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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
p53 sequence
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "p53 sequence" in MCE Product Catalog:
3
3 Cited Publications
Cat. No.: HY-106262B
Purity: 99.73%
Synonyms: KAI-9803 hydrochloride; BMS-875944 hydrochloride
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Cat. No.: HY-P11212
CAS No.: 1193634-36-4
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P53R3 is a potent p53 reactivator and restores sequence-specific DNA binding of p53 hot spot mutants, including p53 R175H, p53 R248W and p53 R273H. P53R3 induces p53-dependent antiproliferative effects with much higher specificity than PRIMA-1. P53R3 enhances the recruitment of wild-type p53 and p53 M237I to several target gene promoters. P53R3 strongly enhances the mRNA, total protein and cell surface expression of the death receptor death receptor 5 (DR5). P53R3 is used for cancer research .
Cat. No.: HY-106262
CAS No.: 949100-39-4
Synonyms: KAI-9803; BMS-875944
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Cat. No.: HY-P3215
CAS No.: 19645-28-4
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Cat. No.: HY-P3222
CAS No.: 20054-93-7
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Cat. No.: HY-P5429
CAS No.: 146064-85-9
Cat. No.: HY-P10610A
Cat. No.: HY-P1286
CAS No.: 172308-76-8
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Cat. No.: HY-P10610
CAS No.: 155314-25-3
Cat. No.: HY-P10295
CAS No.: 155314-26-4
Cat. No.: HY-155991
CAS No.: 2893777-88-1
RUNX-IN-2 (Compound Conjugate 3) covalently binds to the RUNX-binding sequences, and inhibits the binding of RUNX proteins to their target sites. RUNX-IN-2 induces the p53-dependent apoptosis and inhibits cancer cell growth. RUNX-IN-2 inhibits tumor growth in PANC-1 xenograft mice. RUNX-IN-2 has high alkylation efficiency and specificity .
Cat. No.: HY-P1321
CAS No.: 158859-98-4
Synonyms: 1229U91; GW1229
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Cat. No.: HY-186151
CAS No.: 1372406-51-3
UCI-LC0019 is a mutant p53 reactivator. UCI-LC0019 binds to mutant p53, induces wild-type-like conformational change, restores sequence-specific DNA binding activity, activates p53-dependent transcription programs, and does not act via thiol reactivity or glutathione depletion. UCI-LC0019 inhibits proliferation and induces apoptosis in cancer cells harboring mutant p53, with no significant effect on p53 null or wild-type p53 tumors cells. UCI-LC0019 exhibits anti-tumor activity in xenograft mouse models carrying p53R175H mutant tumors. UCI-LC0019 can be used for the research of cancer, such as ovarian cancer .
Cat. No.: HY-P1286A
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
