6 Results for "

parthanatos

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "parthanatos" in MCE Product Catalog:

4
4'-O-Methylbavachalcone
4'-O-Methylbavachalcone
0 Images
4 Cited Publications
Cat. No.: HY-N1910
CAS No.: 20784-60-5
Category:  

Infection Flavonoids Chalcones Leguminosae Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields

Target:  

SARS-CoV Virus Protease Succinate Receptor 1 ERK

4'-O-Methylbavachalcone is an orally active prenylated flavonoid that inhibits the activity of SARS-CoV papain-like protease (PLpro), with an IC50 of 10.1 μM and a Ki of 4.6 μM. 4'-O-Methylbavachalcone inhibits poly (ADP-ribose) polymerase-mediated cell death (parthanatos), reduces cerebral infarct volume, binds to the orthosteric site of SUCNR1, blocks the interaction between succinate and SUCNR1, inhibits SUCNR1 activity, blocks the nuclear translocation of NFATc4, suppresses the activation of the ERK1/2 signaling pathway, inhibits cardiomyocyte hypertrophy and restores the expression of α-actinin. 4'-O-Methylbavachalcone can be used in studies related to ischemic stroke, SARS-CoV and cardiomyocyte hypertrophy .
loading...
    loading...
View All Sizes
1
3',4'-Dimethoxyflavone
3',4'-Dimethoxyflavone
0 Images
1 Cited Publications
Cat. No.: HY-N8572
CAS No.: 4143-62-8
Category:  

other families Flavonoids Flavones Coniogramme japonica (Thunb.) Diels Plants

Target:  

PARP Reactive Oxygen Species (ROS) Aryl Hydrocarbon Receptor

3',4'-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3',4'-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3',4'-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3',4'-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3',4'-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects .
loading...
    loading...
View All Sizes
MKA031
MKA031
0 Images
Cat. No.: HY-149308
CAS No.: 2951012-00-1
Purity:  98.69%
Target:  

Macrophage migration inhibitory factor (MIF)

Research Areas:  

Infection

MKA031 (compound 6y) is a non-competitive MIF inhibitor with an IC50 value of 1.7 μM. MKA031 (compound 6y) interferes with MIF/AIF interaction, MIF nuclear translocation, and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced dependent cell death. MKA031 can be used in the study of chronic hepatitis C virus infection .
loading...
    loading...
View All Sizes
3',4'-Dimethoxyflavone (Standard)
3',4'-Dimethoxyflavone (Standard)
0 Images
Cat. No.: HY-N8572R
CAS No.: 4143-62-8
Category:  

other families Flavonoids Flavones Coniogramme japonica (Thunb.) Diels Plants

Target:  

Reference Standards PARP Reactive Oxygen Species (ROS) Aryl Hydrocarbon Receptor

3',4'-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3',4'-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3',4'-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3',4'-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3',4'-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects .
loading...
    loading...
View All Sizes
PAANIB-1
PAANIB-1
0 Images
Cat. No.: HY-182935
CAS No.: 2634726-71-7
Target:  

Macrophage migration inhibitory factor (MIF)

Research Areas:  

Neurological Disease

PAANIB-1 is a parthanatos associated apoptosis-inducing factor nuclease (PAAN)/macrophage migration inhibitor factor (MIF) inhibitor. PAANIB-1 exhibits neuroprotective activity. PAANIB-1 can be used for the research of Parkinson's disease .
loading...
    loading...
View All Sizes
PROTAC MLKL Degrader-3
PROTAC MLKL Degrader-3
0 Images
Cat. No.: HY-182343
Target:  

PROTACs Mixed Lineage Kinase PARP

Research Areas:  

Cancer

PROTAC MLKL Degrader-3 is a MLKL PROTAC degrader with DC50 values of 248.9 nM (Hepa1-6) and 271.3 nM (HepG2), respectively. PROTAC MLKL Degrader-3 induces proteasome- and cereblon-dependent MLKL degradation via ubiquitination. PROTAC MLKL Degrader-3 reduces intratumoral MLKL levels and inhibits tumor growth in mice. PROTAC MLKL Degrader-3 can be used in the research of hepatocellular carcinoma .
loading...
    loading...
View All Sizes
Assay Types