nerve growth factor (NGF)

By Targets:	Apoptosis (2) Histamine Receptor (4) Reactive Oxygen Species (2) Trk Receptor (5)
By Research Areas:	Cancer (5) Endocrinology (5) Inflammation/Immunology (9) Neurological Disease (12)

Targets Recommended: Nuclear Hormone Receptor 4A/NR4A FGFR VEGFR TGF-beta/Smad PDGFR TGF-β Receptor GHSR EGFR IGF-1R

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17622

Tavilermide

2 Publications Verification

MIM-D3
Trk Receptor Inflammation/Immunology

Tavilermide is a selective, partial agonist of TrkA, or a nerve growth factor (NGF) mimetic.

Tavilermide 2 Publications Verification MIM-D3	Trk Receptor	Inflammation/Immunology
Tavilermide is a selective, partial agonist of TrkA, or a nerve growth factor (NGF) mimetic.

HY-N12170

Kissoone C	Others	Neurological Disease
Kissoone C (compound 3) is a three-membered ring sesquiterpene isolated from valerian root. Kissoone C can enhance the activity of nerve growth factor (NGF)-mediated neurite outgrowth in PC12D cells .

HY-N12566

Erinacin B	Others	Neurological Disease
Erinacin B is a active product that can be extracts from the mycelia of Hericium erinaceum. Erinacin B shows potent stimulating activity of nerve growth factor (NGF)-synthesis .

HY-N3938

Gelsemiol	Others	Neurological Disease
Gelsemiol is the main active ingredient in Verbena littoralis H. B. K.. Gelsemiol enhanced nerve growth factor (NGF) -induced axonal elongation in PC12D cells .

HY-117517

NG-012	Others	Cancer
NG-012, potentiator of nerve growth factor (NGF), were isolated from the culture broth of Penicillium verruculosum F-4542. NG-012 potentiates the neurite outgrowth induced by NGF in rat pheochromocytoma cell line (PC12) .

HY-110166

PD 90780 1 Publications Verification	Others	Neurological Disease
PD 90780 is a non peptide antagonist of **nerve growth factor (NGF)*. PD 90780 interacts with NGF, prevents NGF* binds with p75 ^NTR. PD 90780 inhibits NGF-p75 ^NTR interaction with IC₅₀s of 23.1 and 1.8 µM in PC12 cells and PC12 ^nnr5 cells, respectively .

HY-108466

Ro 08-2750 2 Publications Verification	Apoptosis	Neurological Disease Cancer
Ro 08-2750 is a non-peptide and reversible **nerve growth factor (NGF)** inhibitor which binds to NGF, and with an IC₅₀ of ~ 1 µM. Ro 08-2750 inhibits NGF binding to p75 ^NTR selectively over TRKA . Ro 08-2750 is a selective _{MSI RNA-binding} activity inhibitor, with an IC₅₀ of 2.7 μM .

HY-18314

GW 441756 5 Publications Verification	Trk Receptor Apoptosis	Neurological Disease Cancer
GW 441756 is a potent and specific nerve growth factor (NGF) receptor tyrosine kinases A (TrkA) inhibitor (IC₅₀=2 nM), which eliminates the BmK NSPK-induced neurite outgrowth .

HY-P99297

Bedinvetmab ZTS-00508841	Trk Receptor	Inflammation/Immunology
Bedinvetmab (ZTS-00508841) is a canine monoclonal antibody (mAb) targeting **nerve growth factor (NGF)*. Bedinvetmab inhibits NGF* interaction with tropomyosin receptor kinase A (trkA) and p75 neurotrophin receptor (p75NTR) receptors. Bedinvetmab can be used for the research of osteoarthritis pain in dogs .

HY-N0380

Nardosinone	Others	Neurological Disease
Nardosinone, isolated from Nardostachys chinensis, is the first enhancer of the neuritogenic action of dbcAMP and staurosporine. Nardosinone may become a useful pharmacological tool for studying the mechanism of action of not only nerve growth factor (NGF) but also both the neuritogenic substances .

HY-N3928

Garciniaxanthone E	Others	Neurological Disease
Garciniaxanthone E is a xanthone compound. Garciniaxanthone E significantly enhances cellular nerve growth factor (NGF)-mediated neurite outgrowth in PC12D cells. Garciniaxanthone E contributes to basic research and medicinal development in neurodegenerative diseases .

HY-N12172

Kissoone A

Others Others

Kissoone A (compound 1) is a three-membered ring sesquiterpene isolated from valerian root .

