP
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GL0388 is a Bax activator that results in Bax insertion into mitochondrial membrane. GL0388 shows antiproliferative activities against various cancer cells, with IC50s of 0.299-1.57 μM. GL0388 activates Bax and induce Bax-mediated apoptosis. GL0388 suppresses breast cancer xenograft tumor growth in vivo .
Cat. No.: HY-P4116A
Synonyms: pHLIP TFA
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Cat. No.: HY-P1753
CAS No.: 943790-62-3
Cat. No.: HY-119682
CAS No.: 18304-79-5
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Bax agonist 1 (compound SMBA2) is a Bax agonist (Ki=57.2 nM). Bax agonist 1 induces Bax conformational changes by blocking S184 phosphorylation, promoting Bax insertion into the mitochondrial membrane and forming Bax oligomers, which induce cytochrome c release and apoptosis in malignant cancer cells expressing Bax. Bax agonist 1 can be used in lung cancer research .
Cat. No.: HY-185564
CAS No.: 118680-70-9
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F6OM, a nonionic fluorinated octyl maltoside derivative, is a surfactant. F6OM readily interacts with and completely solubilizes phospholipid vesicles via a heterogeneous solubilization mechanism, without compromising membrane order at subsolubilizing concentrations. F6OM promotes bilayer insertion of an integral membrane enzyme in the absence of micelles to support functional refolding of integral membrane proteins. F6OM can be used for membrane-protein applications .
Cat. No.: HY-187529
CAS No.: 1144496-95-6
PUN-96956 is an inhibitor of the β-barrel assembly machine (BAM) complex. By inhibiting the folding of β-barrel outer membrane proteins (OMPs) and their insertion into the outer membrane, PUN-96956 disrupts outer membrane integrity and induces the cell envelope stress response. PUN-96956 can be used in studies of bacterial infections caused by ESKAPE pathogens, uropathogenic Escherichia coli, and Gram-positive bacteria .
Cat. No.: HY-D3422
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AM1-44 is a fixable, cationic styryl fluorescent dye primarily used for labeling nerve terminals and synaptic vesicles. In its free state, AM1-44 exhibits extremely weak fluorescence; upon insertion into the cell membrane, its fluorescence increases, and after endocytosis into vesicles and release via exocytosis, its fluorescence decreases. Therefore, it can be used to study synaptic activity, synaptic vesicle cycling, neurotransmitter release, and synaptic plasticity (Ex/Em = 480/598-600 nm in membrane environment) .
Cat. No.: HY-187415A
Synonyms: DOPE-PEG2000-Mal-Cys-TAASGVRSMH
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DOPE-PEG2000-TAASGVRSMH is an amphiphilic lipid-PEG-peptide conjugate composed of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) , polyethylene glycol 2000 (PEG2000) , and the TAASGVRSMH peptide.
DOPE provides a hydrophobic phospholipid anchor for membrane insertion, PEG2000 forms a hydrophilic spacer that enhances circulation stability, and the TAASGVRSMH peptide serves as a tumor-vasculature-homing ligand identified by in vivo phage display.
This conjugate can be used to functionalize liposomes and lipid nanoparticles for targeted drug delivery to tumor vasculature.
DOPE provides a hydrophobic phospholipid anchor for membrane insertion, PEG2000 forms a hydrophilic spacer that enhances circulation stability, and the TAASGVRSMH peptide serves as a tumor-vasculature-homing ligand identified by in vivo phage display.
This conjugate can be used to functionalize liposomes and lipid nanoparticles for targeted drug delivery to tumor vasculature.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
