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Results for "

leukotriene synthesis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (1) Leukotriene Receptor (9) Apoptosis (3) Autophagy (2) COX (4) Drug Derivative (1) Drug Isomer (1) Endogenous Metabolite (3) ERK (2) FLAP (2) HIF/HIF Prolyl-Hydroxylase (2) Isotope-Labeled Compounds (1) Keap1-Nrf2 (2) Lipoxygenase (13) NF-κB (2) Orthopoxvirus (1) p38 MAPK (2) PI3K (2) Platelet-activating Factor Receptor (PAFR) (1) Potassium Channel (1) PROTAC Linkers (3) Reference Standards (1) Xanthine Oxidase (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (3) Infection (2) Inflammation/Immunology (17) Metabolic Disease (2) Neurological Disease (2)

By Targets:

DNA/RNA Synthesis (1)

Leukotriene Receptor (9)

Apoptosis (3)

Autophagy (2)

COX (4)

Drug Derivative (1)

Drug Isomer (1)

Endogenous Metabolite (3)

ERK (2)

FLAP (2)

HIF/HIF Prolyl-Hydroxylase (2)

Isotope-Labeled Compounds (1)

Keap1-Nrf2 (2)

Lipoxygenase (13)

NF-κB (2)

Orthopoxvirus (1)

p38 MAPK (2)

PI3K (2)

Platelet-activating Factor Receptor (PAFR) (1)

Potassium Channel (1)

PROTAC Linkers (3)

Reference Standards (1)

Xanthine Oxidase (1)

By Research Areas:

Cancer (6)

Cardiovascular Disease (3)

Infection (2)

Inflammation/Immunology (17)

Metabolic Disease (2)

Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Leukotriene Receptor DNA/RNA Synthesis

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-107608

Leukotriene B4 5 Publications Verification LTB4; 5(S),12(R)-DiHETE	Endogenous Metabolite PROTAC Linkers Leukotriene Receptor	Inflammation/Immunology Cancer
Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-124108

Eicosatetraynoic acid ETYA	COX Lipoxygenase Orthopoxvirus Potassium Channel DNA/RNA Synthesis Drug Derivative	Infection Neurological Disease Inflammation/Immunology Cancer
Eicosatetraynoic acid (ETYA) is a non-metabolizable analog of Arachidonic acid (HY-109590) and also an inhibitor of the lipoxygenase (LOX)/cyclooxygenase (COX) pathway (ID₅₀= 8 μM and 4 μM). Eicosatetraynoic acid acts as a suicide substrate to inhibit the production of inflammatory mediators such as leukotrienes and prostaglandins. Eicosatetraynoic acid acts directly on cell membranes and membrane proteins to exert a wide range of effects, including blocking potassium channels, increasing cell membrane fluidity, elevating intracellular calcium levels, inhibiting DNA synthesis in tumor cells, inducing differentiation of certain cells, and specifically inhibiting the assembly and replication of orthopoxviruses. Eicosatetraynoic acid alleviates acute lung injury induced by chemicals such as phosgene .

HY-N0493

Pectolinarigenin 2 Publications Verification	COX Lipoxygenase NF-κB p38 MAPK ERK HIF/HIF Prolyl-Hydroxylase Keap1-Nrf2 PI3K Apoptosis Autophagy	Neurological Disease Inflammation/Immunology Cancer
Pectolinarigenin is an orally active dual inhibitor of COX-2/5-LOX with anti-inflammatory, antioxidant, antitumor and neuroprotective activities. Pectolinarigenin exerts neuroprotective and anti-inflammatory effects on astrocyte inflammation via the NFκB and MAPK pathways. Pectolinarigenin inhibits LPS-induced phosphorylation of ERK1/2, N-FκB and p38MAPK, directly inhibits the enzymatic activity or binding of COX-2, 5-LOX and HIF-1α, and reduces the level of XIAP. Pectolinarigenin modifies Keap1 to promote nuclear accumulation of Nrf2, induces ARE-mediated antioxidant enzyme expression, and possesses direct free radical scavenging activity. Pectolinarigenin reduces the release of NO, proinflammatory mediators and leukotrienes, and increases the level of IL-10. Pectolinarigenin induces G₂/M cell cycle arrest, apoptosis (Apoptosis) and autophagy (Autophagy) via the PI3K/AKT/mTOR signaling pathway. Pectolinarigenin reduces renal crystal deposition and inhibits melanin synthesis. Pectolinarigenin inhibits inflammation and alleviates allergy in mouse models of inflammation. Pectolinarigenin alleviates renal injury, inflammation and oxidative stress in mice by inhibiting HIF-1α activity. Pectolinarigenin can be used for the research of neurodegenerative diseases, inflammatory/allergic diseases, calcium oxalate nephrocalcinosis, gastric cancer, melasma, post-inflammatory diseases and chloasma .

HY-W073687

2,4,6-Triiodophenol	Apoptosis	Others
2,4,6-Triiodophenol is an orally active and potent leukotriene B₄ (LTB₄) *synthesis* inhibitor. 2,4,6-Triiodophenol can induce mouse blastocysts apoptosis .

