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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
oxidative cleavage
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "oxidative cleavage" in MCE Product Catalog:
26
26 Cited Publications
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Endocrinology Cancer
IU1 is a selective, reversible USP14 inhibitor with an IC50 of 4-5 μM. IU1 binds USP14’s catalytic cleft to block deubiquitinase activity. IU1 induces calpain-dependent Tau cleavage, causes ATP deficits, reduces E1~Ub thioester levels and 26S proteasome assembly. IU1 enhances 26S proteasome chymotrypsin-like activity, modulates LC3B-dependent autophagy flux, reduces cancer cell proliferation and migration, and blocks G0/G1 to S phase cell cycle transition in follicular thyroid cancer cells. IU1 activates autophagy-lysosomal and ubiquitin-proteasome pathways, triggers apoptosis, and reduces cervical cancer cell growth. IU1 enhances degradation of proteasome substrates linked to neurodegenerative disease, accelerates oxidized protein degradation, and increases oxidative stress resistance. IU1 can be used for the research of Alzheimer’s disease, follicular thyroid cancer, ischemic stroke, cervical cancer, and neurodegenerative disease .
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3-Phenoxybenzaldehyde (m-Phenoxybenzaldehyde) is the major product of CYP6AA3-mediated deltamethrin metabolism, generated by oxidative cleavage of deltamethrin. 3-Phenoxybenzaldehyde often serves as an intermediate .
Cat. No.: HY-W015464
CAS No.: 16284-60-9
Cat. No.: HY-14811
CAS No.: 251111-30-5
Synonyms: ZGN-440; CKD-732 free base
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Beloranib (ZGN-440; CKD-732 free base) is a selective, irreversible inhibitor of methionine aminopeptidase MetAP2 that suppresses appetite and increases energy expenditure. Beloranib blocks the enzymatic cleavage of N-terminal methionine from nascent proteins by forming a covalent bond with MetAP2, thereby regulating fatty acid metabolism, adrenergic signaling, and hypothalamic NF-κB expression. Beloranib significantly reduces food intake, body weight, and fat accumulation, while improving glucose tolerance, insulin sensitivity, and lipid metabolism. Beloranib also elevates energy expenditure and fat oxidation levels, without affecting body temperature, spontaneous activity, or the inflammatory cytokine IL-1β. Beloranib can be used in research on obesity and hypothalamic obesity .
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Other disease Ketones, Aldehydes, Acids Other Diseases Disease markers Endogenous metabolite Disease Research Fields
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Pigment blue 60 (Indanthrene) is an anthraquinone-based dye used as a model in studies of conjugated polymer degradation. Pigment blue 60 targets YfeX-like peroxidases, binds to the catalytic pocket, and undergoes oxidative cleavage. Pigment blue 60 serves as a carbon and energy source for Pseudomonas aeruginosa. Pigment blue 60 is efficiently removed and degraded by Pseudomonas aeruginosa .
Cat. No.: HY-14811A
CAS No.: 529511-79-3
Synonyms: ZGN-440 hemioxalate; ZGN-433 hemioxalate; CDK732 hemioxalate
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Beloranib (ZGN-440; CKD-732 free base) hemioxalate is a selective, irreversible inhibitor of methionine aminopeptidase MetAP2 that suppresses appetite and increases energy expenditure. Beloranib hemioxalate blocks the enzymatic cleavage of N-terminal methionine from nascent proteins by forming a covalent bond with MetAP2, thereby regulating fatty acid metabolism, adrenergic signaling, and hypothalamic NF-κB expression. Beloranib hemioxalate significantly reduces food intake, body weight, and fat accumulation, while improving glucose tolerance, insulin sensitivity, and lipid metabolism. Beloranib hemioxalate also elevates energy expenditure and fat oxidation levels, without affecting body temperature, spontaneous activity, or the inflammatory cytokine IL-1β. Beloranib hemioxalate can be used in research on obesity and hypothalamic obesity .
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Cat. No.: HY-W015464S1
CAS No.: 1219795-09-1
Cat. No.: HY-W015464R
CAS No.: 16284-60-9
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Cat. No.: HY-107852
CAS No.: 17040-19-6
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Demeton-S-methyl sulfone is an organophosphorus insecticide metabolite.Demeton-S-methyl sulfone serves as a substrate for metabolic breakdown.Demeton-S-methyl sulfone forms via oxidation of demeton S-methyl sulfoxide in sugar-beet cell suspension cultures.Demeton-S-methyl sulfone undergoes thioester bond cleavage, producing ethanethiols that convert into S-methylated compounds or S-glucosides .
Cat. No.: HY-D3461
CAS No.: 2770784-56-8
Cat. No.: HY-180786
CAS No.: 3085711-53-8
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DdBIC is a pyroptosis inducer. DdBIC binds to Nur77 and triggers its translocation to mitochondria, activates SDHA to deplete succinyl-CoA, disrupts heme homeostasis, induces electron leakage, and elicits mitochondrial ROS production. DdBIC induces mitochondrial ROS that oxidatively activates OMA1, promotes OPA1 cleavage and its release into the cytoplasm, activates the integrated stress response via PERK, and ultimately activates granzyme B to cleave GSDMC. DdBIC can be used for the study of melanoma .
Cat. No.: HY-D3401
CAS No.: 3121511-17-6
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LHA585 is a fluorescent probe targeting the lipid hydrogen abstraction process for the early detection of ferroptosis (Ferroptosis). Its detection mechanism relies on the reactivity of its own 4-phenyl-3-methylbut-2-enyl moiety with biologically relevant oxidative radicals, including peroxyl radicals (ROO·), alkoxyl radicals (RO·), hydroxyl radicals (HO·), and peroxynitrite anions (ONOO−); upon hydrogen abstraction from this structure, radical rearrangement and radical cleavage occur, releasing a xanthene radical which converts into a highly fluorescent rhodamine dye in biological environments, thereby achieving a fluorescence turn-on ratio of up to 360-fold. LHA585 is non-fluorescent in its native state, possesses excellent membrane permeability due to its non-polar property, and the rhodamine dye generated after oxidation diffuses into mitochondria. The excitation wavelength of LHA585 is 561 nm, and its emission wavelength ranges from 570 to 620 nm .
Cat. No.: HY-W015464S
CAS No.: 1330037-21-2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
