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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
31 Results for "
log PL
" in MedChemExpress (MCE) Product Catalog:
Products (31)
31 Results for "log PL" in MCE Product Catalog:
34
Takinib (EDHS-206) is an orally active and selective TAK1 inhibitor (IC50=9.5 nM), more than 1.5 log more potent than the second and third ranked targets, IRAK4 (120 nM) and IRAK1 (390 nM), respectively. Takinib is an inhibitor of autophosphorylated TAK1 that non-competitively binds within the ATP binding pocket. Takinib induces apoptosis following TNFα stimulation in cell models of rheumatoid arthritis and metastatic breast cancer. Takinib is also a P. falciparum protein kinase 9 (PfPK9) inhibitor (KD(app) of 0.46 μM) .
2
2 Cited Publications
FzM1 is a negative allosteric modulator (NAM) of Frizzled receptor FZD4. FzM1 reduces WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=?6.2). FzM1 binds to an allosteric binding site located in intracellular loop 3 (ICL3) of FZD4 and alters the conformation of the receptor, ultimately inhibiting the WNT/β-catenin cascade .
1
Diethyl butylmalonate is a competitive inhibitor of succinate dehydrogenase. Diethyl butylmalonate exerts anti-inflammatory effects by inhibiting ROS production. Diethyl butylmalonate also has neuroprotective activity. In addition, Diethyl butylmalonate shows toxicity to T. pyriformis, with its log(IGC50 -1) being 0.557. Diethyl butylmalonate can be used in the research of diseases such as Alzheimer's disease .
1
1 Cited Publications
製品番号: HY-P72076
純度: ≥ 90%, as determined by reducing SDS-PAGE.
別名: ALOX12; PLatelet 12-LOX; Arachidonate 12-Lipoxygenase, 12S Type; log12; 12S-LOX; Arachidonate 15-Lipoxygenase,15S-Type; Polyunsaturated Fatty Acid Lipoxygenase ALOX12; PLatelet-Type 12-Lipoxygenase; Arachidonate 12-Lipoxygenase, 12S-Type; Arachidonate 12-Lipoxygenase; Arachidonate (12S)-Lipoxygenase; Linoleate (13S)-Lipoxygenase; Arachidonate (15S)-Lipoxygenase; Linoleate 13S-Lipoxygenase; PLatelet-Type Lipoxygenase 12; 12-LOX; Lipoxin Synthase 12-LO; 12LO; 12S-Lipoxygenase
Species:
Human
Source:
E. coli
Target:
6-Hydroxyluteolin (Compound 17) is a flavonoid derivative and also an inhibitor of Aldose reductase, with an experimental -log IC50 value of 6.690. 6-Hydroxyluteolin can be isolated from the leaves of multiple plant families, including Plantaginaceae, Globulariaceae and Labiatae. 6-Hydroxyluteolin serves as a phylogenetic marker for higher plants. 6-Hydroxyluteolin can be used in the research of diabetic cataract .
Category:
製品番号: HY-E0225
The 0.5 mL SBS Rack is a 96-well biobank storage rack suitable for -80°C environments. It can hold 0.5 mL externally threaded cryogenic vials with 2D codes on the bottom, and supports automated sample tracking, detection, and laboratory information system integration. The 0.5 mL SBS Rack can be used with camera-based reading devices to scan and log biobank vials with 2D codes into databases, enabling rapid identification of aliquoted samples .
製品番号: HY-148361
CAS 番号: 510716-65-1
Fluorogen binding modulator-1 (PubChem SID 125240934) is a fluorogen activating protein (FAP)-fluorogen binding modulator with -log EC50s of 6.61 and 6.37 for AM2.2-β2AR and AM2.2-GPR32, respectively .
製品番号: HY-44178S
CAS 番号: 1189865-34-6
製品番号: HY-W012232
CAS 番号: 3558-69-8
研究分野:
2,6-Diphenylpyridine is a proton acceptor (log(P) = 5) and a tridentate [C^N^C] dianionic ligand. 2,6-Diphenylpyridine efficiently transfers protons through a direct pathway at the interface of two immiscible electrolyte solutions. 2,6-Diphenylpyridine as a tridentate ligand and can form mononuclear and binuclear complexes with gold(III). 2,6-Diphenylpyridin is applicable to research in electrochemical ion transfer kinetics and organometallic chemistry .
製品番号: HY-B1714
CAS 番号: 91757-46-9
Target:
研究分野:
NSC 601980 analog is an analogue of NSC601980. In yeast screening experiments, NSC 601980 exhibited antitumor activity, effectively inhibiting cell proliferation in both COLO 205 and HT29 cell lines, with Log GI 50 values of -6.6 and -6.9, respectively.
製品番号: HY-100332
CAS 番号: 752186-89-3
Target:
研究分野:
CP 375 is a Fe 3+ chelating agent, with a log K1 value of 14.50.
製品番号: HY-126218
CAS 番号: 111687-37-7
HSV-TK substrate is a substrate for HSV-TK, and induces multi-log cytotoxicity in HSV-TK-expressing and bystander cells. HSV-TK substrate shows antitumor activity .
製品番号: HY-132303
CAS 番号: 1432054-03-9
Target:
MK-8262 is an orally active and potent cholesteryl ester transfer protein (CETP) inhibitor with an IC50 of 53 nM and a log D of 5.3. MK-8262, a bistrifluoromethyl analogue, has the potential for coronary heart disease (CHD) correlated high-density lipoprotein (HDL) and low-density lipoprotein (LDL) research .
製品番号: HY-162154
CAS 番号: 2738323-08-3
SARS-CoV-2-IN-75 (compound 13) is a SARS-CoV-2 inhibitor based on chloroacetamide inhibition. SARS-CoV-2-IN-75 inhibits cellular SARS-CoV-2 replication with an EC68 (half-log reduction in viral titer) of 3 μM .
製品番号: HY-117471
CAS 番号: 21236-52-2
Target:
研究分野:
Antiarrhythmic agent-3 is an antiarrhythmic drug with the activity of enhancing antiarrhythmic efficacy and improving inhibition index. The antiarrhythmic effect of antiarrhythmic agent-3 is related to its hydrophobicity (log P). The central nervous system toxicity of antiarrhythmic agent-3 is related to the combined effect of its hydrophobicity and acid constant (pKa) .
研究分野:
Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride inhibites phosphodiesterase 3 (PDE3), phosphodiesterase 4 (PDE4) and phosphodiesterase 5 (PDE5) activities with -log IC50 values of 3.44, 4.16 and approximately 3.8, respectively. Fenspiride can be used for the research of respiratory diseases .
製品番号: HY-A0027AS
CAS 番号: 1246911-67-0
Fenspiride (hydrochloride) (Standard) is the analytical standard of Fenspiride (hydrochloride). This product is intended for research and analytical applications. Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride inhibites phosphodiesterase 3 (PDE3), phosphodiesterase 4 (PDE4) and phosphodiesterase 5 (PDE5) activities with -log IC50 values of 3.44, 4.16 and approximately 3.8, respectively. Fenspiride can be used for the research of respiratory diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