HY-113120

Stearidonic acid 6Z,9Z,12Z,15Z-Octadecatetraenoic acid	Lipoxygenase	Metabolic Disease
Stearidonic acid (6Z,9Z,12Z,15Z-Octadecatetraenoic acid) is an orally active polyunsaturated fatty acid found in blackcurrant seed oil. Stearidonic acid can inhibit 5-lipoxygenase and reduce leukotriene and 5-HETE synthesis. Stearidonic acid can increase the content of eicosapentaenoic acid (EPA) in red blood cells. Stearidonic acid can be used for the research of metabolic disease .

HY-14460

AM679	FLAP	Inflammation/Immunology
AM679 is a potent, selective 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC₅₀ of 2 nM in a human FLAP membrane binding assay. AM679 markedly reduces the respiratory syncytial virus-driven ocular pathology as well as the synthesis of cysteinyl leukotrienes (CysLTs) in the eye .

HY-107608S

Leukotriene B4-d4 LTB4-d₄; 5(S),12(R)-DiHETE-d₄	PROTAC Linkers Endogenous Metabolite Leukotriene Receptor	Inflammation/Immunology Cancer
Leukotriene B4-d₄ is the deuterium labeled Leukotriene B4. Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-120571

L-674573	Leukotriene Receptor Lipoxygenase	Cancer
L-674573 is a quinoline **leukotriene synthesis** inhibitor, inhibiting Calcimycin (HY-N6687)- and N-Formyl-Met-Leu-Phe (HY-P0224)-induced leukotriene production with IC₅₀s of 100 nM and 50 nM, respectively. L-674573 selectively inhibits Calcimycin- and N-Formyl-Met-Leu-Phe-induced 5-lipoxygenase translocation .

HY-14165

Veliflapon BAY X 1005; DG-031	FLAP Leukotriene Receptor	Cardiovascular Disease Inflammation/Immunology
Veliflapon (BAY X 1005; DG-031) is an orally active and selective 5-lipoxygenase activating protein (FLAP) inhibitor . Veliflapon inhibits the synthesis of the leukotrienes B4 and C4 .

HY-169138

ZD 2138	Lipoxygenase	Inflammation/Immunology
ZD 2138 is a selective 5-lipoxygenase (5-lipoxygenase) inhibitor with an IC₅₀ of 20-50 nM. ZD 2138 inhibits cytokine-induced rolling and adhesion of leukocytes on bovine aortic endothelial cells. ZD 2138 is applicable to research related to inflammatory diseases such as acute asthma .

HY-151173

XO/COX/LOX-IN-1	Xanthine Oxidase Lipoxygenase COX	Metabolic Disease Inflammation/Immunology
XO/COX/LOX-IN-1 is a XO/COX/LOX inhibitor with an IC₅₀ of 3.2 μM against rat XO, 10.83 μM against 5-LOX, 12.67 μM against COX-1, and 8.31 μM against COX-2. XO/COX/LOX-IN-1 binds to the active sites of XO, 5-LOX, COX-1 and COX-2, thereby blocking enzyme activities associated with uric acid, leukotriene, prostaglandin synthesis and inflammatory pathways. XO/COX/LOX-IN-1 can be used in the research of hyperuricemia and inflammation .

HY-118019

Scandenolide	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
Scandenolide is a sesquiterpene lactone that can be found in Philippines medicinal plant Mikania cordata. Scandenolide inhibits leukotriene and platelet activating factor synthesis in leukocytes .

HY-107608S1

Leukotriene B4-d5 LTB4-d₅	Isotope-Labeled Compounds Endogenous Metabolite PROTAC Linkers Leukotriene Receptor	Inflammation/Immunology Cancer
Leukotriene B4-d₅ (LTB4-d₅) is deuterium labeled Leukotriene B4. Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-120760

L-691831	Lipoxygenase	Others
L-691831 is a ligand for 5-lipoxygenase activating protein binding assays that has utility as a tool for studying 5-lipoxygenase activating protein (FLAP) related activities. L-691831 can be used to measure the affinity of FLAP on the leukocyte membrane for leukotriene synthesis inhibitors, with binding being correlated with inhibition of leukotriene synthesis.

HY-U00299

LTB4-IN-1	Leukotriene Receptor	Inflammation/Immunology
LTB4-IN-1 (Compound 6) is a **leukotriene synthesis (LTB4) inhibitor with an IC₅₀** of 70 nM .

HY-168015

5-Oxo leukotriene B4	Drug Isomer	Infection
5-Oxo leukotriene B4 is a byproduct in the synthesis of 12-oxo LTB4 (HY-130497) with antiviral activity. 5-Oxo leukotriene B4 is promising for research of viral infections caused by human and animal enveloped RNA viruses .

HY-106064A

Piriprost potassium U 60257B	Leukotriene Receptor	Inflammation/Immunology
Piriprost (U-60,257B) potassium is an inhibitor of *leukotriene* synthesis. Piriprost potassium inhibits the release of both leukotriene and histamine with an IC₅₀ of 0.11 μM from isolated porcine lung cells. Piriprost potassium increases alkaline phosphatase (ALP) activity in cultured endometrial stromal cells .