Kissoone A	Others	Others
Kissoone A (compound 1) is a three-membered ring sesquiterpene isolated from valerian root .

HY-I0021

Bepotastine 1 Publications Verification	Histamine Receptor	Inflammation/Immunology Endocrinology
Bepotastine is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF). Bepotastine has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research .

HY-I0021A

Bepotastine tosylate	Histamine Receptor	Inflammation/Immunology Endocrinology
Bepotastine tosylate is a selective and orally active second-generation histamine H1 receptor antagonist. Bepotastine tosylate can suppress the expression of nerve growth factor (NGF). Bepotastine tosylate can be used in studies of allergic rhinitis, allergic conjunctivitis and urticaria/pruritus .

HY-A0015

Bepotastine besilate 1 Publications Verification	Histamine Receptor	Inflammation/Immunology Endocrinology
Bepotastine besilate is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF). Bepotastine besilate has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research .

HY-146524

TRK-IN-18	Trk Receptor	Cancer
TRK-IN-18 is a potent inhibitor of TRK. Tropomyosin-related kinases (Trks) are a family of receptor tyrosine kinases activated by neurotrophins, a group of soluble growth factors including Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT-3) and Neurotrophin-4/5 (NT-4/5). TRK-IN-18 has the potential for the research of cancer diseases (extracted from patent WO2021148805A1, compound 7) .

HY-146523

TRK-IN-17	Trk Receptor	Cancer
TRK-IN-17 is a potent inhibitor of TRK. Tropomyosin-related kinases (Trks) are a family of receptor tyrosine kinases activated by neurotrophins, a group of soluble growth factors including Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT-3) and Neurotrophin-4/5 (NT-4/5). TRK-IN-17 has the potential for the research of cancer diseases (extracted from patent WO2021148807A1, compound 3) .

HY-124637

ALE-0540	Others	Neurological Disease
ALE-0540, a nonpeptidic small molecule, is a nerve growth factor receptor antagonist. ALE-0540 inhibits the binding of NGF to tyrosine kinase (Trk) A or both p75 and TrkA with IC₅₀ values of 5.88 μM and 3.72 μM, respectively. ALE-0540 can be used to examine mechanisms leading to the development of agents for the treatment of pain .

HY-A0015R

Bepotastine besilate (Standard)	Histamine Receptor	Inflammation/Immunology Endocrinology
Bepotastine (besilate) (Standard) is the analytical standard of Bepotastine (besilate). This product is intended for research and analytical applications. Bepotastine besilate is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF). Bepotastine besilate has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research .

HY-A0015A

(Rac)-Bepotastine besilate	Others	Inflammation/Immunology Endocrinology
(Rac)-Bepotastine (besilate) is the isomer of Bepotastine (besilate) (HY-A0015), and can be used as an experimental control. Bepotastine besilate is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF). Bepotastine besilate has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research .

HY-120251A

Leteprinim potassium AIT-082	Reactive Oxygen Species	Neurological Disease
Leteprinim potassium (AIT-082), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim potassium is a hypoxanthine derivative neurotrophic agent. Leteprinim potassium can induce *brain-derived neurotrophic factor* (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim potassium reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim potassium increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species** .

HY-120251

Leteprinim AIT-082 free acid	Reactive Oxygen Species	Neurological Disease
Leteprinim (AIT-082 free acid), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim is a hypoxanthine derivative neurotrophic agent. Leteprinim can induce *brain-derived neurotrophic factor* (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species** .

Cat. No.	Product Name	Target	Research Area

HY-P99195

Fasinumab	Inhibitory Antibodies	Inflammation/Immunology
Fasinumab (Anti-Human NGF) is a human IgG4 monoclonal antibody to nerve growth factor (NGF). Fasinumab can be used in acute sciatica and knee osteoarthritis (OA) studies .

HY-P99200

Fulranumab

Inhibitory Antibodies Neurological Disease

Fulranumab is a human IgG2 monoclonal antibody against nerve growth factor (NGF) and can be used for the research of pain .

Fulranumab	Inhibitory Antibodies	Neurological Disease
Fulranumab is a human IgG2 monoclonal antibody against nerve growth factor (NGF) and can be used for the research of pain .

HY-P99627

Frunevetmab NV-02	Inhibitory Antibodies	Inflammation/Immunology
Frunevetmab (NV-02) is a felinized anti-nerve **growth factor (NGF) monoclonal antibody with a K_d** of 20 pM. Frunevetmab can effectively decrease osteoarthritis (OA) pain in cats .

