Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
nitroxides
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "nitroxides" in MCE Product Catalog:
3
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier .
1
1 Cited Publications
Research Areas:
PTIO is a specific scavenger of NO and redox mediator. PTIO reacts with •NO to form the corresponding imino nitroxides and •NO2. PTIO enhances organic contaminants oxidation by permanganate .
Cat. No.: HY-W002004
CAS No.: 14691-88-4
Synonyms: 4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl
Cat. No.: HY-130509
CAS No.: 81213-52-7
Synonyms: Otmpmms
Target:
Research Areas:
MTSSL (Otmpmms) is a highly reactive thiol-specific spin label that can be used to label thiol residues in proteins for the determination of protein structure and dynamics, as well as studies on protein-protein interactions. MTSSL serves as a nitroxide labeling reagent for cysteine residues in recombinant mouse prion protein (moPrP C) mutants. MTSSL can be applied in studies of transmissible spongiform encephalopathies (prion diseases) .
Target:
Research Areas:
Tempone (4-Oxo-Tempo) is a nitroxide radical spin label and ROS scavenger. Tempone induces cytotoxicity in lymphoma cells. Tempone serves as a substrate for intracellular reduction to hydroxylamine, rapidly equilibrates between intracellular and extracellular compartments, reduces nitroxide radical spin labels at the ubiquinol site of the respiratory chain, and acts as an alternative terminal electron acceptor when electron flow to oxygen is blocked. Tempone serves as a superoxide sensor, a T2-weighted MRI contrast agent, and a dynamic nuclear polarization polarizing agent for 13C. Tempone inhibits superoxide and peroxynitrite, hydroxyl radical generation, nitrotyrosine formation, and poly (ADP-ribose) formation, and alleviates renal dysfunction and injury in ischemia/reperfusion and hydrogen peroxide-induced injury. Tempone can be used for research on ischemia-reperfusion injury, acute renal failure, and lymphoma .
Cat. No.: HY-P4545
CAS No.: 67482-93-3
Target:
Research Areas:
Cat. No.: HY-P4561
CAS No.: 90331-82-1
Cat. No.: HY-W001187S
CAS No.: 205679-68-1
Cat. No.: HY-P4725
CAS No.: 133233-38-2
Target:
Research Areas:
Cat. No.: HY-129242S
CAS No.: 80404-14-4
Synonyms: 4-Oxo-Tempo-15N,d16
Tempone- 15N,d16 (4-Oxo-Tempo 15N,D16) is the deuterated, 15N-labeled Tempone (HY-129242). Tempone (4-Oxo-Tempo) is a nitroxide radical spin label and ROS scavenger. Tempone induces cytotoxicity in lymphoma cells. Tempone serves as a substrate for intracellular reduction to hydroxylamine, rapidly equilibrates between intracellular and extracellular compartments, reduces nitroxide radical spin labels at the ubiquinol site of the respiratory chain, and acts as an alternative terminal electron acceptor when electron flow to oxygen is blocked. Tempone serves as a superoxide sensor, a T2-weighted MRI contrast agent, and a dynamic nuclear polarization polarizing agent for 13C. Tempone inhibits superoxide and peroxynitrite, hydroxyl radical generation, nitrotyrosine formation, and poly (ADP-ribose) formation, and alleviates renal dysfunction and injury in ischemia/reperfusion and hydrogen peroxide-induced injury. Tempone can be used for research on ischemia-reperfusion injury, acute renal failure, and lymphoma .
Cat. No.: HY-W776833
CAS No.: 384342-58-9
Synonyms: Otmpmms-15N,d15
Cat. No.: HY-W002004S1
CAS No.: 70588-04-4
Synonyms: 4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl-d17
Cat. No.: HY-131898R
CAS No.: 18390-00-6
Research Areas:
PTIO (Standard) is the analytical standard of PTIO. This product is intended for research and analytical applications. PTIO is a specific scavenger of NO and redox mediator. PTIO reacts with •NO to form the corresponding imino nitroxides and •NO2. PTIO enhances organic contaminants oxidation by permanganate .
Cat. No.: HY-P4556
CAS No.: 50572-79-7
Target:
Research Areas:
Cat. No.: HY-129242S1
CAS No.: 36763-53-8
Synonyms: 4-Oxo-Tempo-d16
Tempone-d16 (4-Oxo-Tempo-d16) is the deuterated-labeled Tempone (HY-129242). Tempone (4-Oxo-Tempo) is a nitroxide radical spin label and ROS scavenger. Tempone induces cytotoxicity in lymphoma cells. Tempone serves as a substrate for intracellular reduction to hydroxylamine, rapidly equilibrates between intracellular and extracellular compartments, reduces nitroxide radical spin labels at the ubiquinol site of the respiratory chain, and acts as an alternative terminal electron acceptor when electron flow to oxygen is blocked. Tempone serves as a superoxide sensor, a T2-weighted MRI contrast agent, and a dynamic nuclear polarization polarizing agent for 13C. Tempone inhibits superoxide and peroxynitrite, hydroxyl radical generation, nitrotyrosine formation, and poly (ADP-ribose) formation, and alleviates renal dysfunction and injury in ischemia/reperfusion and hydrogen peroxide-induced injury. Tempone can be used for research on ischemia-reperfusion injury, acute renal failure, and lymphoma .
Cat. No.: HY-130509S
CAS No.: 1404308-02-6
Synonyms: Otmpmms-15N
Cat. No.: HY-128463S
CAS No.: 119391-92-3
Cat. No.: HY-W271506
CAS No.: 10135-38-3
Synonyms: 3,3,5,5-Tetramethyl-1-pyrroline 1-oxide
Research Areas:
TMPO (3,3,5,5-Tetramethyl-1-pyrroline 1-oxide) is a spin trap targeting free radicals. TMPO is capable of scavenging superoxide, hydroxyl radicals and inhibits thymocyte apoptosis with EC50 values of 19.1 mM (MPS-induced) to 30.7 mM (Etoposide-induced) for inhibiting DNA fragmentation. TMPO reacts with intracellular free radicals to form stable nitroxide radical products, reducing oxidative stress (e.g., decreasing peroxide levels, maintaining glutathione content) and blocking oxidative events in the apoptotic pathway. TMPO is promising for research of apoptosis in immune cells like thymocytes .
Cat. No.: HY-W002004S
CAS No.: 97461-87-5
Synonyms: 4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl-d17,15N
Cat. No.: HY-179316
CAS No.: 22690-04-6
Target:
Research Areas:
4-Phosphonooxy-tempo is an anionic nitroxide spin probe. 4-Phosphonooxy-tempo can be transported by a band 3 protein to permeate the membrane and then react with reductants contained in cytosol. 4-Phosphonooxy-tempo can be used as biomembrane anion channel functional probe .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
