13 Results for "

mitochondrial targeting peptide

" in MedChemExpress (MCE) Product Catalog:
Products (13)

13 Results for "mitochondrial targeting peptide" in MCE Product Catalog:

Cat. No.: HY-P10285
CAS No.: 286380-05-0
Synonyms: D-(KLAKLAK)2
Research Areas:  

Cancer

d-KLA Peptide (D-(KLAKLAK)2), KLA peptide (HY-P5345) isomer, is a pro-apoptosis peptide. d-KLA Peptide can specifically target mitochondria and induce apoptosis by destroying the mitochondrial membrane. d-KLA Peptide increases caspase 3/7 activity, exerts proapoptotic activity and enhances antitumor efficacy in mouse melanoma models .
loading...
    loading...
Cat. No.: HY-P5345
CAS No.: 184240-26-4
KLA peptide is a naturally occurring Antibiotic peptide that is nontoxic outside of cells but is toxic when it enters into the interior of targeted cells. KLA peptide can induce cell Apoptosis by disrupting mitochondrial membranes and activating Caspase. MG1-KLA, formed by the coupling of KLA peptide with MG1, can selectively induce apoptosis in pro-inflammatory microglia. KLA peptide can be used for the research of liver fibrosis. KLA peptide can be used for the research of neonatal hypoxic-ischemic encephalopathy.
loading...
    loading...
Cat. No.: HY-P3707
CAS No.: 1926163-30-5
Target:  

Apoptosis

Research Areas:  

Cancer

Tumor targeted pro-apoptotic peptide (CNGRC-GG-D(KLAKLAK)2) is an anti-tumor peptide. Tumor targeted pro-apoptotic peptide disrupts mitochondrial membranes and promotes apoptosis, showing anticancer activity in mice .
loading...
    loading...
Cat. No.: HY-P10285S
Synonyms: D-(KLAKLAK)2-d30
d-KLA Peptide (D-(KLAKLAK)2)-d30 is the deuterium labeled d-KLA Peptide (HY-P10285). d-KLA Peptide, KLA peptide (HY-P5345) isomer, is a pro-apoptosis peptide. d-KLA Peptide can specifically target mitochondria and induce apoptosis by destroying the mitochondrial membrane. d-KLA Peptide increases caspase 3/7 activity, exerts proapoptotic activity and enhances antitumor efficacy in mouse melanoma models .
loading...
    loading...
Cat. No.: HY-155077
Target:  

JNK

Research Areas:  

Cancer

JNK-IN-12 (compound P2) is a mitochondrial-targeted JNK inhibitor (IC50=66.3 nM), consisting of a mitochondrial-specific cell-penetrating peptide and a specific inhibitor of JNK, SP600125 (HY-12041). JNK-IN-12 doesn't inhibit nuclear JNK signaling, but does inhibit mitochondrial JNK phosphorylation. JNK-IN-12 helps to improve the Parkinson's disease (PD) both in vitro and in vivo .
loading...
    loading...
Cat. No.: HY-P11638A
Mitochondrial-targeted peptide BP29 acetate is a mitochondria-targeted iron chelator linked to a mitochondria-homing SS-peptide. Mitochondrial-targeted peptide BP29 acetate protects human primary skin fibroblasts against ultraviolet A-induced oxidative damage to mitochondrial membranes, ATP depletion, and necrotic cell death. Mitochondrial-targeted peptide BP29 acetate prevents hydrogen peroxide-induced oxidative stress and cytotoxicity in both healthy and Friedreich's ataxia skin fibroblasts. Mitochondrial-targeted peptide BP29 acetate can be used for the research of Friedreich's ataxia .
loading...
    loading...
Cat. No.: HY-P11638
Mitochondrial-targeted peptide BP29 is a mitochondria-targeted iron chelator linked to a mitochondria-homing SS-peptide. Mitochondrial-targeted peptide BP29 protects human primary skin fibroblasts against ultraviolet A-induced oxidative damage to mitochondrial membranes, ATP depletion, and necrotic cell death. Mitochondrial-targeted peptide BP29 prevents hydrogen peroxide-induced oxidative stress and cytotoxicity in both healthy and Friedreich's ataxia skin fibroblasts. Mitochondrial-targeted peptide BP29 can be used for the research of Friedreich's ataxia .
loading...
    loading...
Cat. No.: HY-P11637
Target:  

