Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
p53 variant
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "p53 variant" in MCE Product Catalog:
연구분야:
U7D-1 is a USP7 PROTAC degrader that induces selective proteasomal degradation of USP7. U7D-1 destabilizes and downregulates the expression of variant PRC1 complex subunits PCGF1, RING1A and PCGF6, and also slightly reduces the protein level of KDM2B. U7D-1 decreases cell viability, arrests neuroblastoma cells at the G0/G1 cell cycle phase, and downregulates the expression of target genes of PAX3::FOXO1 in FP-RMS cells. U7D-1 increases the level of cleaved PARP in FP-RMS cells, induces cell apoptosis, and upregulates the expression of muscle differentiation markers MYH1 and MYF5. U7D-1 inhibits the growth and proliferation of p53 wild-type and mutant cancer cells, and regulates the apoptosis pathway and E2F pathway. U7D-1 is applicable to studies on neuroblastoma, fusion-positive rhabdomyosarcoma, p53-mutant cancers and cancer-related research .
Cat. No.: HY-186091
CAS No.: 2097535-26-5
Target:
연구분야:
AcdK is a non-natural amino acid and a precursor of allysine. AcdK allows site-specific incorporation into target proteins in E. coli via the amber suppression strategy. AcdK enables site-specific lysine dimethylation or monomethylation modification of target proteins. AcdK can synthesize site-specific lysine-methylated variants of histone H3 and p53, which is applicable for investigating the substrate specificity and catalytic function of epigenetic enzymes .
Cat. No.: HY-P701593
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MDM2; MDM2 Oncogene, E3 Ubiquitin Protein Ligase; MDM2 Proto-Oncogene; Mdm2 p53 Binding Protein Homolog (Mouse); HDM2; p53-Binding Protein; E3 Ubiquitin-Protein Ligase Mdm2; MDM2 variant FB55; Oncoprotein Mdm2; MDM2 variant FB30; MDM2 Proto-Oncogene, E3 U
Species:
Human
Source:
E. coli
Cat. No.: HY-P701594
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MDM2; MDM2 Oncogene, E3 Ubiquitin Protein Ligase; MDM2 Proto-Oncogene; Mdm2 p53 Binding Protein Homolog (Mouse); HDM2; p53-Binding Protein; E3 Ubiquitin-Protein Ligase Mdm2; MDM2 variant FB55; Oncoprotein Mdm2; MDM2 variant FB30; MDM2 Proto-Oncogene, E3 U
Species:
Human
Source:
E. coli
Cat. No.: HY-P7307
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF10B; ZTNFR9; TNF Receptor Superfamily Member 10b; CDNA FLJ76289, Highly Similar To Homo Sapiens Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B), Transcript variant 1, MRNA; TRAIL-R2; p53-Regulated DNA Damage-Inducible Cell Death R
Species:
Human
Source:
HEK293
Cat. No.: HY-P70821
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF10B; ZTNFR9; TNF Receptor Superfamily Member 10b; CDNA FLJ76289, Highly Similar To Homo Sapiens Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B), Transcript variant 1, MRNA; TRAIL-R2; p53-Regulated DNA Damage-Inducible Cell Death R
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P74497
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF10B; ZTNFR9; TNF Receptor Superfamily Member 10b; CDNA FLJ76289, Highly Similar To Homo Sapiens Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B), Transcript variant 1, MRNA; TRAIL-R2; p53-Regulated DNA Damage-Inducible Cell Death R
Species:
Human
Source:
HEK293
Cat. No.: HY-P78220
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: TNFRSF10B; ZTNFR9; TNF Receptor Superfamily Member 10b; CDNA FLJ76289, Highly Similar To Homo Sapiens Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B), Transcript variant 1, MRNA; TRAIL-R2; p53-Regulated DNA Damage-Inducible Cell Death R
Species:
Human
Source:
HEK293
Cat. No.: HY-P71378
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF10B; ZTNFR9; TNF Receptor Superfamily Member 10b; CDNA FLJ76289, Highly Similar To Homo Sapiens Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B), Transcript variant 1, MRNA; TRAIL-R2; p53-Regulated DNA Damage-Inducible Cell Death R
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P72977
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF10B; ZTNFR9; TNF Receptor Superfamily Member 10b; CDNA FLJ76289, Highly Similar To Homo Sapiens Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B), Transcript variant 1, MRNA; TRAIL-R2; p53-Regulated DNA Damage-Inducible Cell Death R
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P74498
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF10B; ZTNFR9; TNF Receptor Superfamily Member 10b; CDNA FLJ76289, Highly Similar To Homo Sapiens Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B), Transcript variant 1, MRNA; TRAIL-R2; p53-Regulated DNA Damage-Inducible Cell Death R
Species:
Human
Source:
HEK293
Cat. No.: HY-P78363
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: TNFRSF10B; ZTNFR9; TNF Receptor Superfamily Member 10b; CDNA FLJ76289, Highly Similar To Homo Sapiens Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B), Transcript variant 1, MRNA; TRAIL-R2; p53-Regulated DNA Damage-Inducible Cell Death R
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P78530
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: TNFRSF10B; ZTNFR9; TNF Receptor Superfamily Member 10b; CDNA FLJ76289, Highly Similar To Homo Sapiens Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B), Transcript variant 1, MRNA; TRAIL-R2; p53-Regulated DNA Damage-Inducible Cell Death R
Species:
Human
Source:
HEK293
Cat. No.: HY-P78567
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF10B; ZTNFR9; TNF Receptor Superfamily Member 10b; CDNA FLJ76289, Highly Similar To Homo Sapiens Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B), Transcript variant 1, MRNA; TRAIL-R2; p53-Regulated DNA Damage-Inducible Cell Death R
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P70806
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF10B; ZTNFR9; TNF Receptor Superfamily Member 10b; CDNA FLJ76289, Highly Similar To Homo Sapiens Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B), Transcript variant 1, MRNA; TRAIL-R2; p53-Regulated DNA Damage-Inducible Cell Death R
Species:
Human
Source:
HEK293
Cat. No.: HY-P72779
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF10B; ZTNFR9; TNF Receptor Superfamily Member 10b; CDNA FLJ76289, Highly Similar To Homo Sapiens Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B), Transcript variant 1, MRNA; TRAIL-R2; p53-Regulated DNA Damage-Inducible Cell Death Receptor(Killer); TRAILR2; Tumor Necrosis Factor Receptor-Like Protein ZTNFR9; KILLER; Death Domain Containing Receptor For TRAIL/Apo-2L; DR5; Apoptosis Inducing Protein TRICK2A/2B; Tumor Necrosis Factor Receptor Superfamily, Member 10b; Apoptosis Inducing Receptor TRAIL-R2; Tumor Necrosis Factor Receptor Superfamily Member 10B; Cytotoxic TRAIL Receptor-2; TRICK2A; TNFRSF10B Protein; TRICKB; Fas-Like Protein; CD262; TRAIL Receptor 2; TNF-Related Apoptosis-Inducing Ligand Receptor 2; CD262 Antigen; Death Receptor 5; KILLER/DR5; TRICK2; TRICK2B
Species:
Human
Source:
E. coli
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
