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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
nucleoside modification
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "nucleoside modification" in MCE Product Catalog:
4
Category:
Natural Products Other disease Disease markers Endogenous metabolite Disease Research Fields Cancer
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5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer used to synthesize locked nucleic acid (LNA) analog oligonucleotides. It can be used as a building block of antisense oligonucleotides (ASOs) to target complementary RNA sequences. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) locks the furanose ring into an N-type conformation through 2',4'-constrained ethyl (cEt) modification, enhancing hybridization affinity and mismatch discrimination with RNA, while significantly improving the resistance of oligonucleotides to exonuclease digestion. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) mediates RNase H-dependent mRNA degradation or inhibits translation by forming a stable hybrid with RNA, thereby achieving gene expression regulation. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is mainly used in the development of antisense drugs, gene function research and oligonucleotide synthesis related to disease treatment .
Cat. No.: HY-45409
CAS No.: 146954-75-8
Synonyms: 2'-F-dU Phosphoramidite
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DMT-2’ Fluoro-dU Phosphoramidite (2'-F-dU Phosphoramidite) is a uridine phosphoramidite with a fluorine in the 2’ position. DMT-2’ Fluoro-dU Phosphoramidite could be used for nucleoside modification and synthesis of DNA .
Cat. No.: HY-Y0973
CAS No.: 56602-33-6
5'-O-DMT-N4-Bz-2'-F-dC is a nucleoside with protective and modification effects.
5'-O-TBDMS-dT is a nucleoside with protective and modification effects.
5'-O-TBDMS-Bz-dA is a nucleoside with protective and modification effects.
Cat. No.: HY-100096A
CAS No.: 2733287-29-9
Synonyms: (Rac)-Emtricitabine sulfoxide; (Rac)-Emtricitabine Degradant-III
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(Rac)-Emtricitabine S-oxide ((Rac)-Emtricitabine sulfoxide; (Rac)-Emtricitabine Degradant-III) is Emtricitabine S-oxide (HY-100096) racemic modification. Emtricitabine S-oxide is a major degradation product of Emtricitabine. Emtricitabine is a potent nucleoside reverse transcriptase inhibitor used for the treatment of HIV infection.
Cat. No.: HY-15350
CAS No.: 148311-89-1
Synonyms: LY 300046 hydrochloride
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Trovirdine hydrochloride, a phenethylthiazolylthiourea (PETT) derivative, is an HIV reverse transcriptase (RT) non-nucleoside inhibitor (NNI). A novel computer model of the RT/NNI binding pocket revealed spatial gaps around Trovirdine hydrochloride's pyridyl ring. Docking studies suggested that replacing this planar ring with a nonplanar piperidinyl or piperazinyl ring could better occupy the binding pocket, enhancing anti-HIV activity. Synthesized heterocyclic compounds based on this modification demonstrated greater potency than Trovirdine hydrochloride, effectively inhibiting HIV replication at nanomolar concentrations without cytotoxicity in infected peripheral blood mononuclear cells .
Cat. No.: HY-W1119950
CAS No.: 1644649-86-4
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3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite is an adenine nucleotide monomer precursor used in solid-phase synthesis of oligonucleotides, particularly modified oligonucleotides, such as those with DNA chain end modifications. 3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite, with trityl (Tr), cyanoethyl (CE), and dimethylformamidine (DMF) protecting groups, is a ddNTP adenosine nucleoside useful in applications such as solid-phase oligonucleotide synthesis, probe design, and chain-termination sequencing .
Cat. No.: HY-160199
CAS No.: 213206-31-6
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3'-L-Histidyl-AMP is applicable for nucleoside modification (DNA, RNA) .
Cat. No.: HY-160199A
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3'-L-histidyl-AMP (disodium) is applicable for nucleoside modification (DNA, RNA) .
Cat. No.: HY-W018179
CAS No.: 81256-88-4
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5'-DMT-3'-TBDMS-Bz-rA is a nucleoside with protective and modification effects.
5'-O-DMT-N6-Me-2'-dA is a nucleoside with protective and modification effects.
Cat. No.: HY-Z15868
CAS No.: 39638-73-8
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5-Hydroxycytidine is the RNA modified nucleoside that can be found in the 23S rRNA of bacteria E. coli. 5-Hydroxycytidine modifies at the C2501 site, exhibits a higher modification level in stationary cells. 5-Hydroxycytidine exhibits a higher modification level in radiation resistant Radius than in E. coli .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
