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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
neutral proteases
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "neutral proteases" in MCE Product Catalog:
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4
4 Cited Publications
Cat. No.: HY-100227
CAS No.: 76684-89-4
Research Areas:
E 64c is a derivative of naturally occurring epoxide inhibitor of cysteine proteases, a Calcium-activated neutral protease (CANP) inhibitor and a very weak irreversible cathepsin C inhibitor. E 64c exhibits entry-blocking effect for MERS-CoV.
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1 Cited Publications
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Z-Leu-Arg-AMC is a fluorogenic peptide substrate for cysteine proteases (e.g., Cathepsin) (Ex=350 nm，Em=460 nm). Z-Leu-Arg-AMC is preferentially cleaved by Cathepsin K and S under weakly acidic conditions, while its hydrolysis relies on residual Cathepsin S activity at neutral pH. Z-Leu-Arg-AMC serves as a substrate for recombinant Sphenophorus levis Cathepsin L, falcipain-2, falcipain-3, berghepain-2, knowlepain-2, vivapain-2, as well as falcipain-2 chimeras and constructs. It enables quantitative detection of cysteine protease activity in human inflammatory bronchoalveolar lavage fluid via fluorescence generation. Z-Leu-Arg-AMC can be used in research related to pulmonary inflammatory diseases and malaria .
Cat. No.: HY-131577A
CAS No.: 42613-33-2
Synonyms: Dispase I
Neutral protease I (Dispase I) is a rapid, effective, gentle and neutral protease that can separate intact epidermis from the dermis. Neutral protease I can also separate intact epithelial sheets in culture from the substratum. Neutral protease I preserves the viability of the epithelial cells while cleaving the basement membrane zone region. Neutral protease I can also be used to prevent clumping in suspension cultures. Neutral protease I cleaves fibronectin and type IV collagen, but not laminin, type V collagen, serum albumin, or transferrin .
Synonyms: FAGLA
FA-Gly-Leu-NH2 (FAGLA) is a dipeptide substrate for proteases that can be hydrolyzed by thermophilic proteases and neutral proteases, showing pH-dependent variations in kcat/Km .
Cat. No.: HY-P4582
CAS No.: 110906-89-3
Synonyms: Suc-FAAF-pNA
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Cat. No.: HY-E70531
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Collagenase/Neutral protease 2 (animal free) is an animal-free mixture of collagenase and neutral protease that can be used for stem cell and other primary cell isolation and bioprocessing applications without the introduction of potential animal-borne pathogens. It has higher casein activity than Collagenase/Neutral Protease 1 (animal free).
Cat. No.: HY-106058
CAS No.: 84518-80-9
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NCO-700 is a dual cathepsin B and calcium-activated neutral protease (CANP) inhibitor with IC50 values of 0.8 and 46 μM, respectively. NCO-700 reduces the degradation of myocardial fibrin by inhibiting protease activity. NCO-700 also has inhibitory effects on hormone-independent tumor cells, such as prostate cancer cells, and induces apoptosis. NCO-700 can be used to study myocardial ischemia and refractory hormone-independent tumors .
Cat. No.: HY-E70530
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Collagenase/Neutral protease 1 (animal free) is an animal-free mixture of collagenase and neutral protease that can be used for stem cell and other primary cell isolation and bioprocessing applications without the introduction of potential animal-borne pathogens.
Cat. No.: HY-P11734
CAS No.: 72682-75-8
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Cat. No.: HY-K6023
MCE Cardiomyocyte Dissociation Solution is specifically designed for the dissociation of cardiomyocytes following PSC differentiation and selection. It contains highly active collagenase, dispase, and neutral protease, which work synergistically with a low concentration of recombinant serine protease to efficiently and gently dissociate densely adherent cardiomyocytes into a single-cell suspension.
Cat. No.: HY-113875
CAS No.: 101470-42-2
Synonyms: Collagenase inhibitor CI-2
Z-Acp-leu-metyr-MA (Collagenase inhibitor CI-2) is a mammalian tissue collagenase inhibitor, with an IC50 of 200 μM against human rheumatoid synovial collagenase, 30 μM against mouse bone collagenase, 60 μM against rabbit bone proteoglycanase, 25 μM against mouse bone neutral protease, and >100 μM against rabbit macrophage neutral protease. Z-Acp-leu-metyr-MA inhibits parathyroid hormone-induced bone collagen matrix resorption in cultured embryonic mouse calvariae .
Cat. No.: HY-106058A
CAS No.: 84579-82-8
NCO-700 sulfate is a dual cathepsin B and calcium-activated neutral protease (CANP) inhibitor with IC50 values of 0.8 and 46 μM, respectively. NCO-700 sulfate reduces the degradation of myocardial fibrin by inhibiting protease activity. NCO-700 sulfate also has inhibitory effects on hormone-independent tumor cells, such as prostate cancer cells, and induces apoptosis. NCO-700 sulfate can be used to study myocardial ischemia and refractory hormone-independent tumors .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