Fluorescent Dye

Research Areas:  

Neurological Disease

Mitochondrial-targeted peptide BP19 is a fluorescent probe for the selective measurement of labile iron in the mitochondriairon. Mitochondrial-targeted peptide BP19 exhibits iron-selective sensing activity with mitochondrial accumulation, reduced fluorescence in iron-loaded cells, and fluorescence reinstatement upon iron chelation. Mitochondrial-targeted peptide BP19 evaluates mitochondrial labile iron levels in cultured fibroblasts with Friedreich's ataxia .
loading...
    loading...
Cat. No.: HY-P12011
Research Areas:  

Neurological Disease

MTS peptide is a short peptide with a mitochondria-targeting sequence. In F-M-LNP, MTS peptide is displayed on the particle surface via thiol-maleimide conjugation, and is specifically responsible for being recognized by the mitochondrial proteins TOMM20/22, "anchoring" the nanoparticles to the outer mitochondrial membrane, followed by membrane potential-independent bilayer membrane penetration mediated by fluorinated lipids. MTS peptide can be used in the research of Leber's hereditary optic neuropathy .
loading...
    loading...
Cat. No.: HY-P12338
HNSS peptide is a chimeric hybrid peptide composed of the neuroprotective peptide S14G-Humanin and the mitochondria-targeted antioxidant peptide SS31. HNSS peptide is readily cleared in vivo and can be combined with nanocarriers to improve its stability. HNSS can be delivered via the FGFR1-targeting nanocarrier FGL-NP (Cit), ameliorating mitochondrial dysfunction, Aβ deposition, tau hyperphosphorylation, and cholinergic neuronal damage, and alleviating memory deficits in Alzheimer's disease mice. HNSS peptide is applicable for Alzheimer's disease-related research .
loading...
    loading...
Cat. No.: HY-P5345A
KLA peptide acetate is a naturally occurring Antibiotic peptide that is nontoxic outside of cells but is toxic when it enters into the interior of targeted cells. KLA peptide acetate can induce cell Apoptosis by disrupting mitochondrial membranes and activating Caspase. MG1-KLA acetate, formed by the coupling of KLA peptide acetate with MG1, can selectively induce apoptosis in pro-inflammatory microglia. KLA peptide acetate can be used for the research of liver fibrosis. KLA peptide acetate can be used for the research of neonatal hypoxic-ischemic encephalopathy .
loading...
    loading...
Cat. No.: HY-P11486
NOTA-RHAU18 is a conjugate of the chelator NOTA and the peptide RHAU18. NOTA-RHAU18 can be used to synthesize the radiolabeled peptide probe [ 18F]AlF-NOTA-RHAU18. [ 18F]AlF-NOTA-RHAU18 targets mitochondrial DNA G4. [ 18F]AlF-NOTA-RHAU18 can be used to visualize and detect solid tumors in homozygous mice. [ 18F]AlF-NOTA-RHAU18 can also be used in PET imaging studies .
loading...
    loading...
Cat. No.: HY-181124
Synonyms: Idebenone-2S-FrFK-NH2
Idebenone-SS-20 (Idebenone-2S-FrFK-NH2) is a Idebenone (HY-N0303) derivative conjugated to the mitochondria-targeting peptide SS-20. Idebenone-SS-20 shows neuroprotective and anti-inflammatory effects. Idebenone-SS-20 can preserve mitochondrial membrane potential, enhance ATP production, reduce ROS accumulation, maintain mitochondrial morphology and elevate NAD+/NADH ratio. Idebenone-SS-20 confers robust neuroprotection in a murine model of transient middle cerebral artery occlusion. Idebenone-SS-20 can be used for the research of cerebral .
loading...
    loading...
  • 1