HY-113628

ABT-080 VML-530	Leukotriene Receptor	Inflammation/Immunology
ABT-080 is an orally active inhibitor of leukotriene biosynthesis. ABT-080 simultaneously blocks the leukotriene pathways leading to the synthesis of LTB₄ and LTC₄, but does not inhibit PGH2 biosynthesis. ABT-080 can block bronchoconstriction and be used in the research of asthma and related inflammations

HY-112553

HZ52	Lipoxygenase	Inflammation/Immunology
HZ52 is a potent, reversible 5-lipoxygenase inhibitor, blocking leukotriene synthesis with an IC₅₀ of 0.7 μM in intact human polymorphonuclear leukocytes .

HY-118848

A63162	Lipoxygenase Leukotriene Receptor	Inflammation/Immunology
A63162 is a specific 5-lipoxygenase (5-LOX) inhibitor. A63162 inhibits mitogen (PHA)-induced horse mononuclear cell (BMC) proliferation and inhibits Calcimycin (HY-N6687)-induced leukotriene LTB4 synthesis at the same concentration. A63162 can be used in the study of chronic obstructive pulmonary disease, arthritis and inflammatory bowel disease .

HY-103158

BW B70C	Lipoxygenase	Others
BW B70C is a potent, selective and orally activearachidonic acid 5-lipoxygenase inhibitor. BW B70C inhibits both acute and allergic bronchoconstriction and late-phase eosinophil accumulation subsequent to allergen inhalation in guinea-pigs. BW B70C prevents leukotriene C4 synthesis and reduces leucocyte migration to the airways lumen as well as albumin microvascular leakage. BW B70C has the potential for the research of anti-asthma agent .

HY-114796

tHGA	Lipoxygenase	Inflammation/Immunology
tHGA is a compound with anti-inflammatory activity and has the activity to inhibit soybean 15-LOX. tHGA showed significant inhibitory effects in experiments on human leukocytes, with an IC₅₀ value of 0.42 μM, which is close to the effect of commonly used standard NDGA. tHGA concentration-dependently inhibits the synthesis of 5-LOX products, especially the cysteine leukotriene LTC(4), with an IC₅₀ value of 1.80 μM. and showed no cytotoxicity. The anti-inflammatory effects of tHGA do not appear to be through redox or metal chelation mechanisms, as the compound was negative in these bioactivity tests. tHGA works through a dual LOX/COX inhibition mechanism and has higher selectivity for 5-LOX and COX-2, with an IC₅₀ value of 0.40 μM .

HY-N0493R

Pectolinarigenin (Standard)	Reference Standards COX Lipoxygenase NF-κB p38 MAPK ERK HIF/HIF Prolyl-Hydroxylase Keap1-Nrf2 PI3K Apoptosis Autophagy	Inflammation/Immunology
Pectolinarigenin (Standard) is the analytical standard of Pectolinarigenin. This product is intended for research and analytical applications. Pectolinarigenin is an orally active dual inhibitor of COX-2/5-LOX with anti-inflammatory, antioxidant, antitumor and neuroprotective activities. Pectolinarigenin exerts neuroprotective and anti-inflammatory effects on astrocyte inflammation via the NFκB and MAPK pathways. Pectolinarigenin inhibits LPS-induced phosphorylation of ERK1/2, N-FκB and p38MAPK, directly inhibits the enzymatic activity or binding of COX-2, 5-LOX and HIF-1α, and reduces the level of XIAP. Pectolinarigenin modifies Keap1 to promote nuclear accumulation of Nrf2, induces ARE-mediated antioxidant enzyme expression, and possesses direct free radical scavenging activity. Pectolinarigenin reduces the release of NO, proinflammatory mediators and leukotrienes, and increases the level of IL-10. Pectolinarigenin induces G₂/M cell cycle arrest, apoptosis (Apoptosis) and autophagy (Autophagy) via the PI3K/AKT/mTOR signaling pathway. Pectolinarigenin reduces renal crystal deposition and inhibits melanin synthesis. Pectolinarigenin inhibits inflammation and alleviates allergy in mouse models of inflammation. Pectolinarigenin alleviates renal injury, inflammation and oxidative stress in mice by inhibiting HIF-1α activity. Pectolinarigenin can be used for the research of neurodegenerative diseases, inflammatory/allergic diseases, calcium oxalate nephrocalcinosis, gastric cancer, melasma, post-inflammatory diseases and chloasma.

HY-182557

KC-11404	Lipoxygenase	Cardiovascular Disease Inflammation/Immunology
KC-11404 is an orally active antihistamine and 5-lipoxygenase inhibitor, with an IC₅₀ of 0.9 μM against guinea pig 5-lipoxygenase. KC-11404 inhibits histamine-induced contraction of isolated guinea pig ileum with an IC₅₀ of 0.26 μM. KC-11404 inhibits PAF-induced rabbit platelet aggregation with an IC₅₀ of 2.0 μM. It inhibits the histamine phase of antigen-induced bronchoconstriction and PAF-induced bronchoconstriction in guinea pigs. KC-11404 can be used for the research of asthma .

Cat. No.	상품명	Category	Target	Chemical Structure