HY-P99297

Bedinvetmab ZTS-00508841	Trk Receptor	Inflammation/Immunology
Bedinvetmab (ZTS-00508841) is a canine monoclonal antibody (mAb) targeting **nerve growth factor (NGF)*. Bedinvetmab inhibits NGF* interaction with tropomyosin receptor kinase A (trkA) and p75 neurotrophin receptor (p75NTR) receptors. Bedinvetmab can be used for the research of osteoarthritis pain in dogs .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0380

Nardosinone	Neurological Disease Classification of Application Fields Terpenoids Sesquiterpenes Source classification Nardostachys jatamansi (D. Don) DC. Plants Valerianaceae Disease Research Fields	Others
Nardosinone, isolated from Nardostachys chinensis, is the first enhancer of the neuritogenic action of dbcAMP and staurosporine. Nardosinone may become a useful pharmacological tool for studying the mechanism of action of not only nerve growth factor (NGF) but also both the neuritogenic substances .

HY-N12170

Kissoone C	Structural Classification Terpenoids Sesquiterpenes Source classification Valeriana officinalis Linn. Plants Valerianaceae	Others
Kissoone C (compound 3) is a three-membered ring sesquiterpene isolated from valerian root. Kissoone C can enhance the activity of nerve growth factor (NGF)-mediated neurite outgrowth in PC12D cells .

HY-N12566

Erinacin B	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	Others
Erinacin B is a active product that can be extracts from the mycelia of Hericium erinaceum. Erinacin B shows potent stimulating activity of nerve growth factor (NGF)-synthesis .

HY-N3938

Gelsemiol	Structural Classification Iridoids Terpenoids Source classification Populus tomentosa Plants Salicaceae	Others
Gelsemiol is the main active ingredient in Verbena littoralis H. B. K.. Gelsemiol enhanced nerve growth factor (NGF) -induced axonal elongation in PC12D cells .

HY-117517

NG-012	Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields Cancer	Others
NG-012, potentiator of nerve growth factor (NGF), were isolated from the culture broth of Penicillium verruculosum F-4542. NG-012 potentiates the neurite outgrowth induced by NGF in rat pheochromocytoma cell line (PC12) .

HY-N3928

Garciniaxanthone E	Structural Classification Flavonoids Garcinia xanthochymus Hook. f. ex T. Anders. Flavonones Source classification Guttiferae Plants	Others
Garciniaxanthone E is a xanthone compound. Garciniaxanthone E significantly enhances cellular nerve growth factor (NGF)-mediated neurite outgrowth in PC12D cells. Garciniaxanthone E contributes to basic research and medicinal development in neurodegenerative diseases .

HY-N12172

Kissoone A	Structural Classification Terpenoids Sesquiterpenes Source classification Valeriana officinalis Linn. Plants Valerianaceae	Others
Kissoone A (compound 1) is a three-membered ring sesquiterpene isolated from valerian root .

Species:	Human (7) Rat (1) Mouse (5)
Tag:	His (4) Tag Free (8)
Source:	HEK293 (2) CHO (2) E. coli (9)

Cat. No.	Compare	Product Name	Species	Source

HY-P73316

	Beta-NGF Protein, Human (CHO) 2 Publications Verification Beta-NGF; Beta-nerve growth factor; NGF; NGFB	Human	CHO
	Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Human (CHO) is produced by CHO cells (S122-R239), with tag free.

HY-P73317

	Beta-NGF Protein, Mouse (CHO) Beta-NGF; Beta-nerve growth factor; NGF; NGFB	Mouse	CHO
	Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Mouse (CHO) is produced by CHO cells (S122-G241), with tag free.

HY-P7660

	Beta-NGF Protein, Human (HEK293) rHuBeta-NGF; Beta-nerve growth factor; Beta-NGF;	Human	HEK293
	Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Human (HEK293) is produced by HEK293 cells (S122-R239), with tag free.

HY-P702778

	beta-NGF Protein, Rat (HEK293, His) Beta-nerve growth factor; Ngf; Beta-NGF; Ngfb; beta nerve growth factor	Rat	HEK293
	Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss.

HY-P700018AF

	Animal-Free Beta-NGF Protein, Human (His) β-nerve growth factor; NGF-β	Human	E. coli
	Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Animal-Free Beta-NGF Protein, Human (His) is produced by E.coli (S122-A241), with C-terminal His-tag.

HY-P7661

	Beta-NGF Protein, Mouse (120a.a) 1 Publications Verification rMuBeta-NGF; Beta-nerve growth factor; Beta-NGF;	Mouse	E. coli
	Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Mouse (120a.a) is produced by E.coli (S122-G241), with tag free.

