2. Apoptosis
  3. MDM-2/p53
  4. PNC-28

PNC-28 is a peptide from the mdm-2-binding domain (residues 17–26) of the p53 protein which contains a membrane crossing-penetratin sequence. PNC-28 can be used for pancreatic cancer research.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

PNC-28

PNC-28 Chemical Structure

CAS No. : 392661-17-5

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Based on 1 publication(s) in Google Scholar

Other Forms of PNC-28:

PNC-28 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

PNC-28 is a peptide from the mdm-2-binding domain (residues 17–26) of the p53 protein which contains a membrane crossing-penetratin sequence. PNC-28 can be used for pancreatic cancer research[1][2].

In Vitro

PNC-28 (0-0.5 mg/mL) blocks growth of a lethal human pancreatic cancer cell line[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PNC-28 Related Antibodies

Cell Proliferation Assay[2]

Cell Line: MiaPaCa-2 human pancreatic carcinoma cells
Concentration: 0.1, 0.3, and 0.5 mg/mL
Incubation Time: daily
Result: Showed dependent induction of tumor cell death starting at 0.1 mg/ml.
In Vivo

PNC-28 (2 mg/mouse, SC or IP, for 14 days) blocks the growth of BMRPA1. Tuc3 cells in vivo[1].
PNC-28 (1-20 mg/mouse, SC, for 14 days) inhibits BMRPA1. Tuc3 tumor growth especially if delivered directly to the tumor [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic Nu/Nu mice (7–8 weeks, 22–24 g, injected i.p. with BMRPA1.Tuc3 cells)[1]
Dosage: 2 mg/mouse
Administration: Implanted s.c. or i.p., with 14 days mini-osmotic pumps releasing PNC-28 at a rate of 0.25 μl/hr
Result: No ascites was seen in the PNC-28-treated animals. strongly effective in inhibiting this particular tumor.
Animal Model: Athymic Nu/Nu mice (7–8 weeks, 22–24 g, injected i.p. with BMRPA1.Tuc3 cells)[1]
Dosage: 1 mg/mouse, 10 mg/mouse and 20 mg/mouse
Administration: When the tumors reached sizes from 40 to 260 mg/mouse, mini-osmotic pumps were implanted s.c. that released, over a period of 14 days
Result: Resulted in a significant level of tumor growth inhibition in a dose-related manner.
Molecular Weight

3509.13

Formula

C164H255N47O37S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

ETFSDLWKLLKKWKMRRNQFWVKVQRG
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (7.12 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2850 mL 1.4249 mL 2.8497 mL
5 mM 0.0570 mL 0.2850 mL 0.5699 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.2850 mL 1.4249 mL 2.8497 mL 7.1243 mL
5 mM 0.0570 mL 0.2850 mL 0.5699 mL 1.4249 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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PNC-28 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PNC-28392661-17-5PNC28PNC 28MDM-2/p53anti-tumorpancreatic cancer cellBMRPA1. TUC-3 cellsMiaPaCa-2lactate dehydrogenaseLDHascitesInhibitorinhibitorinhibit

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