Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
39 Results for "
peptidoglycan synthesis
" in MedChemExpress (MCE) Product Catalog:
Products (39)
39 Results for "peptidoglycan synthesis" in MCE Product Catalog:
8
Research Areas:
Methicillin sodium salt (Meticillin sodium) is a β-lactam, semi-synthetic antibiotic related to penicillin antibiotic. Methicillin sodium salt inhibits penicillin-binding proteins involved in the synthesis of peptidoglycan. Methicillin sodium salt inhibits S. aureus with a MIC value of 2.1 μg/mL. Methicillin sodium salt can be used for the research of inflammation .
6
Research Areas:
Ceftiofur sodium is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur sodium exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur sodium also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 .
6
6 Cited Publications
Cat. No.: HY-N7102
CAS No.: 80370-57-6
Research Areas:
Ceftiofur is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 .
6
6 Cited Publications
Cat. No.: HY-B0026
CAS No.: 103980-44-5
Research Areas:
Ceftiofur hydrochloride is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur hydrochloride exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur hydrochloride also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 .
5
Target:
Research Areas:
Cephalothin (Cephalotin) sodium is a semi-synthetic cephalosporin antibiotic and beta-lactam antibiotic. Cephalothin inhibits class C β-lactamase AmpC, with an Ki of 0.32 µM. Cephalothin sodium binds to penicillin-binding proteins, interfering with the cross-linking of peptidoglycan in the cell wall and thus hindering the normal synthesis of the bacterial cell wall. Cephalothin sodium shows antibacterial activity against a variety of bacteria. Cephalothin sodium can be used in hematological and nephrotoxicity studies .
5
Target:
Research Areas:
Cephalothin (Cephalotin) is a semi-synthetic cephalosporin antibiotic and beta-lactam antibiotic. Cephalothin inhibits class C β-lactamase AmpC, with an Ki of 0.32 µM. Cephalothin binds to penicillin-binding proteins, interfering with the cross-linking of peptidoglycan in the cell wall and thus hindering the normal synthesis of the bacterial cell wall. Cephalothin shows antibacterial activity against a variety of bacteria. Cephalothin can be used in hematological and nephrotoxicity studies .
1
1 Cited Publications
Synonyms: T-91825; PPI-0903M
Target:
Research Areas:
Ceftaroline (T-91825) is a cephalosporin compound and the active form of Ceftaroline fosamil (HY-14737). Ceftaroline exhibits activity against Gram-positive bacteria, Gram-negative bacteria, and some anaerobic bacteria. Ceftaroline binds to penicillin-binding proteins 2 and 2A, thereby inhibiting the synthesis of bacterial peptidoglycan and cell wall, and acts as a bactericide, synergist, and resistance inhibitor. Ceftaroline can be used in research related to complicated skin and soft tissue infections, community-acquired pneumonia, Enterococcus faecalis infective endocarditis, and bacterial infections .
1
1 Cited Publications
Cat. No.: HY-B1924
CAS No.: 213997-73-0
Synonyms: N-Demethylvancomycin monohydrochloride; NVCM monohydrochloride
Norvancomycin hydrochloride is a cell wall synthesis inhibitor targeting peptidoglycan precursors of Gram-positive bacteria and cannot pass the blood-brain barrier. Norvancomycin hydrochloride can competitively bind to peptidoglycan precursors, irreversibly inhibit bacterial cell wall synthesis, and exert antibacterial activity. Norvancomycin hydrochloride is mainly used in the study of Gram-positive bacterial infections, especially infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE). Norvancomycin hydrochloride can also be incorporated into the bionic calcium phosphate coating of titanium implants to enhance antibacterial activity and inhibit postoperative orthopedic infections .
1
1 Cited Publications
Cat. No.: HY-B1596
CAS No.: 68401-81-0
Target:
Research Areas:
Ceftizoxime is a bacterial inhibitor which acts by interfering with bacterial cell wall synthesis and inhibiting cross-linking of the peptidoglycan.
1
Target:
Research Areas:
Telavancin hydrochloride (TD-6424 hydrochloride) is a bactericidal agent that exhibits inhibitory activity against Staphylococcus aureus. Telavancin hydrochloride inhibits bacterial cell wall synthesis by binding to the lipid-linked N-acetylglucosamine-N-muramyl pentapeptide (with a D-Ala-D-Ala terminus), a peptidoglycan precursor, and blocks the transglycosylation and transpeptidation steps. Telavancin hydrochloride disrupts bacterial membrane barrier function, induces dissipation of bacterial membrane potential, and causes leakage of cytoplasmic ATP and potassium ions, with its activity restricted exclusively to bacterial membranes. Telavancin hydrochloride can be used in research on bacterial infections, central venous catheter-related bloodstream infections, and Gram-positive bacterial pneumonia .