HY-P70449

	Beta-NGF Protein, Human (120a.a) Beta-nerve growth factor; Beta-NGF; NGF; NGFB	Human	E. coli
	Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Human (120a.a) is produced by E.coli (S122-A241), with tag free.

HY-P70530

	Beta-NGF Protein, Mouse (110a.a) Beta-nerve growth factor; Beta-NGF; NGF; NGFB	Mouse	E. coli
	Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Mouse (110a.a) is produced by E.coli (M130-R239), with tag free.

HY-P72488

	pro-Beta-NGF Protein, Human (223a.a) Beta-nerve growth factor; Beta-NGF; NGF; NGFB	Human	E. coli
	Pro-Beta-NGF protein plays a crucial role in the development and maintenance of the nervous system by binding to NTRK1 and NGFR receptors. Immature NGF precursors act as ligands for the SORCS2-NGFR complex, triggering signaling pathways affecting RAC1/2, the actin cytoskeleton, and neuronal growth. pro-Beta-NGF Protein, Human (223a.a) is the recombinant human-derived pro-Beta-NGF protein, expressed by E. coli , with tag free. The total length of pro-Beta-NGF Protein, Human (223a.a) is 223 a.a., with molecular weight of ~30 kDa.

HY-P700162AF

	Animal-Free Beta-NGF Protein, Mouse (His) beta-NGF; beta-nerve growth factor; NGF; NGFB	Mouse	E. coli
	Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Animal-Free Beta-NGF Protein, Mouse (His) is produced by E.coli (S122-G241), with C-terminal His-tag.

HY-P70530A

	Beta-NGF Protein, Mouse (110a.a, His) Beta-nerve growth factor; Beta-NGF; NGF; NGFB	Mouse	E. coli
	Beta-NGF protein is essential for the development and maintenance of the nervous system and binds to NTRK1 and NGFR receptors to initiate signaling cascades that regulate neuronal processes. The NGF precursor proNGF acts as a ligand for the SORCS2-NGFR receptor and activates pathways affecting RAC1/2, the actin cytoskeleton, and neuronal growth. Beta-NGF Protein, Mouse (110a.a, His) is the recombinant mouse-derived Beta-NGF protein, expressed by E. coli , with N-6*His labeled tag. The total length of Beta-NGF Protein, Mouse (110a.a, His) is 110 a.a., with molecular weight of ~12.0 kDa.

HY-P70456

	Neurotrophin-3 Protein, Human Neurotrophin-3; NT-3; HDNF; nerve growth factor 2; NGF-2; Neurotrophic factor; NTF3	Human	E. coli
	Neurotrophin-3 Protein, Human is a recombinant Neurotrophin-3 protein expressed in E. coli system. Neurotrophin-3 is widely expressed in the nervous system. Neurotrophin-3 reduces cellular damage, improves neuronal regeneration in different models of lesions.

HY-P70456AF

	Animal-Free Neurotrophin-3 Protein, Human Neurotrophin-3; NT-3; HDNF; nerve growth factor 2; NGF-2; Neurotrophic factor; NTF3	Human	E. coli
	Animal-Free Neurotrophin-3 Protein, Human is a recombinant Neurotrophin-3 protein expressed in E. coli system. Neurotrophin-3 is widely expressed in the nervous system. Neurotrophin-3 reduces cellular damage, improves neuronal regeneration in different models of lesions.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81121

	NGFB Antibody NGF; Beta nerve growth factor; NGF-beta; Beta nerve growth factor precursor; Beta NGF; HSAN5; MGC161426; MGC161428; nerve growth factor beta; nerve growth factor beta polypeptide; nerve growth factor beta subunit; NGF B; NID67; NGF beta; NGF-B; NGF_HUMAN. NGF-β; NGF β; NGFβ; β NGF; β-NGF; .	ELISA, IHC-P, IHC-F, ICC/IF	Human, Rat, Dog
	NGFB Antibody is an unconjugated, approximately 13/32 kDa, rabbit-derived, anti-NGFB polyclonal antibody. NGFB Antibody can be used for: ELISA, IHC-P, IHC-F, ICC, IF expriments in human, rat, dog, and predicted: mouse, chicken, pig, cow, horse, rabbit background without labeling.

HY-P81500

	p75 NGF Receptor Antibody (YA1245) NGFR; TNFRSF16; Tumor necrosis factor receptor superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD antigen CD271	IHC-P	Human

HY-P83029

	NGFR Antibody (YA2774) NGFR; TNFRSF16; Tumor necrosis factor receptor superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD antigen CD271	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat


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nerve growth factor (NGF)

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