1
1 Cited Publications
Cat. No.: HY-105049A
Target:
Research Areas:
Ceftaroline hydrochloride is a cephalosporin compound and the active form of Ceftaroline fosamil (HY-14737). Ceftaroline hydrochloride exhibits activity against Gram-positive bacteria, Gram-negative bacteria, and some anaerobic bacteria. Ceftaroline hydrochloride binds to penicillin-binding proteins 2 and 2A, thereby inhibiting the synthesis of bacterial peptidoglycan and cell wall, and acts as a bactericide, synergist, and resistance inhibitor. Ceftaroline hydrochloride can be used in research related to complicated skin and soft tissue infections, community-acquired pneumonia, Enterococcus faecalis infective endocarditis, and bacterial infections .
Target:
Cat. No.: HY-N9459
CAS No.: 1078691-95-8
Synonyms: D-Glucosamine Hydrochloride
Target:
Target:
Research Areas:
Cat. No.: HY-N7101
CAS No.: 87239-81-4
Synonyms: U-76,252; CS-807
Research Areas:
Cefpodoxime Proxetil is an orally active broad spectrum third-generation cephalosporin with potent antibacterial activity against both Gram-positive and Gram-negative bacteria including staphylococci, streptococci, Haemophilus influenzae, Neisseria gonorrhoeae, Escherichia coli, Klebsiella pnuemoniae, Citrobacter spp, and Proteus spp. Cefpodoxime Proxetil binds to penicillin binding proteins (PBPs), which inhibits peptidoglycan synthesis, finally results in interfering bacterial cell wall biosynthesis. Cefpodoxime Proxetil can be used against skin structure infections, acute otitis media, pharyngitis, tonsillitis, upper respiratory tract infection, urinary tract infections and sexually transmitted diseases .
Synonyms: 3-Succinylated cholic acid
Target:
Research Areas:
3-sucCA is an orally available bacterial bile acid that exerts anti-MASH effects by promoting the growth of Akkermansia muciniphila. By remodeling the intestinal microbiota and promoting the growth of Akkermansia, 3-sucCA can improve intestinal barrier damage and reduce chronic low-level inflammation, thereby alleviating the progression of metabolic dysfunction-associated steatohepatitis (MASH). 3-sucCA accelerates the synthesis of cell wall peptidoglycan and has in vivo efficacy in the mouse MAFL-MASH model. 3-sucCA levels are low in the MAFLD model and are mainly used in the study of MASH .
Cat. No.: HY-135532
CAS No.: 74469-00-4
Target:
Research Areas:
Amoxicillin-clavulanate potassium is an orally active antibacterial composition consisting of Amoxicillin (HY-B0467A) and the β-lactamase inhibitor Clavulanate potassium (HY-A0256A). In Amoxicillin-clavulanate potassium, Amoxicillin binds to bacterial penicillin-binding proteins to inhibit peptidoglycan synthesis and exert a bactericidal effect; Clavulanate potassium protects Amoxicillin from hydrolysis by β-lactamase. Amoxicillin-clavulanate potassium exhibits antibacterial activity against β-lactamase-producing Gram-positive and Gram-negative bacteria. Amoxicillin-clavulanate potassium dose-dependently interferes with the function of ameloblasts at the maturation stage, disrupts the enamel mineralization process, and induces enamel developmental defects. Amoxicillin-clavulanate potassium can be used in research related to bacterial infections .
Cat. No.: HY-W587753
CAS No.: 22601-59-8
Target:
Research Areas:
Target:
Research Areas:
A40926 is a glycopeptide antibiotic that targets the bacterial cell wall peptidoglycan precursor D-alanyl-D-alanine (D-Ala-D-Ala). A40926 irreversibly inhibits cell wall synthesis by competitively binding to this target, and has high bactericidal activity against Gram-positive bacteria (such as Staphylococcus, Streptococcus) and Neisseria gonorrhoeae, with MIC=0.06-2 μg/mL, and is also effective against penicillin-resistant strains. A40926 blocks peptidoglycan cross-linking, destroys cell wall integrity, and causes bacterial lysis and death. A40926 has a fat-soluble fatty acid structure, which can increase serum concentrations and prolong the duration of action (e.g., the terminal half-life in rats is 61.22 h) .
CDFI is an antibacterial agent that targets the bacterial cell wall. CDFI inhibits the lipid II flippase MurJ in the peptidoglycan synthesis pathway. CDFI can be used for the research of Staphylococcus aureus infections .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
